R Gebhardt

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids
    Christina Ende
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 70:1006-8. 2004
  2. ncbi Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Dev Dyn 239:45-55. 2010
  3. ncbi Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010
  4. ncbi Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma
    Madeleine Austinat
    Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Cancer 7:21. 2008
  5. ncbi New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures
    Rolf Gebhardt
    Institute of Biochemistry, University of Leipzig, Leipzig, Germany
    Drug Metab Rev 35:145-213. 2003
  6. ncbi Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Arzneimittelforschung 53:823-30. 2003
  7. ncbi Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites
    R Gebhardt
    Institut fur Biochemie, Universitatsklinikum Leipzig, Germany
    Med Sci Monit 7:316-20. 2001
  8. ncbi 4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    J Cell Mol Med 14:1276-93. 2010
  9. ncbi Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver
    Rolf Gebhardt
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Prog Histochem Cytochem 41:201-66. 2007
  10. ncbi Variable influence of kaempferol and myricetin on in vitro hepatocellular cholesterol biosynthesis
    R Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 69:1071-4. 2003

Collaborators

Detail Information

Publications60

  1. ncbi Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids
    Christina Ende
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 70:1006-8. 2004
    ..Our results add a novel function to the long list of biological effects of these ubiquitous plant constituents that may contribute to and enhance their modulating influence on extracellular matrix degradation and remodelling...
  2. ncbi Organ patterning in the adult stage: the role of Wnt/beta-catenin signaling in liver zonation and beyond
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Dev Dyn 239:45-55. 2010
    ....
  3. ncbi Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Universitätsklinikum Leipzig und Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Mol Cancer 9:2. 2010
    ..In the present work we investigated whether carnosine also affects tumor growth in vivo and may therefore be considered for human cancer therapy...
  4. ncbi Correlation between beta-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma
    Madeleine Austinat
    Institute for Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Mol Cancer 7:21. 2008
    ....
  5. ncbi New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures
    Rolf Gebhardt
    Institute of Biochemistry, University of Leipzig, Leipzig, Germany
    Drug Metab Rev 35:145-213. 2003
    ..Representative results with test substances and recommendations for application of these in vitro systems, as well as standard operation procedures are given...
  6. ncbi Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Arzneimittelforschung 53:823-30. 2003
    ....
  7. ncbi Anticholestatic activity of flavonoids from artichoke (Cynara scolymus L.) and of their metabolites
    R Gebhardt
    Institut fur Biochemie, Universitatsklinikum Leipzig, Germany
    Med Sci Monit 7:316-20. 2001
    ..These results demonstrate that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate-induced cholestasis. Flavonoids and their metabolites may contribute significantly to this effect...
  8. ncbi 4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    J Cell Mol Med 14:1276-93. 2010
    ....
  9. ncbi Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver
    Rolf Gebhardt
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Prog Histochem Cytochem 41:201-66. 2007
    ....
  10. ncbi Variable influence of kaempferol and myricetin on in vitro hepatocellular cholesterol biosynthesis
    R Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 69:1071-4. 2003
    ..These opposing effects on cholesterol biosynthesis are exerted in an indirect manner and seem possible though differential modulation of the complex regulation of HMGCoA reductase...
  11. ncbi Enhanced matrix degradation after withdrawal of TGF-beta1 triggers hepatocytes from apoptosis to proliferation and regeneration
    E Arendt
    Institute of Biochemistry, University of Leipzig, Leipzig, Germany
    Cell Prolif 38:287-99. 2005
    ....
  12. ncbi Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-beta1 transgenic mice and multiple starved mice
    Elke Ueberham
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Liebigstrasse 16, D 04103 Leipzig, Germany
    J Hepatol 41:75-81. 2004
    ....
  13. ncbi Prevention of taurolithocholate-induced hepatic bile canalicular distortions by HPLC-characterized extracts of artichoke (Cynara scolymus) leaves
    R Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 68:776-9. 2002
    ..These results demonstrate that artichoke leaf extracts exert a potent anticholestatic action at least in the case of taurolithocholate. This effect may contribute to the overall hepatoprotective influence of this herbal formulation...
  14. ncbi Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli
    Elke Ueberham
    Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany
    J Cell Mol Med 12:622-38. 2008
    ..We could show that the liver specific expression of p16(INK4a) leads to a faster differentiation of hepatocytes and an activation of oval cells already in postnatal mice without negative consequences on liver function...
  15. ncbi Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis
    Elke Ueberham
    University of Leipzig, Institute for Biochemistry, Germany
    Hepatology 37:1067-78. 2003
    ..In conclusion, this model will enable the analysis of fibrogenesis at progressive stages and help in elucidating the cellular changes during development and regression of liver fibrosis caused by elevated TGF-beta1 expression...
