Research Topics
Genomes and Genes | Robert JasterSummaryAffiliation: University of Rostock Country: Germany Publications
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Publications
Extracellular signal regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cellsR Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, Germany
Gut 51:579-84. 2002..Pancreatic stellate cells (PSCs) have been implicated in pancreatic fibrosis as they synthesise increased amounts of extracellular matrix proteins in response to activation by profibrogenic mediators such as cytokines...- Regulation of pancreatic stellate cell function in vitro: biological and molecular effects of all-trans retinoic acidRobert Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Strasse 6, 18057 Rostock, Germany
Biochem Pharmacol 66:633-41. 2003..We hypothesise that inhibition of AP-1 signalling may be involved in the mediation of biological effects of ATRA on PSCs... - Role of STAT5 in interferon-alpha signal transduction in Ba/F3 cellsR Jaster
Institute of Medical Biochemistry, Medical Faculty of the University Rostock, Germany
Cell Signal 11:331-5. 1999..In summary our results suggest that, despite the capability of IFN-alpha to stimulate DNA binding of STAT5, this transcription factor does not play a pivotal role in IFN-alpha signalling in Ba/F3 cells... - Crucial role of fibrogenesis in pancreatic diseasesRobert Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Strasse 6, 18057 Rostock, Germany
Best Pract Res Clin Gastroenterol 22:17-29. 2008..While some putative inhibitors of fibrogenesis have been tested in animal models of pancreatic fibrosis for their in vivo efficiency, clinical studies still remain to be performed... - Molecular characteristics of autoimmune pancreatitisRobert Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Str 6, 18057 Rostock, Germany
Curr Pharm Des 12:3781-6. 2006..In this review, we describe the characteristic features of AIP and focus on the molecular pathogenesis of the disease... - Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cellsRobert Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, Rostock, 18057, Germany
J Cell Mol Med 9:670-82. 2005..In conclusion, our data suggest an active role of PPARgamma in the induction of a quiescent PSC phenotype. PPARgamma-regulated genes in PSCs may serve as novel targets for the development of antifibrotic therapies... - Molecular regulation of pancreatic stellate cell functionRobert Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E, Heydemann Str, 6, 18057 Rostock, Germany
Mol Cancer 3:26. 2004..In the future, targeting regulators of the PSC activation process might become a promising approach for the treatment of pancreatic fibrosis... - Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatinRobert Jaster
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Str 6, Germany
Biochem Pharmacol 65:1295-303. 2003..Together, our data suggest that lovastatin, through the interruption of Ras signalling, interferes with PSC activation. The antifibrotic efficiency of statins should be tested in animal models of chronic pancreatitis... - Interferon-alpha inhibits proliferation of Ba/F3 cells by interfering with interleukin-3 actionR Jaster
Institute of Medical Biochemistry, Medical Faculty of the University of Rostock, Germany
Cell Signal 11:769-75. 1999.... - Galectin-1 is an inductor of pancreatic stellate cell activationBrit Fitzner
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Str 6, 18057 Rostock, Germany
Cell Signal 17:1240-7. 2005..Together, our data implicate gal-1 in PSC activation and suggest further studies to analyse the role of endogenous lectins in the development of pancreatic fibrosis in vivo... - Molecular insights into connective tissue growth factor action in rat pancreatic stellate cellsAnna Karger
Department of Medicine, University of Rostock, E Heydemann Str 6, 18057 Rostock, Germany
Cell Signal 20:1865-72. 2008..CTGF promotes fibrogenesis both directly by enhancing PSC proliferation and matrix protein synthesis, and indirectly through the release of proinflammatory cytokines that may accelerate the process of chronic inflammation... - Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expressionPeter Brock
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, Rostock, Germany
J Cell Mol Med 10:884-95. 2006..In summary, our data suggest that PSC are suitable targets for gene therapy modulating cellular interactions in the pancreas... - Synergistic growth inhibitory effects of the dual endothelin-1 receptor antagonist bosentan on pancreatic stellate and cancer cellsBrit Fitzner
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Str 6, 18057, Rostock, Germany
Dig Dis Sci 54:309-20. 2009..Together, our results indicate that bosentan exerts antifibrotic and antitumor effects in vitro. Its efficiency in vivo warrants further investigation... - Inhibitory effects of interferon-gamma on activation of rat pancreatic stellate cells are mediated by STAT1 and involve down-regulation of CTGF expressionBrit Fitzner
Department of Medicine, Division of Gastroenterology, University of Rostock, E Heydemann Str 6, 18057, 18057 Rostock, Germany
