Research Topics
Genomes and Genes
| Michael MorcosSummaryAffiliation: University of Heidelberg Country: Germany Publications
| Collaborators
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Detail Information
Publications
Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory studyM Morcos
Department of Internal Medicine I, University of Heidelberg, Bergheimerstr 58, 69115 Heidelberg, Germany
Diabetes Res Clin Pract 52:175-83. 2001..Furthermore, progression of the disease might be inhibited by antioxidant drugs. A placebo-controlled study is needed...- Activation of tubular epithelial cells in diabetic nephropathyMichael Morcos
Department of Internal Medicine 1, University of Heidelberg, Bergheimerstrasse 58, 69115 Heidelberg, Germany
Diabetes 51:3532-44. 2002.... - The model Caenorhabditis elegans in diabetes mellitus and Alzheimer's diseaseMichael Morcos
Department of Internal Medicine 1, Endocrinology and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
J Alzheimers Dis 16:897-908. 2009..elegans. So far, C. elegans research has contributed to a better understanding of the function of AD-related genes and the development of this disease... - Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cellsM Morcos
Department of Internal Medicine 1 Endocrinology, Metabolism and Clinical Chemistry, University of Heidelberg, Germany
Horm Metab Res 40:752-9. 2008..Most importantly, rosiglitazone effects on NFkappaB activation were maximal at later time points, indicating that rosiglitazone treatment confers long lasting renoprotective effects... - Long-term treatment of central Cushing's syndrome with rosiglitazoneM Morcos
University of Heidelberg, Department of Internal Medicine, Endocrinology, Metabolism and Clinical Chemistry Heidelberg, Germany
Exp Clin Endocrinol Diabetes 115:292-7. 2007..Some studies revealed beneficial effects of the PPARgamma (Peroxisome-Proliferator-Activator- Receptor-gamma)-agonist rosiglitazone (RG) in in vitro studies, animal models and short term clinical studies... - Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetesPer M Humpert
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
Cardiovasc Diabetol 6:9. 2007..Since previous data were partly divergent, the aim of this study was to compare sRAGE and esRAGE in a head-to-head analysis in patients with type 2 diabetes (T2DM) with albuminuria... - Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathyZdenka Djuric
Department of Internal Medicine I and Clinical Chemistry, Ruprecht Karls University, Heidelberg, Germany
Acta Diabetol 47:79-82. 2010..The finding that homozygous carriers of the SDF-1 3'A genotype are more frequent in diabetes patients with proliferative retinopathy suggests a possible role of this genotype in the development of sight-threatening diabetic retinopathy... - C. elegans as model for the study of high glucose- mediated life span reductionAndreas Schlotterer
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
Diabetes 58:2450-6. 2009..Establishing Caenorhabditis elegans as a model for glucose toxicity-mediated life span reduction... - Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamilyAngelika Bierhaus
University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
J Clin Invest 114:1741-51. 2004..These data demonstrate, for the first time to our knowledge, that the RAGE-NF-kappaB axis operates in diabetic neuropathy, by mediating functional sensory deficits, and that its inhibition may provide new therapeutic approaches... - SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetesPer M Humpert
Medizinische Klinik 1, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
Diabetes Care 28:934-6. 2005 - Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegansAndreas Schlotterer
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Germany
Aging Cell 9:420-32. 2010..These results show that APE1/EXO-3, p53/CEP-1, and thioredoxin affect each other and that these interactions determine aging as well as neuronal structure and function... - Posttranslationally modified proteins as mediators of sustained intestinal inflammationMartin Andrassy
Department of Medicine I, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Am J Pathol 169:1223-37. 2006..Thus, CML-mps generated in inflammatory lesions have the capacity to elicit a RAGE-dependent intestinal inflammatory response... - Alanine-aminotransferase levels predict impaired glucose tolerance in a worksite populationChristoph Oberlinner
Department of Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, 69120, Germany
Acta Diabetol 47:161-5. 2010..These data point to an important role of the liver in insulin resistance and the development of impaired glucose tolerance in the relatively young and small population studied... - Plasma sRAGE is independently associated with urinary albumin excretion in type 2 diabetesPer M Humpert
Department of Medicine 1, University of Heidelberg, Heidelberg, Germany
