Research Topics
| M ObermannSummaryAffiliation: University of Duisburg-Essen Country: Germany Publications
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Detail Information
Publications
Medication overuse headacheMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Expert Opin Drug Saf 5:49-56. 2006..The only effective treatment concept is consequent withdrawal therapy. Data of prospective studies on relapse rates and predictors of relapse after successful withdrawal therapy are presented...- Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of cisplatin-induced neuropathyMin Suk Yoon
Department of Neurology, University of Duisburg Essen, Essen, Germany
BMC Neurosci 10:77. 2009..We investigated in a mouse model by which mechanism recombinant erythropoietin (rhEPO) protects the peripheral nervous system from structural and functional damage caused by cisplatin treatment with special emphasis on DNA damage burden... - Impaired trigeminal nociceptive processing in patients with trigeminal neuralgiaM Obermann
Department of Neurology, University Duisburg Essen, Essen, Germany
Neurology 69:835-41. 2007..Between the attacks the patient is usually asymptomatic, but a constant dull background pain may persist in some cases. The mechanisms associated with the development of this chronic pain are not well understood... - Efficacy of pregabalin in the treatment of trigeminal neuralgiaM Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Cephalalgia 28:174-81. 2008..020). Concomitant chronic facial pain appears to be a clinical predictor of poor treatment outcome. PGB appears to be effective in the treatment of trigeminal neuralgia... - Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathyMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Pain 138:79-86. 2008..The method of pain-related evoked potential conduction appears to be a sensitive, fast, non-invasive technique for the detection of small-fiber neuropathy and may prove to become a valuable diagnostic asset... - Increased basal-ganglia activation performing a non-dystonia-related task in focal dystoniaM Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Eur J Neurol 15:831-8. 2008.... - [Acute headache: what you should not at all fail to do]M Obermann
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MMW Fortschr Med 150:44-7. 2008 - Epidemiology of unilateral headachesMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Expert Rev Neurother 8:1313-20. 2008..This has led to improved treatment strategies in primary patient care that may prevent prolonged suffering of affected patients in the future... - Update on trigeminal neuralgiaMark Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Expert Rev Neurother 9:323-9. 2009..Continuous scientific research works towards a better understanding of trigeminal neuralgia and has accomplished a greater insight into the underlying pathophysiological mechanisms... - Temporal summation of trigeminal pain in human anterior cingulate cortexMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Neuroimage 46:193-200. 2009..These findings indicate that pACC codes temporal summation of trigeminal nociception and in this regard may be important for the development of central sensitization observed in chronic head and facial pain... - Gray matter changes related to chronic posttraumatic headacheMark Obermann
Department of Neurology, University of Duisburg Essen, 45122 Essen, Germany
Neurology 73:978-83. 2009..Although up to 15% of patients with whiplash injury develop chronic headache, the basis and mechanisms of this posttraumatic headache are not well understood... - Management of medication-overuse headacheMark Obermann
University of Duisburg Essen, Department of Neurology, Hufelandstr 55, 45122 Essen, Germany
Expert Rev Neurother 7:1145-55. 2007..Management of MOH remains difficult; the only effective treatment concept is consequent withdrawal therapy... - Migraine with isolated facial pain: a diagnostic challengeM Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Cephalalgia 27:1278-82. 2007.... - Sensory disinhibition on passive movement in cervical dystoniaMark Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Mov Disord 25:2627-33. 2010..The observed sensory overactivation suggests a general disinhibition of the somatosensory system in CD as it was not limited to the motor-system or the direct neuronal representation of the affected dystonic musculature alone... - Trigeminal neuralgia and persistent idiopathic facial painMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Expert Rev Neurother 11:1619-29. 2011..The etiology and underlying pathophysiology of TN, and more so PIFP, remain unknown. Treatment is based on only few randomized controlled clinical trials and insufficiently evaluated surgical procedures... - Headache attributable to nonvascular intracranial disordersMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Curr Pain Headache Rep 15:314-23. 2011..The clinical presentation of all these disorders can be diverse and often mimics the characteristics of primary headaches, which may delay the diagnosis... - Post-traumatic headacheMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Expert Rev Neurother 9:1361-70. 2009.... - Substantia nigra hyperechogenicity and CSF dopamine depletion in HIVMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
J Neurol 256:948-53. 2009..Our results indicate changes in the nigrostriatal system in HIV-infected patients that are detectable as hyperechogenic SN precede prominent extrapyramidal symptoms and cognitive dysfunction... - Morphometric changes of sensorimotor structures in focal dystoniaMark Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Mov Disord 22:1117-23. 2007..They also demonstrate structural similarities of the investigated focal dystonias, possibly reflecting a shared common pathophysiological origin... - Hypnic headacheMark Obermann
Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, Essen, Germany
Expert Rev Neurother 10:1391-7. 2010..Lithium, indomethacin and melatonin were promoted as potent medical treatments, while almost every other drug commonly used to treat headache or other pain syndromes was reported to be effective in single case reports on hypnic headache... - Electrically evoked nociceptive potentials for early detection of diabetic small-fiber neuropathyD Mueller
