Markus Gastpar

..The objective of this double-blind, multi-center clinical study was to demonstrate the non-inferiority of hypericum extract versus sertraline in the treatment of moderate depression...

..The combination of improved efficacy and good tolerability may have important implications for patient adherence to therapy and subsequent long-term outcomes...

..The primary objective of this 3-arm design study was to demonstrate the non-inferiority of hypericum extract STW3-VI (900 mg) to the SSRI citalopram (20 mg) and superiority of hypericum over placebo...

..WS 1490 was well tolerated, with no influence on liver function tests and only one trivial adverse event (tiredness) attributable to the study drug...

..Readers are invited to comment prior to the publication of the definitive text of the guidelines...

..Therefore, the hypothesis that depressive symptoms are predictive of a favorable treatment response was not supported by the present study...

..To examine quality of life and subjective well-being as predictors of symptomatic treatment outcome...

..The present study applied the symptom-severity component of these criteria to a sample of inpatients in order to determine the rates of remission during inpatient treatment and to explore predictors of remission...

..To examine the influencing factors and predictors of early improvement in schizophrenia patients...

..To evaluate the predictive validity of early response compared to other well-known predictor variables in acutely ill first-episode patients...

..The aim of our study was to investigate antipsychotic treatment strategies in acute schizophrenic episodes in a German university hospital...

..Furthermore, these linking results were compared with those derived from randomized controlled trials to examine if the baseline severity might influence the linking results...

..To assess criteria and to identify predictive factors for functional outcome. The criteria should cover all domains proposed by the Remission in Schizophrenia Working Group...

..Risperidone has better extrapyramidal tolerability and treatment retention rate than the equivalent dose of haloperidol in these patients...

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..Early improvement with treatment is thought to be important in patients with first-episode schizophrenia, yet a valid definition is still outstanding...

..To evaluate depressive symptoms regarding their association with the acute outcome in first-episode schizophrenia comparing risperidone and haloperidol...

..Relapse and its predictors were examined among patients with schizophrenia in the year after hospital discharge...

..Such surveys should be carried out more frequently and simultaneously in different centers. Critical comparisons could help to optimize treatment...

..To develop evidence-based practice guidelines for the pharmacological treatment of opioid abuse and dependence...

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..The aim was to investigate the hypothesis that patients with first episode schizophrenic disorders have a more favorable treatment response than those with multiple episodes...

..To examine the predictive validity of early improvement in a naturalistic sample of inpatients and to identify the criterion that best defines early improvement...

..Purpose was to assess suicidality before and at the time of admission in patients with schizophrenia and compare outcome differences...

..Risperidone was not administered with respect to possible EPS. However, ziprasidone was tolerated well and appeared to be effective...

..The results of this investigation indicate that oxcarbazepine may be a potentially useful agent for the treatment of ADHD in adults. However, placebo-controlled randomized trials are needed to provide evidence...

..Regarding the high success rate in the placebo group the influence of psychosocial treatment in studies investigating drug effects on the course of alcohol dependence has to be considered...

..Adults with ADHD show indicators of lowered cognitive performance under medication. These are related more to memory and attention under high mental load than to response inhibition or simple attention or motor performance...

..344, p = 0.028). These results support the view that thiamine deficiency rather than direct neurotoxic effects of alcohol is the main causative factor for the development of alcoholic cerebellar degeneration...

..Therefore, the purpose of the present study was to compare the IDAP in unmedicated depressed patients with that of healthy control subjects...

..The combination of GP and CLO was safe...

..The purpose of the study was to examine opiate-related deaths in the German town Essen (inhabitants about 600,000) from 1990-1994. Sociodemographic data, psychiatric comorbidity and purity of the used opioids were of focussed interest...

..Nevertheless, the question arises whether self-reports of drinking are more reliable than gamma-GT as a measure of recent alcohol consumption...

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..These age-dependent changes have to be taken into account in interpretation of disease related MR changes of cerebellar nuclei in patients with degenerative or acquired cerebellar ataxia...

..Possible pharmacological and non-pharmacological therapeutic strategies in patients with ADHD and substance abuse are discussed...