  16. ncbi Long-term expression of foreign genes in normal human epidermal keratinocytes after transfection with lipid/DNA complexes
    S Zellmer
    Institute of Biochemistry, Medical Faculty, University Leipzig, Germany
    Histochem Cell Biol 115:41-7. 2001
    ..Transfected keratinocytes, cultivated at the air-liquid interface, expressed the marker gene beta-galactosidase for at least 7 weeks...
  17. ncbi An intronic silencer element is responsible for specific zonal expression of glutamine synthetase in the rat liver
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Hepatology 41:1225-32. 2005
    ....
  18. ncbi Comparison of uptake and neuroprotective potential of seven zinc-salts
    Sanja Pavlica
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Leipzig, Germany
    Neurochem Int 56:84-93. 2010
    ..The differences in accumulation of zinc-salts were not specific and unique to PC12 cells, since similar results were obtained in rat primary hepatocytes and endothelial HUVEC cells...
  19. ncbi E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells
    Elke Ueberham
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    J Mol Histol 38:359-68. 2007
    ..In human cirrhotic liver samples E-cadherin expression was found as a common feature of both, typical and atypical reactions, and, thus, can also serve as an indication of the progenitor cell compartment activation...
  20. ncbi Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects
    Uwe Ueberham
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Eur J Neurosci 22:50-64. 2005
    ..Neuroprotective effects were observed after short-term expression of TGF-beta1. Death of striatal neurons induced by 3-nitropropionic acid was markedly reduced after induced TGF-beta1 expression...
  21. ncbi Response of sinusoidal mouse liver cells to choline-deficient ethionine-supplemented diet
    Elke Ueberham
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Comp Hepatol 9:8. 2010
    ....
  22. ncbi Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes
    Sebastian Zellmer
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Hepatology 52:2127-36. 2010
    ..The transcription factors ETF, E2F1, and SP-1 seem to play a pronounced role in mediating proliferation-dependent differential gene expression. Similar events, but on a shorter time-scale, occur very early after liver damage in vivo...
  23. ncbi Heterogeneous expression of suppressor of cytokine signalling 2 (SOCS-2) in liver tissue
    Sebastian Zellmer
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    J Anat 215:176-83. 2009
    ..Presumably, the heterogeneous distribution of SOCS-2 may contribute to the pericentral preference of growth hormone action via differential feedback...
  24. ncbi Hepatic expression of glutamine synthetase in rats is controlled by STAT5 and TCF transcription factors
    Max Werth
    , , , Leipzig, Germany
    Hepatology 44:967-75. 2006
    ..In conclusion, the GS 5' enhancer contains elements important for GS expression in cells carrying an activated form of beta-catenin as previously shown in experimentally induced hepatocellular carcinomas...
  25. ncbi Glucocorticoid induced expression of glutamine synthetase in hepatoma cells
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 296:1026-32. 2002
    ..However, evidence is presented that aside from a primary effect on transcription glucocorticoids mediate their effect on the expression of GS also at the posttranscriptional level...
  26. ncbi A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids
    Frank Gaunitz
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstrasse 16, 04103 Leipzig, Germany
    Mol Endocrinol 18:63-9. 2004
    ..This yet unknown factor was designated GS silencer-binding protein. It is absent in FAO cells that respond to glucocorticoids with enhanced expression of GS and present in HepG2 cells that do not respond...
  27. ncbi Dioxin mediates downregulation of the reduced folate carrier transport activity via the arylhydrocarbon receptor signalling pathway
    Sandra Halwachs
    Institute of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    Toxicol Appl Pharmacol 246:100-6. 2010
    ....
  28. ncbi Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes
    A Garten
    University Hospital for Children and Adolescents, University of Leipzig, Germany
    Biochem Biophys Res Commun 391:376-81. 2010
    ..In primary human hepatocytes, secreted NAMPT was less active. Our results demonstrate that human hepatocytes are a potential source of circulating NAMPT...
  29. ncbi Synthesis and biological evaluation of new derivatives of emodin
    Lars Teich
    , , Pharmazie und Psychologie, , , 04103 Leipzig, Germany
    Bioorg Med Chem 12:5961-71. 2004
    ....
  30. ncbi Mathematical modelling of liver regeneration after intoxication with CCl(4)
    Stefan Höhme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Chem Biol Interact 168:74-93. 2007
    ....
  31. ncbi Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity
    Thore Santel
    Institute of Biochemistry, University of Leipzig, Leipzig, Germany
    PLoS ONE 3:e3508. 2008
    ..Inhibitors of glyoxalases are considered as anti-inflammatory and anti-carcinogenic agents. The recent finding that various polyphenols modulate Glo1 activity has prompted us to assess curcumin's potency as an Glo1 inhibitor...