Department of Neurology, University of Duisburg Essen, Essen, Germany
Eur J Neurol 17:834-41. 2010.... - Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structuresI Ayzenberg
Department of Neurology, University of Essen, Essen, Germany, and Institute of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
Cephalalgia 26:1106-14. 2006..A transient facilitation was found of trigeminal and somatic nociceptive systems in MOH, which was more pronounced on a supraspinal level... - Population-based validation of a German-language self-administered headache questionnaireM S Yoon
Department of Neurology, University of Essen, Hufelandstrasse 55, Essen, Germany
Cephalalgia 28:605-8. 2008.... - Prevalence of facial pain in migraine: a population-based studyM S Yoon
Department of Neurology, University of Duisburg Essen, Essen, Germany
Cephalalgia 30:92-6. 2010..23, P < 0.001). In one case isolated facial pain without headache was the leading symptom of migraine. Our results demonstrate that facial pain is not unusual in migraine, whereas isolated facial migraine is extremely rare... - Prevalence of cluster headache in a population-based sample in GermanyZ Katsarava
Department of Neurology, University Hospital Essen, Essen, Germany
Cephalalgia 27:1014-9. 2007..7 +/- 12.7 years). All suspected cases (N = 182) were interviewed by a neurologist. Four subjects with CH (three men) were identified. The 1-year prevalence of CH was estimated to be 119/100,000 (95% confidence interval 3, 238/100,000)... - Incidence and predictors of chronic headache attributed to whiplash injuryM Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Cephalalgia 30:528-34. 2010..024), and depression (OR 3.3, 95% CI 1.2, 9.4; P = 0.024). The lack of a control group limits the conclusions that can be drawn from this study. Identified predictors closely resemble those found in chronic primary headache disorders... - Prevalence of trigeminal autonomic symptoms in migraine: a population-based studyM Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Cephalalgia 27:504-9. 2007..Migraine patients with accompanying autonomic symptoms seem to experience their pain more unilateral and more severe than non-UA patients... - Chronic migraine: classification and comparisonsZ Katsarava
Department of Neurology, University of Essen, Hufelandstrasse 55, Essen, Germany
Cephalalgia 31:520-9. 2011.... - Structural gray and white matter changes in patients with HIVMichael Küper
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, 45122, Essen, Germany
J Neurol 258:1066-75. 2011..This pattern of atrophy is consistent with motor dysfunction and dysexecutive syndrome found in HIV patients with HIV-associated neurocognitive disorder... - Lateralized central facilitation of trigeminal nociception in cluster headacheD Holle
Department of Neurology, University of Duisburg Essen, Essen, Germany
Neurology 78:985-92. 2012..To investigate whether central facilitation of trigeminal pain processing is part of the pathophysiology of cluster headache (CH)... - Symptomatic migraine and pontine vascular malformation: evidence for a key role of the brainstem in the pathophysiology of chronic migraineM Obermann
Department of Neurology, University Duisburg-Essen, Essen, Germany
Cephalalgia 26:763-6. 2006 - Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesiaMin Suk Yoon
Department of Neurology, University of Duisburg Essen, Essen, Germany
Neurosci Bull 26:282-8. 2010..The present study was aimed to investigate the effect of recombinant human erythropoietin (rhEPO) on cisplatin-induced visceral hyperalgesia... - Sensory neuropathy in patients with cryoglobulin negative hepatitis-C infectionMin Suk Yoon
Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
J Neurol 258:80-8. 2011..5%) is higher than previously reported and (4) we found that detection of HCV associated neuropathy depends on the evaluation method... - Prevalence of primary headaches in Germany: results of the German Headache Consortium StudyM S Yoon
Department of Neurology, Ruhr University Bochum, Gudrunstr 56, 44791, Bochum, Germany
J Headache Pain 13:215-23. 2012..The prevalence with respect to episodic and chronic primary headache disorders in Germany is comparable to other European countries and the USA... - Cavernous malformation with hemorrhage of the conus medullaris and progressive sensory lossM Obermann
Department of Neurology, University Duisburg Essen, Germany
Clin Neuropathol 25:95-7. 2006..It is essential to achieve complete removal during the first operation to avoid any residues that may lead to further bleeding... - Post-traumatic headache: is it for real? Crossfire debates on headache: proMark Obermann
Department of Neurology, University of Duisburg Essen, Essen, Germany
Headache 50:710-5. 2010..Investigators should refrain from oversimplifying these complex mechanisms as hysteric exaggeration of everyday complains and from implying greed as motivation for this potentially very disabling disease... - Carotid intima-media thickness in HIV-infected individuals: relationship of premature atherosclerosis to neuropsychological deficits?Ozgur Yaldizli
Department of Neurology, University of Duisburg-Essen, Germany
Eur Neurol 55:166-71. 2006..IMT did not correlate with the severity of immunodeficiency... - Intrathecal viral replication and cerebral deficits in different stages of human immunodeficiency virus diseaseGabriele Arendt
Department of Neurology, University Hospital of Dusseldorf UKD, Dusseldorf, Germany
J Neurovirol 13:225-32. 2007..Lumbar puncture should be performed in all positive patients to identify members of this subgroup and to ascertain what characteristic factors they have in common in order to improve therapy... - The electrophysiology of cluster headacheDagny Holle
Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Curr Pain Headache Rep 13:155-9. 2009..Cortical and brainstem reflexes are reviewed to illuminate the pathophysiology of CH... - Increased activity of serotonin uptake in platelets in medication overuse headache following regular intake of analgesics and triptansIlya Ayzenberg
Department of Neurology, University of Duisburg Essen, Hufelandstr 55, Essen 45122, Germany
J Headache Pain 9:109-12. 2008....