Research Topics
Species | Jürgen MarklSummaryAffiliation: University of Mainz Country: Germany Publications
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Detail Information
Publications
10-A cryoEM structure and molecular model of the Myriapod (Scutigera) 6x6mer hemocyanin: understanding a giant oxygen transport proteinJürgen Markl
Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
J Mol Biol 392:362-80. 2009..Moreover, we detected histidine clusters, notably in Scutigera, allowing us to advance hypotheses as to how the hexamers are allosterically coupled in centipede hemocyanin and why they act more independently in diplopod hemocyanin...- Molluscan mega-hemocyanin: an ancient oxygen carrier tuned by a ~550 kDa polypeptideBernhard Lieb
Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
Front Zool 7:14. 2010..Moreover, we introduce and describe a more complex type of hemocyanin tridecamer discovered in fresh/brackish-water cerithioid snails (Leptoxis, Melanoides, Terebralia)... - Limulus polyphemus hemocyanin: 10 A cryo-EM structure, sequence analysis, molecular modelling and rigid-body fitting reveal the interfaces between the eight hexamersAndreas G Martin
Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
J Mol Biol 366:1332-50. 2007..The molecular model shows the amino acid residues involved, and reveals that several of the interfaces are intriguingly histidine-rich and likely to transfer allosteric signals between the different levels of the nested hierarchy... - Comparative 11A structure of two molluscan hemocyanins from 3D cryo-electron microscopyUlrich Meissner
Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
Micron 38:754-65. 2007..The arc is attached to the wall through a feature termed the anchor, a previously undescribed structural element of the hemocyanin wall... - Nautilus pompilius hemocyanin: 9 A cryo-EM structure and molecular model reveal the subunit pathway and the interfaces between the 70 functional unitsChristos Gatsogiannis
Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
J Mol Biol 374:465-86. 2007..Thus, the 9 A structure of Nautilus hemocyanin provides fundamentally new insight into the architecture and function of molluscan hemocyanins... - Type I keratin cDNAs from the rainbow trout: independent radiation of keratins in fishMichael Schaffeld
Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
Differentiation 70:282-91. 2002..Within this second branch, the teleost keratins form a separate, highly bootstrap-supported twig. This tree leaves little doubt that the teleost Ie keratins diversified independently from the mammalian Ie keratins... - Type II keratin cDNAs from the rainbow trout: implications for keratin evolutionMichael Schaffeld
Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
Differentiation 70:292-9. 2002..The tree also indicates that the published zebrafish sequences represent IIe keratins and that the biochemically identified K8 ortholog in zebrafish has not yet been sequenced... - Recombinant functional multidomain hemoglobin from the gastropod Biomphalaria glabrataVanessa Moeller
Institute of Zoology, Johannes Gutenberg University, Mainz, Germany
IUBMB Life 63:323-8. 2011..The covalently linked dimer of BgHb1, but not the monomer, is capable to form aggregates closely resembling native BgHb molecules in the electron microscope... - The hemocyanin from a living fossil, the cephalopod Nautilus pompilius: protein structure, gene organization, and evolutionSandra Bergmann
Institute of Zoology, Johannes Gutenberg University, Mainz, Germany
J Mol Evol 62:362-74. 2006..This reveals that the last common ancestor of Nautilus and Octopus lived 415 +/- 24 million years ago, in close agreement with fossil records from the early Devonian... - Red blood with blue-blood ancestry: intriguing structure of a snail hemoglobinBernhard Lieb
Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
Proc Natl Acad Sci U S A 103:12011-6. 2006.... - Quaternary structure of the European spiny lobster (Palinurus elephas) 1x6-mer hemocyanin from cryoEM and amino acid sequence dataUlrich Meissner
Institute of Zoology, University of Mainz, Muellerweg 6, D 55099 Mainz, Germany
J Mol Biol 325:99-109. 2003..By molecular modelling, we have found the putative locations for the amino acid sequence (597-605) and the C-terminal end (654-657), which are absent in the available P.interruptus X-ray data... - Gene structure and hemocyanin isoform HtH2 from the mollusc Haliotis tuberculata indicate early and late intron hot spotsBenjamin Altenhein
