Ursula Hoffmann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis
    Ursula Hoffmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Infect Dis 38:867-72. 2006
  2. ncbi New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Crit Care 10:134. 2006
  3. ncbi Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Lab 51:373-9. 2005
  4. ncbi Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Br J Haematol 133:550-7. 2006
  5. ncbi Prognostic value of platelet-derived growth factor in patients with severe sepsis
    Martina Brueckmann
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg Mannheim, Germany
    Growth Factors 25:15-24. 2007
  6. ncbi Macrophage migration inhibitory factor (MIF) and manganese superoxide dismutase (MnSOD) as early predictors for survival in patients with severe sepsis or septic shock
    Thorsten Brenner
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Surg Res 164:e163-71. 2010
  7. ncbi Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis
    Martina Brueckmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Circulation 112:527-34. 2005
  8. ncbi Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis
    Michael Behnes
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Crit Care 23:537-41. 2008
  9. ncbi N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias
    Martina Brueckmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 42:896-902. 2004
  10. ncbi Time-course of neopterin levels in patients suffering from severe sepsis treated with and without Drotrecogin-alpha (activated)
    Michael Behnes
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Infect Dis 40:503-8. 2008

Collaborators

Detail Information

Publications26

  1. ncbi Matrix-metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis
    Ursula Hoffmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Infect Dis 38:867-72. 2006
    ..14-17.6, p = 0.014). Our results indicate that MMP-9, TIMP-2 and TIMP-1 are elevated in severe sepsis. Furthermore, TIMP-1 may serve as a useful laboratory marker to predict the clinical outcome of patients presenting with severe sepsis...
  2. ncbi New horizons: NT-proBNP for risk stratification of patients with shock in the intensive care unit
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Crit Care 10:134. 2006
    ....
  3. ncbi Increased plasma levels of NT-proANP and NT-proBNP as markers of cardiac dysfunction in septic patients
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Lab 51:373-9. 2005
    ..71; p<0.001). NT-proANP and NT-proBNP may serve as useful laboratory markers to indicate myocardial dysfunction and may help to differentiate between survivors and non-survivors of severe sepsis...
  4. ncbi Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Br J Haematol 133:550-7. 2006
    ..Further clinical trials are needed to confirm the in vivo relevance of these data...
  5. ncbi Prognostic value of platelet-derived growth factor in patients with severe sepsis
    Martina Brueckmann
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg Mannheim, Germany
    Growth Factors 25:15-24. 2007
    ..The in vitro effect of rhAPC on PDGF-BB-messenger RNA synthesis and release of PDGF-BB into supernatants was measured by reverse transcriptase-polymerase chain reaction and ELISA-methods...
  6. ncbi Macrophage migration inhibitory factor (MIF) and manganese superoxide dismutase (MnSOD) as early predictors for survival in patients with severe sepsis or septic shock
    Thorsten Brenner
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Surg Res 164:e163-71. 2010
    ..However, their exact pathophysiologic function and prognostic value are still poorly understood...
  7. ncbi Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis
    Martina Brueckmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Circulation 112:527-34. 2005
    ..CONCLUSIONS: NT-proBNP may serve as useful laboratory marker to predict survival in patients presenting with severe sepsis...
  8. ncbi Levels of oxidized low-density lipoproteins are increased in patients with severe sepsis
    Michael Behnes
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    J Crit Care 23:537-41. 2008
    ....
  9. ncbi N-terminal pro-atrial natriuretic peptide as a biochemical marker of long-term interventional success after radiofrequency catheter ablation of paroxysmal supraventricular tachyarrhythmias
    Martina Brueckmann
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 42:896-902. 2004
    ..NT-proANP may serve as a useful laboratory marker to describe the long-term interventional success after RF ablation...
  10. ncbi Time-course of neopterin levels in patients suffering from severe sepsis treated with and without Drotrecogin-alpha (activated)
    Michael Behnes
    First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Scand J Infect Dis 40:503-8. 2008
    ..05). In conclusion, Drotrecogin- alpha (activated) was associated with a significant decrease of neopterin plasma levels in septic patients. Neopterin concentrations appear to depend on renal function and enterohepatic circulation...
  11. ncbi Redox responses in patients with sepsis: high correlation of thioredoxin-1 and macrophage migration inhibitory factor plasma levels
    Thorsten Brenner