Cell Signal 19:782-90. 2007..Our data further support the hypothesis that IFN-gamma interferes with stellate cell activation in the pancreas and suggest activated STAT1 as an inductor of a quiescent PSC phenotype... - Antifibrogenic effects of histone deacetylase inhibitors on pancreatic stellate cellsRobin Bülow
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Str 6, 18057 Rostock, Germany
Biochem Pharmacol 74:1747-57. 2007..Together, the results suggest that HDACI exert antifibrogenic effects on PSC. Interruption of AP-1 signaling and autocrine loops enhancing PSC activation might be key mechanisms of HDACI action... - Early rise in inflammation and microcirculatory disorder determine the development of autoimmune pancreatitis in the MRL/Mp-mouseHeiko Sorg
Institute for Experimental Surgery, Division of Gastroenterology, University of Rostock, Rostock, Germany
Am J Physiol Gastrointest Liver Physiol 295:G1274-80. 2008..The present study shows that the onset of AIP is characterized by an inflammatory response and microcirculatory failure, most probably constituting initiators and propagators of this autoimmune disease... - Delayed response toward activation stimuli in pancreatic stellate cellsAnne Glass
Institute for Medical Informatics and Biometry, Department of Medicine, University of Rostock, Germany
Pancreas 33:293-300. 2006..There is little information available regarding the dynamics of the complex processes initiated by an activating stimulus in quiescent stellate cells... - Studies on mechanisms of interferon-gamma action in pancreatic cancer using a data-driven and model-based approachFalko Lange
Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany
Mol Cancer 10:13. 2011..To elucidate the molecular action of IFN?, we have established a mathematical model of STAT1 activation and combined experimental studies with computer simulations... - Inhibition of lymphocyte apoptosis by pancreatic stellate cells: impact of interleukin-15Gisela Sparmann
Division of Gastroenterology, Department of Medicine, University of Rostock, D 18057 Rostock, Germany
Am J Physiol Gastrointest Liver Physiol 289:G842-51. 2005..This effect and the stimulation of PSCs by lymphocytes may lead to a circulus vitiosus, resulting in the persistence of inflammatory processes and the development of fibrosis during chronic pancreatitis... - Bone marrow-derived pancreatic stellate cells in ratsGisela Sparmann
Division of Gastroenterology, Department of Internal Medicine, University of Rostock, 18057 Rostock, Germany
Cell Res 20:288-98. 2010..Increased numbers of resting PSCs after regeneration point toward enhanced recruitment of BM-derived cells to the pancreas and/or re-acquisition of a quiescent state after inflammation-induced activation... - Involvement of AP-1 proteins in pancreatic stellate cell activation in vitroBrit Fitzner
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, E.-Heydemann-Strasse 6, Rostock, Germany
Int J Colorectal Dis 19:414-20. 2004..In further studies, it should be analyzed whether signaling pathways involved in PSC activation might be suitable targets for antifibrotic therapies... - Interleukin-4 gene transfer into rat pancreas by recombinant adenovirusPeter Brock
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, Rostock, Germany
Scand J Gastroenterol 40:1109-17. 2005..CONCLUSIONS: Our data suggest that the injection of recombinant adenoviruses into the left gastric artery is a promising approach to achieving expression of therapeutic transgenes in the pancreas... - Interferon-gamma treatment accelerates and aggravates autoimmune pancreatitis in the MRL/Mp-mouseBrit Fitzner
Department of Medicine, Division of Gastroenterology, University of Rostock, Rostock, Germany
Pancreatology 9:233-9. 2009..Here, we have directly tested the effects of interferon-gamma (IFN-gamma) by applying it to AIP-prone MRL/Mp mice... - Molecular determinants of the profibrogenic effects of endothelin-1 in pancreatic stellate cellsAnika Jonitz
Department of Medicine II, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Str 6, 18057 Rostock, Germany
World J Gastroenterol 15:4143-9. 2009..To gain molecular insights into the expression and functions of endothelin-1 (ET-1) in pancreatic stellate cells (PSC)... - Interferon-alpha inhibits interleukin-3-induced proliferation of Ba/F3 cells in a protein kinase R-dependent mannerKatrin Schröder
Division of Gastroenterology, Department of Medicine, Medical Faculty, University of Rostock, E Heydemann Str 6, 18057 Rostock, Germany
Cell Signal 16:167-74. 2004..They also suggests that activation of STAT1, an essential mediator of IFN effects, is insufficient for growth inhibition if PKR is not expressed... - Inhibitory effects of interferons on pancreatic stellate cell activationJan-Tido Baumert
Department of Medicine, Division of Gastroenterology, Medical Faculty, University of Rostock, 18057 Rostock, Germany
World J Gastroenterol 12:896-901. 2006..CONCLUSION: IFN-beta and particularly IFN-gamma display inhibitory effects on PSC activation in vitro and should be tested regarding their in vitro efficiency. Growth inhibition by IFN-gamma action requires STAT1... - Identification of quantitative trait loci for murine autoimmune pancreatitisFarahnaz Asghari
