M Otto

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi Differential adhesion of polymorphous neutrophilic granulocytes to macro- and microvascular endothelial cells under flow conditions
    M Otto
    Institute of Pathology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pathobiology 69:159-71. 2001
  2. ncbi Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery
    A Gaumann
    Institute of Pathology, University of Mainz, Mainz, Germany
    Cancer 92:1237-44. 2001
  3. ncbi Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath
    T Hansen
    Institute of Pathology, Johannes Gutenberg-University, Mainz, Germany
    Mod Pathol 14:318-24. 2001
  4. ncbi Detection of mRNA by non-radioactive direct primed in situ reverse transcription
    J Kriegsmann
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Histochem Cell Biol 116:199-204. 2001
  5. ncbi Current trends in biocompatibility testing
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Proc Inst Mech Eng H 212:75-84. 1998
  6. ncbi Biomaterial-induced sarcoma: A novel model to study preneoplastic change
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Am J Pathol 156:1455-67. 2000
  7. ncbi [Cytokeratin expression in botryoid odontogenic cyst. A rare differential keratocyst and ameloblastoma diagnosis]
    G Weibrich
    Klinik fur Mund, Kiefer und Gesichtschirurgie, Johannes Gutenberg Universitat Mainz
    Mund Kiefer Gesichtschir 4:309-14. 2000
  8. ncbi [Myospherulosis of the middle ear -- a rare differential diagnosis of cholesteatoma]
    T Hansen
    Institut fur Pathologie, Johannes Gutenberg Universitat Mainz
    Laryngorhinootologie 83:445-9. 2004
  9. ncbi [Growth stimulation of human osteoblast-like cells by thrombocyte concentrates in vitro]
    G Weibrich
    Klinik fur Mund, Kiefer und Gesichtschirurgie, Universitatsklinik Mainz, Augustusplatz 2, 55131 Mainz
    Mund Kiefer Gesichtschir 6:168-74. 2002
  10. ncbi Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin
    A Gaumann
    Institute of Pathology, University Clinics Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    Virchows Arch 442:529-37. 2003

