Research Topics
| Stefan JohnSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
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Detail Information
Publications
Renal replacement strategies in the ICUStefan John
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Chest 132:1379-88. 2007....- Renal replacement therapy in the treatment of acute renal failure-intermittent and continuousStefan John
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Erlangen, Germany
Semin Dial 19:455-64. 2006..Moreover, it will be discussed whether patients with sepsis and septic shock benefit from early RRT initiation, the use of increased RRT doses, and increased removal of inflammatory mediators by RRT... - Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertensionMarkus P Schneider
Department of Medicine IV/Nephrology, , Erlangen, Germany
Am J Hypertens 18:1111-7. 2005..We conclude that NAC is therefore not an effective superoxide scavenger in vivo. Other, nonimmediate effects such as the generation of glutathione may explain the beneficial effects of NAC in conditions associated with oxidative stress... - Nitric oxide and reactive hyperemia: role of location and duration of ischemiaUlrike Raff
Department of Nephrology and Hypertension, University of Erlangen Nuremberg, Germany
Am J Hypertens 23:865-9. 2010.... - Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patientsStefan John
Department of Medicine IV, University of Erlangen Nurnberg, Erlangen, Germany
Am Heart J 149:473. 2005..We investigated whether improvement in NO availability in hypercholesterolemia can be achieved rapidly with statins before lipid-lowering therapy is complete... - Life-threatening thrombotic thrombocytopenic purpura associated with dental foci. Report of two casesMatthias Fenner
Department of Oral and Maxillofacial Surgery, University of Erlangen Nuremberg, Germany
J Clin Periodontol 31:1019-23. 2004..The therapy requires a multi-disciplinary team approach involving dentistry. Even if TTP is immediately treated in an adequate manner, it still shows a mortality of up to 20%... - Enhanced levels of platelet P-selectin and circulating cytokines in young patients with mild arterial hypertensionChristian Stumpf
Medical Clinic II, University of Erlangen Nuremberg, Erlangen, Germany
J Hypertens 23:995-1000. 2005..Therefore, the present pilot study was designed to examine the role of platelet P-selectin and various inflammatory mediators in young patients with moderate AH without signs of target organ damage... - Effect of elevated triglyceride levels on endothelium-dependent vasodilation in patients with hypercholesterolemiaMarkus P Schneider
Department of Medicine/Nephrology, , , Germany
Am J Cardiol 91:482-4. 2003 - Practice and perception--a nationwide survey of therapy habits in sepsisFrank M Brunkhorst
Anesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Germany
Crit Care Med 36:2719-25. 2008..To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock... - Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertensionChristian Delles
Department of Medicine IV/Nephrology, , , Germany
Kidney Int 61:1462-8. 2002..The effects of eprosartan on RPF are mediated, at least in part, by an increased bioavailability of nitric oxide in the renal vasculature... - Assessment of endothelial function of the renal vasculature in human subjectsChristian Delles
Department of Medicine/Nephrology, , Germany
Am J Hypertens 15:3-9. 2002..The prolonged effect of L-NMMA and L-arginine must be taken into account in study protocols using both substances. Thus, stimulation and blockade of NO synthase cannot be examined in the same protocol... - Effect of AT1 receptor blockade on endothelial function in essential hypertensionArnfried U Klingbeil
Department of Medicine IV, , , Germany
Am J Hypertens 16:123-8. 2003..CONCLUSIONS: The AT(1) receptor blockade with valsartan improved basal NO production and release. The effect seems to be BP independent, as BP reduction with HCTZ failed to increase NO availability... - The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemiaMarkus P Schneider
Universitat Erlangen Nurnberg, Medizinische Klinik IV 4, Klinikum Nürnberg Süd, Breslauer Strasse 201, D 90471 Nuremberg, Germany
Clin Sci (Lond) 105:97-103. 2003.... - Vitamin C augments the renal response to L-arginine in smokersMarkus P Schneider
Department of Medicine/Nephrology, , Germany
Nephrol Dial Transplant 18:1512-7. 2003..arginine alone induced a similar increase of RPF. The co-infusion of vitamin C and -arginine led to a greater increase of RPF and GFR in smokers. This might suggest that oxidative stress is increased in the renal vasculature of smokers... - Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemiaStefan John
Department of Medicine IV, , , Breslauerstr 201, , Germany
Curr Hypertens Rep 5:199-207. 2003..Statins and blockers of the renin-angiotensin system seem to have such antioxidative effects independent from their effects on lipid profiles or blood pressure control... - Intensive insulin therapy and pentastarch resuscitation in severe sepsisFrank M Brunkhorst
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University, Jena, Germany
N Engl J Med 358:125-39. 2008..The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids... - Acute renal failure in patients with severe sepsis and septic shock--a significant independent risk factor for mortality: results from the German Prevalence StudyMichael Oppert
Department of Nephrology and Medical Intensive Care, Charite Universitatsmedizin Berlin, Humboldt University, 13353 Berlin, Germany
Nephrol Dial Transplant 23:904-9. 2008..Further, it is not known whether ARF is an independent risk factor for mortality in septic patients or merely an indicator of disease severity... - Impact of NO-synthase inhibition on renal hemodynamics in normotensive and hypertensive subjectsJohannes Jacobi
Department of Medicine/Nephrology, , Germany
J Hypertens 20:525-30. 2002..8 +/- 3.9 versus -4.1 +/- 3.8 beats/min, P = NS) to a similar extent in both groups. CONCLUSION : Basal NO synthesis of the renal vasculature is not impaired in patients with established essential hypertension... - Epidemiology of sepsis in Germany: results from a national prospective multicenter studyChristoph Engel
Institute of Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107, Leipzig, Germany
Intensive Care Med 33:606-18. 2007..To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size... - AT1-receptor blockade improves augmentation index: a double-blind, randomized, controlled studyArnfried U Klingbeil
Department of Medicine IV, , Germany
J Hypertens 20:2423-8. 2002..01). CONCLUSIONS: Blood pressure reduction with the AT receptor antagonist valsartan but not with hydrochlorothiazide reduced the augmentation index in essential hypertension... - Angiotensin converting enzyme inhibition and angiotensin II AT1-receptor blockade reduce the levels of asymmetrical N(G), N(G)-dimethylarginine in human essential hypertensionChristian Delles
Department of Medicine/Nephrology, , , Germany
Am J Hypertens 15:590-3. 2002..CONCLUSIONS: Levels of ADMA were reduced with enalapril and eprosartan therapy. Our results suggest a specific action of these drugs on ADMA levels that is independent of BP...