  32. ncbi Inhibition of cholesterol biosynthesis in HepG2 cells by artichoke extracts is reinforced by glucosidase pretreatment
    Rolf Gebhardt
    , , 04103 Leipzig, Germany
    Phytother Res 16:368-72. 2002
    ..These findings emphasize the importance of beta-glucosidase-dependent liberation of luteolin for the ability of artichoke extracts to inhibit hepatic cholesterol biosynthesis...
  33. ncbi Protective effects of flavonoids and two metabolites against oxidative stress in neuronal PC12 cells
    Sanja Pavlica
    Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    Life Sci 86:79-86. 2010
    ....
  34. ncbi Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells
    F Gaunitz
    Medizinische Fakultat, Institut fur Biochemie, Universitat Leipzig, Liebigstrasse 16, Leipzig, 04103, Germany
    Biochem Biophys Res Commun 284:377-83. 2001
    ..This nuclear protein, designated as upstream binding factor of the GS gene (UFGS) seems to play an important role in high-level expression of GS in liver...
  35. ncbi Oxidative stress, plant-derived antioxidants and liver fibrosis
    R Gebhardt
    Institut of Biochemistry, University of Leipzig, Germany
    Planta Med 68:289-96. 2002
    ..This review briefly summarizes current views of the mechanisms of fibrogenesis and recent findings on the antifibrotic potential of plant-derived antioxidants...
  36. ncbi Acquisition of blood--tissue barrier--supporting features by hepatic stellate cells and astrocytes of myofibroblastic phenotype. Inverse dynamics of metallothionein and glial fibrillary acidic protein expression
    G H Buniatian
    Institut fur Biochemie, Universitat Leipzig, Medizinische Facultät, Liebig Str 16, D 04103 Leipzig, Germany
    Neurochem Int 38:373-83. 2001
    ..In addition, this study shows that, at least in cell culture, an enrichment of perivascular cells in GFAP results in the disappearance of protective functions...
  37. ncbi Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells
    Sanja Pavlica
    , , , Liebigstr. 16, Leipzig, 04103, Germany
    Free Radic Res 39:1377-90. 2005
    ..These findings suggest that two dietary antioxidants, EA and CGA, may have protective properties against oxidative stress induced in CNS...
  38. ncbi Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling
    Inge Lindner
    Institute of Biochemistry, Department of Ophthalmology, University of Leipzig, Leipzig, Germany
    Cancer Res 70:277-87. 2010
    ..Notably, LRP1 antibodies could phenocopy the effects of A2M*. Our findings suggest a pathway of tumor suppression in astrocytoma that might be tractable to therapeutic exploitation...
  39. ncbi In vitro screening of plant extracts and phytopharmaceuticals: novel approaches for the elucidation of active compounds and their mechanisms
    R Gebhardt
    Institut fur Biochemie, Medizinische Fakultat, Universität Leipziq, Germany
    Planta Med 66:99-105. 2000
    ..Furthermore, they may give full insight into not only the therapeutic potential but also the possible dangers of phytopharmaceuticals and may eventually lead to hints on new therapeutic fields that can be further explored...
  40. ncbi A novel model of fibroblast-mediated cartilage destruction
    U Sack
    Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Leipzig, Germany
    Scand J Immunol 61:18-28. 2005
    ....
  41. ncbi Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their inhibitor TIMP-1 by cultured HUVEC cells
    K Meyer
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Cell Biol Toxicol 20:253-60. 2004
    ..These results suggest that DADS may mediate some of the biological effects ascribed to garlic preparations through affecting MMP-TIMP balance...
  42. ncbi From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age
    Amalya Hovhannisyan
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 75:1371-80. 2009
    ....
  43. ncbi Comparative in vitro toxicity of seven zinc-salts towards neuronal PC12 cells
    Sanja Pavlica
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    Toxicol In Vitro 23:653-9. 2009
    ..In conclusion, Zn(2+)-salts could be divided into three categories with high (zinc-citrate, zinc-sulphate), moderate (zinc-orotate, zinc-acetate, zinc-chloride(,) zinc-gluconate) and low cytotoxicity (zinc-histidinate)...
  44. ncbi Functional interactions of Cu-ATPase ATP7B with cisplatin and the role of ATP7B in the resistance of cells to the drug
    Karoline Leonhardt
    Department of Medicine II and Department of Biochemistry, University of Leipzig, 04103 Leipzig, Germany
    J Biol Chem 284:7793-802. 2009
    ..The link between changes in copper homeostasis and cisplatin resistance was confirmed by treating the Huh7 cells with copper chelator and increasing their resistance to cisplatin.cisplatin...
  45. ncbi Co-cultivation of liver epithelial cells with hepatocytes
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Methods Mol Biol 188:337-46. 2002
  46. ncbi Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration
    Stefan Hoehme
    Interdisciplinary Centre for Bioinformatics IZBI, University of Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    Proc Natl Acad Sci U S A 107:10371-6. 2010
    ..The results of this analysis clearly confirmed the model prediction. We believe our procedure is widely applicable in the systems biology of tissues...
