Research Topics
| Michael SchlosserSummaryAffiliation: University of Greifswald Country: Germany Publications
| Collaborators
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Detail Information
Publications
Immunogenicity of polymeric implants: long-term antibody response against polyester (Dacron) following the implantation of vascular prostheses into LEW.1A ratsM Schlosser
Institute of Pathophysiology, Ernst Moritz Arndt University, Karlsburg, Germany
J Biomed Mater Res 61:450-7. 2002..We conclude that specific polymer antibodies may indeed provide an additional parameter for biocompatibility testing as well as a possible serological marker of an inflammatory response to implants...- Prevalence of diabetes-associated autoantibodies in schoolchildren: the Karlsburg Type 1 Diabetes Risk StudyMichael Schlosser
Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Greifswalder Str 11b, D 17495 Karlsburg, Germany
Ann N Y Acad Sci 1037:114-7. 2004..6, 98.8, and 85.5% of probands with multiple AAbs, respectively. Thus, combined AAb screening in the general population identifies those probands at risk for diabetes... - Antibody response to collagen after functional implantation of different polyester vascular prostheses in pigsM Schlosser
Institute of Pathophysiology of the Ernst Moritz Arndt University Greifswald, Karlsburg D 17495, Germany
J Biomed Mater Res A 72:317-25. 2005..Thus, humoral immune response against implant components may provide a further parameter in describing biocompatibility but also a potential marker that may facilitate monitoring of individual perigraft reaction... - Determination of glutamic acid decarboxylase (GAD65) in pancreatic islets and its in vitro and in vivo degradation kinetics in serum using a highly sensitive enzyme immunoassayMichael Schlosser
Department of Medical Biochemistry and Molecular Biology, Ernst Moritz Arndt University of Greifswald, Karlsburg, Germany
Dis Markers 24:191-8. 2008..These results should be taken into consideration in further studies aimed at examining the diagnostic relevance of GAD65... - Multiple and high-titer single autoantibodies in schoolchildren reflecting the genetic predisposition for type 1 diabetesMichael Schlosser
Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
Ann N Y Acad Sci 1005:98-108. 2003..8; p<0.001). It is concluded that probands with multiple and high-titer single AAbs in the general population have the same genetic predisposition for T1D as patients and are therefore at highest risk for the disease... - The Karlsburg type 1 diabetes risk study of a normal schoolchild population: association of beta-cell autoantibodies and human leukocyte antigen-DQB1 alleles in antibody-positive individualsMichael Schlosser
Institute of Pathophysiology, Ernst Moritz Arndt University of Greifswald, Karlsburg D-17495, Germany
J Clin Endocrinol Metab 87:2254-61. 2002..009). The study shows that also in the general population the multiple AAbs or high level single AAbs predict rather certainly a HLA-DQB1-mediated diabetes susceptibility as shown for first degree relatives of type 1 diabetic patients... - Examination of the inflammatory response following implantation of titanium plates coated with phospholipids in ratsAlexandra Kochanowski
Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, Ernst Moritz Arndt University of Greifswald, Greifswalder Str 11c, 17495 Karlsburg, Germany
J Mater Sci Mater Med 22:1015-26. 2011..Together with earlier in vitro results, this demonstrates the potential of phospholipids for implant surface modification... - Serum profile of pro- and anti-inflammatory cytokines in rats following implantation of low-temperature plasma-modified titanium platesUwe Walschus
Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, Ernst Moritz Arndt University of Greifswald, Greifswalder Str 11c, 17495, Karlsburg, Germany
J Mater Sci Mater Med 23:1299-307. 2012..Concluding, different plasma modifications induce specific serum cytokine profiles and associations indicating distinct inflammatory responses... - Evaluation of the biocompatibility of a new vascular prosthesis coating by detection of prosthesis-specific antibodiesUwe Walschus
Research Group of Predictive Diagnostics, Department of Medical Biochemistry and Molecular Biology, Ernst Moritz Arndt University Greifswald, Greifswalder Str 11c, 17495 Karlsburg, Germany
J Mater Sci Mater Med 19:1595-600. 2008..In conclusion, the overall immunogenicity of the polymer-coated graft was comparable to the gelatine-coated graft. The detection of prosthesis-specific antibodies seems to be useful for in vivo biocompatibility testing... - Morphometric immunohistochemical examination of the inflammatory tissue reaction after implantation of calcium phosphate-coated titanium plates in ratsUwe Walschus
