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Genomes and Genes | S SegererSummaryAffiliation: University of Munich Country: Germany Publications
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Publications
Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammationStephan Segerer
Medizinische Poliklinik Innenstadt, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
J Am Soc Nephrol 18:1835-44. 2007..Both clusters of basic residues in CCL5 are necessary for sufficient binding of CCL5 to tissue sections...- Expression of the chemokine receptor CXCR1 in human glomerular diseasesS Segerer
Medizinische Poliklinik Innenstadt, University of Munich, Germany
Kidney Int 69:1765-73. 2006..CXCR1 might be involved in the recruitment of PMNs to the glomerular tuft, which could be targeted by CXCR1-blocking agents... - Role of chemokines for the localization of leukocyte subsets in the kidneyStephan Segerer
Medizinische Poliklinik, University of Munich, Munich, Germany
Semin Nephrol 27:260-74. 2007.... - Chemokines in renal diseasesStephan Segerer
Klinikum der Universitat, Medizinische Poliklinik Innenstadt, University of Munich, Pettenkoferstr 8a, 80336 Munich, Germany
ScientificWorldJournal 5:835-44. 2005..Chemokine receptor blockade has approached clinical applications in nonrenal diseases and awaits the application in patients with kidney diseases... - B cells and tertiary lymphoid organs in renal inflammationS Segerer
Medizinische Poliklinik, University of Munich, Munich, Germany
Kidney Int 73:533-7. 2008..In this way, they could enhance the local immune response to persisting autoantigens in the tubulointerstitium... - Compartment specific expression of dendritic cell markers in human glomerulonephritisS Segerer
Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
Kidney Int 74:37-46. 2008..Their number correlated with serum creatinine, which further emphasizes the significance of interstitial DCs in progressive glomerular diseases... - Role of CXCR3 in cellular but not humoral renal allograft rejectionStephan Segerer
Medizinische Poliklinik, Klinikum Innenstadt, University of Munich, Munich, Germany
Transpl Int 18:676-80. 2005..CXCR3-positive cells infiltrate renal allografts during cellular rejection, whereas C4d deposition is not associated with the recruitment of these cells... - CXCR3 is involved in tubulointerstitial injury in human glomerulonephritisStephan Segerer
Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
Am J Pathol 164:635-49. 2004..Therefore interstitial CXCR3, as well as CCR5-positive T cells might play an important role during progressive loss of renal function, and are potential therapeutic targets in human glomerular diseases... - When renal allografts turn DARCStephan Segerer
Medizinische Poliklinik, Klinikum Innenstadt der Universitat, Pettenkoferstrasse 8a, 80336 Munich, Germany
Transplantation 75:1030-4. 2003..Because DARC is expressed at the site of C4d deposition and might be involved in inflammatory cell recruitment, the authors evaluated the expression of DARC in different forms of human renal allograft rejection... - The role of chemokines and chemokine receptors in progressive renal diseasesStephan Segerer
Medizinische Poliklinik, University of Munich, Germany
Am J Kidney Dis 41:S15-8. 2003..This overview gives a short introduction into chemokines and current aspects of their role in progressive human kidney diseases... - Expression of the C-C chemokine receptor 5 in human kidney diseasesS Segerer
Medizinische Poliklinik, Klinikum Innenstadt der Ludwig Maximilians Universität, Munich, Germany
Kidney Int 56:52-64. 1999..Chemokines are proteins that contribute to the migration of leukocytes to sites of tissue injury. CCR5 is a receptor for the C-C chemokine RANTES, which is expressed in inflammatory kidney diseases and transplant rejection... - [RS3PE-syndrome]S Segerer
Klinikum Innenstadt der Ludwig Maximilians Universität, Munchen
Z Rheumatol 58:35-8. 1999..Movement of both shoulders and wrists was painful. Low-dose corticosteroid therapy resulted in a rapid improvement of the edema and the inflammatory symptoms... - Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritisH J Anders
Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University Munich, Munich, Germany
J Am Soc Nephrol 12:919-31. 2001..After initiating GN, MCP-1 and RANTES and their receptors are readily downregulated... - Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetesS G Sayyed
Nephrological Center, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
Diabetologia 52:2445-54. 2009.... - Expression of DARC, CXCR3 and CCR5 in giant cell arteritisH Bruhl
Medical Policlinic, University of Munich, Munich, Germany
Rheumatology (Oxford) 44:309-13. 2005..We studied the expression of CCR5, CXCR3 and that of the Duffy antigen/receptor of chemokine (DARC), a chemokine internalizing receptor (interceptor), in parallel to the expression of the CCR5 ligand RANTES/CCL5... - Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport diseaseVolha Ninichuk