Diabetes Care 29:1111-3. 2006 - No association of the 94T/G polymorphism in the adiponectin gene with diabetic complicationsG Rudofsky
Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Heidelberg, Germany
Diabetes Obes Metab 7:455-9. 2005..This study examined a possible association of the T/G polymorphism at nucleotide 94 in the adiponectin gene with the prevalence of diabetic complications... - New treatments for diabetic neuropathy: pathogenetically oriented treatmentAngelika Bierhaus
Department of Medicine I, University of Heidelberg, Germany
Curr Diab Rep 3:452-8. 2003.... - RAGE expression in the human peritoneal membraneLars P Kihm
Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
Nephrol Dial Transplant 23:3302-6. 2008..This study investigates the in vivo expression of RAGE in the peritoneal membrane of uraemic human patients... - Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistanceMaximilian von Eynatten
Department of Medicine I Endocrinology and Metabolism, University of Heidelberg, INF 410, D 69120 Heidelberg, Germany
Diabetes Care 27:2925-9. 2004..Recently, dramatically increased LPL activity was reported in mice overexpressing adiponectin. We therefore speculated that adiponectin may directly affect LPL in humans... - Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetesGottfried Rudofsky
Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
Diabetes Care 29:89-94. 2006..We studied the association between polymorphisms in the UCP genes and diabetes complications in patients with type 1 diabetes... - Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegansMichael Morcos
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Aging Cell 7:260-9. 2008..elegans lifespan. In contrast, knock-down of CeGly increases MG modifications of mitochondrial proteins and mitochondrial ROS production, and decreases C. elegans lifespan... - External electric muscle stimulation improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathyPer M Humpert
Medizinische Klinik 1 und Klinische Chemie, University Hospital, Heidelberg, Germany
Pain Med 10:413-9. 2009..However, differential effects on specific symptoms of neuropathy as well as determinants of treatment response have not been described... - Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaBA Bierhaus
Department of Medicine I and Department of Neurology, University of Heidelberg, Heidelberg, Germany
Diabetes 50:2792-808. 2001.... - A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetesG Rudofsky
Department of Medicine I, Otto Meyerhof Zentrum and Department of Nephrology, University of Heidelberg, Germany
Exp Clin Endocrinol Diabetes 112:135-41. 2004..The observed difference between type 1 and type 2 diabetes might point to diverse pathomechanisms of nephropathy in both types of diabetes... - Tissue factor as a link between wounding and tissue repairJiang Chen
University of Heidelberg, Department of Medicine I, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Diabetes 54:2143-54. 2005..These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes... - Evidence of left ventricular contractile asynchrony by echocardiographic phase imaging in patients with type 2 diabetes mellitus and without clinically evident heart diseaseGrigorios Korosoglou
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Am J Cardiol 98:1525-30. 2006..05) and showed higher intraobserver variability (5.6% vs 3.2%, p <0.05). In conclusion, this is the first study showing increased left ventricular asynchrony in patients with DM and no clinical evidence of heart disease... - [AGE-RAGE: a hypothesis or a mechanism?]Berend Isermann
Abteilung Endokrinologie und Stoffwechsel, Universitätsklinik Heidelberg, Heidelberg
Herz 29:504-9. 2004..Thus, further studies are needed for the characterization of the ligand-RAGE-interaction. These studies will provide a rationale for the development of new therapeutic approaches for accelerated atherosclerosis in diabetes mellitus... - The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complicationsG Rudofsky
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
Horm Metab Res 41:308-13. 2009..In conclusion these data suggest no major influence of the -174G>C variant in the promoter region of the IL-6 gene on the development of microvascular complications in patients with diabetes... - Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patientP M Humpert
Department of Medicine I, University Clinics Heidelberg, Germany
Exp Clin Endocrinol Diabetes 113:538-40. 2005..Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders... - Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers after renal transplantationC Morath
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 23:33-6. 2009..In addition, we review their influence on morphologic and biochemical markers as well as on renal function, graft and patient survival after renal transplantation... - Simultaneous pancreas-kidney transplantation in type 1 diabetesC Morath
