Research Topics
Genomes and GenesSpecies | Matthias SimonSummaryAffiliation: University of Bonn Country: Germany Publications
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Publications
Alternative splicing of the p15 cdk inhibitor in glioblastoma multiformeM Simon
Neurochirurgische Klinik, Universitatskliniken Bonn, Germany
Acta Neuropathol 102:167-74. 2001..This novel mechanism of loss of p15 might complement alterations of the INK4a tumor suppressor gene in some glioblastomas, resulting in combined loss of p16, p15 and p14ARF...- Interinstitutional variance of postoperative radiotherapy and follow up for meningiomas in Germany: impact of changes of the WHO classificationM Simon
Neurochirurgische Universitatsklinik, Sigmund Freud Str 25, 53105 Bonn
J Neurol Neurosurg Psychiatry 77:767-73. 2006..To document and critically analyse the impact of the revised WHO 2000 histological classification for meningiomas on postoperative radiotherapy/radiosurgery indications and MRI follow up protocols... - Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomasMatthias Simon
Neurochirurgische Universitatsklinik, D 53105 Bonn, Germany
Oncol Rep 16:127-32. 2006..We would like to point out that such candidate genes which may code for potent growth suppressors (like p16) or even toxic gene products can be successfully investigated using the approach detailed in this manuscript... - Genetic risk profiles identify different molecular etiologies for gliomaMatthias Simon
Neurochirurgische Klinik, Universitatskliniken Bonn, Bonn, Germany
Clin Cancer Res 16:5252-9. 2010..Because gliomas are heterogeneous in histology, molecular alterations, and clinical behavior, we have investigated these polymorphisms for potential correlations with tumor histology and patient survival... - Variant of the CHEK2 gene as a prognostic marker in glioblastoma multiformeMatthias Simon
Department of Neurosurgery, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Neurosurgery 59:1078-85; discussion 1085. 2006..Patients with LFS experience a variety of cancers, including malignant astrocytomas. We investigated a potential role for a CHEK2 gene polymorphism in glioblastomas... - Conditional expression of the tumor suppressor p16 in a heterotopic glioblastoma model results in loss of pRB expressionMatthias Simon
Neurochirurgische Klinik, Universitat Bonn, Germany
J Neurooncol 60:1-12. 2002..Loss of pRB following p16 expression might severely limit the potential benefit of p16 gene therapy for glioblastoma... - Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progressionM Simon
Neurochirurgische Universitatsklinik, Bonn, Germany
J Neurooncol 55:149-58. 2001..Inactivation of p16/p15- and pl4ARF-dependent pathways possibly in conjunction with telomerase activation might be critical steps for a meningioma cell towards escape from senescence, that is, immortalization... - Surgical management of intracranial gliomasMatthias Simon
Department of Neurosurgery, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
Recent Results Cancer Res 171:105-24. 2009..There will be an increasing pressure on neurosurgeons to justify the costs involved by showing that patients will actually benefit from complex treatments in highly specialized centers... - Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous systemMatthias Simon
Neurochirurgische Klinik and Institut für Klinische Biochemie, Universitatskliniken Bonn, Germany
J Neurosurg 104:945-9. 2006..The authors studied whether sequence variations in ACVRL1 or ENG are associated with the development of clinically sporadic arteriovenous dysplasias and aneurysms of the CNS... - Polymorphisms of homocysteine metabolism are associated with intracranial aneurysmsAlexander Semmler
Department of Neurology, University of Bonn, Bonn, Germany
Cerebrovasc Dis 26:425-9. 2008..We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms... - Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient populationDelia Kurzwelly
Division of Clinical Neurooncology, Department of Neurology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
J Neurooncol 100:187-92. 2010..Our results suggest the hypothesis that folate and methionine metabolism is relevant to susceptibility to PCNSL... - NOA-05 phase 2 trial of procarbazine and lomustine therapy in gliomatosis cerebriMartin Glas