Nephrological Center, Medical Policlinic, University of Munich, Germany
J Am Soc Nephrol 16:977-85. 2005..These data identify CCR1 as a potential therapeutic target for Alport disease or other progressive nephropathies associated with interstitial macrophage infiltrates... - Efficient renal recruitment of macrophages and T cells in mice lacking the duffy antigen/receptor for chemokinesVolker Vielhauer
Medizinische Poliklinik, Campus Innenstadt, Ludwig Maximilians University Munich, Munich, Germany
Am J Pathol 175:119-31. 2009.... - Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstructionVaclav Eis
Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
J Am Soc Nephrol 15:337-47. 2004..Therefore, CCR1 is a promising target for therapeutic intervention in leukocyte-mediated fibrotic tissue injury, e.g. progressive renal fibrosis... - The source matters: no impact of the CCL2/MCP-1-1-2518G polymorphism of the donor on renal allograft outcome during the first year after transplantationI Lehmann
Medizinische Poliklinik, Campus Innenstadt, University of Munich, Germany
Transplant Proc 40:3359-61. 2008..The impact on the long-term outcomes needs further evaluation... - The role of interstitial macrophages in nephropathy of type 2 diabetic db/db miceVolha Ninichuk
Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
Am J Pathol 170:1267-76. 2007..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy... - Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone miceGuillermo Perez de Lema
Klinikum der Universitat Munchen, Medizinische Poliklinik Innenstadt, Munich, Germany
J Am Soc Nephrol 16:3592-601. 2005..These results identify Ccr2 as an additional possible target for the treatment of lupus nephritis... - Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cellsPrashant S Patole
Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
J Am Soc Nephrol 16:1326-38. 2005..g., glomerular mesangial cells, to produce cytokines and chemokines, factors that can aggravate autoimmune tissue injury, e.g., lupus nephritis... - Expression of the chemokine receptor CCR1 in human renal allograftsVerena Mayer
Medizinische Poliklinik Innenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
Nephrol Dial Transplant 22:1720-9. 2007..CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts... - Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/TrifJulia Lichtnekert
Medizinische Poliklinik, Klinikum der Universität Innenstadt, Pettenkoferstr 8a, 80336 Munich, Germany
Am J Physiol Renal Physiol 296:F867-74. 2009..We therefore conclude that apoptotic cell RNA is a poor activator of Trif signaling in mesangial cells and that necrotic cells' releases rather activate mesangial cells via the Tlr2/Myd88 signaling pathway... - Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritisPrashant S Patole
Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstr 8a, 80336 Munich, Germany
J Autoimmun 29:52-9. 2007..We conclude that a number of mechanisms protect the host from additive effects of TLR3-TLR7 coactivation on renal pathology in vivo... - Toll-like receptor-7 modulates immune complex glomerulonephritisRahul D Pawar
Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
J Am Soc Nephrol 17:141-9. 2006.... - The contribution of B cells to renal interstitial inflammationFlorian Heller
Medizinische Poliklinik Innenstadt, University of Munich, Germany
Am J Pathol 170:457-68. 2007..CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system... - Developmental expression and functional significance of Kir channel subunits in ureteric bud and nephron epitheliaGerald S Braun
Physiologisches Institut, Ludwig Maximilians Universitat, 80336 Munich, Germany
Pflugers Arch 445:321-30. 2002..In summary, Kir6.1/SUR2 channel subunits are highly expressed during early development of ureteric bud and nephron epithelia where Kir6.1/SUR2 activity regulates cell proliferation... - Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) miceOnkar Kulkarni
Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
J Pharmacol Exp Ther 328:371-7. 2009..We propose anti-Ccl2 Spiegelmer therapy as a novel strategy to reduce CYC toxicity in the treatment of severe lupus... - Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) miceHans Joachim Anders
Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
J Am Soc Nephrol 15:1504-13. 2004..This is the first evidence that, in advanced chronic renal injury, blockade of CCR1 can halt disease progression and improve renal function by selective inhibition of interstitial leukocyte recruitment and fibrosis... - CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndromeVolker Vielhauer
Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
Kidney Int 66:2264-78. 2004..We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis... - Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db miceVolha Ninichuk
Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
Am J Pathol 172:628-37. 2008.... - Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient miceV Ninichuk
Medical Polyclinic, Nephrological Center, University of Munich, Munich, Germany
