T Krieg

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy
    Nicolas Hunzelmann
    Department of Dermatology and Venerology, University of Cologne, Cologne, Germany
    Arthritis Res Ther 11:R30. 2009
  2. ncbi Skin disease: a cardinal feature of systemic sclerosis
    T Krieg
    Department of Dermatology, University of Cologne, Cologne, Germany
    Rheumatology (Oxford) 48:iii14-8. 2009
  3. ncbi The extracellular matrix of the dermis: flexible structures with dynamic functions
    Thomas Krieg
    Department of Dermatology, Medical Faculty, University of Cologne, Cologne, Germany
    Exp Dermatol 20:689-95. 2011
  4. ncbi Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions
    Thomas Krieg
    Department of Dermatology, University of Koln, Kerpener Strasse, D 50924 Koln, Germany
    Arthritis Res Ther 9:S4. 2007
  5. ncbi Cell-matrix interactions in dermal repair and scarring
    Beate Eckes
    Department of Dermatology, University of Cologne, Cologne, Germany
    Fibrogenesis Tissue Repair 3:4. 2010
  6. ncbi Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1
    T Yamamoto
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, Cologne, 50924, Germany
    Biochem Biophys Res Commun 281:200-5. 2001
  7. ncbi Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype
    D Kessler
    Department of Dermatology, Joseph-Stelzmann Strasse 9, University of Cologne, , Germany
    J Biol Chem 276:36575-85. 2001
  8. ncbi Contraction-dependent apoptosis of normal dermal fibroblasts
    S Niland
    Department of Dermatology, University of Koln, and Institute of Physiological Chemistry, University of Munster, Germany
    J Invest Dermatol 116:686-92. 2001
  9. ncbi Fibroblast expression of collagen integrin receptors alpha1beta1 and alpha2beta1 is not changed in systemic scleroderma
    K Herzhoff
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Br J Dermatol 141:218-23. 1999
  10. ncbi Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop
    T Yamamoto
    Department of Dermatology, University of Cologne, Germany
    J Immunol 164:6174-9. 2000

Detail Information

Publications114 found, 100 shown here

  1. ncbi High frequency of corticosteroid and immunosuppressive therapy in patients with systemic sclerosis despite limited evidence for efficacy
    Nicolas Hunzelmann
    Department of Dermatology and Venerology, University of Cologne, Cologne, Germany
    Arthritis Res Ther 11:R30. 2009
    ..The objective of this study was to determine the extent to which SSc patients are treated with corticosteroids and immunosuppressive agents...
  2. ncbi Skin disease: a cardinal feature of systemic sclerosis
    T Krieg
    Department of Dermatology, University of Cologne, Cologne, Germany
    Rheumatology (Oxford) 48:iii14-8. 2009
    ..These include the intravenous prostanoid iloprost and the dual endothelin receptor antagonist bosentan, which is approved in Europe for the prevention of new digital ulcers...
  3. ncbi The extracellular matrix of the dermis: flexible structures with dynamic functions
    Thomas Krieg
    Department of Dermatology, Medical Faculty, University of Cologne, Cologne, Germany
    Exp Dermatol 20:689-95. 2011
    ..They now permit to design new concepts for the treatment of more common diseases associated with the accumulation of connective tissue and alterations of the biomechanical properties of the extracellular matrix...
  4. ncbi Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions
    Thomas Krieg
    Department of Dermatology, University of Koln, Kerpener Strasse, D 50924 Koln, Germany
    Arthritis Res Ther 9:S4. 2007
    ..The tight skin mouse (Tsk-1) model of cutaneous fibrosis suggests that numerous other genes may also be important...
  5. ncbi Cell-matrix interactions in dermal repair and scarring
    Beate Eckes
    Department of Dermatology, University of Cologne, Cologne, Germany
    Fibrogenesis Tissue Repair 3:4. 2010
    ..Understanding this complex interplay is important to provide a basis for designing effective wound therapy and for strategic interference with mechanisms that have gone out of control in fibrotic conditions...
  6. ncbi Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1
    T Yamamoto
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, Cologne, 50924, Germany
    Biochem Biophys Res Commun 281:200-5. 2001
    ..Our data indicate that IL-10 differentially regulates TGF-beta and MCP-1 in the modulation of ECM proteins and therefore suggest that IL-10 plays a role in the regulation of tissue remodeling...
