Robert H Goertsches

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. ncbi Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks
    Robert H Goertsches
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    J Neurol 255:48-57. 2008
  2. ncbi Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS
    Robert H Goertsches
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18047 Rostock, Germany
    Pharmacogenomics 11:147-61. 2010
  3. ncbi Integrative modeling of transcriptional regulation in response to antirheumatic therapy
    Michael Hecker
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
    BMC Bioinformatics 10:262. 2009
  4. ncbi Sieving treatment biomarkers from blood gene-expression profiles: a pharmacogenomic update on two types of multiple sclerosis therapy
    Robert H Goertsches
    University of Rostock, Department of Neurology, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Pharmacogenomics 12:423-32. 2011
  5. ncbi Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis
    Robert Goertsches
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, 08035 Barcelona, Spain
    Mult Scler 14:412-4. 2008
  6. ncbi MS therapy research applying genome-wide RNA profiling of peripheral blood
    R Goertsches
    Department of Immunology, Clinic of Neurology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Int MS J 14:98-107. 2007
  7. ncbi Detection of apoptotic cells in cerebrospinal fluid of patients suffering from neurological disease
    R Goertsches
    Institute of Immunology, University of Rostock, Rostock, Germany
    J Neuroimmunol 188:175-80. 2007
  8. ncbi Multiple sclerosis therapy monitoring based on gene expression
    Robert Goertsches
    Department of Immunology, University of Rostock, Schillingallee 70, D 18055 Rostock, Germany
    Curr Pharm Des 12:3761-79. 2006
  9. ncbi Immunoglobulins--basic considerations
    Eilhard Mix
    University of Rostock, Dept of Neurology, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 253:V9-17. 2006
  10. ncbi Plasma osteopontin levels in multiple sclerosis
    Manuel Comabella
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Escola d Infermeria 2a planta, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Neuroimmunol 158:231-9. 2005

Collaborators

Detail Information

Publications18

  1. ncbi Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks
    Robert H Goertsches
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    J Neurol 255:48-57. 2008
    ....
  2. ncbi Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS
    Robert H Goertsches
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18047 Rostock, Germany
    Pharmacogenomics 11:147-61. 2010
    ..In multiple sclerosis patients, treatment with recombinant IFN-beta (rIFN-beta) is partially efficient in reducing clinical exacerbations. However, its molecular mechanism of action is still under scrutiny...
  3. ncbi Integrative modeling of transcriptional regulation in response to antirheumatic therapy
    Michael Hecker
    Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Jena, Germany
    BMC Bioinformatics 10:262. 2009
    ..Etanercept is known to reduce disease symptoms and progression in RA, but the underlying molecular mechanisms have not been fully elucidated...
  4. ncbi Sieving treatment biomarkers from blood gene-expression profiles: a pharmacogenomic update on two types of multiple sclerosis therapy
    Robert H Goertsches
    University of Rostock, Department of Neurology, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Pharmacogenomics 12:423-32. 2011
    ..We will discuss recurrently reported biomarker candidates, emphasizing those of immunologically meaning, and review studies with network module outputs...
  5. ncbi Evidence for association of chromosome 10 open reading frame (C10orf27) gene polymorphisms and multiple sclerosis
    Robert Goertsches
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, 08035 Barcelona, Spain
    Mult Scler 14:412-4. 2008
    ..Transcript expression in brain lesions from MS patients was increased. These findings suggest C10orf27 as a candidate gene for MS susceptibility and pathogenesis...
  6. ncbi MS therapy research applying genome-wide RNA profiling of peripheral blood
    R Goertsches
    Department of Immunology, Clinic of Neurology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Int MS J 14:98-107. 2007
    ..This work reviews the state of the art in MS therapy research applying genomewide screening methods at the transcriptome level in peripheral blood cells of humans...
  7. ncbi Detection of apoptotic cells in cerebrospinal fluid of patients suffering from neurological disease
    R Goertsches
    Institute of Immunology, University of Rostock, Rostock, Germany
    J Neuroimmunol 188:175-80. 2007
    ..In contrast, expression of the anti-apoptotic protein Bcl-2 did not differ between investigated patient groups...
  8. ncbi Multiple sclerosis therapy monitoring based on gene expression
    Robert Goertsches
    Department of Immunology, University of Rostock, Schillingallee 70, D 18055 Rostock, Germany
    Curr Pharm Des 12:3761-79. 2006
    ..It discusses implications in understanding disease pathogenicity, diagnostic markers, the identification of new therapeutic targets and a classification of patients towards the advent of tailored therapies...
  9. ncbi Immunoglobulins--basic considerations
    Eilhard Mix
    University of Rostock, Dept of Neurology, Gehlsheimer Str 20, 18147, Rostock, Germany
    J Neurol 253:V9-17. 2006
    ..The generation of genetically engineered monoclonal Abs (mAbs) has revolutionized the diagnostic and therapeutic potential of Abs in almost all disciplines of modern medicine...
  10. ncbi Plasma osteopontin levels in multiple sclerosis
    Manuel Comabella
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Escola d Infermeria 2a planta, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Neuroimmunol 158:231-9. 2005
    ....
  11. ncbi mtDNA nt13708A variant increases the risk of multiple sclerosis
    Xinhua Yu
    Section of Immunogenetics, University of Rostock, Rostock, Germany
    PLoS ONE 3:e1530. 2008
    ..Mitochondrial DNA (mtDNA) polymorphism is a possible factor contributing to the maternal parent-of-origin effect in multiple sclerosis (MS) susceptibility...
  12. ncbi Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis
    Robert Goertsches
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron HUVH, Escuela de Enfermeria 2 a planta, Psg Vall d Hebron 119 129, 08035 Barcelona, Spain
    J Neuroimmunol 164:140-7. 2005
    ..No association was detected between different genotypes and disease severity measured by the Multiple Sclerosis Severity Score (MSSS). These findings suggest a potentially important role for the ADAMTS14 gene in predisposition to MS...
  13. ncbi Comparative genomics for the investigation of autoimmune diseases
    Steffen Möller
    University of Rostock, Institutes of Immunology, Schillingallee 70, 18057 Rostock, Germany
    Curr Pharm Des 12:3707-22. 2006
    ....
  14. ncbi Deficient Fas expression by CD4+ CCR5+ T cells in multiple sclerosis
    Eva Julià
    Unitat de Neuroimmunologia Clinica, Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neuroimmunol 180:147-58. 2006
    ..To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis...
  15. ncbi Changes in the activation level of NF-kappa B in lymphocytes of MS patients during glucocorticoid pulse therapy
    Martin Eggert
    Department of Internal Medicine, Rostock Clinic South, Südring 81, 18059 Rostock, Germany
    J Neurol Sci 264:145-50. 2008
    ..In summary, pulse therapy resulted in a decreased level of activated p65 NF-kappaB subunits leading to decreased levels of transcriptionally active pro-inflammatory NF-kappaB...
  16. ncbi Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
    Maria Ban
    University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Neuroimmunol 179:108-16. 2006
    ..Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1...
  17. ncbi A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease
    Robert Goertsches
    Neuroimmunology Unit, Hospital Vall d'Hebron, Barcelona, Spain
    J Neuroimmunol 143:124-8. 2003
    ..Our results provide support for the presence of multiple coding regions that contain MS susceptibility genes of small or moderate effect...