Department of Medical Biochemistry and Molecular Biology, Ernst Moritz Arndt University Greifswald, Karlsburg, Germany
Acta Biomater 5:776-84. 2009.... - The influence of antimicrobial treatments on the cytocompatibility of polyurethane biosensor membranesTh von Woedtke
Institute of Pharmacy, The Ernst Moritz Arndt University of Greifswald, D 17487 Greifswald, Germany
Biosens Bioelectron 19:269-76. 2003.... - Implantation of non-toxic materials from glucose sensors: evidence for specific antibodies detected by ELISAM Schlosser
, , Karlsburg, Germany
Horm Metab Res 26:534-7. 1994..Thus immunogenicity is suggested to be considered as a parameter in biocompatibility testing of implantable medical devices... - Diabetes Antibody Standardization Program: First evaluation of assays for autoantibodies to IA-2?Michael Schlosser
Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, University ofGreifswald, Karlsburg, Germany
Diabetes Care 34:2410-2. 2011..Autoantibodies to IA-2? (IA-2?A) are important risk markers of type 1 diabetes. We report the first Diabetes Antibody Standardization Program (DASP) evaluation of IA-2?A assays... - Preproinsulin-specific CD8+ T cells secrete IFNgamma in human type 1 diabetesSilvia Rathmann
Department of Internal Medicine I, Division of Endocrinology, University of Ulm, Robert-Koch Str. 8, 89081 Ulm, Germany
Ann N Y Acad Sci 1037:22-5. 2004..Further investigations defining epitope specificity, cytokine secretion, and cytotoxic capacity are important to clarify their role in T1D development... - Digital image analysis for morphometric evaluation of tissue response after implanting alloplastic vascular prosthesesRoland Zippel
Department of Surgery, Hospital Riesa/Grossenhain, D-01589 Riesa, Germany
Microsc Microanal 12:366-75. 2006..9 microm on day 14 to 1228.0 microm on day 116. In conclusion, digital image analysis was found to be an efficient and reproducible method for the morphometric evaluation of a peri-prosthetic tissue response... - GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetesAnja Mayr
Diabetes Research Institute, Munich, Germany
Diabetes 56:1527-33. 2007..We asked whether autoantibodies to GAD (GADAs) are heterogeneous in affinity and epitope recognition and whether diabetes-related GADA are restricted to high-affinity responses... - Immune response against polyester implants is influenced by the coating substancesLutz Wilhelm
Department of Surgery, University of Greifswald, Greifswald D 17487, Germany
J Biomed Mater Res A 83:104-13. 2007..Our results showed a specific immune reaction as a result of the applied polymer, which varied due to the surface-coating and individual factors... - Local tissue reaction and differentiation of the prosthesis-specific antibody response following functional implantation of vascular grafts in pigsRoland Zippel
Department of Surgery, Hospital Riesa Grossenhain, Riesa, Germany
J Biomed Mater Res B Appl Biomater 85:334-42. 2008..These results indicate a possible association between local inflammatory reactions and humoral immune responses, influenced by properties of vascular grafts... - Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65AbsCarolyn J Padoa
Department of Medicine, University of Washington, Seattle 98195, USA
Diabetes 52:2689-95. 2003..These GAD65-specific rFabs should prove useful in predicting type 1 diabetes and in the study of conformational GAD65Ab epitopes... - Th2 dominance of T helper cell response to preproinsulin in individuals with preclinical type 1 diabetesIvana Durinovic-Bello
Department of Internal Medicine I, University of Ulm, Ulm, Germany
Ann N Y Acad Sci 958:209-13. 2002..In contrast, in PBMCs of T1D patients higher IFN-gamma and IL-10 secretion was found. Our data delineate characteristic cytokine patterns in peripheral T lymphocytes from patients at different stages of the T1D development... - Relationship between T and B cell responses to proinsulin in human type 1 diabetesIvana Durinovic-Bello
Department of Internal Medicine I, Division of Endocrinology, University of Ulm, Ulm, Germany
Ann N Y Acad Sci 1005:288-94. 2003.... - Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization ProgramPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
Clin Immunol 122:85-90. 2007..This workshop has demonstrated that different laboratories are able to reproduce IAA affinity results and that considering IAA affinity is likely to improve the diagnostic performance of IAA assays... - Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetesJosef Endl
Division of Endocrinology and Diabetes, Ulm University, Robert Koch Strasse 8, D 89081 Ulm, Germany
Diabetes 55:50-60. 2006..The CD134 costimulatory molecule may also provide a novel therapeutic target in type 1 diabetes...