  7. ncbi Fibroblasts in mechanically stressed collagen lattices assume a "synthetic" phenotype
    D Kessler
    Department of Dermatology, Joseph-Stelzmann Strasse 9, University of Cologne, , Germany
    J Biol Chem 276:36575-85. 2001
    ....
  8. ncbi Contraction-dependent apoptosis of normal dermal fibroblasts
    S Niland
    Department of Dermatology, University of Koln, and Institute of Physiological Chemistry, University of Munster, Germany
    J Invest Dermatol 116:686-92. 2001
    ....
  9. ncbi Fibroblast expression of collagen integrin receptors alpha1beta1 and alpha2beta1 is not changed in systemic scleroderma
    K Herzhoff
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
    Br J Dermatol 141:218-23. 1999
    ..These observations indicate that any abnormal response of SSc fibroblasts to their matrix environment is not controlled at the level of receptor expression...
  10. ncbi Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop
    T Yamamoto
    Department of Dermatology, University of Cologne, Germany
    J Immunol 164:6174-9. 2000
    ..These data demonstrate that MCP-1 up-regulates MMP-1 mRNA expression and synthesis in human skin fibroblasts at a transcriptional level and provide evidence that this is mediated by an IL-1 alpha autocrine loop...
  11. ncbi Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis
    T Yamamoto
    Department of Dermatology, University of Cologne, Joseph Stelzmann Street 9, 50924, Cologne, Germany
    J Dermatol Sci 26:133-9. 2001
    ..These findings suggest that MCP-1 plays a role in recruiting monocyte/macrophages in the lesional skin of scleroderma and that activated fibroblasts in scleroderma are involved in this process...
  12. ncbi Regulation of connective tissue homeostasis in the skin by mechanical forces
    B Eckes
    Department of Dermatology, University of Cologne, Germany
    Clin Exp Rheumatol 22:S73-6. 2004
    ..Mechanical tension can therefore be regarded as an additional important regulatory parameter, which we would like to better understand with respect to mechanosensing cellular structures and specific or shared signaling pathways...
  13. ncbi Apoptosis in v-myc-transfected MSU-1.1 fibroblasts is induced by cell-matrix contact and differs from that of normal dermal fibroblasts
    S Niland
    Department of Dermatology, University of Cologne, Germany
    In Vitro Cell Dev Biol Anim 37:606-12. 2001
    ..1. Further, apoptosis by MSU-1.l fibroblasts was also observed in anchored, i.e., restrained collagen lattices, an environment that supports proliferation of NDF...
  14. ncbi Role of stem cell factor and monocyte chemoattractant protein-1 in the interaction between fibroblasts and mast cells in fibrosis
    T Yamamoto
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Dermatol Sci 26:106-11. 2001
    ..Our data may indicate an important interaction of fibroblasts and mast cells, via SCF and MCP-1, in the induction of fibrosis...
  15. ncbi The registry of the German Network for Systemic Scleroderma: frequency of disease subsets and patterns of organ involvement
    N Hunzelmann
    Department of Dermatology and Venerology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Rheumatology (Oxford) 47:1185-92. 2008
    ..To improve the detection and follow-up of patients presenting with different disease manifestations, an interdisciplinary registry was founded with contributions from different subspecialties involved in the care of patients with SSc...
  16. ncbi Impaired wound healing in embryonic and adult mice lacking vimentin
    B Eckes
    Department of Dermatology, University of Cologne, Koln, Germany
    J Cell Sci 113:2455-62. 2000
    ..These observations reveal an in vivo phenotype for the vimentin-deficient mouse, and challenge the dogma that key morphogenetic events occurring during development require generation of significant tractional forces by mesenchymal cells...
  17. ncbi BM-40 and MMP-2 expression are not coregulated in human melanoma cell lines
    R Nischt
    Department of Dermatology, University of Cologne, D 50924, Cologne, Germany
    Cancer Lett 162:223-30. 2001
    ..This was further corroborated by the finding that exogenous BM-40 failed to alter synthesis and activation of proMMP-2...
  18. ncbi Integrin alpha2beta1 is required for regulation of murine wound angiogenesis but is dispensable for reepithelialization
    Manon C Zweers
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:467-78. 2007
    ..Both ultrastructurally and functionally, these new blood vessels appeared intact. In conclusion, our data show unique and overlapping functions of alpha2beta1 integrin during murine cutaneous wound healing...
  19. ncbi High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts
    T Yamamoto
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 31:2936-41. 2001
    ..Moreover, increased responsiveness of scleroderma fibroblasts to MCP-1 could result in a continuation of the fibrotic response...
