Research Topics
Genomes and Genes
Species | Bernd HoppeSummaryAffiliation: University of Cologne Country: Germany Publications
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Detail Information
Publications
Diagnostic and therapeutic strategies in hyperoxaluria: a plea for early interventionBernd Hoppe
University Children's Hospital, Division of Paediatric Nephrology, University of Cologne, Josef-Stelzmann Strasse 9, D-50931 Cologne, Germany
Nephrol Dial Transplant 19:39-42. 2004- Nephrocalcinosis in preterm infants: a single center experienceBernd Hoppe
Pediatric Nephrology, University Children s Hospital, Josef Stelzmann Strasse 9, 50924 Cologne, Germany
Pediatr Nephrol 17:264-8. 2002..The numbers have, however, increased over the past few years. From the follow-up it was obvious that long-term observation of preterm infants is necessary and that complications might arise in the long run... - Hypocitraturia as a risk factor for nephrocalcinosis after kidney transplantationLudwig Stapenhorst
Division of Pediatric Nephrology, Department of Pediatrics, University Children s Hospital, 50924, Cologne, Germany
Pediatr Nephrol 20:652-6. 2005..Both findings can increase the risk for urolithiasis or nephrocalcinosis... - Oxalate degrading bacteria: new treatment option for patients with primary and secondary hyperoxaluria?Bernd Hoppe
University Children s Hospital Cologne, Division of Pediatric Nephrology, University of Cologne, Kerpenerstrasse 62, 50931 Cologne, Germany
Urol Res 33:372-5. 2005..O. formigenes might be a promising new therapeutic tool in patients with primary and secondary hyperoxaluria... - A United States survey on diagnosis, treatment, and outcome of primary hyperoxaluriaBernd Hoppe
Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
Pediatr Nephrol 18:986-91. 2003..As isolated KTx failed in 59% of patients, combined liver-kidney Tx seems to be the better choice in place of isolated KTx as the primary transplant procedure... - Diagnostic and therapeutic approaches in patients with secondary hyperoxaluriaBernd Hoppe
University Children s Hospital, Pediatric Nephrology, D 50924 Cologne, Germany
Front Biosci 8:e437-43. 2003.... - Absorptive hyperoxaluria leads to an increased risk for urolithiasis or nephrocalcinosis in cystic fibrosisBernd Hoppe
University Children s Hospital Cologne, Germany, USA
Am J Kidney Dis 46:440-5. 2005..To better elucidate its pathophysiological characteristics, we prospectively studied patients with CF by determining these parameters and performing renal ultrasonography twice yearly... - Reduction of plasma oxalate levels by oral application of Oxalobacter formigenes in 2 patients with infantile oxalosisBernd Hoppe
Department of Pediatric and Adolescent Medicine, Division of Pediatric Nephrology, University Hospital, Cologne, Germany
Am J Kidney Dis 58:453-5. 2011..Therefore, O formigenes therapy may be helpful as a bridging procedure until transplant in such patients... - Urinary NAG in children with urolithiasis, nephrocalcinosis, or risk of urolithiasisPrzemyslaw Sikora
Division of Pediatric Nephrology, University Children's Hospital, Josef-Stelzmann Strasse 9, 50924 Cologne, Germany
Pediatr Nephrol 18:996-9. 2003..The mechanism of cell damage in these conditions however, seems to be complex. Neither HyOx nor HC alone were sufficient to induce severe tubular damage expressed as an increase in NAG excretion in our patients... - Renal allograft calcification -- prevalence and etiology in pediatric patientsSandra Habbig
Department of Pediatrics, Division of Pediatric Nephrology, University Hospital, Cologne, Germany
Am J Nephrol 30:194-200. 2009..Persistent hyperparathyroidism, hypercalcemia and concomitant hypercalciuria were identified as major risk factors. We aimed to determine the prevalence and risk factors for such calcifications in children... - Hypocitraturia is one of the major risk factors for nephrocalcinosis in very low birth weight (VLBW) infantsPrzemyslaw Sikora
Division of Pediatric Nephrology, University Children's Hospital Cologne, Cologne, Germany
Kidney Int 63:2194-9. 2003..The urinary excretions in VLBW infants seem to depend on birth weight, age, and clinical condition. Hence, supplementation with alkali citrate may have a beneficial effect in the prevention of NC... - Primary hyperoxaluria--the German experienceBernd Hoppe
Division of Pediatric Nephrology, Children s Hospital Cologne, University of Cologne, Cologne, Germany
