Research Topics
Genomes and Genes
| Michael KabeschSummaryAffiliation: University of Munich Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populationsMichael Kabesch
University Children s Hospital, Ludwig Maximilians University Munich, Munchen, Germany
J Allergy Clin Immunol 111:813-7. 2003..Because these polymorphisms lead to changes in LPS recognition, they may affect the development of asthma and allergies...- The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populationsMichaela Schedel
University Children s Hospital, Ludwig Maximilian s University Munich, Germany
Respir Res 7:91. 2006..Thus, we tried to further elucidate the role of ADAM33 polymorphisms (SNPs) in a genetic analysis of German case control and longitudinal populations... - Why Old McDonald had a farm but no allergies: genes, environments, and the hygiene hypothesisMichael Kabesch
University Children's Hospital Munich, Ludwig Maximilians University, Germany
J Leukoc Biol 75:383-7. 2004 - IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthmaMichael Kabesch
University Children s Hospital Munich, Germany
J Allergy Clin Immunol 117:269-74. 2006..IgE production, a hallmark of asthma and atopic disease, may be under genetic control. Genes of the IL-4 and IL-13 pathway, central for IgE regulation, have so far only been assessed in studies of single gene effects... - Glutathione S transferase deficiency and passive smoking increase childhood asthmaM Kabesch
University Children s Hospital, Ludwig Maxmilians University Munich, Lindwurmstrasse 4, D 80337 Munich, Germany
Thorax 59:569-73. 2004..It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma... - Candidate gene association studies and evidence for gene-by-gene interactionsMichael Kabesch
University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, Munchen D 80337, Germany
Immunol Allergy Clin North Am 25:681-708. 2005..It can be expected that from this area of research new and exciting results will follow soon... - G-Protein-coupled receptor polymorphisms are associated with asthma in a large German populationMichael S D Kormann
University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
Am J Respir Crit Care Med 171:1358-62. 2005..Initial association studies in a Finnish and Canadian population suggested an association with asthma and elevated serum IgE levels... - IRF-1 gene variations influence IgE regulation and atopyMichaela Schedel
University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
Am J Respir Crit Care Med 177:613-21. 2008..The development of atopic diseases is characterized by skewed immune responses to common allergens. Only recently, interferons have been identified to play a crucial role in these mechanisms... - Toll-like receptor heterodimer variants protect from childhood asthmaMichael S D Kormann
University Children s Hospital, Ludwig Maximilians Universitat, Munich, Germany
J Allergy Clin Immunol 122:86-92, 92.e1-8. 2008..Toll-like receptors (TLRs) represent a major group of receptors for the specific recognition of pathogen-associated molecular patterns of microbes capable of activating innate and adaptive immunity... - A comprehensive analysis of interleukin-4 receptor polymorphisms and their association with atopy and IgE regulation in childhoodBernd Woitsch
University Children s Hospital Munich, Munich, Germany
Int Arch Allergy Immunol 135:319-24. 2004..Based on their putative functional role, polymorphisms A148G, T1432C and A1652G, located in the coding region of IL4Ra, were selected for association and haplotype studies in a large German population sample (n = 1,120)... - CX3CR1 polymorphisms are associated with atopy but not asthma in German childrenMartin Depner
University Children s Hospital, Ludwig Maximilians University Munich, Munich, Germany
Int Arch Allergy Immunol 144:91-4. 2007..Thus, amino acid changes in CX3CR1 may influence the development of atopy but not asthma in German children. Potentially, other factors such as environmental effects may modify the role of CX3CR1 polymorphisms... - A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levelsMichaela Schedel
University Children's Hospital, Ludwig Maximilian University-Munich, Lindwurmstrasse 4, D-80337 Munich, Germany
J Allergy Clin Immunol 114:1100-5. 2004..CONCLUSION: The data indicate that within the IL-4/IL-13 pathway, genetic variants in the STAT6 gene significantly contribute to the regulation of serum IgE levels... - HLX1 gene variants influence the development of childhood asthmaKathrin Suttner
University Children s Hospital, Ludwig Maximilian University of Munich, Munich, Germany
J Allergy Clin Immunol 123:82-88.e6. 2009..Only recently, the homeobox transcription factor H.20-like homeobox 1 (HLX1), interacting closely with T-box transcription factor, has been identified as an important regulator of T(H)1 differentiation and suppressor of T(H)2 commitment... - Exposure to environmental microorganisms and childhood asthmaMarkus J Ege
University Children s Hospital Munich, Munich, Germany
N Engl J Med 364:701-9. 2011..In previous studies, markers of microbial exposure have been inversely related to these conditions... - Gene by environment interactions and the development of asthma and allergyMichael Kabesch
University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
Toxicol Lett 162:43-8. 2006..In the long run, it may contribute significantly to the development of new and better-tailored drugs for one of the major diseases of the 21st century... - Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretionAnna Lluis
University Children s Hospital Munich, Department of Pulmonary and Allergy, LMU Munich, Germany