  20. ncbi Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
    J Brinckmann
    Department of Dermatology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Matrix Biol 24:459-68. 2005
    ....
  21. ncbi Ras-induced spreading and wound closure in human epidermal keratinocytes
    Michael Tscharntke
    Department Dermatology, University of Cologne and Centre for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    FASEB J 19:1836-8. 2005
    ..Our results suggest that growth factor-induced, Ras-mediated changes of keratinocyte shape may be an important mechanism that determines the speed of wound epithelialization...
  22. ncbi Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
    Athanasios Stratis
    Department of Dermatology and Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    J Clin Invest 116:2094-104. 2006
    ....
  23. ncbi Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
    Lisa Siewe
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 36:3248-55. 2006
    ..These results show that different innate immune responses can be subject to control by IL-10 from different cellular sources...
  24. ncbi Plasmin modulates vascular endothelial growth factor-A-mediated angiogenesis during wound repair
    Detlev Roth
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 168:670-84. 2006
    ..Inactivation of the plasmin cleavage site Arg110/Ala111 may preserve the biological function of VEGF165 in therapeutic angiogenesis under conditions in which proteases are highly active, such as wound repair and inflammation...
  25. ncbi Expanding the keratin mutation database: novel and recurrent mutations and genotype-phenotype correlations in 28 patients with epidermolytic ichthyosis
    M J Arin
    Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50931 Cologne, Germany
    Br J Dermatol 164:442-7. 2011
    ..The presence of palmoplantar keratoderma suggests KRT1 mutations, whereas KRT10 mutations in most instances give rise to the nonpalmoplantar variants...
  26. ncbi Increased deposition of fibulin-2 in solar elastosis and its colocalization with elastic fibres
    N Hunzelmann
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50924 Cologne, Germany
    Br J Dermatol 145:217-22. 2001
    ..Fibulin-2 is a 195-kDa protein belonging to a novel family of extracellular matrix proteins that might be involved in microfibril and elastic fibre organization...
  27. ncbi Circulating type I collagen degradation products: a new serum marker for clinical severity in patients with scleroderma?
    N Hunzelmann
    Department of Dermatology, University of Cologne, Germany
    Br J Dermatol 139:1020-5. 1998
    ....
  28. ncbi [Current pathophysiological aspects of systemic sclerosis]
    T Krieg
    Klinik und Poliklinik fur Dermatologie und Venerologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50924, Koln, Germany
    Z Rheumatol 65:275-8. 2006
    ..This review describes the major advancemades during recent years for the understanding of the pathophysiology of systemic scleroderma...
  29. ncbi [Chronic wounds. Novel approaches in research and therapy]
    S A Eming
    Klinik und Poliklinik fur Dermatologie und Venerologie, Universitat zu Koln, Joseph Stelzmann Strasse 9, 50931 Koln
    Hautarzt 58:939-44. 2007
    ..This review focuses on new developments in wound healing research and the resulting non-operative therapeutic implications...
  30. ncbi [Organ-specific diagnosis in patients with systemic sclerosis: Recommendations of the German Network for Systemic Sclerosis (DNSS)]
    N Hunzelmann
    Klinik und Poliklinik fur Dermatologie und Venerologie, Klinikum der Universität zu Köln, 50924 Köln, Deutschland
    Z Rheumatol 67:334-6, 337-40. 2008
    ....
  31. ncbi Molecular mechanisms of VEGF-A action during tissue repair
    Sabine A Eming
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Investig Dermatol Symp Proc 11:79-86. 2006
    ..These observations support the concept that VEGF-A and VEGF-A receptors are important mediators in tissue repair. Further, our data provide mechanisms how VEGF-A-mediated interactions are disturbed during impaired healing...
  32. ncbi Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes
    Pierre Shephard
    Department of Dermatology, University of Cologne, Germany
    Thromb Haemost 92:262-74. 2004
    ..Our results dissect the roles of TGF-beta and ET-1 on mechanical force generation in keratinocyte-fibroblast co-cultures, and identify GM-CSF as an inducer of myofibroblasts acting indirectly...
  33. ncbi A human keratin 10 knockout causes recessive epidermolytic hyperkeratosis
    Felix B Müller
    Department of Dermatology, University of Cologne, 50924 Köln, Germany
    Hum Mol Genet 15:1133-41. 2006
    ..Identification of the heterogeneity of this disorder has a major impact for the accurate genetic counseling of patients and their families and also has implications for gene-therapy approaches...