Am J Nephrol 25:276-81. 2005..Primary hyperoxaluria (PH) is a heterogeneous disease with variable age of onset and inconsistent progression into renal failure (ESRF)... - Detection of polyomavirus BK and JC in children with kidney diseases and renal transplant recipientsAndreas Muller
Department of Pediatrics, University of Bonn, Bonn, Germany
Pediatr Infect Dis J 24:778-81. 2005..Testing for polyomavirus DNA in plasma has been described as a sensitive and specific method to discover viral nephropathy in adult patients. We were now interested in polyomavirus status in a pediatric patient setting... - The primary hyperoxaluriasBernd Hoppe
Division of Pediatric Nephrology, Department of Pediatrics, University Hospital, Cologne, Germany
Kidney Int 75:1264-71. 2009..Promising areas of investigation are being identified. Knowledge of the spectrum of disease expression, early diagnosis, and initiation of treatment before renal failure are essential to realize a benefit for patients... - Nephrocalcinosis and urolithiasis in childrenSandra Habbig
Division of Pediatric Nephrology, Department of Pediatrics, University of Cologne, Cologne, Germany
Kidney Int 80:1278-91. 2011.... - Evidence of true genotype-phenotype correlation in primary hyperoxaluria type 1Bernd Hoppe
Division of Pediatric Nephrology, Department of Pediatrics, University Hospital Cologne, Cologne, Germany
Kidney Int 77:383-5. 2010..Harambat and co-workers report on this situation, presenting data on a major population of genotyped patients... - Transplantation procedures in children with primary hyperoxaluria type 1: outcome and longitudinal growthFlorian Brinkert
Department of Pediatrics, Pediatric Gastroenterology and Hepatology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Transplantation 87:1415-21. 2009..Sometimes a sequential approach for LKTx (first liver, then kidney) has been recommended... - Hyperoxaluria after ethylene glycol poisoningLudwig Stapenhorst
Department of Pediatrics, University Children s Hospital, 50924, Cologne, Germany
Pediatr Nephrol 23:2277-9. 2008..Metabolic acidosis, hypocalcaemia, and neurological symptoms had not occurred. Four weeks after discharge, both plasma and urinary oxalate levels were normal... - The case: A boy with recurrent stonesBodo B Beck
Division of Pediatric Nephrology, Department of Pediatrics, University Hospital Cologne, Cologne, Germany
Kidney Int 74:133-4. 2008 - Successful plasma therapy for atypical hemolytic uremic syndrome caused by factor H deficiency owing to a novel mutation in the complement cofactor protein domain 15Christoph Licht
Division of Pediatric Nephrology, Children's Hospital of the University of Cologne, Cologne, Germany
Am J Kidney Dis 45:415-21. 2005..Based on the measured factor H half-life of about 6 days, regular plasma infusions in 2-week intervals were given, which prevented further aHUS episodes and stopped the decline of kidney function... - Community-acquired pneumonia due to Bordetella holmesii in a patient with frequently relapsing nephrotic syndromeChristina Dörbecker
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstr 19 21, 50935 Cologne, Germany
J Infect 54:e203-5. 2007..Herein, we describe a patient with severe relapse of nephrotic syndrome associated with bacteremic B. holmesii pneumonia... - Diagnostic examination of the child with urolithiasis or nephrocalcinosisBernd Hoppe
Department of Pediatrics, Division of Pediatric Nephrology, University Children s Hospital Cologne, Kerpenerstr 62, 50924, Cologne, Germany
Pediatr Nephrol 25:403-13. 2010..The stone is not the disease itself; it is only one serious sign! Therefore, thorough and early diagnostic examination is mandatory for every infant and child with the first stone event, or with nephrocalcinosis... - Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT)Matthias T F Wolf
Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
Pediatr Nephrol 24:55-60. 2009..Six previously known and seven new single nucleotide polymorphisms (SNPs) were detected. As no UMOD mutations were identified in these 96 patients with CAKUT, UMOD mutations do not seem to be a significant cause of CAKUT in this cohort... - Uromodulin is expressed in renal primary cilia and UMOD mutations result in decreased ciliary uromodulin expressionFrank Zaucke
Center for Biochemistry, Medical Faculty, University Children s Hospital, University of Cologne, Cologne, Germany