Kidney Int 70:121-9. 2006..The maintenance of interstitial vasculature is associated with less interstitial fibrosis but, is insufficient to delay renal failure and survival of COL4A3-deficient mice... - Cerebral angiitis in four patients with chronic GVHDP Sostak
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilian University, Munich, Germany
Bone Marrow Transplant 45:1181-8. 2010..Infiltrating cells, in analogy to typical target organs of GVHD such as skin or liver, expressed CD11a and CCR5. These findings could be of etiopathological, diagnostic and therapeutic relevance... - Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupusRahul D Pawar
Medizinische Poliklinik, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
J Am Soc Nephrol 18:1721-31. 2007..Hence, TLR-7 is proposed as a novel and potential therapeutic target in systemic lupus erythematosus... - Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrierRahul D Pawar
Medical Policlinic, University of Munich, Munich, Germany
Immunology 128:e206-21. 2009..LPS also induced moderate albuminuria. In summary, bacterial lipopeptide and LPS can aggravate glomerulonephritis but only lipopeptide potently induces severe albuminuria in MRL(lpr/lpr) mice... - Chemokines and chemokine receptors in renal pathologyStephan Segerer
Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
Curr Opin Nephrol Hypertens 12:243-9. 2003..Although the treatment of patients with renal diseases using chemokine receptor blocking agents has not yet reached clinical practice, a recent body of data indicates that human renal disease might be amenable to such approaches... - Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related proteinMaciej Lech
Medizinische Poliklinik University of Munich, Munich, Germany
J Immunol 183:4109-18. 2009..Thus, loss of function mutations in the SIGIRR gene predispose to acute renal failure because SIGIRR prevents overshooting tissue injury by suppressing the postischemic activation of intrarenal myeloid cells... - Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal gangliaTobias Derfuss
Institute of Clinical Neuroimmunology, University Clinic, Munich, Germany
Brain Pathol 17:389-98. 2007..Thus, HSV-1 IE genes are expressed in human TG and the infiltrating T-cells bear several characteristics that suggest viral antigenic stimulation... - Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responsesRamanjaneyulu Allam
Medical Policlinic, University of Munich, Germany
Eur J Immunol 38:3487-98. 2008..We conclude, 3P-RNA or non-CpG DNA both trigger autoimmune disease in MRL(lpr/lpr) mice by specifically activating adaptive immunity but similarly enhance inflammation on the tissue level... - Interstitial inflammation in Alport syndromeJan Jedlicka
Medizinische Poliklinik Campus Innenstadt, University of Munich, 80336 Munich, Germany
Hum Pathol 41:582-93. 2010..The degree of infiltration correlated with renal function. We speculate that targeting T lymphocytes, for example, by CXCR3 blocking agents, might be a novel approach to inhibit disease progression in patients with Alport syndrome... - Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr miceOnkar Kulkarni
Nephrological Center, Ludwig Maximilians University, 80336 Munich, Germany
J Am Soc Nephrol 18:2350-8. 2007..Thus, mNOX-E36-based inhibition of CCL2 represents a novel strategy for the treatment of autoimmune tissue injury, such as lupus nephritis... - Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritisRahul D Pawar
Medical Poliklinik, University of Munich, Munich, Germany
J Am Soc Nephrol 17:3365-73. 2006..In summary, among the ligands tested, CpG-DNA triggers lupus nephritis in genetically predisposed hosts. These data support the concept that systemic lupus erythematosus is triggered by pathogens that release CG-rich DNA... - Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritisPrashant S Patole
Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
Kidney Int 68:2582-7. 2005..Toll-like receptor-4 (TLR4) mutant mice infected with uropathogenic Escherichia coli lack renal CXCL2 mRNA expression, subsequent neutrophil recruitment, and renal abscess formation... - CCR10 is expressed in cutaneous T-cell lymphomaMike Notohamiprodjo
Medical Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany
Int J Cancer 115:641-7. 2005..Our data support a potential role of CXCR3 in CTCL and strongly suggest that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in this group of lymphoproliferative disorders... - Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) micePrashant S Patole
Nephrological Center, Medizinische Poliklinik, , , Germany
Nephrol Dial Transplant 21:3062-73. 2006..CONCLUSION: Thus, cell-type-specific expression and regulation of TLRs may be involved in infection-associated exacerbation of immune complex glomerulonephritis of MRLlpr/lpr mice... - A complex pattern of chemokine receptor expression is seen in osteosarcomaIrene von Luettichau
Children s Hospital Medical Center, University of Technology, Munich, Germany
