Research Topics

D M Kofler

Affiliation: University of Cologne

Country: Germany

Engagement of the B-cell antigen receptor (BCR) allows efficient transduction of ZAP-70-positive primary B-CLL cells by recombinant adeno-associated virus (rAAV) vectors
D M Kofler
KKG Gene Therapy, GSF-National Research Center for Environment and Health, Munich, Germany
Gene Ther 11:1416-24. 2004
Current status of immunotherapy in B cell malignancies
D M Kofler
Department of Internal Medicine I, University of Cologne, Cologne, Germany
Curr Drug Targets 7:1371-4. 2006
The potential of gene transfer into primary B-CLL cells using recombinant virus vectors
C M Wendtner
Medical Clinic III, Klinikum Grosshadern Medical Center, Munchen, German
Leuk Lymphoma 45:897-904. 2004

Engagement of the B-cell antigen receptor (BCR) allows efficient transduction of ZAP-70-positive primary B-CLL cells by recombinant adeno-associated virus (rAAV) vectors
D M Kofler
KKG Gene Therapy, GSF-National Research Center for Environment and Health, Munich, Germany
Gene Ther 11:1416-24. 2004
..e.m. 6.7%) of cells, respectively, and could be specifically blocked by heparin, a soluble competitor of HSPG (P<0.0001). In summary, engagement of the BCR on ZAP-70 positive B-CLL cells allows efficient rAAV-mediated gene delivery...
Current status of immunotherapy in B cell malignancies
D M Kofler
Department of Internal Medicine I, University of Cologne, Cologne, Germany
Curr Drug Targets 7:1371-4. 2006
..At the moment it remains unclear if the novel immunotherapeutic strategies will be able to play a similar role in the treatment of B cell malignancies than the already established antibody-based immunotherapy...
The potential of gene transfer into primary B-CLL cells using recombinant virus vectors
C M Wendtner
Medical Clinic III, Klinikum Grosshadern Medical Center, Munchen, German
Leuk Lymphoma 45:897-904. 2004
..This will make it possible to establish the potential clinical role of gene therapy for CLL patients...