Division of Clinical Neuro oncology, Department of Neurology, University of Bonn Medical Center, Bonn, Germany
Ann Neurol 70:445-53. 2011.... - The methylenetetrahydrofolate reductase (MTHFR) variant c.677C>T (A222V) influences overall survival of patients with glioblastoma multiformeMichael Linnebank
University Hospital Bonn, Department of Neurology, Bonn, Germany
Neuro Oncol 10:548-52. 2008..89, p = 0.015). These data suggest the MTHFR c.677C>T variant is a risk factor for survival in GBM patients... - Combined surgery, radiation, and PCV chemotherapy for astrocytomas compared to oligodendrogliomas and oligoastrocytomas WHO grade IIIRudolf A Kristof
Department of Neurosurgery, University of Bonn, Germany
J Neurooncol 59:231-7. 2002..This is in accordance with results in patients treated by surgery with adjuvant radiation alone. The efficacy of additional adjuvant PCV chemotherapy in prolonging TTP and TTD has to be verified in prospective controlled studies... - Association of genetic variants of methionine metabolism with methotrexate-induced CNS white matter changes in patients with primary CNS lymphomaMichael Linnebank
University Hospital Bonn, Department of Neurology, Bonn, Germany
Neuro Oncol 11:2-8. 2009..73; p < 0.001), in addition to male gender (chi(2) = 11.95; p = 0.001). These data strengthen the hypothesis that MTX effects are influenced by methionine metabolism, which may offer new strategies to improve MTX-based therapies... - Tumor recurrence and malignant progression of gangliogliomasMichael Majores
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Cancer 113:3355-63. 2008..Most gangliogliomas (GGs) are benign tumors, but tumor recurrence and malignant progression are observed in some patients... - Insular gliomas: the case for surgical managementMatthias Simon
Neurochirurgische Klinik, Universitatskliniken Bonn, Klinikum rechts der Isar, Munchen, Germany
J Neurosurg 110:685-95. 2009..Treatment for insular (paralimbic) gliomas is controversial. In this report the authors summarize their experience with microsurgical resection of insular tumors... - Surgery for spinal cord ependymomas: outcome and prognostic factorsAzize Boström
Department of Neurosurgery University Hospital Bonn Medical Center, Bonn, Germany
Neurosurgery 68:302-8; discussion 309. 2011..Spinal cord tumors account for 5% to 10% of all primary central nervous system tumors. The most common intramedullary neoplasms are ependymomas, composing 50% to 60% of spinal neuroepithelial tumors in adults... - Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutationAchim Temme
Department of Neurosurgery, Section Experimental Neurosurgery Tumor Immunology, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
J Neuropathol Exp Neurol 69:632-42. 2010..These results suggest that loss of p53 function and dysregulated Aurora B protein levels might represent factors that drive the development of multinucleated cells in gcGB... - uPA/PAI-1 expression and uPA promoter methylation in meningiomasJulia Annabel Kandenwein
Neurochirurgische Klinik, Universitatskliniken Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
J Neurooncol 103:533-9. 2011..Our data suggest PAI-1 (and possibly to a lesser degree uPA) as potential prognostic markers in meningiomas. uPA expression in meningiomas might, in part, be controlled by promoter methylation... - Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitroCéline Lugnier
Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, Bonn, Germany
J Neuropathol Exp Neurol 68:1136-46. 2009..Future studies will be needed to characterize the roles of these TSC1 sequence variants in the genesis of dysplastic epileptogenic developmental brain lesions... - Long-term survival with glioblastoma multiformeDietmar Krex
Department of Neurosurgery, Carl Gustav Carus University Hospital, University of Technology, Dresden, Germany
Brain 130:2596-606. 2007.... - Frequent recurrence and progression in pilocytic astrocytoma in adultsCarsten Stuer
Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany
