Research Topics
Genomes and Genes
| Neil SmythSummaryAffiliation: University of Cologne Country: Germany Publications
| Collaborators
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Detail Information
Publications
Role of brain insulin receptor in control of body weight and reproductionJ C Bruning
Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
Science 289:2122-5. 2000..Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction...- Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasisSabine D Jordan
Department of Mouse Genetics and Metabolism, Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
Cell Mol Life Sci 67:3255-73. 2010.... - Basement membranes in skin are differently affected by lack of nidogen 1 and 2Sharada Mokkapati
Department of Dermatology, University of Cologne, Cologne, Germany
J Invest Dermatol 128:2259-67. 2008..In summary, our results indicate that in skin the laminin composition of the various BMs determines whether nidogens are required for their assembly and stabilization... - The ablation of the Ca(v)2.3/E-type voltage-gated Ca2+ channel causes a mild phenotype despite an altered glucose induced glucagon response in isolated islets of LangerhansAlexey Pereverzev
Institute of Neurophysiology, University of Cologne, Robert Koch Str 39, D 50931 Köln, Germany Center of Molecular Medicine Cologne, University of Cologne, Robert Koch Str 39, D 50931 Köln, Germany
Eur J Pharmacol 511:65-72. 2005..This was most obvious at the level of isolated islets suggesting that Ca(v)2.3 containing R-type voltage-gated Ca2+ channels are involved in the glucose-mediated signalling to glucagon release in mice... - Loss of nidogen-1 and -2 results in syndactyly and changes in limb developmentKerstin Böse
Center for Biochemistry and Center for Molecular Medicine, Medical Faculty, University of Cologne, D 50924 Cologne, Germany
J Biol Chem 281:39620-9. 2006..Further, in certain animals more severe changes in bone formation occur, providing evidence for the interplay between growth factors and the extracellular matrix... - Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitabilityAnju Vasudevan
Center for Biochemistry and Center for Molecular Medicine Cologne, University of Cologne, Joseph Stelzmann Str 52, 50931 Koln, Germany
Hippocampus 20:608-20. 2010..Nidogen-1 is thus essential for normal network excitability and plasticity... - Nidogens-Extracellular matrix linker moleculesMatthew S P Ho
Center for Biochemistry and Center for Molecular Medicine, Medical Faculty, University of Cologne, D 50924 Cologne, Germany
Microsc Res Tech 71:387-95. 2008..A number of studies, most compellingly those in C. elegans, demonstrated that nidogens may have other nonstructural roles and be involved in axonal pathfinding and synaptic transmission... - Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic cocultureRoswitha Nischt
Department of Dermatology, University of Cologne, Cologne, Germany
J Invest Dermatol 127:545-54. 2007.... - Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformationsMarkus Schmitz
Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
Matrix Biol 27:67-85. 2008..Later in development, the growth plate was irregularly shaped and prematurely invaded by bony tissue. In addition, a fusion of the third and fourth sternebrae was frequently observed... - Binding of netrin-4 to laminin short arms regulates basement membrane assemblyFiona I Schneiders
Center for Biochemistry, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
J Biol Chem 282:23750-8. 2007..When added to explant cultures, netrin-4 retards salivary gland branching morphogenesis... - Eukaryotic expression and purification of recombinant extracellular matrix proteins carrying the strep II tagNeil Smyth
University of Cologne, Cologne, Germany
Methods Mol Biol 522:63-72. 2009..Second, most ECM proteins are at least to some extent glycosylated and often heavily so, and the use of the mammalian system offers the best approximation to the sugar structures present in the native form of the molecule... - PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasisAndre Kleinridders
Institute for Genetics, Department of Mouse Genetics and Metabolism, University of Cologne, Cologne, Germany
Mol Cell Biol 29:3173-85. 2009..Taken together, the results of this study identify PLRG1 as a critical nuclear regulator of p53-dependent cell cycle progression and apoptosis during both embryonic development and adult tissue homeostasis... - Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in miceBernhard L Bader
Department of Dermatology, University of Cologne, 50924 Cologne, Germany
Mol Cell Biol 25:6846-56. 2005..However, despite the ubiquitous presence of nidogens in basement membranes, defects do not occur in all tissues or in all basement membranes, suggesting a varying spectrum of roles for nidogens in the basement membrane... - Antifibrotic, nephroprotective potential of ACE inhibitor vs AT1 antagonist in a murine model of renal fibrosisOliver Gross
Medical Faculty University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
Nephrol Dial Transplant 19:1716-23. 2004..We used this animal model to compare the potential of ACE inhibitor vs AT1 antagonist to prevent renal fibrosis irrespective of blood pressure-dependent involvement by the renin system... - Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channelsAlexey Pereverzev
Institute of Neurophysiology, University of Cologne, D 50931 Köln, Germany
Mol Endocrinol 16:884-95. 2002..3-deficient mice has dual components related to endocrine and neurological defects. The present findings provide direct evidence of a functional role for the Ca(v)2.3 subunit in hormone secretion and glucose homeostasis... - Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularizationIrina Semkova
Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
FASEB J 20:1689-91. 2006..The specific overexpression of FasL in RPE layer reduced CNV formation in our laser model. Our results strongly point to the FasL-Fas pathway as a potential therapeutic target in controlling pathological choroidal neovascularization... - Plastin 1 binds to keratin and is required for terminal web assembly in the intestinal epitheliumEva Maria S Grimm-Günter
Center for Biochemistry, Medical Faculty, University of Cologne, D 50931 Cologne, Germany
Mol Biol Cell 20:2549-62. 2009.... - Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1Michael Tscharntke
Department of Dermatology, University of Cologne, Center for Molecular Medicine, CMMC, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
J Cell Sci 120:1480-90. 2007..We conclude that Rac1 is functionally required for normal epidermal wound healing and, in this context, exerts a dual function - namely the regulation of keratinocyte proliferation and migration... - Molecular analysis of laminin N-terminal domains mediating self-interactionsUwe Odenthal
Center for Biochemistry and Center for Molecular Medicine, Faculty of Medicine, University of Cologne, Joseph-Stelzmann-Strasse 52, Cologne D-50931, Germany
J Biol Chem 279:44504-12. 2004.... - DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuriaOliver Gross
Medical Faculty, University of Cologne, Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
Kidney Int 66:102-11. 2004..The interaction between type IV collagen and cell surface receptors is believed important for normal renal function as well as significant in chronic renal diseases and we therefore analyzed mice with a targeted deletion of DDR1...