Research Topics
| Hanns Martin LorenzSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
| Collaborators
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Detail Information
Publications
Technology evaluation: adalimumab, Abbott laboratoriesHanns M Lorenz
Rheumatology Institute for Clinical Immunology, Department of Medicine III, University of Erlangen Nuremberg, Germany
Curr Opin Mol Ther 4:185-90. 2002..65 million in that year rising to pounds sterling 30.14 million in 2010. In March 2001, ABN AMRO predicted sales of $73 million in 2003 rising to $392 million in 2007...- Biological agents: a novel approach to the therapy of rheumatoid arthritisH M Lorenz
Department of Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Expert Opin Investig Drugs 9:1479-90. 2000..Similar encouraging results might evoke from trials employing other TNF-alpha-directed agents like the fully human mAb D(2)E7 or the p75 TNF-alpha-receptor-Ig construct, etanercept... - Perspectives for TNF-alpha-targeting therapiesHanns Martin Lorenz
Institute for Clinical Immunology and Rheumatology, Department of Medicine, University of Erlangen Nuremberg, Germany
Arthritis Res 4:S17-24. 2002..Combination partners other than methotrexate will be established as suitable cotreatment along with anti-TNF-alpha biologicals. Forthcoming new indications for TNF-alpha-targeted therapies are discussed... - Abetimus (La Jolla pharmaceuticals)Hanns Martin Lorenz
University of Erlangen Nuremberg, Department of Medicine III, Institute of Clnical Immunol Rheumatology, Germany
Curr Opin Investig Drugs 3:234-9. 2002..The patents also cover methods of synthesis and use [269583]. In November 2001, Morgan Keegan & Co estimated sales to be US $150 million in 2003, rising to US $600 million in 2005 [439326]... - Hyporesponsiveness to gammac-chain cytokines in activated lymphocytes from patients with systemic lupus erythematosus leads to accelerated apoptosisHanns Martin Lorenz
Department of Medicine III, Institute for Clinical Immunology Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
Eur J Immunol 32:1253-63. 2002.... - [New therapy developments in rheumatoid arthritis]H M Lorenz
Abt für Rheumatologie Inst für Klin Immunologie Medizinische Klinik III Universität Erlangen Nürnberg Krankenhausstr 12 91054 Erlangen, Germany
Z Rheumatol 60:326-32. 2001.... - The pathogenesis of autoimmune diseasesH M Lorenz
Institute for Clinical Immunology, Department of Medicine III, University of Erlangen Nuremberg, Erlangen, Germany
Scand J Clin Lab Invest Suppl 235:16-26. 2001..An intriguing hypothesis postulates a central role for a dysregulated apoptosis in the development of SLE. In this review we will concentrate on pathogenetic concepts of autoimmune diseases as exemplified by RA and SLE... - TNF inhibitors in the treatment of arthritisH M Lorenz
Department of Medicine III, Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12 91054 Erlangen, Germany
Curr Opin Investig Drugs 1:188-93. 2000..In particular, clinical trials testing anti-TNF alpha agents either alone or in combination with MTX have proven the feasibility and efficacy of these novel approaches... - T-cell-activation inhibitors in rheumatoid arthritisHanns Martin Lorenz
Department of Medicine III, Rheumatology Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
BioDrugs 17:263-70. 2003.... - Interleukin-4 supports interleukin-12-induced proliferation and interferon-gamma secretion in human activated lymphoblasts and T helper type 1 cellsMartin A Kriegel
Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
Immunology 119:43-53. 2006..These findings should be of importance for the design of cytokine-targeted therapies of human Th-cell-driven diseases... - Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type IIMartin A Kriegel
Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Germany
J Exp Med 199:1285-91. 2004..The defect was persistent and not due to responder cell resistance. These data provide novel insights into the pathogenesis of APS-II and possibly human autoimmunity in general... - A fast, simple and sensitive method for the detection and quantification of detergent-resistant membranesNorbert Blank
Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Glueckstrasse 4a, Germany
J Immunol Methods 271:25-35. 2002..The presence of protein in these fractions was confirmed by silver-stained polyacrylamide gels. We confirmed the presence of adaptor molecules (LAT) and Src kinases (Lck) in the DRM containing fractions 4 to 6... - Anti-HLA-DR-triggered monocytes mediate in vitro T cell anergyMartin A Kriegel
Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen Nuremberg, Erlangen, Germany