Cancer 110:2799-808. 2007..To the authors' knowledge, the literature contains only scarce data regarding piloA in adults... - Surgical treatment of choroid plexus tumorsAzize Boström
Department of Neurosurgery, University Hospital of Bonn Medical Center, Germany
Acta Neurochir (Wien) 153:371-6. 2011..The purpose of this study is to evaluate the results of microsurgical treatment for choroid plexus tumors (CPT) in adult patients... - The diagnostic utility of human papillomavirus-testing in combination with immunohistochemistry in advanced gynaecologic pelvic tumours: a new diagnostic approachTjoung Won Park
Departmetn of Obstetrics and Gynaecology, University of Bonn, D 53105 Bonn, Germany
Int J Oncol 24:829-36. 2004..The proposed diagnostic approach is helpful in the identification and management of pelvic tumours of unknown primary origin... - Residual tumor cells are unique cellular targets in glioblastomaMartin Glas
Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Germany
Ann Neurol 68:264-9. 2010..Our findings suggest a need for characterization of residual tumor cells to optimize diagnosis and treatment of GBM... - Telomerase activity and expression of the telomerase catalytic subunit, hTERT, in meningioma progressionM Simon
Neurochirurgische Universitätsklinik und Neuropathologisches Institut der Universität, Bonn, Germany
J Neurosurg 92:832-40. 2000..The authors have investigated a series of benign, atypical, and anaplastic/malignant meningiomas for telomerase activity and expression of the telomerase catalytic subunit human telomerase reverse transcriptase (hTERT)... - Stroke prevention during surgery for deep-seated gliomasG Neuloh
Department of Neurosurgery, University of Bonn, 53105 Bonn, Germany
Neurophysiol Clin 37:383-9. 2007..This study determines the feasibility and clinical utility of MEP monitoring for ischemic complication avoidance during surgery for deep-seated, specifically insular gliomas... - Functional evidence for a role of combined CDKN2A (p16-p14(ARF))/CDKN2B (p15) gene inactivation in malignant gliomasM Simon
Neurochirurgische Klinik, Universitatskliniken Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Acta Neuropathol 98:444-52. 1999..Therefore, homozygous co-deletions of CDKN2A and CDKN2B rather than mutations targeting individual transcripts are frequently selected for in these tumors... - Low-grade gliomas -- current conceptsJ Schramm
Department of Neurosurgery, University of Bonn, Bonn, Germany
Zentralbl Neurochir 67:55-66. 2006..e., classification and neuropathology, MR imaging, stereotactic biopsy, microsurgery, interstitial radiotherapy/brachytherapy, radiotherapy, wait and see strategy)... - The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiformeAlexander Semmler
Department of Neurology, University Hospital Bonn, Sigmund Freud Strasse, 25, 53105 Bonn, Germany
Cancer Epidemiol Biomarkers Prev 15:2314-6. 2006..72/0.26/0.02 and controls AA/AG/GG: 0.57/0.38/0.05, degrees of freedom = 2; chi(2) = 17.86 (Pearson); P < 0.001]. No association between glioblastoma multiforme and the two other polymorphisms was observed... - Computer-based assessment of cognitive functions in brain tumor patientsKlaus Fliessbach
Department of Epileptology, University of Bonn, Bonn, Germany
J Neurooncol 100:427-37. 2010..It can be carried out within a short period of time by non-academic personnel and is therefore applicable to large cohorts, e.g., within clinical trials... - Comparative analysis of the NF2, TP53, PTEN, KRAS, NRAS and HRAS genes in sporadic and radiation-induced human meningiomasT Joachim
Department of Neuropathology, University of Bonn Medical Center, Bonn, Germany
Int J Cancer 94:218-21. 2001..Our data suggest that, while there is a certain overlap in the mutational spectrum, NF2 mutations may not play such a prominent role in the pathogenesis of radiation-induced compared to sporadic meningiomas... - Richter syndrome and brain involvement: low-grade lymphoma relapsing as cerebral high-grade lymphomaMoritz Stuplich
Department of Neurology, Division of Clinical Neurooncology, University of Bonn Medical Center, Germany
