Research Topics
Genomes and Genes
| Saleh Mohamed IbrahimSummaryAffiliation: University of Rostock Country: Germany Publications
| Collaborators
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Detail Information
Publications
Molecular responses to hypoxia in tumor cellsManfred Kunz
University of Rostock, Department of Dermatology and Venereology, Augustenstr, 80 84, 18055 Rostock, Germany
Mol Cancer 2:23. 2003..Interfering with these pathways might open perspectives for future innovative treatment of highly aggressive metastasizing tumors...- A proinflammatory role for Fas in joints of mice with collagen-induced arthritisHoang Tu-Rapp
Department of Immunology, University of Rostock, Rostock, Germany
Arthritis Res Ther 6:R404-14. 2004..These findings suggest that impairment of immune tolerance by increased T-cell reactivity does not lead to enhanced susceptibility to CIA and point to a role of Fas in joint destruction... - Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritisXinhua Yu
Immunogenetics Group, University of Rostock, Schillingallee, 18055 Rostock, Germany
Arthritis Res Ther 9:R3. 2007..Of these 117 genes, 21 were located inside the support intervals of the 8 small-effect QTL and thus were considered as candidate genes... - Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritisGabor Eros
Institute for Experimental Surgery, University of Rostock, Rostock, Germany
Arthritis Res Ther 11:R43. 2009..We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis)... - Modulation of granulocyte-endothelium interactions by antileukoproteinase: inhibition of anti-type II collagen antibody-induced leukocyte attachment to the synovial endotheliumBettina Sehnert
Department of Internal Medicine III and Institute of Clinical Immunology, Friedrich Alexander University of Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Arthritis Res Ther 8:R95. 2006.... - Perforin deficiency attenuates collagen-induced arthritisKristin Bauer
Institute of Immunology, University of Rostock, Rostock, Germany
Arthritis Res Ther 7:R877-84. 2005..Thus, pfp-mediated cytotoxicity is involved in the initiation of tissue damage in arthritis, but pfp-independent cytotoxic death pathways might also contribute to CIA... - Dissecting the genetic basis of rheumatoid arthritis in mouse modelsSaleh M Ibrahim
Section of Immunogenetics, University of Rostock, Schillingallee 70, 18055 Rostock, Germany
Curr Pharm Des 12:3753-9. 2006..In this post-genome era, the sequencing of the human and some murine genomes as well as advances in global screening technologies offer an opportunity to accelerate the progress... - Genomics, proteomics, metabolomics: what is in a word for multiple sclerosis?Saleh M Ibrahim
Department of Immunology, University of Rostock, Rostock, Germany
Curr Opin Neurol 18:231-5. 2005..Some recent publications using novel global screening methods at the genome, transcriptome, proteome and metabolome levels are discussed... - Gene-expression profile of collagen-induced arthritisSaleh Mohamed Ibrahim
Institute of Immunology, University of Rostock, Schillingallee 70, Rostock, 18055, Germany
J Autoimmun 18:159-67. 2002..The profile of gene expression supports current theoretical models of disease progression and might open new perspectives for both diagnosis and treatment of arthritis... - Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitisS M Ibrahim
Department of Immunology, University of Rostock, Rostock, Germany
Brain 124:1927-38. 2001..Of the 104 genes with defined chromosomal locations, 51 mapped to known EAE-linked quantitative trait loci and as such are putative candidate genes for susceptibility to EAE... - Fine mapping of collagen-induced arthritis quantitative trait loci in an advanced intercross lineXinhua Yu
Immunogenetics Group, University of Rostock, Rostock, Germany
J Immunol 177:7042-9. 2006..In addition, this study revealed that Cia27 and Trmq3 controlling anti-CII IgG2a Ab and CD4:CD8 T cell ratio, respectively, also regulated CIA clinical phenotypes... - High resolution mapping of Cia3: a common arthritis quantitative trait loci in different speciesXinhua Yu
Section of Immunogenetics, University of Rostock, Germany
J Immunol 182:3016-23. 2009..6 Mb genomic region on mouse chromosome 6 and identified candidate genes. This will aid in the search for susceptibility gene(s) controlling arthritis development within Cia3 and its counterpart regions in rat and human genomes... - mtDNA nt13708A variant increases the risk of multiple sclerosisXinhua Yu
Section of Immunogenetics, University of Rostock, Rostock, Germany
PLoS ONE 3:e1530. 2008..Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility... - MS characterization of qualitative protein polymorphisms in the spinal cords of inbred mouse strainsStefan Mikkat
Core Facility Proteome Analysis, Medical Faculty, University of Rostock, Rostock, Germany
Proteomics 10:1050-62. 2010.... - Mutation of mitochondrial ATP8 gene improves hepatic energy status in a murine model of acute endotoxemic liver failureChristian Eipel
Institute for Experimental Surgery, University of Rostock, Schillingallee 69 a, 18055 Rostock, Germany
Life Sci 88:343-9. 2011..Therefore, the implications of mitochondrial (dys)function in the development of multiple organ failure are profound. We investigated whether a mutation in the ATPase subunit-8 gene affects the course of endotoxemic acute liver failure... - Association of a common polymorphism in the promoter of UCP2 with susceptibility to multiple sclerosisSusanne Vogler
Department of Immunology, University of Rostock, Germany
J Mol Med (Berl) 83:806-11. 2005..Thus, UCP2 promoter polymorphism may contribute to MS susceptibility by regulating the level of UCP2 protein in the central nervous and/or the immune systems... - Selecting SNPs for association studies based on population frequencies: a novel interactive tool and its application to polygenic diseasesSteffen Möller
University of Rostock, Institute of Immunology, Schillingallee 70, 18055 Rostock, Germany
In Silico Biol 4:417-27. 2004..This tool is recommended to be used in conjunction with microarray analyses or marker association studies that link genes or chromosomal loci to particular diseases... - Collection of soluble variants of membrane proteins for transcriptomics and proteomicsSteffen Möller
University of Rostock, Institute of Immunology, Schillingallee 70, 18057 Rostock, Germany
In Silico Biol 5:295-311. 2005..The findings then are confirmed by a comparison with identified proteins of a recent global proteomics study of human blood plasma. Finally, a tool to determine novel soluble variants by proteomics is provided... - Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cellsManfred Kunz
Department of Dermatology and Venereology and Institute of Immunology and Proteome Center, University of Rostock, 18055 Rostock, Germany
J Biol Chem 278:45651-60. 2003..This may argue for a hypoxia-induced selection process during tumor progression toward melanoma cells with constitutive high Cyr61 expression... - In silico fine-mapping: narrowing disease-associated loci by intergenomicsPablo Serrano-Fernandez
Institute of Immunology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Bioinformatics 21:1737-8. 2005..Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits. AVAILABILITY: http://qtl.pzr.uni-rostock.de/qtlmix.php CONTACT: serrano@pzr.uni-rostock.de... - The functional -443T/C osteopontin promoter polymorphism influences osteopontin gene expression in melanoma cells via binding of c-Myb transcription factorJulia Schultz
Department of Dermatology and Venereology, University of Rostock, Rostock, Germany
Mol Carcinog 48:14-23. 2009..These findings might be a feasible explanation for different OPN expression levels in metastatic tumors and may also have prognostic and therapeutic relevance... - Proteome analysis of diseased joints from mice suffering from collagen-induced arthritisPeter Lorenz
Institute of Immunology, Medical Faculty, University of Rostock, Rostock, Germany
Clin Chem Lab Med 41:1622-32. 2003..This study provides us with the framework for more detailed approaches to understanding the complex disease arthritis that go beyond global proteomics... - Dissecting the effects of mtDNA variations on complex traits using mouse conplastic strainsXinhua Yu
Section of Immunogenetics, University of Rostock, Rostock 18055, Germany
