Research Topics
| Lars FischerSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Ranking of patient and surgeons' perspectives for endpoints in randomized controlled trials--lessons learned from the POVATI trial [ISRCTN 60734227]Lars Fischer
Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
Langenbecks Arch Surg 396:1061-6. 2011....- To whom do the results of the multicenter, randomized, controlled INSECT trial (ISRCTN 24023541) apply? - assessment of external validityLars Fischer
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, 69120, Germany
BMC Surg 12:2. 2012..ABSTRACT: A response to Seiler et al: Interrupted or continuous slowly absorbable sutures for closure of primary elective midline abdominal incisions: a multicenter randomized trial (.. - Four years of teaching principles in clinical trials--a continuous evaluation of the postgraduate workshop for surgical investigators at the study center of the German Surgical SocietyLars Fischer
Department of Surgery, University of Heidelberg, Germany
J Surg Educ 66:15-9. 2009..Therefore, a clinical investigator course focusing particularly on the issues of surgical trials was initiated in 2005. The structure of this course is demonstrated here as well as the results of its evaluation over the last 4 years... - Variability of surgical knot tying techniques: do we need to standardize?Lars Fischer
Department of Surgery, University of Heidelberg INF 110, 69120, Heidelberg, Germany
Langenbecks Arch Surg 395:445-50. 2010..However, there is no consensus in the literature on the best/safest technique. The aim of this study was to survey the various techniques used by German surgeons at the different stages of their training... - How many CT detector rows are necessary to perform adequate three dimensional visualization?Lars Fischer
Department of Surgery, University of Heidelberg, Germany
Eur J Radiol 74:e144-8. 2010..The main goal of this study was to examine whether the increased amount of CT detector rows is correlated with improved quality of the 3D images... - A historically controlled, single-arm, multi-centre, prospective trial to evaluate the safety and efficacy of MonoMax suture material for abdominal wall closure after primary midline laparotomy. ISSAAC-Trial [NCT005725079]Lars Fischer
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
BMC Surg 8:12. 2008..The development of improved suture materials which would reduce postoperative complications may help to lower its frequency... - Reasons for explantation of totally implantable access ports: a multivariate analysis of 385 consecutive patientsLars Fischer
Department of General, Visceral and Trauma Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
Ann Surg Oncol 15:1124-9. 2008..The objective of this study was to analyze factors leading to explantation of totally implanted access ports (TIAPs) and to assess its occurrence and clinical relevance... - Evaluation of the safety and efficacy of MonoMax® suture material for abdominal wall closure after primary midline laparotomy-a controlled prospective multicentre trial: ISSAAC [NCT005725079]Markus Albertsmeier
Department of Surgery, University of Munich, Grosshadern Campus, Marchioninistr 15, 81377, Munchen, Germany
Langenbecks Arch Surg 397:363-71. 2012..The ISSAAC study aimed to assess the safety and efficacy of the new ultra-long-term absorbable, elastic monofilament suture material MonoMax® for abdominal wall closure... - Teaching on Three-Dimensional Presentation Does Not Improve the Understanding of According CT Images: A Randomized Controlled StudyRebecca Metzler
a Department of Surgery, University of Heidelberg, Heidelberg, Germany
Teach Learn Med 24:140-8. 2012..04). Conclusions: This randomized controlled study shows that correct interpretation of 2D imaging does not differ in students trained with either 3D or 2D... - LigaSure versus conventional dissection technique in pancreatoduodenectomy: a pilot studyTobias Gehrig
Department of General, Abdominal and Transplant Surgery, Ruprecht Karls University of Heidelberg, Germany
Am J Surg 201:166-70. 2011..Therefore, LigaSure (Valleylab, Boulder, CO) provides an alternative to conventional dissection techniques. The aim of the present study was to describe the feasibility, safety, and cost efficiency of LigaSure in pancreatoduodenectomy... - Three-dimensional visualisation improves understanding of surgical liver anatomyJudith Beermann