    Department of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Mediators Inflamm 2010:985614. 2010
    ..949). Conclusions. Proinflammatory/~oxidative and anti-inflammatory/~oxidative agents show a high correlation in order to maintain a redox homeostasis and to avoid the harmful effects of an excessive inflammatory/oxidative response...
  12. ncbi Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Thromb Haemost 93:743-50. 2005
    ....
  13. ncbi Transforming growth factor beta 1 (TGF-beta 1) in atrial fibrillation and acute congestive heart failure
    Michael Behnes
    First Department of Medicine, University Medical Centre Mannheim, Medical Faculty of Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
    Clin Res Cardiol 100:335-42. 2011
    ..Transforming growth factor beta 1 (TGF-beta 1) represents a central regulator of cardiac fibrosis. This study investigates serum levels of TGF-beta 1 in patients with AF and aCHF...
  14. ncbi Coagulation activation is associated with interleukin-6 plasma levels in patients with mechanical prosthetic heart valves
    Volker Liebe
    First Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    In Vivo 20:427-30. 2006
    ..The D-dimer antigen and IL-6 may be more sensitive than INR and CRP to detect these states and, therefore, could prove valuable additional markers, e.g., in determining the efficacy of new anticoagulant drugs...
  15. ncbi Matrix metalloproteinases and their inhibitors: promising novel biomarkers in severe sepsis?
    Ursula Hoffmann
    1st Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Crit Care 13:1006. 2009
    ..The measurement of MMP-9 and MMP-10 and their inhibitor TIMP-1 in the intensive care setting could be an attractive noninvasive tool for determination of outcome of septic patients...
  16. ncbi Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Cytokine 26:106-13. 2004
    ....
  17. ncbi Tumor necrosis factor alpha promotes an osteoblast-like phenotype in human aortic valve myofibroblasts: a potential regulatory mechanism of valvular calcification
    Jens J Kaden
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany
    Int J Mol Med 16:869-72. 2005
    ..In addition, the data demonstrate direct mechanistic evidence that aortic valve calcification may be actively regulated by an inflammatory process involving TNF-alpha...
  18. ncbi Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction
    Stefan Hofer
    Department of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Crit Care 13:R93. 2009
    ..Furthermore, the prognostic value of newly developed cell death serum biomarkers is of great interest...
  19. ncbi Clinical and laboratory effects of recombinant human activated protein C in the treatment of a patient with sepsis-induced multiple organ failure
    Martina Brueckmann
    1st Department of Medicine, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68167, Mannheim, Germany
    Thromb Res 109:259-63. 2003
    ..To evaluate clinical and laboratory effects of the administration of recombinant human activated protein C (rhAPC) in the treatment of a 25-year-old patient with septic shock and multiple organ failure secondary to perinephritic abscesses...
  20. ncbi Long-term prognostic value of mid-regional pro-adrenomedullin and C-terminal pro-endothelin-1 in patients with acute myocardial infarction
    Michael Behnes
    1First Department of Medicine, Faculty of Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Chem Lab Med 46:204-11. 2008
    ..However, the prognostic value of both biomarkers in predicting long-term clinical events after acute myocardial infarction remains unclear...
  21. ncbi A comparative evaluation of electrical velocimetry and inert gas rebreathing for the non-invasive assessment of cardiac output
    Frederik Trinkmann
    First Department of Medicine Cardiology, Angiology, Pneumology, Intensive Care, Universitatsmedizin Mannheim, University of Heidelberg, Germany
    Clin Res Cardiol 100:935-43. 2011
    ..The aim of our study was to evaluate whether a novel ICG algorithm (electrical velocimetry) and IGR can be used interchangeably in the clinical setting...
  22. ncbi Association of changes in D-dimer and other coagulation markers with changes in Marder score after treatment of acute venous thrombosis
    Job Harenberg
    Forth Department of Medicine, University Hospital, Faculty of Clinical Medicine Mannheim of the Ruprecht Karls, University of Heidelberg, Mannheim, Germany
    J Thromb Thrombolysis 14:73-8. 2002
    ..An association between changes in these markers and changes in venographic Marder scores in patients with acute deep vein-thrombosis treated with low-molecular-weight (LMWH) or unfractionated heparin (UFH) has not been reported...
  23. ncbi A new language of natriuretic peptides in sepsis?
    Ursula Hoffmann
    Crit Care Med 36:2686-7. 2008
  24. ncbi Prognostic value of natriuretic peptides in severe sepsis
    Martina Brueckmann
    Crit Care Med 35:1805-6; author reply 1806. 2007
  25. ncbi Beyond sepsis: activated protein C and heat stroke
    Martina Brueckmann
    Crit Care Med 34:2020-1. 2006
  26. ncbi Time course of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients presenting with acute coronary syndrome
    Thomas Bertsch
    Clin Chem Lab Med 43:660-3. 2005