  34. ncbi Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrin
    Zhi Gang Zhang
    Department of Dermatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    J Cell Sci 119:1886-95. 2006
    ..The deficits observed for alpha2-deficient fibroblasts appeared to be linked to alterations in the distribution of force-bearing focal adhesions and deregulation of Rho-GTPase activation...
  35. ncbi Novel and recurrent mutations in keratin KRT5 and KRT14 genes in epidermolysis bullosa simplex: implications for disease phenotype and keratin filament assembly
    Felix B Müller
    Department of Dermatology, University of Cologne, Cologne, Germany
    Hum Mutat 27:719-20. 2006
    ..Detailed knowledge of the spectrum of EBS mutations and their genotype-phenotype correlation is essential for accurate genetic counselling and prenatal diagnosis...
  36. ncbi T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    Axel Roers
    Dept of Dermatology, University of Cologne, Josef Stelzmann Str 9, 50931 Cologne, Germany
    J Exp Med 200:1289-97. 2004
    ..Our data highlight the importance of T cell-derived IL-10 in the regulation of T cell responses and demonstrate that endotoxic shock and the irritant response of the skin are controlled by IL-10 from other cell types...
  37. ncbi Silicone granuloma of the face treated with minocycline
    Meral J Arin
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Am Acad Dermatol 52:53-6. 2005
    ..Treatment of siliconomas is difficult and granulomas involving the face are a therapeutic challenge. We present a 43-year-old woman with a severely disfiguring facial silicone granuloma who was successfully treated with minocycline...
  38. ncbi Inflammation in wound repair: molecular and cellular mechanisms
    Sabine A Eming
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Invest Dermatol 127:514-25. 2007
    ..In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response...
  39. ncbi Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1
    Michael Tscharntke
    Department of Dermatology, University of Cologne, Center for Molecular Medicine, CMMC, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Cell Sci 120:1480-90. 2007
    ..We conclude that Rac1 is functionally required for normal epidermal wound healing and, in this context, exerts a dual function - namely the regulation of keratinocyte proliferation and migration...
  40. ncbi Scleroderma: from pathophysiology to novel therapeutic approaches
    Nicolas Hunzelmann
    Department of Dermatology, University of Cologne, Koln, Germany
    Exp Dermatol 19:393-400. 2010
    ..g. tyrosine kinase inhibitors, are currently being investigated for the treatment of this life-threatening disease...
  41. ncbi Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds
    Sabine A Eming
    Department of Dermatology, Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Institute for Oral and Musculoskeletal Biology, University of Cologne, Cologne, Germany
    J Proteome Res 9:4758-66. 2010
    ..This analysis therefore represents an important basis for the search for potential biomarkers, which give rise to a better understanding and monitoring of disease progression in chronic wounds...
  42. ncbi Increased expression of VEGF in glomeruloid reactive angioendotheliomatosis
    Sabine A Eming
    Department of Dermatology, University of Cologne, Cologne, Germany
    Dermatology 207:398-401. 2003
    ..This case suggests a possible role of epidermally derived VEGF in endothelial cell proliferation in RAE...
  43. ncbi Merkel cell polyomavirus DNA in persons without merkel cell carcinoma
    Ulrike Wieland
    Institute of Virology, University of Cologne, Koeln, Germany
    Emerg Infect Dis 15:1496-8. 2009
    ..MCPyV was also found in anogenital and oral samples (31%) and eyebrow hairs (50%) of HIV-positive men and in forehead swabs (62%) of healthy controls. MCPyV thus appears to be widespread...
  44. ncbi Long-term efficacy, curative potential, and prognostic factors of radiotherapy in primary cutaneous B-cell lymphoma
    Hans Theodor Eich
    Department of Radiation Oncology, University of Cologne, Cologne, Germany
    Int J Radiat Oncol Biol Phys 55:899-906. 2003
    ..To evaluate the efficacy of RT, patient data from two centers were analyzed and compared with recent reports in the literature...
  45. ncbi Accelerated wound closure in mice deficient for interleukin-10
    Sabine A Eming
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 170:188-202. 2007
    ..These results show for the first time that IL-10 can impede wound repair...
  46. ncbi Gene transfer in tissue repair: status, challenges and future directions
    Sabine A Eming
    University of Cologne, Department of Dermatology, Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Expert Opin Biol Ther 4:1373-86. 2004
    ..This article summarises repair mechanisms and their failure, and gives an overview of techniques and studies applied to gene transfer in tissue repair. It also provides perspectives on potential targets for gene transfer technology...
