Research Topics
Genomes and Genes
| Frank LeithäuserSummaryAffiliation: University of Ulm Country: Germany Publications
| Collaborators
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Detail Information
Publications
In situ characterization of genetically targeted (green fluorescent) single cells and their microenvironment in an adoptive hostF Leithäuser
Departments of Pathology and Medical Microbiology and Immunology, University of Ulm, Ulm, Germany
Am J Pathol 158:1975-83. 2001....- Clustering of colonic lamina propria CD4(+) T cells to subepithelial dendritic cell aggregates precedes the development of colitis in a murine adoptive transfer modelF Leithäuser
Department of Pathology, University of Ulm, Ulm, Germany
Lab Invest 81:1339-49. 2001..The data suggest that pathogenic T cell responses inducing inflammatory bowel disease are primed or restimulated in situ in junctional CD4(+) T cell/DC aggregates... - Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphomaF Leithäuser
Department of Pathology, University of Ulm, Germany
Blood 98:2762-70. 2001..Moreover, our data indirectly suggest that regulation by extrinsic signals contributes to the immunoglobulin-negative phenotype of PMBL... - Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitisFrank Leithäuser
Department of Pathology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
Am J Pathol 168:1898-909. 2006..We conclude that DC aggregates are structures involved in the expansion and/or differentiation of CD103+ CD25- CD4+ Foxp3-expressing regulatory T cells... - IL-20 receptor 2 signaling down-regulates antigen-specific T cell responsesChristian Wahl
University Medical Center, Center of Internal Medicine, Department of Internal Medicine I, Ulm, Germany
J Immunol 182:802-10. 2009..For the first time, we provide evidence that IL-19, IL-20, and IL-24 are part of a signaling network that normally down-modulates T cell responses in mice... - Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphomaSergey W Popov
Department of Pathology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
Cancer Res 67:6555-64. 2007..Thus, accessibility of the target sequences seems to be a major limiting factor for AID-dependent somatic gene diversification in PMBL... - MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitisTamara Krajina
Department of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany
Eur J Immunol 34:705-14. 2004..Hence, regulatory CD25+ T cells within (or developing from) the DP T cell population of MHC class II-deficient mice control the colitogenic potential of CD25- CD4+ T cells... - KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphomaHanfeng Guan
Institute of Physiological Chemistry, University of Ulm, Germany
Blood 116:1469-78. 2010..We conclude that epigenetic silencing of KLF4 in B-cell lymphomas and particularly in cHL may favor lymphoma survival by loosening cell-cycle control and protecting from apoptosis... - Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 proteinIngo Melzner
Department of Pathology, University of Ulm, Ulm, Germany
Int J Cancer 118:1941-4. 2006..Therefore, we conclude that loss of SOCS-1 function either by mutation or by the complete deletion of the gene plays an important role in the dysregulation of JAK/STAT signaling in Karpas1106P and PMBL... - Breaking tolerance in hepatitis B surface antigen (HBsAg) transgenic mice by vaccination with cross-reactive, natural HBsAg variantsReinhold Schirmbeck
Department of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany
Eur J Immunol 33:3342-52. 2003..Hence, vaccination with natural HBsAg variants from different HBV sero/genotypes can prime cross-reactive, specific CD8(+) T cell immunity that breaks tolerance to HBsAg... - IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus entry mediator deficiencyChristian Wahl
Department of Internal Medicine I, University of Ulm, Ulm, Germany
J Immunol 182:4521-8. 2009..Hence, HVEM expression promotes pathogenic, proinflammatory Th1 responses but down-modulates protective IL-22 responses of T cells in this model of acute hepatitis... - Myc regulates embryonic vascular permeability and remodelingEniko Kokai
Institute of Physiological Chemistry, Ulm University, Ulm, Germany
Circ Res 104:1151-9. 2009..Thus, the net outcome of an excess of vascular endothelial growth factor-A and angiopoietin-2 in the face of an elevated cellular turnover appears to be a defect in vascular integrity... - Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic miceAnja C Utz
Department of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
J Histochem Cytochem 58:1-15. 2010..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials... - Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivoHeidrun Hirner
Department of General, Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
PLoS ONE 7:e29709. 2012..Our data show that inactivating mutations in CK1? impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo...