Research Topics
Species | B HinzSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
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Publications
Dexamethasone megadoses stabilize rat liver lysosomal membranes by non-genomic and genomic effectsB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Pharm Res 17:1489-93. 2000..Membrane-stabilizing effects may be part of glucocorticoid action during high-dose glucocorticoid therapy. The present study investigates the mode of action of dexamethasone megadoses on rat liver lysosomal membranes...- Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesicBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
FASEB J 21:2343-51. 2007..In view of the observed COX-1 suppression, physicochemical factors (lack of acidity) rather than differential COX-1 inhibition may be responsible for dipyrone's favorable gastrointestinal tolerability compared with acidic COX inhibitors... - Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenacBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Clin Pharmacol Ther 74:222-35. 2003..This study investigated whether biotransformation to metabolites (4'-hydroxy-aceclofenac, diclofenac, 4'-hydroxy-diclofenac) contributes to inhibitory effects on the cyclooxygenase (COX) isozymes in vitro and ex vivo... - Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanismBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
FASEB J 19:1929-31. 2005..Induction of COX-2- and subsequent MMP-1 expression in the NPE may represent a potential mechanism underlying the IOP-lowering and antiglaucomatous action of latanoprost... - Pain and osteoarthritis: new drugs and mechanismsBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich Alexander University Erlangen Nuremberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Curr Opin Rheumatol 16:628-33. 2004..This review discusses the recent literature on drugs used for symptomatic pain relief in patients with osteoarthritis (OA) as well as potential mechanisms underlying their pharmacologic action... - Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cellsBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Mol Pharmacol 66:1643-51. 2004.... - R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid raftsBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biochem Biophys Res Commun 324:621-6. 2004..Together, our results suggest that R(+)-MA induces COX-2 expression in human neuroglioma cells via a pathway linked to lipid raft microdomains... - Bioavailability of diclofenac potassium at low dosesBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Br J Clin Pharmacol 59:80-4. 2005..However, given the considerable first-pass metabolism of diclofenac, the degree of absorption of diclofenac-K at low doses remained to be determined. The aim of this study was to determine the bioavailability of low-dose diclofenac-K... - [Immunomodulators for treatment of rheumatoid arthritis]Burkhard Hinz
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Pharm Unserer Zeit 34:304-12. 2005 - Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatographyBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biomed Chromatogr 17:268-75. 2003..The developed procedure was applied to assess the pharmacokinetics of aceclofenac and its metabolites following administration of a single 100 mg oral dose of aceclofenac to three healthy male volunteers... - Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophagesB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Biochem Biophys Res Commun 272:744-8. 2000..In conclusion, upregulation of COX-2 expression via an autocrine feed-forward loop may in part contribute to the well-known capacity of PGE(2)/cAMP to modulate inflammatory processes... - Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugsB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, Erlangen, D 91054, Germany
Biochem Biophys Res Commun 278:790-6. 2000..PGE(2), a cAMP-elevating final product of the COX-2 pathway, may autoregulate COX-2 expression in human monocytes via a positive feedback mechanism... - Rapid non-genomic feedback effects of glucocorticoids on CRF-induced ACTH secretion in ratsB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Pharm Res 17:1273-7. 2000.... - Nitric oxide inhibits inducible nitric oxide synthase mRNA expression in RAW 264.7 macrophagesB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, Erlangen, D 91054, Germany
Biochem Biophys Res Commun 271:353-7. 2000..In conclusion, NO may control the extent of iNOS mRNA expression by a negative autoregulatory feedback... - Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophagesB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Pharm Res 18:151-6. 2001..7 macrophages, the present study investigates the influence of optically pure enantiomers of the nonsteroidal anti-inflammatory drug flurbiprofen on lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression... - Cyclooxygenase-2--10 years laterBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
J Pharmacol Exp Ther 300:367-75. 2002..The present review assesses recent advances in COX-2 research, with particular emphasis on new insights into pathophysiological and physiological functions of this isoenzyme... - 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanismBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Biochem Biophys Res Commun 302:415-20. 2003..Moreover, it is concluded that both inhibition of proinflammatory gene expression and restoration of LPS-induced decrease of PPAR-gamma expression may contribute to the biological action of 15d-PGJ(2)... - R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanismR Ramer
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, Erlangen, D-91054, Germany
Biochem Biophys Res Commun 286:1144-52. 2001..In conclusion, induction of COX-2 expression may represent a novel mechanism by which cannabinoids mediate PG-dependent effects within the central nervous system... - Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cellsRobert Ramer
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen, Erlangen, Germany
Mol Pharmacol 64:1189-98. 2003..Induction of COX-2 expression via ceramide represents a hitherto unknown mechanism by which cannabinoids mediate biological effects within the central nervous system... - Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinasesSusanne Rösch
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biochem Biophys Res Commun 338:1171-8. 2005..Positive feedback regulation of COX-2 may contribute to the production of outflow-facilitating PGs and consequently to regulation of IOP... - Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamideBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen-Nuremberg, Germany
Adv Exp Med Biol 525:145-52. 2003 - Upregulation of tissue inhibitor of matrix metalloproteinases-1 confers the anti-invasive action of cisplatin on human cancer cellsR Ramer