  47. ncbi Interrelation of immunity and tissue repair or regeneration
    Sabine A Eming
    Department of Dermatology, University of Cologne, Germany
    Semin Cell Dev Biol 20:517-27. 2009
    ..Finally, we report on new mechanistic insights on how these inflammatory pathways impair healing under pathological conditions and discuss therapeutic implications...
  48. ncbi Biomarkers for skin involvement and fibrotic activity in scleroderma
    P Moinzadeh
    Department of Dermatology, Medical Faculty, University of Cologne, Cologne, Germany
    J Eur Acad Dermatol Venereol 26:267-76. 2012
    ....
  49. ncbi Bullous pemphigoid in a patient treated with UVA-1 phototherapy for disseminated morphea
    C Sacher
    Department of Dermatology, University of Cologne, Germany
    Dermatology 202:54-7. 2001
    ..Immunosuppressive therapy resulted in regression of all blisters. After ruling out other possible causes, such as neoplasias or drugs, we conclude that UVA-1 has to be regarded as the most likely trigger of the disease...
  50. ncbi CD40L induces matrix-metalloproteinase-9 but not tissue inhibitor of metalloproteinases-1 in cervical carcinoma cells: imbalance between NF-kappaB and STAT3 activation
    S Smola-Hess
    Institute of Virology, University of Cologne, Fürst Pückler Str 56, Cologne, 50935, Germany
    Exp Cell Res 267:205-15. 2001
    ..Selective CD40-mediated signaling through NF-kappaB but not STAT3 correlates to a shift of the balance between MMP-9 and TIMP-1 toward the protease...
  51. ncbi Differential roles of macrophages in diverse phases of skin repair
    Tina Lucas
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 184:3964-77. 2010
    ..These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events...
  52. ncbi Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functions
    Beate Eckes
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Investig Dermatol Symp Proc 11:66-72. 2006
    ..Unraveling the integrated functions of fibroblasts, collagen integrin receptors, collagen fibrils, and mechanical tension will be important to understand the molecular mechanisms underlying tissue repair and fibrosis...
  53. ncbi Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis
    Athanasios Stratis
    Department of Dermatology, University of Cologne and Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    J Invest Dermatol 126:614-20. 2006
    ..Our results identify a primary role for IKK2 in the development of skin inflammation and confirm its requirement for the maintenance of skin homeostasis...
  54. ncbi TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
    Manolis Pasparakis
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Nature 417:861-6. 2002
    ..Our results suggest that the critical function of IKK2-mediated NF-kappa B activity in epidermal keratinocytes is to regulate mechanisms that maintain the immune homeostasis of the skin...
  55. ncbi Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1
    Pierre Shephard
    Departments of Dermatology and Virology, University of Cologne, Cologne, Germany
    Am J Pathol 164:2055-66. 2004
    ..This biphasic differentiation event is regulated by the balance of endogenous TGF-beta and IL-1 activity and is reminiscent of myofibroblast differentiation at early and later stages of wound healing...
  56. ncbi Identification of novel and known KRT5 and KRT14 mutations in 53 patients with epidermolysis bullosa simplex: correlation between genotype and phenotype
    M J Arin
    Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Br J Dermatol 162:1365-9. 2010
    ..Basal epidermolysis bullosa simplex (EBS) is a hereditary skin blistering disorder resulting in most cases from missense mutations in the keratin 5 (KRT5) or keratin 14 (KRT14) genes...
  57. ncbi Comparison of patients with and without digital ulcers in systemic sclerosis: detection of possible risk factors
    C Sunderkotter
    Department of Dermatology, University of Munster, Von Esmarch Str 58, 48149 Munster, Germany
    Br J Dermatol 160:835-43. 2009
    ..For optimal management it would be useful to identify the risk factors for DU. Such statistical analyses have been rare because they require a high number of patients...
  58. ncbi Early increase in serum levels of the angiogenesis-inhibitor endostatin and of basic fibroblast growth factor in melanoma patients during disease progression
    P Kurschat
    Department of Dermatology and Center for Molecular Medicine CMMC, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
    Br J Dermatol 156:653-8. 2007
    ..Therefore, these factors have been suggested as diagnostic and in some studies as prognostic tumour markers...
  59. ncbi Enhanced contact allergen- and UVB-induced keratinocyte apoptosis in the absence of CD95/Fas/Apo-1
    A Hedrych-Ozimina
    Department of Dermatology, Center for Molecular Medicine, University of Cologne, Joseph Stelzmann Strasse 9, Cologne 50924, Germany
    Cell Death Differ 18:155-63. 2011
    ....