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 23:115-20. 2009..We give a short overview on SPK transplantation, with a focus on the effects of this procedure on diabetic complications as well as patient and kidney graft survival... - [The unsolved problem of diabetes mellitus type 2 and associated complications]M Morcos
Medizinische Klinik Krehl Klinik, Abteilung Innere Medizin 1 und Klinische Chemie, Universitatsklinikum Heidelberg, INF 410, 69120 Heidelberg, Deutschland
Chirurg 80:398, 400-4, 406-9. 2009..Finally, generating treatment guidelines is extremely difficult as clinical studies targeting vascular endpoints need more than 10 years to become informative, partly due to the so-called glycaemic memory... - Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single mealS Schiekofer
Department of Medicine I, University of Heidelberg, Heidelberg, Germany
Exp Clin Endocrinol Diabetes 114:160-7. 2006..CONCLUSION: Postprandial mononuclear NF-kappaB activation after a single meal is independent of the AGE-content of the ingested protein... - [Diabetic nephropathy]M Morcos
, Endokrinologie, Stoffwechsel und Klinische Chemie, ,
Dtsch Med Wochenschr 132:1039-42. 2007 - Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patientsP M Humpert
Department of Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
Diabetologia 50:1517-22. 2007.... - [Oral diabetes treatment. Which substance is indicated at which time?]A Hamann
Abteilung Innere Medizin I, Universitatsklinikum Heidelberg
Internist (Berl) 45:1356-63. 2004..This recommendation for monotherapy of overweight type 2 diabetics is supported by an endpoint study. In contrast, no equivalent evidence is available on any of the possible options for oral combination therapy... - Improved vascular function upon pioglitazone treatment in type 2 diabetes is not associated with changes in mononuclear NF-kappaB binding activityG Rudofsky
Department Medicine I and Clinical Chemistry, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
Horm Metab Res 39:665-71. 2007.... - A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetesG Rudofsky
Division of Endocrinology and Metabolism, Department of Medicine, University of Heidelberg, Germany
Exp Clin Endocrinol Diabetes 116:14-7. 2008..We studied the association between a functionally relevant M55V polymorphism in the SUMO4 gene with microvascular diabetic complications in patients with type 1 diabetes... - sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetesP M Humpert
Universitätsklinikum Heidelberg Medizinische Klinik 1 und Klinische Chemie, Heidelberg, Germany
Horm Metab Res 39:899-902. 2007..01) and presence of retinopathy (beta=-0.19, p<0.05). In contrast to classical risk factors, plasma soluble RAGE and endogenous secretory RAGE are not associated with measures of diabetic neuropathy in type 2 diabetes patients... - A mechanism converting psychosocial stress into mononuclear cell activationAngelika Bierhaus
Department of Medicine I, University of Heidelberg, Otto Meyerhof Zentrum, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 100:1920-5. 2003..Activation of NF-kappaB represents a downstream effector for the neuroendocrine response to stressful psychosocial events and links changes in the activity of the neuroendocrine axis to the cellular response... - Variants in the human beta 1-, beta 2-, and beta 3-adrenergic receptor genes are not associated with morbid obesity in children and adolescentsJ Tafel
Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universitatsklinikum Heidelberg, 69115 Heidelberg, Germany
Diabetes Obes Metab 6:452-5. 2004..We therefore investigated the possible association of polymorphisms in the beta-adrenergic receptor genes with early onset obesity... - Human glomerular mesangial cells express CD16 and may be stimulated via this receptorM Morcos
Institute of Immunology and Serology, Medical Faculty of Mannheim, University of Heidelberg, Germany
Kidney Int 46:1627-34. 1994..The occupancy of CD16 by immune complexes that may be deposited in various forms of glomerulonephritis might contribute to the perpetuation of inflammatory processes in the kidney... - Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery diseaseT Forst
Institute for Clinical Research and Development, Parcusstrasse 8, D 55116 Mainz, Germany
Atherosclerosis 197:311-7. 2008..No changes in these parameters could be observed during placebo treatment. Even before effects on glucose metabolism could be obtained, pioglitazone exerts immediate effects on plasma markers of plaque vulnerability and inflammation... - [Adrenal cortex and steroids. Supplementary therapy in the perioperative phase]A S Milde
, , Heidelberg
Anaesthesist 54:639-54. 2005..With regard to the broad spectrum of efficacy of glucocorticoids and their side effects, revision and modification of the historical regimen appear prudent...