W Neuhofer

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Cell survival in the hostile environment of the renal medulla
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, D 80336 Munich, Germany
    Annu Rev Physiol 67:531-55. 2005
  2. ncbi Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Germany
    Kidney Int 65:431-41. 2004
  3. ncbi Hypertonicity affects heat shock protein 27 and F-actin localization in Madin-Darby canine kidney cells
    W Neuhofer
    Department of Physiology, University of Munich, Germany
    Kidney Int Suppl 67:S165-7. 1998
  4. ncbi Inhibition of NaCl-induced heat shock protein 72 expression renders MDCK cells susceptible to high urea concentrations
    W Neuhofer
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Pflugers Arch 437:611-6. 1999
  5. ncbi Influence of NaCl, urea, potassium and pH on HSP72 expression in MDCK cells
    W Neuhofer
    Department of Physiology, University of Munich, Germany
    Pflugers Arch 439:195-200. 1999
  6. ncbi Heat shock protein 72, a chaperone abundant in renal papilla, counteracts urea-mediated inhibition of enzymes
    Wolfgang Neuhofer
    Dept of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munchen, Germany
    Pflugers Arch 445:67-73. 2002
  7. ncbi Regulated overexpression of heat shock protein 72 protects Madin-Darby canine kidney cells from the detrimental effects of high urea concentrations
    W Neuhofer
    Department of Physiology, University of Munich, Munich, Germany
    J Am Soc Nephrol 12:2565-71. 2001
  8. ncbi Possible involvement of heat shock protein 25 in the angiotensin II-induced glomerular mesangial cell contraction via p38 MAP kinase
    E Muller
    Institute of Physiology, University of Munich, Munich, Germany
    J Cell Physiol 181:462-9. 1999
  9. ncbi Influence of osmotic stress on heat shock proteins 25 and 72 in mouse mesangial cells
    E Muller
    Department of Physiology, University of Munich, Germany
    Kidney Int Suppl 67:S162-4. 1998
  10. ncbi Cationic amino acid transporter mRNA expression in rat kidney and liver
    A Burger-Kentischer
    Department of Physiology, University of Munich, Germany
    Kidney Int Suppl 67:S136-8. 1998

