Stephan Pleschka

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade
    Stephan Pleschka
    Institute for Medical Virology, Justus Liebig University, Frankfurter Str 107, D 35392 Giessen, Germany
    Biol Chem 389:1273-82. 2008
  2. ncbi Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade
    Henju Marjuki
    Division of Virology, Department of Infectious Diseases, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    Virol J 4:134. 2007
  3. ncbi Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)
    Stephan Pleschka
    Institute for Medical Virology, Justus Liebig University Giessen, Giessen, Germany
    Virol J 6:197. 2009
  4. ncbi NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response
    Zhongfang Wang
    Institute for Medical Virology, Justus Liebig University Giessen, Frankfurter Str 107, D 35392 Giessen, Germany
    J Virol 84:11323-35. 2010
  5. ncbi Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo
    Ruth Pinto
    Institute of Medical Virology, Justus Liebig University Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany
    Antiviral Res 92:45-56. 2011
  6. ncbi Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Exp Med 205:3065-77. 2008
  7. ncbi Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses
    Christian Krawitz
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    BMC Complement Altern Med 11:16. 2011
  8. ncbi The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV
    Wenjun Ma
    Institute of Medical Virology, Justus Liebig University, D 35392 Giessen, Germany
    J Virol 84:2122-33. 2010
  9. ncbi Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling
    Henju Marjuki
    Institute for Medical Virology, Justus-Liebig-University, Frankfurter Strasse 107, D-35392 Giessen, Germany
    J Biol Chem 281:16707-15. 2006
  10. ncbi Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Immunol 177:1817-24. 2006

Collaborators

Detail Information

Publications10

  1. ncbi RNA viruses and the mitogenic Raf/MEK/ERK signal transduction cascade
    Stephan Pleschka
    Institute for Medical Virology, Justus Liebig University, Frankfurter Str 107, D 35392 Giessen, Germany
    Biol Chem 389:1273-82. 2008
    ..This important control center of cellular responses is differently employed to support the replication of several important human pathogenic RNA viruses including influenza, Ebola, hepatitis C and SARS corona viruses...
  2. ncbi Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade
    Henju Marjuki
    Division of Virology, Department of Infectious Diseases, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    Virol J 4:134. 2007
    ....
  3. ncbi Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV)
    Stephan Pleschka
    Institute for Medical Virology, Justus Liebig University Giessen, Giessen, Germany
    Virol J 6:197. 2009
    ..As an alternative approach to the common anti-virals we studied in more detail a commercial standardized extract of the widely used herb Echinacea purpurea (Echinaforce, EF) in order to elucidate the nature of its anti-IV activity...
  4. ncbi NS reassortment of an H7-type highly pathogenic avian influenza virus affects its propagation by altering the regulation of viral RNA production and antiviral host response
    Zhongfang Wang
    Institute for Medical Virology, Justus Liebig University Giessen, Frankfurter Str 107, D 35392 Giessen, Germany
    J Virol 84:11323-35. 2010
    ..Overall, our data suggest that the propagation of NS reassortant influenza viruses is affected at multiple steps of the viral life cycle as a result of the different effects of the NS1 protein on multiple viral and host functions...
  5. ncbi Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo
    Ruth Pinto
    Institute of Medical Virology, Justus Liebig University Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany
    Antiviral Res 92:45-56. 2011
    ..This could provide a new rationale of future therapeutic strategies to treat IV pneumonia...
  6. ncbi Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Exp Med 205:3065-77. 2008
    ..Epithelial cell apoptosis induced by TRAIL-expressing macrophages is identified as a major underlying mechanism...
  7. ncbi Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses
    Christian Krawitz
    Institute for Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, 35392 Giessen, Germany
    BMC Complement Altern Med 11:16. 2011
    ....
  8. ncbi The NS segment of an H5N1 highly pathogenic avian influenza virus (HPAIV) is sufficient to alter replication efficiency, cell tropism, and host range of an H7N1 HPAIV
    Wenjun Ma
    Institute of Medical Virology, Justus Liebig University, D 35392 Giessen, Germany
    J Virol 84:2122-33. 2010
    ....
  9. ncbi Membrane accumulation of influenza A virus hemagglutinin triggers nuclear export of the viral genome via protein kinase Calpha-mediated activation of ERK signaling
    Henju Marjuki
    Institute for Medical Virology, Justus-Liebig-University, Frankfurter Strasse 107, D-35392 Giessen, Germany
    J Biol Chem 281:16707-15. 2006
    ..This may represent an auto-regulative mechanism that coordinates timing of RNP export to a point when all viral components are ready for virus budding...
  10. ncbi Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules
    Susanne Herold
    University of Giessen Lung Center, Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, Giessen, Germany
    J Immunol 177:1817-24. 2006
    ....