Collaborators

Detail Information

Publications26

  1. ncbi Differential adhesion of polymorphous neutrophilic granulocytes to macro- and microvascular endothelial cells under flow conditions
    M Otto
    Institute of Pathology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pathobiology 69:159-71. 2001
    ..The purpose of the present study was to use a dynamic cell culture system to compare the reactions of HUVEC and human pulmonary microvascular EC (HPMEC) to pro-inflammatory stimulation...
  2. ncbi Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery
    A Gaumann
    Institute of Pathology, University of Mainz, Mainz, Germany
    Cancer 92:1237-44. 2001
    ..In particular, members of the Bcl-2 family as well as the Fas system are known to be involved in the regulation of apoptosis in different tumor entities...
  3. ncbi Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath
    T Hansen
    Institute of Pathology, Johannes Gutenberg-University, Mainz, Germany
    Mod Pathol 14:318-24. 2001
    ..Because previous studies showed that osteoclasts express high levels of CD68, cathepsin K, and cystatin C but not of cathepsin B, our study contributes to the view that GC of GCTTS and osteoclasts are closely associated...
  4. ncbi Detection of mRNA by non-radioactive direct primed in situ reverse transcription
    J Kriegsmann
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Histochem Cell Biol 116:199-204. 2001
    ..Contrary to in situ RT-PCR this new method of in situ RT has no background problems due to non-specific amplification or diffusion of the reaction product...
  5. ncbi Current trends in biocompatibility testing
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Proc Inst Mech Eng H 212:75-84. 1998
    ..These include the application of modern techniques of cell and molecular biology, the concepts of tissue remodelling, hybrid organ development and encapsulated cell technology...
  6. ncbi Biomaterial-induced sarcoma: A novel model to study preneoplastic change
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Am J Pathol 156:1455-67. 2000
    ..This model provides the molecular biologist with defined stages in the development of mesenchymal malignancy, with which the multistage tumorigenesis hypothesis can be tested, analogous to the well-known adenoma-carcinoma sequence...
  7. ncbi [Cytokeratin expression in botryoid odontogenic cyst. A rare differential keratocyst and ameloblastoma diagnosis]
    G Weibrich
    Klinik fur Mund, Kiefer und Gesichtschirurgie, Johannes Gutenberg Universitat Mainz
    Mund Kiefer Gesichtschir 4:309-14. 2000
    ..The expression of CK 19 and the lack of expression of p53, as well as the higher proliferation rate of the basal epithelial cell layer by the BOC, may be useful for distinction between the keratocyst...
  8. ncbi [Myospherulosis of the middle ear -- a rare differential diagnosis of cholesteatoma]
    T Hansen
    Institut fur Pathologie, Johannes Gutenberg Universitat Mainz
    Laryngorhinootologie 83:445-9. 2004
    ..In previous otorhinolaryngological studies, myospherulosis was mainly found in paranasal sinuses, while only four otitic cases have been reported...
  9. ncbi [Growth stimulation of human osteoblast-like cells by thrombocyte concentrates in vitro]
    G Weibrich
    Klinik fur Mund, Kiefer und Gesichtschirurgie, Universitatsklinik Mainz, Augustusplatz 2, 55131 Mainz
    Mund Kiefer Gesichtschir 6:168-74. 2002
    ..Basic data about the biologic effect of platelet concentrates (platelet-rich plasma, PRP) are still lacking. This study analyzes the in vitro effect of PRP on the proliferation rate of human osteoblast-like cells (OLC)...
  10. ncbi Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin
    A Gaumann
    Institute of Pathology, University Clinics Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    Virchows Arch 442:529-37. 2003
    ..Our findings underline the fact that multiple factors contribute to chemoresistance and that examination of a spectrum of relevant molecules is probably necessary to plan the best therapy...
  11. ncbi Tissue response and biomaterial integration: the efficacy of in vitro methods
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Biomol Eng 19:211-7. 2002
    ....
  12. ncbi Expression of fibronectin splice variants and oncofetal glycosylated fibronectin in the synovial membranes of patients with rheumatoid arthritis and osteoarthritis
    J Kriegsmann
    Institute of Pathology, Trier, Germany
    Rheumatol Int 24:25-33. 2004
    ..Most remarkably, the expression of ED-B Fn in pannus tissue seems to be associated with the invasive phenotype described in RA tissue...
  13. ncbi Colocalization of C4d deposits/CD68+ macrophages in rheumatoid nodule and granuloma annulare: immunohistochemical evidence of a complement-mediated mechanism in fibrinoid necrosis
    M Knoess
    Department of Pathology, Institute of Pathology, Max Planck Strasse 18 20, Trier, Germany
    Pathol Res Pract 204:373-8. 2008
    ..This mechanism may be involved in any form of "fibrinoid necrosis", since no different patterns of C4d/CD68 expression could be observed in GA. This may explain why RG/GA are not distinguishable morphologically...
  14. ncbi Temperature-controlled high frequency ablation for creation of transmyocardial channels: in vivo validation of a novel method
    U Dietz
    Medical Clinic II, University Hospital, Mainz, Germany
    Cardiology 93:234-41. 2000
    ..We investigated the feasibility and short-term effects of a novel procedure to create intramyocardial channels by means of high frequency (HF) ablation in a rabbit in vivo model...
  15. ncbi [Diagnostic spectrum of synovitis]
    P Knöss
    Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max Planck Strasse 18 20, 54296, Trier, Deutschland
    Z Rheumatol 67:8, 10-4, 16. 2008
    ..5% and 95.5%, respectively. In detritus synovitis the synovitis score is not applicable...
  16. ncbi Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Mol Psychiatry 12:671-80. 2007
    ..CSF Abeta peptides may reflect disease-specific impact of distinct neurodegenerative processes on Abeta peptide metabolism and represent a potential diagnostic biomarker for AD, FTD and DLB...
  17. ncbi [Differential diagnosis of rheumatoid granuloma]
    M Knöss
    Institut fur Pathologie, Trier
    Pathologe 27:409-15. 2006
    ..In the following article, the most important granulomatous entities in the differential diagnosis of RG are introduced and the main diagnostic characteristics are discussed...
  18. ncbi CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 113:1771-8. 2006
    ..Combined evaluation of these biomarkers provides a reasonable accuracy for differential diagnosis of AD and DLB...
  19. ncbi Proposal for a histopathological consensus classification of the periprosthetic interface membrane
    L Morawietz
    , University Hospital Charit, Berlin, Germany
    J Clin Pathol 59:591-7. 2006
    ..The study highlights the importance of non-infectious, non-particle induced loosening of prosthetic devices in orthopaedic surgery (membrane type IV), which was observed in 15.4% of patients...
  20. ncbi Selective reduction of amyloid beta42 discriminates Alzheimer's disease from Huntington's disease: indication for distinct pathological events in amyloid beta peptide aggregation
    B Mollenhauer
    J Neurol Neurosurg Psychiatry 77:1201-3. 2006
  21. ncbi Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia
    J Wiltfang
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    World J Biol Psychiatry 6:69-84. 2005
    ..Novel perspectives offered by recently introduced technologies, e.g, fluorescence correlation spectroscopy (FCS) and surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) are briefly discussed...
  22. ncbi Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease
    B Mollenhauer
    Department of Neurology, Georg August University, Goettingen, Germany
    J Neural Transm 112:933-48. 2005
    ..Follow-up CSF analyses are of limited value for the differentiation of AD and DLB. We conclude that more specific markers have to be established for the differentiation and follow-up of these diseases...
  23. ncbi CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias
    H Schmidt
    Department of Neurology, University of Gottingen, Gottingen, Germany
    Dement Geriatr Cogn Disord 17:204-6. 2004
    ..We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias...
  24. ncbi Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease
    M Otto
    Neurologische Klinik und Poliklinik, Georg August Universitat Gottingen, Germany
    Neurology 58:192-7. 2002
    ..Both tests in a larger group of patients with the differential diagnosis of CJD were evaluated...
  25. ncbi Phospho-tau/total tau ratio in cerebrospinal fluid discriminates Creutzfeldt-Jakob disease from other dementias
    M Riemenschneider
    Department of Psychiatry, Technische Universitat Munchen, Munich, Germany
    Mol Psychiatry 8:343-7. 2003
    ..Although the results have to be confirmed in a larger sample, the preliminary data suggest that simultaneous measurement of total tau and P-tau in CSF may be useful to identify patients with CJD...
  26. ncbi The treatment of peri-implantitis 3
    M Otto
    Implant and Aesthetic Academy
    SADJ 63:360, 362. 2008