Institute of Zoology, Johannes Gutenberg University, 55099, Mainz, Germany
Gene 301:53-60. 2002..Comparison to previously sequenced genes of Octopus dofleini hemocyanin and Haliotis hemocyanin isoform (HtH1) suggests Precambrian and Palaeocoic hot spot of intron gains, followed by 320 million years of absolute stasis... - cDNA sequence, protein structure, and evolution of the single hemocyanin from Aplysia californica, an opisthobranch gastropodBernhard Lieb
Institute of Zoology, Johannes Gutenberg University, D 55128 Mainz, Germany
J Mol Evol 59:536-45. 2004..However, the gene duplication yielding the two distinct hemocyanin isoforms found today in Haliotis tuberculata occurred 343+/-43 million years ago... - The first complete cDNA sequence of the hemocyanin from a bivalve, the protobranch Nucula nucleusSandra Bergmann
Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
J Mol Evol 64:500-10. 2007..Assuming a molecular clock, the last common ancestor of protobranch and gastropods lived 494 million +/- 50 million years ago, in conformity with fossil records from the late Cambrian... - Keyhole limpet hemocyanin: 9-A CryoEM structure and molecular model of the KLH1 didecamer reveal the interfaces and intricate topology of the 160 functional unitsChristos Gatsogiannis
Institute of Zoology, Johannes Gutenberg University, D 55099 Mainz, Germany
J Mol Biol 385:963-83. 2009..In conclusion, the present 9-A data on KLH1 confirm and substantially broaden our recent analysis of the smaller cephalopod hemocyanin and essentially solve the gastropod hemocyanin structure... - Cupredoxin-like domains in haemocyaninsElmar Jaenicke
Institut für Molekulare Biophysik, Johannes Gutenberg Universitat, Jakob Welder Weg 26, 55128 Mainz, Germany
Biochem J 426:373-8. 2010..We propose that the cupredoxin-like domain in both haemocyanin types once served to upload copper to the active site of the oxygen-binding domain... - The refined structure of functional unit h of keyhole limpet hemocyanin (KLH1-h) reveals disulfide bridgesElmar Jaenicke
Institut für Molekulare Biophysik, Johannes Gutenberg Universitat, Jakob Welder Weg 26, Mainz, Germany
IUBMB Life 63:183-7. 2011.... - 3-D reconstruction of hemocyanins and other invertebrate hemolymph proteins by cryo-TEM: an overviewUlrich Meissner
Institute of Zoology, Johannes Gutenberg--University, D-55099, Mainz, Germany
Micron 35:7-9. 2004 - Evolution of molluscan hemocyanins as deduced from DNA sequencingBernhard Lieb
Institute of Zoology, Johannes Gutenberg University, D-55099 Mainz, Germany
Micron 35:117-9. 2004 - Minireview: Recent progress in hemocyanin researchHeinz Decker
Institute for Molecular Biophysics, Johannes Gutenberg University, 55099 Mainz, Germany Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
Integr Comp Biol 47:631-44. 2007.... - 3D reconstruction of the hemocyanin subunit dimer from the chiton Acanthochiton fascicularisJ Robin Harris
Institute of Zoology, Johannes Gutenberg University, D-55099, Mainz, Germany
Micron 35:23-6. 2004.... - Complete hemocyanin subunit sequences of the hunting spider Cupiennius salei: recent hemocyanin remodeling in entelegyne spidersPia Ballweber
Institute of Zoology, Johannes Gutenberg University, D-55099 Mainz, Germany
J Biol Chem 277:14451-7. 2002.... - Topology of the 10 subunits within the decamer of KLH, the hemocyanin of the marine gastropod Megathura crenulataWolfgang Gebauer
Institute of Zoology, University of Mainz, Mainz, Germany
J Struct Biol 139:153-9. 2002..The pattern of labeling also indicates a peripheral localization of the c functional units. The data presented in this paper support only one of two possible models for the subunit orientation within the hemocyanin decamer... - Fish keratinsMichael Schaffeld
Institute of Zoology, Johannes Gutenberg University, 55099 Mainz, Germany
Methods Cell Biol 78:627-71. 2004 - Subunit sequences of the 4 x 6-mer hemocyanin from the golden orb-web spider, Nephila inaurataAnne Averdam
Institute of Zoology, Johannes Gutenberg University, Mainz, Germany
Eur J Biochem 270:3432-9. 2003..Assuming a clock-like evolution of the chelicerate hemocyanins, a timescale for the evolution of the Chelicerata was obtained that agrees with the fossil record... - cDNA sequences of the authentic keratins 8 and 18 in zebrafishMichael Schaffeld
Institute of Zoology, Johannes Gutenburg University, Mainz, Germany
Differentiation 71:73-82. 2003..Moreover, several zebrafish type II keratin sequences published by other authors have now been assigned to epidermal keratins, previously identified biochemically...