Acta Haematol 127:93-5. 2012..This report extends the literature of central nervous system RS and particularly highlights the importance of a thorough diagnostic evaluation of patients with low-grade NHL presenting with neurological symptoms... - Surgical management of intracranial subependymomasJulia Annabel Kandenwein
Neurochirurgische Klinik, Universitatskliniken Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Acta Neurochir (Wien) 153:1469-75. 2011..Intracranial subependymomas are rare, slow-growing and usually non-invasive tumors. The aim of this study was to analyze our experience with the surgical treatment of intracranial subependymomas... - Activation of Akt independent of PTEN and CTMP tumor-suppressor gene mutations in epilepsy-associated Taylor-type focal cortical dysplasiasVolker Schick
Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, 53105, Bonn, Germany
Acta Neuropathol 112:715-25. 2006..Future studies need to determine the origin of insulin pathway activation upstream of TSC1/TSC2 in FCD(IIb)... - Seizures in patients with low-grade gliomas--incidence, pathogenesis, surgical management, and pharmacotherapyD Kurzwelly
Schwerpunkt Klinische Neuroonkologie, Neurologische Klinik, Universitatskliniken Bonn, Bonn, Germany
Adv Tech Stand Neurosurg 35:81-111. 2010..Overall 60-70% of patients may experience recurrent epilepsy during long-term follow-up. Recurrent seizures (not infrequently heralding tumor recurrence) after surgery continue to pose significant clinical problems... - Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesionsV Schick
Department of Neuropathology, University of Bonn Medical Centre, Bonn, Germany
Neuropathol Appl Neurobiol 33:152-62. 2007..However, a potential functional significance of lower expression for the cell-size and cell-cycle regulators CDK1 and cyclinA2 in FCD(IIb) composed of large dysplastic neurones and balloon cells needs to be further resolved... - Diagnostic and molecular pathology of meningiomasChristian Hartmann
Institut für Neuropathologie der Charité, Augustenburger Platz 1, 13353 Berlin, Germany
Expert Rev Neurother 6:1671-83. 2006..Implementing these advances in our daily clinical routine holds the promise of improving diagnostic accuracy... - Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?Michael Weller
Department of General Neurology, University of Tubingen, Tubingen, Germany
Clin Cancer Res 13:6933-7. 2007..Importantly, the possible effect of combined 1p/19q loss has not been studied in patients who were not treated with radiotherapy or chemotherapy... - NF2 mutations in secretory and other rare variants of meningiomasChristian Hartmann
Department of Neuropathology, Charite, Universitatsmedizin Berlin, Germany
Brain Pathol 16:15-9. 2006..In the control group of 25 fibroblastic meningiomas, 11 cases were identified to carry an NF2 mutation. These results support the concept of different molecular subgroups of meningiomas which overlap with histological variants... - Polymorphisms of methionine metabolism and susceptibility to meningioma formation: laboratory investigationAlexander Semmler
Department of Neurology, University Hospital of Bonn, Germany
J Neurosurg 108:999-1004. 2008..The authors investigated the association of 7 functional polymorphisms of methionine metabolism with meningioma formation... - Fine mapping of chromosome 22q tumor suppressor gene candidate regions in astrocytomaChristian Hartmann
Department of Neuropathology, Charit, Campus Virchow Klinikum, Humboldt University, Augustenburgerplatz 1, D-13353 Berlin, Germany
Int J Cancer 108:839-44. 2004..We already performed mutation analysis on 4 candidate genes from these regions (MYO18B, DJ1042K10.2, MKL1 and EP300), but did not find any mutations in astrocytic tumors... - Comprehensive characterization of genomic aberrations in gangliogliomas by CGH, array-based CGH and interphase FISHAlexander Hoischen
Department of Human Genetics, Rheinische Friedrich Wilhelms University of Zürich, Zurich, Switerland
Brain Pathol 18:326-37. 2008..In summary, genomic profiling in a large series of gangliogliomas could distinguish genetic subgroups even in this low-grade tumor... - Molecular genetics of meningiomas: from basic research to potential clinical applicationsMatthias Simon
Neurosurgery 60:787-98; discussion 787-98. 2007....