Katharina Kubatzky

Summary

Affiliation: University of Heidelberg
Location: Heidelberg, Germany
Summary:
Bacterial protein toxins and immune evasion.
Rho GTPase, JAK-STAT and cytokine receptor signalling
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Publications

  1. ncbi Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent
    Dagmar Hildebrand
    Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Infect Immun 79:220-8. 2011
  2. ncbi Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor
    K F Kubatzky
    Max-Planck-Institute of Immunobiology, Freiburg 79108, Germany
    Curr Biol 11:110-5. 2001
  3. ncbi The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression
    Mehtap S Gündogdu
    Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Ruprecht Karls Universitat, Im Neuenheimer Feld 324, Heidelberg, Germany
    Mol Cancer 9:225. 2010
  4. ncbi Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity
    Dagmar Hildebrand
    Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Cell Microbiol 12:1732-45. 2010
  5. ncbi Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways
    Inga Preuss
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Cell Microbiol 12:1174-85. 2010
  6. ncbi Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Germany
    Cell Commun Signal 8:2. 2010
  7. ncbi The small GTPase RhoH is an atypical regulator of haematopoietic cells
    Florian Fueller
    Ruprecht Karls Universitat Heidelberg, Hygiene Institut, Abteilung für Hygiene und Medizinische Mikrobiologie, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Cell Commun Signal 6:6. 2008
  8. ncbi Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin
    Joachim H C Orth
    Institut fur Experimentelle and Klinische Pharmakologie and Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg, Germany
    J Biol Chem 282:3050-7. 2007
  9. ncbi Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function
    Katharina F Kubatzky
    Ludwig Institute for Cancer Research, Bruxelles 1200, Belgium
    J Biol Chem 280:14844-54. 2005
  10. ncbi Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
    Nadine Seubert
    Ludwig Institute for Cancer Research, Brussels B 1200, Belgium
    Mol Cell 12:1239-50. 2003

Collaborators

Detail Information

Publications11

  1. ncbi Pasteurella multocida toxin-stimulated osteoclast differentiation is B cell dependent
    Dagmar Hildebrand
    Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Infect Immun 79:220-8. 2011
    ..These results suggest that the osteoclastic properties characteristic for PMT may result from a cross talk between bone cells and lymphoid cells and that B cells might be an important target of Pasteurella multocida...
  2. ncbi Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor
    K F Kubatzky
    Max-Planck-Institute of Immunobiology, Freiburg 79108, Germany
    Curr Biol 11:110-5. 2001
    ..Thus, efficient signal transduction through EpoR and possibly other preformed receptor oligomers may be determined by the dynamics of TM self assembly...
  3. ncbi The haematopoietic GTPase RhoH modulates IL3 signalling through regulation of STAT activity and IL3 receptor expression
    Mehtap S Gündogdu
    Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Ruprecht Karls Universitat, Im Neuenheimer Feld 324, Heidelberg, Germany
    Mol Cancer 9:225. 2010
    ..Here, we examined the activation of signal transducer and activator of transcription (STAT) proteins in response to stimulation with interleukin 3 (IL3)...
  4. ncbi Pasteurella multocida Toxin-induced Pim-1 expression disrupts suppressor of cytokine signalling (SOCS)-1 activity
    Dagmar Hildebrand
    Department für Infektiologie, Medizinische Mikrobiologie und Hygiene, Im Neuenheimer Feld 324, D 69120 Heidelberg, Germany
    Cell Microbiol 12:1732-45. 2010
    ..Thus we hypothesize that P. multocida Toxin alters host cell signalling using mechanisms that have so far only been known to be employed by oncogenic viral kinases to avoid host immune defence mechanisms...
  5. ncbi Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways
    Inga Preuss
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Cell Microbiol 12:1174-85. 2010
    ..Our data indicate that PMT is a highly potent anti-apoptotic agent, which supports the view of a carcinogenic potential of the toxin...
  6. ncbi Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Germany
    Cell Commun Signal 8:2. 2010
    ..This report gives an overview of the presentations of the conference...
  7. ncbi The small GTPase RhoH is an atypical regulator of haematopoietic cells
    Florian Fueller
    Ruprecht Karls Universitat Heidelberg, Hygiene Institut, Abteilung für Hygiene und Medizinische Mikrobiologie, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    Cell Commun Signal 6:6. 2008
    ..The recent generation of RhoH knockout mice showed a defect in thymocyte selection and TCR signalling of thymic and peripheral T-cells. However, RhoH-deficient mice did not develop lymphomas or showed obvious defects in haematopoiesis...
  8. ncbi Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin
    Joachim H C Orth
    Institut fur Experimentelle and Klinische Pharmakologie and Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104 Freiburg, Germany
    J Biol Chem 282:3050-7. 2007
    ..Because constitutive activation of STATs has been found in a number of cancers, our findings offer a new mechanism for a carcinogenic role of PMT...
  9. ncbi Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function
    Katharina F Kubatzky
    Ludwig Institute for Cancer Research, Bruxelles 1200, Belgium
    J Biol Chem 280:14844-54. 2005
    ..This structure is important for EpoR function because replacement of this motif by consecutive leucines rendered the receptor constitutively active...
  10. ncbi Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
    Nadine Seubert
    Ludwig Institute for Cancer Research, Brussels B 1200, Belgium
    Mol Cell 12:1239-50. 2003
    ..The active and inactive conformations were independently identified by computational searches for low-energy TM dimeric structures. We propose a specific EpoR-activated interface and suggest its use for structural and signaling studies...
  11. ncbi The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins
    Stefan N Constantinescu
    Ludwig Institute for Cancer Research and University of Louvain, Brussels B 1200, Belgium
    J Biol Chem 278:43755-63. 2003
    ..As unliganded EpoR forms TM-dependent but inactive homodimers, we propose that the EpoR can be activated to different extents by homodimeric gp55 proteins, depending on the conformation of the gp55 protein dimer in the TM region...