..Since the improvement of florid psychotic symptoms seems to be markedly higher under trimipramine than the one reported under placebo, our results indicate that trimipramine may have an antipsychotic potency...

..Furthermore, we assessed whether this effect is reversed by mu-opioid receptor blockade during antagonist-supported detoxification under general anesthesia...

..Transient RLS during opiate detoxification merits further interst in order to improve the treatment of sleep disturbances during detoxification and as a model of interaction of the dopaminergic and endorphine system in motor activity...

..The aim of the study was to investigate the antipsychotic potential of trimipramine in a controlled clinical trial comparing its antipsychotic efficacy with that of a neuroleptic...

..Turning away from the help system is not the reason for drug-related death, but an important attendant circumstance...

..To describe the course of positive and negative symptoms during inpatient treatment and examine remission and response rates under routine clinical care conditions...

..Standardized and differential diagnoses of dementias are necessary for an antidementive therapy as well as for the detection of potentially curable diseases...

..Atomoxetine is the first nonstimulant approved by the FDA for the treatment of ADHD and the first medication approved for the treatment of adult ADHD...

..To conclude, assessment of fitness for certain tasks or occupations should be done individually for each patient and should take into account comorbidity, including the extent of alcohol and other drug use...

..Computer anxiety scores at onset of treatment did not exceed normal values. After completion of the training, these scores were significantly reduced and subjective well-being significantly increased...

..02). These findings underscore the usefulness of group psychotherapy in MMT. The delayed effect is comparable to other studies evaluating cognitive-behavioural psychotherapy...

..Maintenance patients were usually the source of the opiates. The results prove the necessity of stringent conditions for take-home dosages, and illustrate deficits in the health care system...

..In patients with major depression, associations of high IDAP with favorable SSRI treatment outcome have been reported. This is the first study to assess the predictive value of the IDAP in SNRI treatment...

..The authors tested the hypothesis that mu-opioid receptor blockade by naloxone induces cardiovascular stimulation mediated by the sympathoadrenal system...

..Guidelines need to be drawn up to establish handover from paediatric to adult ADHD care...

..Patients with ADHD history seemed to experience a drug abuse career with more complications which need to be recognized with focused attention in order to start earlier treatment strategies...

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..The aim of the present study was to evaluate the relative impact of LAAM on QTc-interval, as a measure of pro-arrhythmic risk, in comparison to methadone, the current standard in substitution therapy...

..5-7). CONCLUSIONS: The results are discussed with regard to client-centered therapeutic concepts and to the further development of differential combination strategies...

..From a neuropsychological point of view dissociation in BPD might be regarded as a special form of behavioral inhibition and sustained attention comparable to ADHD. Possible therapeutic strategies of comorbid ADHD and BPD are discussed...

..Standardized consensus criteria for remission in schizophrenia were recently proposed. As yet, the validity of these criteria and their comparability with previously used outcome measures are unclear...

..We report on the first European multi-center, parallel group, flexible dose, open-label, randomized clinical trial comparing LAAM and methadone in patients with opioid dependence...

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..The findings emphasize that hospitalization of addicted patients yields relevant somatic morbidity which has an impact on cost and requires medically supervised detoxification programs...

..Buprenorphine is an additional treatment option for heroin dependent patients, especially for those who do not wish to start or continue with methadone or for those who do not seem to benefit from adequate dosages of methadone...

..However, resolution of acute alcohol withdrawal is associated with a return of plasma cortisol to control levels, and a concomitant increase in peripheral blood monocyte numbers...

..Despite many short-term studies, little is known about the long-term (12-month) effects of these treatments in different settings, i.e. primary care-based (PMC) and specialized substitution centers (SSCs)...

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..The COBRA study provides a unique comprehensive database, informing about the natural allocation and intervention processes in routine care and about the course and outcome of patients treated with buprenorphine or methadone...

..This first part of the guidelines covers the treatment of alcohol dependence; Part 2 will be devoted to the treatment of drug dependence...

..Switching to an agent of a different class is probably optimal for those patients who fail to respond to first-line therapy...

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..Normal values for marker substances in urine were determined. The results suggest that this labeling procedure is a new diagnostic tool to prevent manipulation of urine samples by drug addicts receiving substitution therapy...