Int Immunol 20:601-13. 2008..In summary, anti-HLA-DR treatment can generate tolerogenic monocytes transmitting T cell anergy that may be exploited for future immunomodulatory strategies to treat immune-mediated disease states... - Enhanced killing of B lymphoma cells by granulocyte colony-stimulating factor-primed effector cells and Hu1D10--a humanized human leucocyte antigen DR antibodyBernhard Stockmeyer
Department of Medicine III, University of Erlangen Nurnberg, Erlangen, Germany
Br J Haematol 118:959-67. 2002..These preclinical results form the basis for a phase I/II clinical trial of Hu1D10 in combination with G-CSF... - Cholera toxin binds to lipid rafts but has a limited specificity for ganglioside GM1Norbert Blank
Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
Immunol Cell Biol 85:378-82. 2007.... - Extravasation into synovial tissue induces CCL20 mRNA expression in polymorphonuclear neutrophils of patients with rheumatoid arthritisJudith Schlenk
Institute for Clinical Microbiology, Immunology and Hygiene, University of Erlangen-Nuremberg, Erlangen, Germany
J Rheumatol 32:2291-8. 2005..CONCLUSION: Recruitment of PMN to the synovial microenvironment induces expression of CCL20 mRNA independent of the concentrations of TNF-alpha accumulating in SF of patients with RA... - Inhibition of sphingolipid synthesis impairs cellular activation, cytokine production and proliferation in human lymphocytesNorbert Blank
Department of Internal Medicine V, Division of Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Biochem Pharmacol 71:126-35. 2005..However, inhibition of glucosphingolipid synthesis itself did not inhibit cellular activation. Our data show that glucosphingolipids - in contrast to cholesterol - are not essential for the stabilisation of MM... - Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritisRainer H Straub
Laboratory of Experimental Rheumatology and Neuroendocrino Immunology, Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
Arthritis Rheum 58:976-84. 2008..We undertook this study to investigate the predictive value of hypothalamic-pituitary-adrenal (HPA) axis hormones for clinical improvement during anti-TNF therapy... - Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretionRainer H Straub
Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Arthritis Rheum 48:1504-12. 2003..Beyond local effects, anti-TNF treatment may modulate systemic antiinflammatory pathways such as the hypothalamic-pituitary-adrenal (HPA) axis. This longitudinal anti-TNF therapy study was designed to assess these effects in RA patients... - Atorvastatin inhibits T cell activation through 3-hydroxy-3-methylglutaryl coenzyme A reductase without decreasing cholesterol synthesisNorbert Blank
Department of Medicine V, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany
J Immunol 179:3613-21. 2007..Statins induce both lower levels of low-density lipoprotein cholesterol and inhibition of T cell activation, which might contribute to an inhibition of atherosclerosis... - Mycobacterium kansasii tenosynovitis in a rheumatoid arthritis patient with long-term therapeutic immunosuppressionHanns-Martin Lorenz
Department of Medicine, Division of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
Arthritis Rheum 59:900-3. 2008 - Apoptotic bodies derived from apoptotic lymphoblasts contain a distinct pattern of antigensM Schiller
Department of Medicine V, University of Heidelberg, Heidelberg, Germany
Autoimmunity 40:340-1. 2007 - Purified apoptotic bodies stimulate plasmacytoid dendritic cells to produce IFN-alphaP Heyder
Department of Medicine V, University of Heidelberg, Heidelberg, Germany
Autoimmunity 40:331-2. 2007 - Dysregulation of apoptosis as mechanism supporting the induction of autoimmunityHanns-Martin Lorenz
Department of Medicine V, Division of Rheumatology, University of Heidelberg, Hospitalstrasse 3, 69115 Heidelberg, Germany
Curr Rheumatol Rep 6:249-51. 2004 - The putative role of apoptosis-modified histones for the induction of autoimmunity in Systemic Lupus ErythematosusChristoph Gabler
Department of Medicine III, Institute for Clinical Immunology and Rheumatology, University of Erlangen-Nuremberg, Krankenhausstr. 12, 91054 Erlangen, Germany
Biochem Pharmacol 66:1441-6. 2003.... - Tumor necrosis factor receptor-associated periodic syndrome characterized by a mutation affecting the cleavage site of the receptor: implications for pathogenesisMartin A Kriegel
University of Erlangen-Nuremberg, Erlangen, Germany
Arthritis Rheum 48:2386-8. 2003 - Reduced CD4+,CD25- T cell sensitivity to the suppressive function of CD4+,CD25high,CD127 -/low regulatory T cells in patients with active systemic lupus erythematosusRam Kumar Chowdary Venigalla
University of Heidelberg, Heidelberg, Germany
Arthritis Rheum 58:2120-30. 2008..To overcome this problem, we analyzed the phenotype and function of CD4+,CD25high,CD127(-/low) natural Treg (nTreg) cells isolated from the peripheral blood of patients with SLE...