J Allergy Clin Immunol 127:1587-94.e6. 2011..Regulation of the 17q21 locus and its immunologic relevance early in life have not been well characterized... - The GABRIEL Advanced Surveys: study design, participation and evaluation of biasJon Genuneit
Institute of Epidemiology and Medical Biometry, Ulm University, Ulm LMU Munich, University Children s Hospital, Munich, Germany
Paediatr Perinat Epidemiol 25:436-47. 2011..The GABRIEL Advanced Surveys have created extensive collections of questionnaire data, biomaterial and environmental samples promising new insights into this area of research... - Gene-environment interaction for childhood asthma and exposure to farming in Central EuropeMarkus J Ege
University Children s Hospital Munich, Munich, Germany
J Allergy Clin Immunol 127:138-44, 144.e1-4. 2011..The farming environment has consistently been associated with protection from childhood asthma and atopy, and interactions have been reported with polymorphisms in innate immunity genes... - Environmental factors in infancy and ulcerative colitis in the Central South of Chile: a case-control studyAnja Boneberger
Unit for Occupational and Environmental Epidemiology and Net Teaching, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Munich LMU, Munich, Germany
J Crohns Colitis 5:392-6. 2011..Evidence for the role of the hygiene hypothesis and the development of Ulcerative Colitis (UC) is unclear. We aimed to explore the association between environmental factors in infancy and UC... - Medial position and counterclockwise rotation of the parietal scalp hair-whorl as a possible indicator for non-right-handednessHeinrich Schmidt
Department of Medical Genetics, Dr von Hauner Children s Hospital, University of Munich, Lindwurmstr 4, 80337 Munich, Germany
ScientificWorldJournal 8:848-54. 2008..5-fold for the right-sided, 5.4-fold for the left-sided, and 12.9-fold for the medial-positioned whorl. We conclude that NRH is associated with the position (medial!) and the swirling direction (CCW!) of the PW... - Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord bloodM K Rochat
Children s Hospital, University of Munich, Lindwurmstrasse 4, Munich, Germany
Clin Exp Allergy 40:786-94. 2010..Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown... - Wheeze in preschool age is associated with pulmonary bacterial infection and resolves after antibiotic therapyNicolaus Schwerk
Department of Pneumology, Allergy and Neonatology, University Children s Hospital, Hanover Medical School, Hanover, Germany
PLoS ONE 6:e27913. 2011..We assessed the relevance of bacterial colonization and chronic airway infection in preschool children with severe persistent wheezing and evaluated the outcome of long-time antibiotic treatment on the clinical course in such children... - Candidate genes and the genetic epidemiology of asthmaMichael Kabesch
University Children's Hospital Munich, Germany
Paediatr Respir Rev 5:S23-5. 2004 - A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhoodMichael Kabesch
University Children s Hospital of Munich, Germany
J Allergy Clin Immunol 112:893-8. 2003..Polymorphism C-589T was reported to influence total serum IgE levels and bronchial hyperresponsiveness. However, no study has investigated the putative existence of further SNPs in exons, introns, and flanking regions of the IL4 gene... - Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthmaErik Melen
Institute of Environmental Medicine, Centre for Allergy Research, and Department of Biosciences, Karolinska Institutet, Box 210, Stockholm SE 171 77, Sweden
Am J Respir Crit Care Med 171:1089-95. 2005..A 70-kb haplotype block in the G protein-coupled receptor for asthma susceptibility gene (GPR154; alias GPRA) on chromosome 7p was recently identified to influence susceptibility to asthma and elevated total serum IgE levels in adults... - NOD1 variation, immunoglobulin E and asthmaPirro Hysi
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Hum Mol Genet 14:935-41. 2005..The results indicate that intracellular recognition of specific bacterial products affects the presence of childhood asthma... - Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locusStephan Weidinger
Department of Dermatology and Allergy, Technische Universitat Munchen, Munchen, Germany
PLoS Genet 4:e1000166. 2008..Our data furthermore confirm association of STAT6 variation with serum IgE levels... - A glitch in the switch? Of endotoxin, CD14, and allergyMichael Kabesch
Am J Respir Crit Care Med 174:365-6. 2006 - Filaggrin mutations, atopic eczema, hay fever, and asthma in childrenStephan Weidinger
Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
J Allergy Clin Immunol 121:1203-1209.e1. 2008..However, their role in the development of other atopic diseases such as asthma and rhinitis has not yet been clarified in large population-based studies... - Filaggrin variants confer susceptibility to asthmaW H Irwin McLean
J Allergy Clin Immunol 121:1294-5; author reply 1295-6. 2008 - Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammationLisa Cameron
Functional Genomics Laboratory, and Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
J Immunol 177:8633-42. 2006..Our findings suggest the nuclear milieu dictates the functional outcome of genetic variation... - Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthmaMiriam F Moffatt
National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
Nature 448:470-3. 2007..The results indicate that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma... - Challenges in asthma and allergy for the 21st CenturyMichael Kabesch
Curr Opin Allergy Clin Immunol 8:376-7. 2008 - Positional cloning of a novel gene influencing asthma from chromosome 2q14Maxine Allen
Oxagen, Milton Park, Oxfordshire, UK
Nat Genet 35:258-63. 2003..6 kb (DPP10), which extends over 1 Mb of genomic DNA. DPP10 encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy...