Research Topics
Genomes and Genes | Jonathan C HowardSummaryAffiliation: University of Cologne Country: Germany Publications
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Publications
Evolution of immunity and pathogensJonathan C Howard
Institute for Genetics, University of Cologne, Zulpicher Strasse 47, Cologne, Germany
Eur J Immunol 37:1721-3. 2007..The Cologne Spring Meeting of the Institute of Genetics focuses on a different topic each year. In Spring 2007, the meeting focused on the complex evolutionary relationships between hosts and pathogens...- IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerizationRevathy C Uthaiah
Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
J Biol Chem 278:29336-43. 2003..The present analysis provides essential parameters to understand the molecular mechanism by which IIGP1 participates in this complex resistance program... - A giant GTPase, very large inducible GTPase-1, is inducible by IFNsThorsten Klamp
Institute for Genetics, University of Cologne, Cologne, Germany
J Immunol 171:1255-65. 2003..In addition, we provide evidence that VLIG-1 is polymorphic in mice of different genetic backgrounds and is a member of a small gene family on mouse chromosome 7 with a conserved homologue located on human chromosome 11... - Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPasesSascha Martens
Institute for Genetics, University of Cologne, Cologne, Germany
PLoS Pathog 1:e24. 2005..Targeted deletion of the IIGP1 gene results in partial loss of the IFN-gamma-mediated T. gondii growth restriction in mouse astrocytes... - Introduction: cell-autonomous immunityJonathan C Howard
Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, 50674 Cologne, Germany
Microbes Infect 9:1633-5. 2007..Only a few cell-autonomous resistance mechanisms have been analysed in any depth and there is much more work to be done... - The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondiiJonathan C Howard
Institute for Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
Curr Opin Microbiol 14:414-21. 2011..Thus these two mechanisms form the two poles of a dynamic host-pathogen virulence-resistance relationship with interesting and accessible properties... - The IRG proteins: a function in search of a mechanismJonathan Howard
Institute for Genetics, University of Cologne, Zuelpicher Strasse 47, 50674 Cologne, Germany
Immunobiology 213:367-75. 2008..Failure of hemopoietic stem cells during infection is associated with targeted deletion of one IRG protein, Irgm1. The significance of this non-cell-autonomous phenotype is discussed... - Why didn't Darwin discover Mendel's laws?Jonathan C Howard
Institute for Genetics, University of Cologne, Germany
J Biol 8:15. 2009..Darwin's focus on small quantitative variations as the raw material of evolution may have prevented him from discovering the laws of inheritance... - The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondiiNikolaus Pawlowski
Institute for Genetics, Department of Cell Genetics, University of Cologne, Zülpicher Strasse 47a, 50674 Cologne, Germany
BMC Biol 9:7. 2011.... - Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiJulia P Hunn
Department of Cell Genetics, Institute for Genetics, University of Cologne, Cologne, Germany
EMBO J 27:2495-509. 2008..Accumulation of IRG proteins at the PVM has previously been shown to be associated with a block in pathogen replication: our results relate for the first time the enzymatic properties of IRG proteins to their role in pathogen resistance... - Inactive and active states of the interferon-inducible resistance GTPase, Irga6, in vivoNatasa Papic
Department of Cell Genetics, Institute for Genetics, University of Cologne, 50674 Cologne, Germany
J Biol Chem 283:32143-51. 2008.... - Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondiiTobias Steinfeldt
Institute for Genetics, University of Cologne, Cologne, Germany
PLoS Biol 8:e1000576. 2010..gondii and the mouse are widespread and abundant in the wild and are well-established model species with excellent analytical tools available... - The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineageCemalettin Bekpen
Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
Genome Biol 6:R92. 2005..Surprisingly, there are no reports of p47 function in humans... - Cell-autonomous immunity to Toxoplasma gondii in mouse and manStephanie Könen Waisman
Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
Microbes Infect 9:1652-61. 2007..There are many poorly understood host and pathogen variables that affect the outcome of infection... - Mechanisms regulating the positioning of mouse p47 resistance GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to plasma membrane induced by phagocytosisSascha Martens
Institute for Genetics, University of Cologne, Cologne, Germany
J Immunol 173:2594-606. 2004..Thus, the p47 GTPases are a diverse battery of intracellular defense factors dynamically associated with different membrane systems... - Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell deathYang O Zhao
Institute for Genetics, University of Cologne, Cologne, Germany
PLoS Pathog 5:e1000288. 2009..We conclude that IRG proteins resist infection by avirulent T. gondii by a novel mechanism involving disruption of the vacuolar membrane, which in turn ultimately leads to the necrotic death of the infected cell... - Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cellsYang O Zhao
Institute for Genetics, University of Cologne, Cologne, Germany
PLoS ONE 5:e8648. 2010..In future analyses it should be borne in mind that tagging of Irgm1 leads to loss of Golgi localisation and enhanced localisation on endolysosomal membranes, probably as a result of constitutive activation... - Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuoleAliaksandr Khaminets
Institute for Genetics, University of Cologne, Zulpicher Strasse, Cologne 50674, Germany
Cell Microbiol 12:939-61. 2010..The complex cooperative behaviour of IRG proteins in resisting Toxoplasma may hint at undiscovered complexity also in virulence mechanisms... - The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogensJulia P Hunn
Institute for Genetics, University of Cologne, Zuelpicher Strasse 47a, Cologne, Germany
Mamm Genome 22:43-54. 2011..IRG proteins are targets for polymorphic T. gondii virulence factors, and genetic variation in the IRG system between different mouse strains correlates with resistance and susceptibility to virulent T. gondii strains... - Spontaneous focal activation of invariant natural killer T (iNKT) cells in mouse liver and kidneyJia Zeng
Institute for Genetics, University of Cologne, Zuelpicher Strasse 47a, 50674 Cologne, Germany
BMC Biol 8:142. 2010..It is generally agreed that the immune phenotype of iNKT cells is maintained by repeated activation in peripheral tissues although no explicit evidence for such iNKT cell activity in vivo has so far been reported... - Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10Jorn Coers
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
J Immunol 180:6237-45. 2008..muridarum. These data suggest that C. muridarum has evolved a mechanism to escape the murine IFN-gamma response by restricting access of Irgb10 and possibly other IRG proteins to the inclusion... - MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. 1990Edward V Deverson
Department of Immunology, Institute of Animal Physiology and Genetics, Cambridge Research Station, Cambridge, UK
J Immunol 180:2729-32. 2008 - Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharidesNicolas Lapaque
Centre d Immunologie INSERM CNRS Université Méditerranée, Case 906, 13288 Marseille, Cedex 9, France
Cell Microbiol 8:401-13. 2006..They also reinforce the hypothesis that non-classical lipid As act as virulence factors by favouring the escape from the innate immune system...