Genome Res 19:159-65. 2009..Thus, we have developed a unique genetic resource that will facilitate exploration of the biochemical and physiological roles of mitochondria in complex traits... - Identification of new quantitative trait loci in mice with collagen-induced arthritisKristin Bauer
Institute for Immunology, University of Rostock, Schillingallee 70, 18055 Rostock, Germany
Arthritis Rheum 50:3721-8. 2004..This study sought to identify potential genetic regulatory mechanisms of CIA in major histocompatibility complex-matched (H2-q) F(2) hybrid mice... - Genetic control of leucocyte--endothelial cell interaction in collagen-induced arthritisHoang Tu-Rapp
Institute for Experimental Surgery, University of Rostock, Rostock, Germany
Ann Rheum Dis 69:606-10. 2010..In this study we attempted to define the genetic basis of this stage of disease using genetic linkage studies, in-vivo imaging and expression profiling... - 14-3-3sigma gene silencing during melanoma progression and its role in cell cycle control and cellular senescenceJulia Schultz
Department of Cardiac Surgery, University of Rostock, Rostock, Germany
Mol Cancer 8:53. 2009..The 14-3-3sigma isoform acts as a tumor suppressor and is often inactivated during tumor development... - 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAEEilhard Mix
Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
J Autoimmun 27:251-65. 2006..Monitoring of expression of the newly identified candidate genes and patterns of lymphocyte subpopulations might predict the responsiveness of multiple sclerosis patients to statin treatment... - Tumor-promoting role of signal transducer and activator of transcription (Stat)1 in late-stage melanoma growthJulia Schultz
Institute of Medical Biochemistry and Molecular Biology, University of Rostock, Rostock, Germany
Clin Exp Metastasis 27:133-40. 2010..Taken together, these data suggest that Stat1 might play a role in late-stage melanoma progression. Interference with the Stat1 pathway could have therapeutic implications for late-stage melanoma patients... - Expressionview: visualization of quantitative trait loci and gene-expression data in EnsemblGertrud Fischer
University of Rostock, Institute of Immunology, Joachim-Jungius-Strasse 9, 18059 Rostock, Germany
Genome Biol 4:R77. 2003..It supports the visualization of gene clusters and the selection of functional candidate genes in the context of research on complex traits... - Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitisSusanne Vogler
Department of Immunology, University of Rostock, Germany
Am J Pathol 168:1570-5. 2006..Concomitantly, CD4 and CD8 cells of the UCP2-deficient mice showed increased production of reactive oxygen species. These results suggest a protective function of UCP2 in chronic inflammatory diseases such as multiple sclerosis... - Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of diseaseIgnacio Mazón Peláez
Department of Immunology, University of Rostock, Germany
Hum Mol Genet 14:1977-89. 2005..There were no alterations in the morphological appearance of the myelin sheaths. Our findings suggest a possible role of myelin composition and/or synaptic transmission in susceptibility to EAE... - The mtDNA nt7778 G/T polymorphism affects autoimmune diseases and reproductive performance in the mouseXinhua Yu
Section of Immunogenetics, University of Rostock, Rostock, Germany
Hum Mol Genet 18:4689-98. 2009..Our findings provide direct experimental evidence for the role of mitochondria in autoimmunity and reproduction... - Chronicity of pristane-induced arthritis in rats is controlled by genes on chromosome 14Lena Wester
Institute for Immunology, University of Rostock, Rostock, Germany
J Autoimmun 21:305-13. 2003..We conclude that the active relapsing chronic arthritis is under a unique genetic control that is different from the control of acute arthritis and postulate that the liver plays an important role in this regulation... - Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory moleculesDirk Koczan
Institute of Immunology, University of Rostock, Schillingallee 70, 18055 Rostock, Germany
Eur J Dermatol 15:251-7. 2005..The genes identified in the present report and the molecular mechanisms underlying their regulation might serve as future targets for therapeutic intervention in psoriasis...