Department of Medicine II, Division of Gastroenterology, University of Rostock, E Heydemann Strasse 6, Rostock, Germany
J Med Genet 48:557-62. 2011..Autoimmune pancreatitis (AIP) represents a rare but clinically relevant cause of pancreatic inflammation. Using MRL/Mp mice as a model of spontaneous AIP, the genetic basis of the disease was studied... - Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cellsElisabeth Emonds
Department of Medicine II, Division of Gastroenterology, Medical Faculty, University of Rostock, E Heydemann Strasse 6, Rostock, Germany
World J Gastroenterol 16:1970-8. 2010..To gain molecular insights into the action of the histone deacetylase inhibitor (HDACI) trichostatin-A (TSA) in pancreatic cancer (PC) cells... - Mathematical modelling of interferon-gamma signalling in pancreatic stellate cells reflects and predicts the dynamics of STAT1 pathway activityKatja Rateitschak
Systems Biology and Bioinformatics Group, University of Rostock, 18051 Rostock, Germany
Cell Signal 22:97-105. 2010..We believe that further investigations into mathematical modelling of the STAT1 pathway will improve the understanding of the antifibrotic interferon action... - Interferon-alpha inhibits cell cycle progression by Ba/F3 cells through the antagonisation of interleukin-3 effects on key regulators of G(1)/S transitionHolger Prietzsch
Institute of Medical Biochemistry and Molecular Biology, Medical Faculty, University of Rostock, Rostock, Germany
Cell Signal 14:751-9. 2002.... - Cis-hydroxyproline-induced inhibition of pancreatic cancer cell growth is mediated by endoplasmic reticulum stressChristoph Mueller
Department of Medicine, Division of Gastroenterology, University of Rostock, Ernst-Heydemann-Str. 6, D-18057 Rostock, Germany
World J Gastroenterol 12:1569-76. 2006.... - Generation and characterization of immortalized rat pancreatic stellate cellsGisela Sparmann
Dept of Gastroenterology, University Hospital of Rostock, Ernst Heydemann Strasse 6, D 18057 Rostock, Germany
Am J Physiol Gastrointest Liver Physiol 287:G211-9. 2004..Thus the established cell lines represent a versatile tool to investigate various aspects of PSC biology... - Systems biologists seek fuller integration of systems biology approaches in new cancer research programsOlaf Wolkenhauer
University of Rostock, Rostock, Germany
Cancer Res 70:12-3. 2010.... - cDNA cloning and functional analysis of a truncated STAT5a protein from autonomously growing FDCP-1 cellsT Bittorf
Medical Faculty, Institute of Medical Biochemistry, University of Rostock, Schillingallee 70, PF100888, 18055, Rostock, Germany
Cell Signal 12:721-30. 2000..The results suggest competition of the mutant protein with cytosolic mechanisms regulating STAT5 activity. In conclusion, the data support the hypothesis of an involvement of STAT5 in mitogenic and antiapoptotic signaling... - Activation of the transcription factor NF-kappaB by the erythropoietin receptor: structural requirements and biological significanceT Bittorf
Institute of Medical Biochemistry and Molecular Biology, Medical Faculty, University of Rostock, Schillingallee 70, PF100888, 18055 Rostock, Germany
Cell Signal 13:673-81. 2001..Furthermore, the functional analysis of different receptor forms revealed a correlation of the abilities to induce NF-kappaB activity and to generate antiapoptotic signals... - Activation of STAT5 during EPO-directed suppression of apoptosisT Bittorf
Institute of Medical Biochemistry, Medical Faculty, University of Rostock, Germany
Cell Signal 12:23-30. 2000..We conclude that the transcription factor STAT5 is functionally implicated in the EPO-dependent survival of cells... - Systems biology of JAK-STAT signalling in human malignanciesJulio Vera
Department of Systems Biology and Bioinformatics, University of Rostock, 18051 Rostock, Germany
Prog Biophys Mol Biol 106:426-34. 2011..We describe the modelling workflow that realises a systems biology approach and give an example for interferon-? signalling in pancreatic stellate cells... - Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cellsAnne Caroline Schmöle
Albrecht Kossel Institute for Neuroregeneration AKos, Center for Mental Health, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
Bioorg Med Chem 18:6785-95. 2010..Therefore we conclude that indolylmaleimides act via the canonical Wnt signalling pathway by inhibition of the key enzyme GSK-3beta... - Aging is associated with a shift of fatty metabolism toward lipogenesisAngela Kuhla
Institute for Experimental Surgery, University of Rostock, Schillingallee 69a, D 18057 Rostock, Germany
J Gerontol A Biol Sci Med Sci 66:1192-200. 2011..The dysbalance between the nuclear receptors and their target genes most probably mediates hepatic steatosis and underlines the pathological relevance of nuclear receptor shift toward lipogenesis in fat metabolism of the elderly patient... - Transforming growth factor-beta induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathwayStephan L Haas
Department of Medicine II, Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
Growth Factors 27:289-99. 2009..We conclude that under conditions of upregulated TGF-beta, like fibrosis, NGF levels will also increase in PSC which might contribute to pancreatic wound healing responses...