Research Topics
Species | Steffen FreseSummaryAffiliation: University of Konstanz Country: Germany Publications
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Detail Information
Publications
PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2Steffen Frese
Department of Clinical Research, Division of General Thoracic Surgery, University Hospital Berne, Switzerland
Oncogene 22:5427-35. 2003..In conclusion, apoptosis induced by the combination of Apo2L/TRAIL and PG490 warrants further evaluation as a potential new strategy for the treatment of lung cancer...- Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5Steffen Frese
Division of General Thoracic Surgery, University Hospital Berne and The Tiefenau Laboratory, Department of Clinical Research, University of Berne, Switzerland
Cancer Res 66:5867-74. 2006..Our data suggest that the combination of Apo2L/TRAIL and cardiac glycosides may be a new interesting anticancer treatment strategy... - Structural modification of DNA-a therapeutic option in SLE?Steffen Frese
Department of Clinical Research, University Hospital Bern, Murtenstrasse 50, P O Box 44, CH 3010 Bern, Switzerland
Nat Rev Rheumatol 7:733-8. 2011.... - Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5Manuela Frese-Schaper
Department of Clinical Research, University of Bern, Bern, Switzerland
FEBS Lett 584:2867-71. 2010..In conclusion, inhibition of tissue transglutaminase provides an interesting strategy for sensitization to TRAIL-induced apoptosis in p53-deficient lung cancer cells... - Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancerSteffen Frese
Laboratory of Thoracic Surgery, University Hospital Bern, Murtenstrasse 35 room C807, CH 3010 Berne, Switzerland
Anticancer Res 29:2905-11. 2009..The aim of the present study was the evaluation of these results in a model of primary culture of non-small cell lung cancer... - Enhancement of Apo2L/TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis in non-small cell lung cancer cell lines by chemotherapeutic agents without correlation to the expression level of cellular protease caspase-8 inhibitorSteffen Frese
Division of General Thoracic Surgery, University Hospital Berne, Switzerland
J Thorac Cardiovasc Surg 123:168-74. 2002..Even though the molecular mechanism remains unclear, the combination of Apo2L/TRAIL with chemotherapy may be a promising treatment modality for non-small cell lung cancer... - Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavageSteffen Frese
Division of General Thoracic Surgery, Department of Clinical Research, University Hospital, Murtenstrasse 35, Room C807, CH 3010 Berne, Switzerland
J Thorac Cardiovasc Surg 126:748-54. 2003..We therefore evaluated whether selective depletion of heat shock protein 70 induces cell death in lung cancer cells... - Reversal of established lupus nephritis and prolonged survival of New Zealand black x New Zealand white mice treated with the topoisomerase I inhibitor irinotecanManuela Frese-Schaper
Department of Clinical Research, University Hospital Bern, Bern, Switzerland
J Immunol 184:2175-82. 2010..In conclusion, our data provide evidence that irinotecan might represent an entirely new strategy for the treatment of systemic lupus erythematosus... - Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liverJan Plock
Clinic of Visceral and Transplantation Surgery, Department of Clinical Research, University of Bern, Murtenstrase 35, 3010 Bern, Switzerland
J Hepatol 47:538-45. 2007..We investigated the molecular response of a non-ischemic hypoxic stress in the liver, in particular, to distinguish its hepatoprotective potential... - A large mediastinal tumor with spontaneous regression 30 years after esophageal bypass surgerySteffen Frese
Division of General Thoracic Surgery, University Hospital Berne, Switzerland
Ann Thorac Surg 74:1711-2. 2002..Seven days after admission a chest roentgenogram showed almost complete regression of the tumor, which was supposed to be a mucocele of the colon bypassing the esophagus... - Ex vivo assessment of chemotherapy-induced apoptosis and associated molecular changes in patient tumor samplesFarzaneh Pirnia
Institute of Medical Oncology, University of Bern, Inselspital, Bern, Switzerland
Anticancer Res 26:1765-72. 2006..This culture technique could become an important tool for drug development and for the prediction of in vivo drug efficacy... - TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethalityNadia Corazza
Division of Immunopathology, Institute of Pathology, University of Bern, Bern, Switzerland
J Clin Invest 116:2493-9. 2006..We conclude that TRAIL and Bim are important response modifiers of hepatocyte apoptosis and identify liver damage and lethality as a possible risk of TRAIL-based tumor therapy... - Death receptor 5 mediated-apoptosis contributes to cholestatic liver diseaseKazuyoshi Takeda
Department of Immunology, Juntendo University School of Medicine, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
Proc Natl Acad Sci U S A 105:10895-900. 2008..Thus, TRAIL/DR5-mediated apoptosis may substantially contribute to chronic cholestatic disease, particularly primary sclerosing cholangitis...