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Oncogene 26:5822-7. 2007..Altogether, our data demonstrate a hitherto unknown mechanism by which cisplatin exerts its antimetastatic properties on highly invasive cancer cells... - R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cellsKarin Eichele
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054, Erlangen, Germany
Pharm Res 23:90-4. 2006..CONCLUSION: R(+)-MA-induced apoptosis is mediated via a mitochondrial-dependent pathway that becomes activated, at least in part, through up-regulation of the COX-2 enzyme... - Valdecoxib does not interfere with the CYP2D6 substrate metoprololU Werner
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen Nuremberg, Germany
Int J Clin Pharmacol Ther 44:397-400. 2006..Therefore, the objective of this study was to examine the effect of valdecoxib on the pharmacokinetics of the clinically relevant CYP2D6 substrate metoprolol... - [Specific COX-2 inhibitors: prospects of therapy with new analgesic and anti-inflammatory substances]B Hinz
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Bundesrepublik Deutschland
Wien Klin Wochenschr 111:103-12. 1999..In the present review the perspectives and possible risks of specific COX-2 inhibitors are discussed, as well as additional indications for their implementation (e.g. colon cancer)... - More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxibBurkhard Hinz
Dept of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Arthritis Rheum 54:282-91. 2006.... - Aspirin and acetaminophen: should they be available over the counter?Kay Brune
Department of Experimental and Clinical Pharmacology and Toxicology, FAU Erlangen Nuremberg, Erlangen, Germany
Curr Rheumatol Rep 11:36-40. 2009..Both drugs cause many deaths every year. We recommend that the status of both drugs be changed to prescription only. Their continued availability over the counter poses an unacceptable risk to the general population... - Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humansUlrike Werner
Department of Experimental and Clinical pharmacology and Toxicology and II Medical Clinic, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Clin Pharmacol Ther 74:130-7. 2003..Therefore the objective of this study was to examine the effect of celecoxib and rofecoxib on the pharmacokinetics of the clinically relevant CYP2D6 substrate metoprolol... - A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasmaUlrike Werner
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Biomed Chromatogr 19:113-8. 2005..The presented method was suf fi cient to cover more than 90% of the area under the plasma concentration time curve... - The impact of unlicensed and off-label drug use on adverse drug reactions in paediatric patientsAntje Neubert
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Drug Saf 27:1059-67. 2004..This study investigates, for the first time in a German patient population, the impact of unlicensed and off-label drug use on ADRs in paediatric patients... - The discovery and development of antiinflammatory drugsKay Brune
Friedrich-Alexander University, Erlangen, Germany
Arthritis Rheum 50:2391-9. 2004 - Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatographyAndreas Schmidt
Department of Experimental, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 17:276-81. 2003..1-100 micro g/mL for A77 1726. The developed procedure was applied to assess steady-state plasma concentrations of A77 1726 in patients with rheumatoid arthritis treated with 10 or 20 mg leflunomide per day... - Selective cyclooxygenase-2 inhibitors: similarities and differencesK Brune
Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich Alexander University, Erlangen, Germany
Scand J Rheumatol 33:1-6. 2004..This review discusses the clinically relevant similarities and differences of these substances, with particular emphasis on their diverse pharmacokinetic characteristics... - [Pain therapy with antipyretic analgesics]B Hinz
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054, Erlangen, Deutschland
Orthopade 36:23-31. 2007.... - A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasmaOlga Cheremina
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 20:1033-7. 2006..The validated quantitation range for lumiracoxib was 10-10,000 ng/mL. The developed procedure was applied to assess the pharmacokinetics of lumiracoxib following administration of a single oral 200 mg dose to a healthy male volunteer... - Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatographyAndreas Schmidt
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 20:336-42. 2006..Anandamide levels determined under both conditions were within the validated concentration range with anandamide levels being 2.3-fold higher in plasma from PMSF-treated blood... - Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatographyOlga Cheremina
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 19:777-82. 2005..The developed procedure was applied to assess the pharmacokinetics of oxycodone and its metabolite following administration of a single 20 mg oral dose of oxycodone hydrochloride to one healthy male volunteer... - The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2Eldad Ben-Chetrit
FMF Clinic, Department of Medicine, Hadassah University Hospital, POB 12000, Jerusalem, Israel
Rheumatol Int 25:332-5. 2005..The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX)... - Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in manBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
FASEB J 22:383-90. 2008..In view of its substantial COX-2 inhibition, recently defined cardiovascular warnings for use of COX-2 inhibitors should also be considered for acetaminophen... - Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisalBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Germany
Nat Clin Pract Rheumatol 3:552-60; quiz 1 p following 589. 2007..Moreover, this Review summarizes the pharmacology of COX2 inhibitors with emphasis on their different pharmacokinetic characteristics... - Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1Robert Ramer
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock D 18057, Germany
J Natl Cancer Inst 100:59-69. 2008..Although the antiproliferative activities of cannabinoids have been intensively investigated, little is known about their effects on tumor invasion... - Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cellsBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Biochem Biophys Res Commun 360:441-6. 2007..Overall, our results suggest that certain alkamides derived from E. angustifolia roots may contribute to the pharmacological action of the herbal extract by inhibiting COX-2-dependent PGE2 formation at sites of inflammation... - Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacologyBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, 18057 Rostock, Germany
Trends Pharmacol Sci 29:391-7. 2008..In our opinion, such an approach could reduce unwanted drug effects and obviate drug removals...