  60. ncbi Intermediate molecular weight proteinuria and albuminuria identify scleroderma patients with increased morbidity
    B Seiberlich
    Department of Medicine I, Merheim Medical Center, Cologne General Hospital, Cologne, Germany
    Clin Nephrol 70:110-7. 2008
    ..Renal involvement and systemic vascular damage have been shown to significantly affect prognosis in systemic sclerosis (SSc). However, it is often difficult to assess damage to the renal and systemic vasculature in SSc patients...
  61. ncbi [Molecular mechanisms of healing]
    S Jurk
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str. 9, 50931 Cologne, Allemagne
    Ann Dermatol Venereol 130:574-80. 2003
  62. ncbi Extensive human papillomavirus type 7-associated orofacial warts in an immunocompetent patient
    A Ritzkowsky
    Department of Dermatology, University of Cologne, Germany
    Acta Derm Venereol 81:130-3. 2001
    ..Our data show that HPV7 can lead to perioral, spiky warts and brownish plaques in immunocompetent patients who had never been working as a meat or fish handler...
  63. ncbi BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin
    N Hunzelmann
    Department of Dermatology, University of Cologne, Germany
    J Invest Dermatol 110:122-6. 1998
    ..This study demonstrates that BM-40 that has previously been thought to be exclusively expressed in extracellular matrix producing cells may in fact play a role in differentiation and maintenance of the epidermis...
  64. ncbi Bath-PUVA therapy in three patients with scleredema adultorum
    C M Hager
    Department of Dermatology, University of Cologne, Germany
    J Am Acad Dermatol 38:240-2. 1998
    ..Scleredema adultorum (SA) is a rare connective tissue disorder for which no treatment has proven to be effective...
  65. ncbi Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
    O Langholz
    Department of Dermatology, University of Cologne, Germany
    J Cell Biol 131:1903-15. 1995
    ..The data presented here indicate that different signaling pathways exist leading to the three events discussed here, and that these pathways do not per se depend upon each other...
  66. ncbi The absence of nidogen 1 does not affect murine basement membrane formation
    M Murshed
    Department of Dermatology, Medical Faculty, University of Cologne, Germany
    Mol Cell Biol 20:7007-12. 2000
    ..The results show that nidogen 1 is not required for basement membrane formation or maintenance...
  67. ncbi Anti-CD20 monoclonal antibody (rituximab) in the treatment of pemphigus
    M J Arin
    Department of Dermatology, University of Cologne, 50924 Cologne, Germany
    Br J Dermatol 153:620-5. 2005
    ..CONCLUSIONS: This study highlights the prolonged effect and disease control after one single course of rituximab and further extends the spectrum of treatments of bullous autoimmune disorders...
  68. ncbi Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts
    B Eckes
    Department of Dermatology, University of Cologne, Federal Republic of Germany
    J Cell Sci 111:1897-907. 1998
    ....
  69. ncbi Generation of a novel proteolysis resistant vascular endothelial growth factor165 variant by a site-directed mutation at the plasmin sensitive cleavage site
    Gereon Lauer
    Department of Dermatology, University of Cologne, Cologne, Germany
    FEBS Lett 531:309-13. 2002
    ..These results suggest that the plasmin cleavage site Arg110/Ala111 and the carboxyl-terminal domain play an important role in the mitogenic activity of VEGF165...
  70. ncbi Treatment of chronic wounds: state of the art and future concepts
    Sabine A Eming
    Department of Dermatology, University of Cologne, Germany
    Cells Tissues Organs 172:105-17. 2002
    ....
  71. ncbi Morphometric analysis of murine skin wound healing: standardization of experimental procedures and impact of an advanced multitissue array technique
    Michael Gerharz
    Institute of Pathology, University of Cologne, Cologne, Germany
    Wound Repair Regen 15:105-12. 2007
    ..For the analysis of cellular composition in GT, multitissue arrays are useful tools in wound-healing studies...
  72. ncbi Expression of matrilin-2 in human skin
    Dorothea Piecha
    Department of Dermatology, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    J Invest Dermatol 119:38-43. 2002
    ..These findings demonstrate that matrilin-2 is expressed in normal skin by keratinocytes and fibroblasts and may thus contribute to cutaneous homeostasis...
