Research Topics
Genomes and GenesSpecies | M LacherSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Association of a CXCL9 polymorphism with pediatric Crohn's diseaseMartin Lacher
Dr von Haunersches Kinderspital, Pediatric Surgical Clinic, Research Laboratories, Ludwig Maximilians University of Munich, Lindwurmstr 4, D 80337 Munich, Germany
Biochem Biophys Res Commun 363:701-7. 2007..1 versus 13.8 years). This is the first report of inverse association of the CXCL9 77147452G-->A polymorphism with pediatric CD. Our data may contribute to a better understanding of the pathophysiology underlying CD...
Nuclear pregnane X receptor single nucleotide polymorphism (-25385C/T) is not associated with inflammatory bowel disease in pediatric patientsMartin Lacher
Department of Pediatric Surgery, Dr von Haunersches Kinderspital, Ludwig Maximilians University of Munich, Lindwurmstr, Munich, Germany
J Pediatr Gastroenterol Nutr 49:147-50. 2009..Studies in adults characterized the role of the pregnane X receptor (PXR) in the pathophysiology of inflammatory bowel disease (IBD) with conflicting results; pediatric studies are still lacking...
Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German childrenMartin Lacher
Department of Paediatric Surgery, Research Laboratories, University of Munich, Munich, Germany
Acta Paediatr 98:1835-40. 2009..Therefore, we evaluated this polymorphism in early-onset CD in 152 children and 253 controls and for the first time determined ATG16L1 colonic expression in German CD children...
Association of the interleukin-23 receptor gene variant rs11209026 with Crohn's disease in German childrenM Lacher
Department of Paediatric Surgery, Research Laboratories, University of Munich, Munich, Germany
Acta Paediatr 99:727-33. 2010..We investigated the association of rs11209026 (p.Arg381Gln) and rs7517847 (c.799-3588T>G) into German paediatric inflammatory bowel disease (IBD) patients and analysed IL23R transcriptional activity in colonic tissues...
Early and long term outcome in children with esophageal atresia treated over the last 22 yearsM Lacher
Pediatric Surgical Clinic, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munchen, Germany
Klin Padiatr 222:296-301. 2010..The survival of infants born with esophageal atresia (EA) is > 90% at present. The purpose of this study was to evaluate early complications and long term outcome in children with EA treated at our institution...
NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's diseaseMartin Lacher
Department of Pediatric Surgery, Research Laboratories, University of Munich, D 80337 Munich, Germany
J Pediatr Surg 45:1591-7. 2010..The aim of this study was to investigate the effect of these mutations on disease manifestation and the risk of surgery in a cohort of German childhood-onset CD patients...
Hirschsprung-associated enterocolitis develops independently of NOD2 variantsMartin Lacher
Department of Pediatric Surgery, Research Laboratories, University of Munich, D 80337 Munich, Germany
J Pediatr Surg 45:1826-31. 2010....
The treatment of supracondylar humeral fractures with elastic stable intramedullary nailing (ESIN) in childrenMartin Lacher
Department of Pediatric Surgery, University of Munich, Munich, Germany
J Pediatr Orthop 31:33-8. 2011..Therefore, the aim of the study was to assess both radiologic and functional outcome of supracondylar humeral fractures treated by elastic stable intramedullary nailing (ESIN) in a large pediatric cohort...
Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac diseaseJurgen Glas
Department of Medicine II, Grosshadern, Ludwig Maximilians University, Munich, Germany
Am J Gastroenterol 104:1737-44. 2009..Given the increased prevalence of inflammatory bowel disease (IBD) among celiac disease patients, we investigated the possible involvement of these SNPs in IBD...