Hum Mol Genet 19:1985-97. 2010..Our data add UMOD to the group of proteins expressed in primary cilia, where mutations of the gene lead to cystic kidney disease... - Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategyEdgar A Otto
Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
J Med Genet 48:105-16. 2011..To overcome the broad genetic locus heterogeneity, a strategy of DNA pooling with consecutive massively parallel resequencing (MPR) was devised... - Respiratory and general outcome in neonates with renal oligohydramnios--a single-centre experienceKatrin Mehler
Division of Neonatology and Paediatric Intensive Care Medicine, Children s Hospital, University of Cologne, Cologne, Germany
Nephrol Dial Transplant 26:3514-22. 2011.... - Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9Bettina Mucha
Department of Pediatrics, University of Michigan, Ann Arbor, 48109, USA
Pediatr Res 59:325-31. 2006..Kidney Int 66: 564-570, 2004) indicate that screening of WT1 exons 8 and 9 in patients with sporadic SRNS is sufficient to detect pathogenic WT1 mutations and may open inroads into differential therapy of SRNS... - Cardiorespiratory capacity in children and adolescents on maintenance haemodialysisBettina Schaar
Institute of Health Promotion and Clinical Movement Science, German Sport University Cologne, Cologne, Germany
Nephrol Dial Transplant 26:3701-8. 2011..However, physical endurance was up to now only examined on non-HD days. We were interested in the effect of HD on the cardiorespiratory capacity of children and adolescents on maintenance HD... - Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)Christoph Licht
Department of Pediatric Nephrology and Pediatric Hematology Oncology, University Children s Hospital of Cologne, Cologne, Germany
Kidney Int 66:955-8. 2004..One possible reason is the deficiency of von Willebrand factor-cleaving protease (vWF-CP) resulting in persistence of uncleaved, ultralarge von Willebrand factor multimers (ULvWFM)... - Efficacy and safety of Oxalobacter formigenes to reduce urinary oxalate in primary hyperoxaluriaBernd Hoppe
Division of Paediatric Nephrology, Department of Paediatric and Adolescent Medicine, University Hospital Cologne, Cologne, Germany
Nephrol Dial Transplant 26:3609-15. 2011..Orally administered O. formigenes (Oxabact) was found to significantly reduce urine and plasma oxalate. We aimed to evaluate its effect and safety in a randomized, double-blind, placebo-controlled multicenter study... - Posttransplant lymphoproliferative disease in a child: clinical and molecular characterizationChristoph Licht
Children s Hospital, The University of Cologne, Cologne, Germany
Pediatr Nephrol 17:79-84. 2002..EBV-PCR in plasma was negative (0.02 x 10(6) copies/ml blood) 12 weeks after reduction of immunosuppression. The liver masses completely resolved after 27 months. After a total follow-up of 36 months the child remains in good health... - Atypical presentation of distal renal tubular acidosis in two siblingsVelibor Tasic
Department of Pediatric Nephrology, Children s Hospital, 17 Vodnjanska, Skopje, Macedonia
Pediatr Nephrol 23:1177-81. 2008..In conclusion, proximal tubular dysfunction and hyperoxaluria may be found in children with dRTA and are reversible under appropriate therapy... - A cutaneous disease with multisystem involvement: hypomelanosis of Ito may be associated with proteinuria, focal segmental glomerulosclerosis and end-stage renal diseaseNina Gatter
Nephrol Dial Transplant 22:1796-8. 2007 - Primary hyperoxaluria type 1: is genotyping clinically helpful?Ernst Leumann
Pediatr Nephrol 20:555-7. 2005..Pyridoxine responsiveness can be anticipated in some genotypes (508G>A (Gly170Arg) and 454T>A (Phe153Ile)), but it should still be tested for in all patients. Genetic testing is thus clinically helpful but has clear limitations... - Determination of the calcium oxalate crystallization risk from urine samples: the BONN Risk Index in comparison to other risk formulasNorbert Laube
Division of Experimental Urology, Department of Urology, University of Bonn, Bonn, Germany
J Urol 172:355-9. 2004.... - Genetic analysis: a diagnostic tool for primary hyperoxaluria type 1Christian von Schnakenburg
Pediatr Nephrol 18:482-3; author reply 484. 2003 - MPGN II--genetically determined by defective complement regulation?Christoph Licht
Pediatr Nephrol 22:2-9. 2007..Identification of patients with MPGN II caused by defective complement control may allow treatment by replacement of the missing factor via plasma infusion, thus possibly preventing or at least delaying disease progress...