  73. ncbi E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  74. ncbi Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in beta2 integrin-deficient mice
    Thorsten Peters
    Department of Dermatology, and Allergic Diseases, University of Ulm, Maienweg 12, 89081 Ulm, Germany
    J Leukoc Biol 80:599-607. 2006
    ..It may be of interest to examine human leukocyte-adhesion deficiency type-1 patients closer and search for pathological changes possibly induced via overproduction of IL-6...
  75. ncbi Alternative proteolytic processing of hepatocyte growth factor during wound repair
    Nils Buchstein
    Professor of Dermatology, Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 174:2116-28. 2009
    ....
  76. ncbi Signalling and regulation of collagen I synthesis by ET-1 and TGF-beta1
    Angelika Horstmeyer
    Department of Dermatology, University of Cologne, Cologne, Germany
    FEBS J 272:6297-309. 2005
    ..Thereby, long-time stimulation by ET-1 resulted in a changed ET-receptor subtype ratio and in a biphasic CTGF induction...
  77. ncbi Gene therapy and wound healing
    Sabine A Eming
    Department of Dermatology, University of Cologne, D 50937 Cologne, Germany
    Clin Dermatol 25:79-92. 2007
    ..We have summarized the molecular and cellular basis of repair mechanisms and their failure, and we give an overview of techniques and studies applied to gene transfer in tissue repair...
  78. ncbi Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group
    Thomas K Eigentler
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University, Tuebingen, Germany
    Melanoma Res 18:353-8. 2008
    ..Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended...
  79. ncbi Toll-like receptor-4 deficiency attenuates doxorubicin-induced cardiomyopathy in mice
    Alexander Riad
    Charite Universitatsmedizin Berlin, Germany, Campus Benjamin Franklin, Department of Cardiology and Pneumology, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur J Heart Fail 10:233-43. 2008
    ..Since TLR4 might play a relevant role in cardiac inflammatory signalling, we investigated whether or not TLR4 is involved in Dox-induced cardiotoxicity...
  80. ncbi Mast cell-specific Cre/loxP-mediated recombination in vivo
    Julia Scholten
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Transgenic Res 17:307-15. 2008
    ..Our results show that the Mcpt5 promoter can drive Cre expression in a mast cell-specific fashion. We expect that our Mcpt5-Cre mice will be a useful tool for the investigation of mast cell biology...
  81. ncbi CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis
    Daniel Kess
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 171:5697-706. 2003
    ..This murine inflammatory skin model may also have relevance for human polygenic inflammatory diseases...
  82. ncbi Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    Int J Cancer 123:2605-15. 2008
    ..Collectively, our findings support the concept that IFN-associated host responses play an important role in tumor immunosurveillance in the skin...
  83. ncbi Role of postoperative radiotherapy in the management of Merkel cell carcinoma
    Hans Theodor Eich
    Department of Radiotherapy, University of Cologne, Joseph-Stelzmann Strasse 9, D-50924 Cologne, Germany
    Am J Clin Oncol 25:50-6. 2002
    ..Postoperative radiotherapy to the primary tumor region and the regional lymphatics is effective in the prevention of locoregional recurrence. Prospective clinical trials should be performed to confirm these observations...
  84. ncbi Expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MT1-MMP in skin tumors of human papillomavirus type 8 transgenic mice
    Baki Akgul
    Institute of Virology, University of Cologne, Germany
    Exp Dermatol 15:35-42. 2006
    ..Taken together, these results implicate a role for MMPs in the development of HPV8-induced cutaneous tumors...
  85. ncbi Scleroderma -- news to tell
    Beate Eckes
    Department of Dermatology, University of Cologne, Kerpener Str 62, Cologne, Germany
    Arch Dermatol Res 299:139-44. 2007
    ..Systematic analysis of the pathways involved in the development of the disease together with information derived from novel animal models have helped to better understand the mechanisms that trigger and sustain fibrotic reactions...
  86. ncbi Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis
    Joerg Wenzel
    Department of Dermatology, University of Bonn, Bonn, Germany
    J Invest Dermatol 128:67-78. 2008
    ..Gene expression profiling might complement the diagnostic spectrum in dermatology and may provide new pathogenetic insights...
  87. ncbi High invasive melanoma cells induce matrix metalloproteinase-1 synthesis in fibroblasts by interleukin-1alpha and basic fibroblast growth factor-mediated mechanisms
    Stefanie Löffek
    Department of Dermatology, Center of Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    J Invest Dermatol 124:638-43. 2005
    ..Taken together, our results indicate an essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1...
