Research Topics
| H IhmsenSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
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Detail Information
Publications
Modelling acute tolerance to the EEG effect of two benzodiazepinesHarald Ihmsen
Department of Anaesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Br J Clin Pharmacol 57:153-61. 2004..We studied the development of acute tolerance to the EEG effect of midazolam and the new benzodiazepine Ro 48-6791...- Teletherapeutic drug administration by long distance closed-loop control of propofolH Ihmsen
Department of Anaesthesiology, Universiätsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
Br J Anaesth 98:189-95. 2007..The objective of this pilot study was to investigate the feasibility of an EEG-controlled closed-loop administration of propofol over a long distance of about 200 km... - [Accuracy of target-controlled infusion (TCI) with 2 different propofol formulations]H Ihmsen
Klinik fur Anasthesiologie, Friedrich Alexander Universitat, Erlangen Nurnberg
Anaesthesist 53:937-43. 2004..New TCI systems can be used with any propofol formulation. We compared two different propofol formulations with respect to accuracy of TCI and pharmacokinetics... - [Target-controlled infusion. Clinical relevance and special features when using pharmacokinetic models]H Ihmsen
Anästhesiologische Klinik, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 12, 91054, Erlangen
Anaesthesist 58:708-15. 2009..The aim is to explicate for the user of modern TCI systems the underlying scientific concepts and the relevance for clinical practice... - Development of acute tolerance to the EEG effect of propofol in ratsH Ihmsen
Klinik fur Anasthesiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Br J Anaesth 95:367-71. 2005..The aim of this study was to evaluate acute tolerance by means of EEG-controlled closed-loop anaesthesia as this approach allows precise determination of drug requirement to maintain a defined drug effect... - Propofol in rats: testing for nonlinear pharmacokinetics and modelling acute tolerance to EEG effectsH Ihmsen
University of Erlangen Nuremberg, Department of Anaesthesiology, Erlangen, Germany
Eur J Anaesthesiol 19:177-88. 2002..We investigated pharmacokinetics and pharmacodynamics of propofol in rats with special regard to linearity in pharmacokinetics and development of tolerance... - Stereoselective pharmacokinetics of ketamine: R(-)-ketamine inhibits the elimination of S(+)-ketamineH Ihmsen
Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
Clin Pharmacol Ther 70:431-8. 2001..We investigated the pharmacokinetics of ketamine with special regard to enantiomer-specific differences... - Concentration-effect relations, prediction probabilities (Pk), and signal-to-noise ratios of different electroencephalographic parameters during administration of desflurane, isoflurane, and sevoflurane in ratsHarald Ihmsen
Department of Anesthesiology, Friedrich Alexander UniversityErlangen Nuremberg, Erlangen, Germany
Anesthesiology 108:276-85. 2008..The authors investigated the suitability of different electroencephalographic parameters to quantify the anesthetic effect of desflurane, isoflurane, and sevoflurane in rats... - [Pharmacodynamics of two different propofol formulations]H Ihmsen
Anästhesiologische Klinik, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen
Anaesthesist 55:635-42. 2006..Propofol is nowadays available in various lipid formulations. We compared two different propofol formulations with respect to pharmacodynamics, using the EEG and clinical signs... - Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in childrenC Jeleazcov
Department of Anaesthesiology, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 12, 91054 Erlangen, Germany
Br J Anaesth 100:509-16. 2008..This study describes a pharmacodynamic model during general anaesthesia in children relating the bispectral index (BIS) response to the anaesthetic dosing of propofol, fentanyl, and remifentanil... - EEG-controlled closed-loop dosing of propofol in ratsA Tzabazis
, , Krankenhausstrasse 12, D-91054 Erlangen, Germany
Br J Anaesth 92:564-9. 2004.... - Modelling the pharmacodynamic interaction between remifentanil and propofol by EEG-controlled dosingJ Fechner
Friedrich Alexander Universitat Erlangen Nurnberg, Department of Anaesthesiology, Erlangen, Germany
Eur J Anaesthesiol 20:373-9. 2003..We studied this pharmacodynamic interaction using the median power frequency of the processed electroencephalogram as a control parameter for feedback-controlled dosing of propofol... - Testing and modelling the interaction of alfentanil and propofol on the EEGH Schwilden
Friedrich Alexander Universitat Erlangen Nurnberg, Department of Anaesthesiology, Erlangen, Germany
Eur J Anaesthesiol 20:363-72. 2003..A supra-additive interaction has been reported for clinical signs such as loss of consciousness or loss of the eyelash reflex. This study investigated the type of interaction of alfentanil and propofol on the electroencephalogram... - Interaction of physostigmine and alfentanil in a human pain modelA P Wehrfritz
Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054, Erlangen, Germany
Br J Anaesth 104:359-68. 2010..The aim of this study was to examine the analgesic and antihyperalgesic properties of the cholinesterase inhibitor physostigmine and the opioid alfentanil, alone and in combination, in an experimental pain model in humans... - Population pharmacokinetics of propofol: a multicenter studyJ Schuttler
Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Germany
Anesthesiology 92:727-38. 2000..This method requires accurate knowledge of pharmacokinetics, including the effects of age and weight. The authors performed a multicenter population analysis to quantitate the effects of covariates... - Pharmacokinetic-pharmacodynamic modeling of the new steroid hypnotic eltanolone in healthy volunteersW J Hering
Department of Anesthesiology, Friedrich Alexander University of Erlangen Nuremberg, Germany
Anesthesiology 85:1290-9. 1996..Thus the authors conducted a study to evaluate the pharmacokinetic and pharmacodynamic properties of eltanolone after infusion in healthy volunteers... - Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 in ratsM Schywalsky
University of Erlangen-Nuremberg, Department of Anaesthesiology, Erlangen, Germany
Eur J Anaesthesiol 20:182-90. 2003.... - [Analgo-sedation in intensive care: a quantitative, EEG-based trial with propofol 1% and 2%]S Albrecht
Klinik fur Anasthesiologie, Universitat Erlangen
Anaesthesist 48:794-801. 1999..Moreover, we investigated the pharmacokinetics and pharmacodynamics of propofol with respect to possible tolerance and compared the quality of sedation of both propofol formulations and their lipid load... - Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol)Jörg Fechner
University Erlangen Nurnberg, Department of Anesthesiology, Krankenhausstrasse 12, 91054 Erlangen, Germany
Expert Opin Investig Drugs 18:1565-71. 2009..Fospropofol is the first propofol prodrug that has been intensively studied in man. It has been licensed in 2008 by the FDA for monitored anesthetic care sedation... - Supra-additive effects of tramadol and acetaminophen in a human pain modelJörg Filitz
Department of Anesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Pain 136:262-70. 2008..The results might act as a rationale for combining both analgesics... - Different profiles of buprenorphine-induced analgesia and antihyperalgesia in a human pain modelWolfgang Koppert
Department of Anaesthesiology, University Hospital Erlangen, Krankenhausstrasse 12, D 91054 Erlangen, Germany
Pain 118:15-22. 2005..It will be of major clinical interest whether this difference will translate into improved treatment of pain states dominated by central sensitization... - Binding of propofol to human serum albuminMichael Schywalsky
Klinik fur Anaesthesiologie, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
Arzneimittelforschung 55:303-6. 2005..The measured influence of the albumin concentration on propofol binding might be of relevance in states of hypo- or hyperalbuminaemia which could result in an altered demand of propofol... - Sedation with GPI 15715, a water-soluble prodrug of propofol, using target-controlled infusion in volunteersJörg Fechner
Department of Anesthesiology, University of Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Anesth Analg 100:701-6, table of contents. 2005..9 microg/mL had the highest probability to result in an MOAA/S score of 3, which corresponds with moderate sedation. We observed no serious side effects. We conclude that GPI 15715 produces excellent sedation... - Comparative pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI 15715 and propofol emulsionJörg Fechner
Department of Anesthesiology, University of Erlangen Nuremberg, Germany
Anesthesiology 101:626-39. 2004..The objectives of this crossover study in volunteers were to investigate the pharmacokinetics and pharmacodynamics of GPI 15715 in comparison with propofol emulsion... - Pharmacokinetics and clinical pharmacodynamics of the new propofol prodrug GPI 15715 in volunteersJörg Fechner
Department of Anesthesiology, University of Erlangen Nuremberg, Erlangen, Germany
Anesthesiology 99:303-13. 2003..The objectives of this first study in humans were to investigate the safety, tolerability, pharmacokinetics, and clinical pharmacodynamics of GPI 15715... - Oxycodone clearance is markedly reduced with advancing age: a population pharmacokinetic studyT I Saari
Department of Anaesthesiology, Friedrich Alexander University Erlangen Nuremberg, Krankenhausstr 12, 91054 Erlangen, Germany
Br J Anaesth 108:491-8. 2012..The pharmacokinetic data of oxycodone available for elderly are limited, and there appear to be only little data on the population pharmacokinetics of oxycodone... - Activation of naloxone-sensitive and -insensitive inhibitory systems in a human pain modelWolfgang Koppert
Department of Anesthesiology, University Hospital Erlangen, Erlangen, Germany
J Pain 6:757-64. 2005..Here we show activation of a naloxone-sensitive short-term and a naloxone-insensitive long-term inhibitory system in a new model of electrically induced pain and hyperalgesia...