BMC Cancer 8:23. 2008..In this report we characterized the expression of a series of chemokine receptors in the complex environment that defines osteosarcoma... - Hyperglycemia and hyperlipidemia act synergistically to induce renal disease in LDL receptor-deficient BALB miceMin W Spencer
Department of Pathology, University of Washington, Seattle, Wash. 98195, USA
Am J Nephrol 24:20-31. 2004..LDLR-/- mouse. This model of diabetic nephropathy is unique in its development of tubular lesions and may represent a good model for hyperlipidemia-exacerbated diabetic nephropathy... - Localization of SPARC in developing, mature, and chronically injured human allograft kidneysCharles E Alpers
Department of Pathology, University of Washington School of Medicine, Seattle Washington, USA
Kidney Int 62:2073-86. 2002..This study describes the expression of SPARC during human renal development, in normal kidneys and during renal allograft rejection... - Deletion of the fcgamma receptor IIb in thymic stromal lymphopoietin transgenic mice aggravates membranoproliferative glomerulonephritisAnja S Mühlfeld
Department of Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
Am J Pathol 163:1127-36. 2003..These results emphasize the important role of FcgammaRIIb in regulating immune responses and suggest that modulation of Fcgamma receptor activation or expression may be a useful therapeutic approach for treating glomerular diseases... - Growth factor expression in a murine model of cryoglobulinemiaSekiko Taneda
Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Kidney Int 63:576-90. 2003..These findings extend the paradigms covering these growth factors established in the rat Thy 1 model of mesangiolysis and repairs to a murine model of progressive glomerulonephritis closely resembling human MPGN... - Expression of the fractalkine receptor (CX3CR1) in human kidney diseasesStephan Segerer
Department of Pathology, University of Washington, Seattle, Washington, USA
Kidney Int 62:488-95. 2002..Here we describe the distribution of CX3CR1 positive cells in a variety of kidney diseases and renal development... - Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndromeMarie Louise Koepke
Department of Internal Medicine I, Cologne General Hospital, Merheim Medical Center, and Department of Anatomy I, University of Cologne, Germany
Nephrol Dial Transplant 22:1062-9. 2007..The aim of this study was to examine the anti-fibrotic effect of the HMG-CoA-reductase-inhibitor, cerivastatin, in COL4A3 knockout mice, an animal model of Alport syndrome with progressive renal fibrosis... - Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688Oliver Gross
Department of Internal Medicine I, Medical Faculty University of Cologne, Cologne General Hospital, Merheim Medical Center, Cologne, Germany
Kidney Int 68:456-63. 2005..In the present study, we investigated the nephroprotective potential of the vasopeptidase inhibitor AVE7688 beyond its antihypertensive effects in a mouse model of progressive renal fibrosis... - Expression of the chemokine receptor CXCR3 in human renal allografts--a prospective studyUte Hoffmann
Klinik und Poliklinik fur Innere Medizin II, Universitat Regensburg, Germany
Nephrol Dial Transplant 21:1373-81. 2006..Since chemokines play pivotal roles in this process, our prospective study was performed to evaluate further the role of the chemokine receptor CXCR3... - Expression of cyclooxygenase-1 and cyclooxygenase-2 in human renal allograft rejection-- a prospective studyUte Hoffmann
Klinik und Poliklinik fur Innere Medizin II, University of Regensburg, Germany
Transpl Int 19:203-12. 2006..This is the first prospective study demonstrating a significant induction of both COX-1 and -2 in human allograft biopsies with acute rejection after renal transplantation... - Mononuclear infiltrates in osteosarcoma and chemokine receptor expressionIrene von Luettichau
Clin Cancer Res 12:5253-4; author reply 5254. 2006 - Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritisStephan Segerer
Department of Pathology, University of Washington, Seattle, WA, USA
Am J Kidney Dis 39:876-88. 2002.... - Pioglitazone reverses down-regulation of cardiac PPARgamma expression in Zucker diabetic fatty ratsTheo Pelzer
Department of Medicine, University of Wurzburg, Germany
Biochem Biophys Res Commun 329:726-32. 2005.... - Renal injury in apolipoprotein E-deficient miceMin Wen
Department of Pathology, University of Washington, Seattle, Washington, USA
Lab Invest 82:999-1006. 2002.... - Enhanced expression of Duffy antigen in the lungs during suppurative pneumoniaJanet S Lee
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, USA
J Histochem Cytochem 51:159-66. 2003.... - Cellular injury associated with renal thrombotic microangiopathy in human immunodeficiency virus-infected macaquesStephan Segerer
Department of Pathology, University of Washington, Seattle, Washington 98195, USA
J Am Soc Nephrol 13:370-8. 2002..This pattern of injury, which shares some features of both apoptotic and oncotic necrosis, might be involved in the pathogenesis of HIV-associated renal TMA in this model...