  88. ncbi Expression of pro-inflammatory markers by human dermal fibroblasts in a three-dimensional culture model is mediated by an autocrine interleukin-1 loop
    Daniela Kessler-Becker
    Department of Dermatology, University of Cologne, Joseph-Stelzmann-Strasse 9, D-50931 Cologne, Germany
    Biochem J 379:351-8. 2004
    ..We propose that fibroblasts that are embedded in a matrix environment can actively participate in the regulation of inflammatory processes...
  89. ncbi Trichilemmal cyst nevus: a new complex organoid epidermal nevus
    Iliana Tantcheva Poor
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Am Acad Dermatol 57:S72-7. 2007
    ..Consequently, we propose for this new organoid nevus the names "trichilemmal cyst nevus" or "nevus trichilemmocysticus."..
  90. ncbi Integrin alpha2beta1 deficiency does not affect contact hypersensitivity
    Manon C Zweers
    Department of Dermatology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany
    Arch Dermatol Res 298:201-5. 2006
    ..Our results suggest that the adhesive functions of integrin alpha2beta1 are dispensable for the CHS response; they may be compensated for by the collagen receptor alpha1beta1 or other collagen receptors...
  91. ncbi High plasminogen activator inhibitor type 2 expression is a hallmark of scleroderma fibroblasts in vitro
    Daniela Kessler-Becker
    Department of Dermatology, University of Cologne, Cologne, Germany
    Exp Dermatol 13:708-14. 2004
    ..The data indicate that scleroderma fibroblasts are more sensitive to the induction of PAI-2 expression than control fibroblasts by a presently unknown factor in serum...
  92. ncbi Overexpression of phospholipid-hydroperoxide glutathione peroxidase in human dermal fibroblasts abrogates UVA irradiation-induced expression of interstitial collagenase/matrix metalloproteinase-1 by suppression of phosphatidylcholine hydroperoxide-mediate
    Jutta Wenk
    Department of Dermatology, University of Cologne, 50924 Cologne, Germany
    J Biol Chem 279:45634-42. 2004
    ..Our finding is particularly relevant in light of the already available small molecule mimetics of PHGPx...
  93. ncbi Complete remission of Merkel cell carcinoma of the scalp with local and regional metastases after topical treatment with dinitrochlorbenzol
    Gernot Herrmann
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Am Acad Dermatol 50:965-9. 2004
    ..Together with subsequent irradiation, remission has now lasted for more than 1 year...
  94. ncbi Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography
    Peter Kurschat
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Pathol 197:179-87. 2002
    ..This technology makes it possible to draw conclusions regarding the balance between activated proteases and inhibitors, which are frequently found to be present together in close proximity in vivo...
  95. ncbi The inhibition of matrix metalloproteinase activity in chronic wounds by a polyacrylate superabsorber
    Sabine Eming
    Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
    Biomaterials 29:2932-40. 2008
    ..We conclude that polyacrylate superabsorber particles can rescue the highly proteolytic microenvironment of non-healing wounds from MMP activity so that more conductive conditions allow healing to proceed...
  96. ncbi Defective laminin 5 processing in cylindroma cells
    Lucy Tunggal
    Department of Dermatology, Medical Faculty, Institute for Biochemistry II, University of Cologne, Joseph-Stelzmann-Strasse 52, , Germany
    Am J Pathol 160:459-68. 2002
    ..Together, the results show that multiple molecular defects, including alteration of laminin 5 and its integrin receptors, contribute to structural aberrations of the basement membrane and associated structures in cylindromas...
  97. ncbi Absence of autoantibodies against correctly folded recombinant fibrillin-1 protein in systemic sclerosis patients
    Jurgen Brinckmann
    Department of Dermatology, University of Lubeck, Lubeck, Germany
    Arthritis Res Ther 7:R1221-6. 2005
    ....
  98. ncbi Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen
    Olaf Holtkötter
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Biol Chem 277:10789-94. 2002
    ..Thus, alpha(2)beta(1) plays a supportive rather than an essential role in platelet-collagen interactions. These results are in agreement with the observation that alpha(2)beta(1)-deficient animals suffer no bleeding anomalies...
  99. ncbi Contact of high-invasive, but not low-invasive, melanoma cells to native collagen I induces the release of mature cathepsin B
    Anke Klose
    Department of Dermatology, Center for Molecular Medicine CMMC, University of Cologne, Cologne, Germany
    Int J Cancer 118:2735-43. 2006
    ..These results strongly implicate a pivotal role of cell-matrix interactions for the regulation of cathepsin B localization and activity in melanoma cells...