  47. ncbi Influence of biotransformation of luteolin, luteolin 7-O-glucoside, 3',4'-dihydroxyflavone and apigenin by cultured rat hepatocytes on antioxidative capacity and inhibition of EGF receptor tyrosine kinase activity
    Doreen Schlupper
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Planta Med 72:596-603. 2006
    ..These results show that the biotransformation of flavonoids is very complex and may result not only in a loss but also in a gain of biological activity depending on the individual structural features...
  48. ncbi Liver epithelial cell culture
    Rolf Gebhardt
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Leipzig, Germany
    Methods Mol Biol 188:53-63. 2002
  49. ncbi Carnosine inhibits ATP production in cells from malignant glioma
    Christof Renner
    Klinik und Poliklinik fur Neurochirurgie, Medizinische Fakultät der Universität Leipzig, Leipzig, Germany
    Neurol Res 32:101-5. 2010
    ..In order to understand how this effect is mediated, experiments were performed that addressed a possible influence of carnosine on energy metabolism...
  50. ncbi Antioxidant properties of silybin glycosides
    Pavel Kosina
    Centre for Bioanalytical Research, , , 775 15 Olomouc, Czech Republic
    Phytother Res 16:S33-9. 2002
    ..These results suggest that silybin glycosides are suitable soluble derivatives of silybin for experimental studies and may have therapeutic potential...
  51. ncbi The RL-ET-14 cell line mediates expression of glutamine synthetase through the upstream enhancer/promoter region
    Marianna Kruithof-de Julio
    AMC Liver Center, Academic Medical Center, Amsterdam, The Netherlands
    J Hepatol 43:126-31. 2005
    ..5 kb and that the signal mediator required a functional beta-catenin pathway. CONCLUSIONS: The 'RL-ET-14' factor specifically induces GS expression, working via its upstream enhancer in a beta-catenin-dependent fashion...
  52. ncbi Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage
    Steven Dooley
    Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    Gastroenterology 135:642-59. 2008
    ..The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute to increased rates of apoptosis...
  53. ncbi Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes
    Hong Lei Weng
    Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Mannheim, Germany
    Hepatology 46:1257-70. 2007
    ..We identify ALK5-dependent Smad3 signaling as the responsible pathway inducing CTGF expression, which can be hindered by an activated activin receptor-like kinase 1 pathway and completely inhibited by TGF-beta antagonist Smad7...
  54. ncbi Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects
    Martijn B A van Doorn
    TNO Prevention and Health, Gaubius Laboratory, Leiden, Netherlands
    Am J Clin Nutr 84:1324-9. 2006
    ..Epidemiologic studies suggest that garlic may have beneficial effects on risk factors associated with cardiovascular disease (CVD). However, these findings are not unambiguously supported by randomized placebo-controlled clinical trials...
  55. ncbi Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital
    Sandra Loeppen
    , , Germany
    Cancer Res 62:5685-8. 2002
    ..These data suggest that promotion of hepatocarcinogenesis by PB confers beta-catenin-mutated tumor cells with a selective advantage by up-regulation of GS expression...
  56. ncbi Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy
    Holger A Scheidt
    Junior Research Group Solid-state NMR Studies of the Structure of Membrane-associated Proteins, Biotechnological-Biomedical Center of the University of Leipzig, Liebigstr. 27, D-04103 Leipzig, Germany
    Biochim Biophys Acta 1663:97-107. 2004
    ..From the localization of different flavonoid protons in the membrane, a model for the orientation of the molecules in a lipid bilayer can be deduced. This orientation depends on the position of the polar center of the flavonoid molecule...
  57. ncbi Zonal gene expression in murine liver: Are tumors helping us to solve the mystery?
    Rolf Gebhardt
    Hepatology 44:512; author reply 512-3. 2006
  58. ncbi High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice
    Shmuel E Cohen
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 282:23672-8. 2007
    ..In this manner, insulin signaling in liver plays an important role in leptin homeostasis and fine modulation of leptin action...
  59. ncbi The oxidative biotransformation of losoxantrone (CI-941)
    Ulf D Renner
    Medizinische Klinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Drug Metab Dispos 30:464-78. 2002
    ..Furthermore, the CI-941 metabolism was shown to be extremely suppressed in rat hepatocytes incubated with metyrapone. In contrast to these results, human tumor HepG2 cells did not show any CI-941 biotransformation after incubation...
  60. ncbi Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors
    Felix Glahn
    Institute of Environmental Toxicology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    Arch Toxicol 82:513-24. 2008
    ..This study gives an overview of the most responsive genes...