Niels Grabe

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides
    Niels Grabe
    Institute of Medical Biometry and Informatics, Section Medical Informatics, University Hospital Heidelberg, Heidelberg, Germany
    Cell Oncol 32:109-19. 2010
  2. ncbi Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Germany
    Cancer Res 71:5670-7. 2011
  3. ncbi Aberrant expression of retinoic acid signaling molecules influences patient survival in astrocytic gliomas
    Benito Campos
    Division of Neurological Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Am J Pathol 178:1953-64. 2011
  4. ncbi Spatial quantification and classification of skin response following perturbation using organotypic skin cultures
    Thora Pommerencke
    Hamamatsu Tissue Imaging and Analysis TIGA Center, BIOQUANT, Institute for Medical Biometry and Informatics, University Hospital, University Heidelberg, Heidelberg, Germany
    Bioinformatics 26:2760-6. 2010
  5. ncbi Robust gridding of TMAs after whole-slide imaging using template matching
    Bernd Lahrmann
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany
    Cytometry A 77:1169-76. 2010
  6. ncbi Estimation of immune cell densities in immune cell conglomerates: an approach for high-throughput quantification
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 4:e7847. 2009
  7. ncbi Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice
    Maike Hildenbrand
    Division of Signal Transduction and Growth Control A100, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 130:1922-30. 2010
  8. ncbi Automatic tumor-stroma separation in fluorescence TMAs enables the quantitative high-throughput analysis of multiple cancer biomarkers
    Bernd Lahrmann
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e28048. 2011
  9. ncbi Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas
    Benito Campos
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Cancer Sci 102:387-92. 2011
  10. ncbi The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
    Cancer Immun 9:1. 2009

Collaborators

Detail Information

Publications11

  1. ncbi A virtual microscopy system to scan, evaluate and archive biomarker enhanced cervical cytology slides
    Niels Grabe
    Institute of Medical Biometry and Informatics, Section Medical Informatics, University Hospital Heidelberg, Heidelberg, Germany
    Cell Oncol 32:109-19. 2010
    ..New biomarkers like p16 that specifically highlight abnormal cervical cells can improve cytology performance. Virtual microscopy offers an ideal platform for assisted evaluation and archiving of biomarker-stained slides...
  2. ncbi Localization and density of immune cells in the invasive margin of human colorectal cancer liver metastases are prognostic for response to chemotherapy
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University Hospital Heidelberg, Germany
    Cancer Res 71:5670-7. 2011
    ....
  3. ncbi Aberrant expression of retinoic acid signaling molecules influences patient survival in astrocytic gliomas
    Benito Campos
    Division of Neurological Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Am J Pathol 178:1953-64. 2011
    ..CRBP1 and ALDH1A1 were independent prognostic markers for adverse patient survival. Our data indicate a complex and clinically relevant deregulation of RA signaling, which seems to be a central event in glioma pathogenesis...
  4. ncbi Spatial quantification and classification of skin response following perturbation using organotypic skin cultures
    Thora Pommerencke
    Hamamatsu Tissue Imaging and Analysis TIGA Center, BIOQUANT, Institute for Medical Biometry and Informatics, University Hospital, University Heidelberg, Heidelberg, Germany
    Bioinformatics 26:2760-6. 2010
    ....
  5. ncbi Robust gridding of TMAs after whole-slide imaging using template matching
    Bernd Lahrmann
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany
    Cytometry A 77:1169-76. 2010
    ..The automatic grid analysis of TMAs after whole-slide imaging is highly demanding and requires dedicated algorithms. We demonstrate such a method and evaluate its performance. © 2010 International Society for Advancement of Cytometry...
  6. ncbi Estimation of immune cell densities in immune cell conglomerates: an approach for high-throughput quantification
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 4:e7847. 2009
    ..Integrating virtual microscopy and image processing principally allows the high-throughput evaluation of complete tissue slides...
  7. ncbi Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice
    Maike Hildenbrand
    Division of Signal Transduction and Growth Control A100, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 130:1922-30. 2010
    ..In summary, these data show that aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia...
  8. ncbi Automatic tumor-stroma separation in fluorescence TMAs enables the quantitative high-throughput analysis of multiple cancer biomarkers
    Bernd Lahrmann
    Institute of Medical Biometry and Informatics, University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e28048. 2011
    ..Also, it provides an objective spatial reference system for the multiplex analysis of biomarkers in fluorescence immunohistochemistry...
  9. ncbi Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas
    Benito Campos
    Division of Neurosurgical Research, Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany
    Cancer Sci 102:387-92. 2011
    ..Our findings suggest that "classical" transcriptional repressors are expressed in astrocytic tumors and that the roles of HDAC2 and HDAC3 in these tumors deserve further investigation...
  10. ncbi The localization and density of immune cells in primary tumors of human metastatic colorectal cancer shows an association with response to chemotherapy
    Niels Halama
    Medical Oncology, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany
    Cancer Immun 9:1. 2009
    ..This suggests that immune infiltrates at the invasive margin of liver metastases could be predictive with respect to response to treatment. This is currently being evaluated in a larger patient cohort...
  11. ncbi Nuclear staining and relative distance for quantifying epidermal differentiation in biomarker expression profiling
    Thora Pommerencke
    Hamamatsu Tissue Imaging and Analysis TIGA Center, BIOQUANT, University Heidelberg, Heidelberg, Germany
    BMC Bioinformatics 9:473. 2008
    ..Such methods require measuring tissue differentiation quantitatively while correlating it with biomarker expression intensities...