Collaborators

Detail Information

Publications28

  1. ncbi Cell survival in the hostile environment of the renal medulla
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, D 80336 Munich, Germany
    Annu Rev Physiol 67:531-55. 2005
    ....
  2. ncbi Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Germany
    Kidney Int 65:431-41. 2004
    ....
  3. ncbi Hypertonicity affects heat shock protein 27 and F-actin localization in Madin-Darby canine kidney cells
    W Neuhofer
    Department of Physiology, University of Munich, Germany
    Kidney Int Suppl 67:S165-7. 1998
    ..These results support the notion that HSP27 participates in the modulation of actin dynamics following hypertonic stress...
  4. ncbi Inhibition of NaCl-induced heat shock protein 72 expression renders MDCK cells susceptible to high urea concentrations
    W Neuhofer
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Pflugers Arch 437:611-6. 1999
    ..These results provide further evidence for the protective function of HSP72 against high urea concentrations in renal epithelial cells...
  5. ncbi Influence of NaCl, urea, potassium and pH on HSP72 expression in MDCK cells
    W Neuhofer
    Department of Physiology, University of Munich, Germany
    Pflugers Arch 439:195-200. 1999
    ..The high medullary HSP72 content observed even in diuresis may be due to co-operative effects of medullary solutes on HSP72 expression...
  6. ncbi Heat shock protein 72, a chaperone abundant in renal papilla, counteracts urea-mediated inhibition of enzymes
    Wolfgang Neuhofer
    Dept of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munchen, Germany
    Pflugers Arch 445:67-73. 2002
    ..Hence, in addition to the trimethylamine osmolytes, HSP72 may participate in counteracting urea-mediated effects on protein function in the renal papilla...
  7. ncbi Regulated overexpression of heat shock protein 72 protects Madin-Darby canine kidney cells from the detrimental effects of high urea concentrations
    W Neuhofer
    Department of Physiology, University of Munich, Munich, Germany
    J Am Soc Nephrol 12:2565-71. 2001
    ..These data support the view that HSP72, which is very abundant in the renal inner medulla, is an important component of the defense mechanism of medullary cells against extreme concentrations of urea...
  8. ncbi Possible involvement of heat shock protein 25 in the angiotensin II-induced glomerular mesangial cell contraction via p38 MAP kinase
    E Muller
    Institute of Physiology, University of Munich, Munich, Germany
    J Cell Physiol 181:462-9. 1999
    ..The fact that this function requires phosphorylation of HSP25 would explain the observation that HSP25 does not redistribute in SB 203580-pretreated cells...
  9. ncbi Influence of osmotic stress on heat shock proteins 25 and 72 in mouse mesangial cells
    E Muller
    Department of Physiology, University of Munich, Germany
    Kidney Int Suppl 67:S162-4. 1998
    ..Furthermore, high amounts of HSP25 seem to reduce the requirement for HSP72 after stress exposure, suggesting that, in mesangial cells, HSP25 might assume some functions of HSP72...
  10. ncbi Cationic amino acid transporter mRNA expression in rat kidney and liver
    A Burger-Kentischer
    Department of Physiology, University of Munich, Germany
    Kidney Int Suppl 67:S136-8. 1998
    ..In the kidney, hybridization signals were detected in parietal cells of Bowman's capsule, various tubule cells of outer and inner medulla, in endothelial and interstitial cells of inner medulla, and in papillary epithelial cells...
  11. ncbi Ammonium affects tight junctions and the cytoskeleton in MDCK cells
    M Vastag
    Physiologisches Institut, , Pettenkoferstrasse 12, 80336 Munich, Germany
    Pflugers Arch 449:384-91. 2005
    ....
  12. ncbi Molecular chaperones in the kidney: distribution, putative roles, and regulation
    F X Beck
    Physiologisches Institut der Universität München, Munich, Germany
    Am J Physiol Renal Physiol 279:F203-15. 2000
    ....
  13. ncbi Endothelin in human autoimmune diseases with renal involvement
    W Neuhofer
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Rheumatology (Oxford) 45:iii39-41. 2006
    ....
  14. ncbi Endothelin receptor selectivity in chronic kidney disease: rationale and review of recent evidence
    W Neuhofer
    Department of Internal Medicine, University of Munich, Munich, Germany
    Eur J Clin Invest 39:50-67. 2009
    ..Although preliminary data in humans are promising, the potential role of ERAs in patients with CKD and the question of which receptor subtype should be targeted can only be clarified in randomized clinical trials...
  15. ncbi Heat shock proteins and the cellular response to osmotic stress
    F X Beck
    Physiologisches Institut der Universität München, Munchen, Germany
    Cell Physiol Biochem 10:303-6. 2000
    ..Taken together these results suggest that also in the renal inner medulla, NaCl-induced enhancement of HSP72 expression may help counteract the detrimental effects of high urea concentrations...
  16. ncbi Endothelin and endothelin receptor antagonism in portopulmonary hypertension
    W Neuhofer
    Department of Physiology University of Munich, Munich, Germany
    Eur J Clin Invest 36:54-61. 2006
    ..If these observations can be corroborated by controlled clinical trials, bosentan would offer several advantages over available therapies, which have major drawbacks owing to their invasive and demanding mode of application...
  17. ncbi Role of endothelin and endothelin receptor antagonists in renal disease
    W Neuhofer
    Department of Physiology, University of Munich, Munich, Germany
    Eur J Clin Invest 36:78-88. 2006
    ..Thus, clinical studies are required to assess whether these results can be confirmed in humans, hopefully leading to novel and effective therapeutic options with few side effects...
  18. ncbi Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice
    Franz X Beck
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, 80336, Munich, Germany
    Pflugers Arch 446:100-5. 2003
    ..There were no significant changes of cell Na concentration and Rb uptake in distal convoluted tubule, connecting tubule, principal and intercalated cells...
  19. ncbi Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress
    Christoph Kuper
    Department of Physiology, University of Munich, Munich, Germany
    Am J Physiol Cell Physiol 293:C1971-82. 2007
    ..We conclude that tonicity-induced TGF-alpha release is required for COX-2 expression, PGE(2) synthesis, and survival of renal medullary cells during osmotic stress...
  20. ncbi Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Germany
    J Physiol 583:287-97. 2007
    ..These findings may be relevant in the pathophysiology of medullary damage associated with analgesic drugs...
  21. ncbi Survival in hostile environments: strategies of renal medullary cells
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Munich, Germany
    Physiology (Bethesda) 21:171-80. 2006
    ..This article reviews the strategies adopted by these cells to allow them to survive and fulfill their functions under these extreme conditions...
  22. ncbi Expression and regulation of alphaB-crystallin in the kidney in vivo and in vitro
    Marlies Michl
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    Pflugers Arch 452:387-95. 2006
    ..Moreover, the high abundance of alphaB-crystallin in the renal medulla may be important for cell survival in an environment characterized by extreme interstitial solute concentrations as present during antidiuresis...
  23. ncbi Response of renal medullary cells to osmotic stress
    Franz X Beck
    Physiologisches Institut der Universitat, Munchen, Germany
    Contrib Nephrol 148:21-34. 2005
    ....
  24. ncbi Relationship between intracellular ionic strength and expression of tonicity-responsive genes in rat papillary collecting duct cells
    Wolfgang Neuhofer
    Physiologisches Institut, , Germany
    J Physiol 543:147-53. 2002
    ....
  25. ncbi Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    J Physiol 564:715-22. 2005
    ..These observations indicate that PCD and PI cells employ cell-specific mechanisms for protection against high urea concentrations as present in the renal papilla during antidiuresis...
  26. ncbi Regulation of TonEBP transcriptional activator in MDCK cells following changes in ambient tonicity
    Wolfgang Neuhofer
    , , Germany
    Am J Physiol Cell Physiol 283:C1604-11. 2002
    ..We conclude that intracellular ionic strength and water content are major factors that determine the activity of TonEBP...
  27. ncbi Effect of ammonium on the expression of osmosensitive genes in Madin-Darby canine kidney cells
    Wolfgang Neuhofer
    , Pettenkoferstrasse 12, , Germany
    J Physiol 563:497-505. 2005
    ..These results suggest that, in addition to NaCl, NH4Cl may play a role in regulating the intracellular accumulation of organic osmolytes, the abundance of HSP70 and cell turnover in the renal medulla in vivo...
  28. ncbi Role of focal adhesion kinase (FAK) in renal ischaemia and reperfusion
    Konstantin Holzapfel
    Physiologisches Institut der Ludwig Maximilians Universität München, Pettenkoferstrasse 12, 80336 Munich, Germany
    Pflugers Arch 455:273-82. 2007
    ..Their reformation after ATP repletion paralleled the increase in FAK phosphorylation. These findings suggest an essential role for FAK-signalling during renal ischaemia and early reperfusion...