Department of Surgery, University of Heidelberg, Heidelberg, Germany
Med Educ 44:936-40. 2010..We carried out a randomised trial, based on the identification of complex surgical liver anatomy, to evaluate whether 3-D presentation has a beneficial impact and if gender differences were evident... - Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?Frank Bergmann
Institute of Pathology, University of Heidelberg, Heidelberg, Germany
Am J Gastroenterol 104:171-81. 2009.... - MHC class II expression in pancreatic tumors: a link to intratumoral inflammationMatthias M Gaida
Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg, Germany
Virchows Arch 460:47-60. 2012..Our findings suggest that MHC class II expression on pancreatic tumor cells is induced by the intratumoral inflammatory reaction in pancreatic tumors... - Excessive weight loss after sleeve gastrectomy: a systematic reviewLars Fischer
Department of Surgery, University of Heidelberg, INF 110, 69120, Heidelberg, Germany
Obes Surg 22:721-31. 2012..The clinical significance of sleeve gastrectomy (SG) as a primary bariatric intervention is still under debate. This article aims to systematically analyze excessive weight loss (EWL) in patients after SG... - Duodenum-preserving pancreatic head resection versus pancreatoduodenectomy for surgical treatment of chronic pancreatitis: a systematic review and meta-analysisMarkus K Diener
Department of General, Visceral and Trauma Surgery, University of Heidelberg, Heidelberg, Germany
Ann Surg 247:950-61. 2008.... - Insertion of totally implantable venous access devices: an expertise-based, randomized, controlled trial (NCT00600444)Phillip Knebel
Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
Ann Surg 253:1111-7. 2011..Comparison of two different insertion techniques for implantation of totally implantable access ports (TIAP)... - Limits of Couinaud's liver segment classification: a quantitative computer-based three-dimensional analysisLars Fischer
Department of Surgery, University of Heidelberg, INF Feld 110, 69120 Heidelberg, Germany
J Comput Assist Tomogr 26:962-7. 2002..As the position and shape of these segments are variable and their borders are hidden within the homogeneous liver mass, the accuracy of segment identification methods needs computer-aided reevaluation... - Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumorsPhilipp Mayer
Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany Medical Clinic Gastroenterology and Gastrointestinal Oncology, Vivantes Klinikum Am Urban, Dieffenbachstrasse 1, D 10967 Berlin, Germany
Endocr Relat Cancer 19:217-32. 2012..HSP90 is expressed in the vast majority of PET and its inhibition reveals significant treatment effects in vitro. Thus, HSP90 qualifies as a promising new target... - Does preoperative analysis of intrahepatic venous anastomoses improve the surgeon's intraoperative decision making? Pilot data from a case reportLars Fischer
Department of Surgery, University of Heidelberg, INF 110, D 69120 Heidelberg, Germany
Patient Saf Surg 2:19. 2008..Three-dimensional (3D) visualization is thought to improve the anatomical understanding of clinicians, thus improving patient safety... - Hemostatic efficacy of TachoSil in liver resection compared with argon beam coagulator treatment: an open, randomized, prospective, multicenter, parallel-group trialLars Fischer
Department of Surgery, University of Heidelberg, Heidelberg, Germany
Surgery 149:48-55. 2011..The aim of this trial was to confirm previous results demonstrating the efficacy and safety of a fixed combination tissue sealant versus argon beam coagulation (ABC) treatment in liver resection... - The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasmsSimon Schimmack
Gastrointestinal Pathobiology Research Group, Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, Connecticut University Hospital of General, Visceral, and Transplantation Surgery of Heidelberg, Heidelberg, Germany
Cancer 118:2763-75. 2012..Given the role of internexin alpha (INA) in neuronal development, the authors assessed its function in neuroendocrine cell systems and the clinical implications of its expression as a GEP-NEN biomarker... - The segments of the hepatic veins-is there a spatial correlation to the Couinaud liver segments?Lars Fischer
Department of Surgery, University of Heidelberg, Heidelberg, Germany
Eur J Radiol 53:245-55. 2005..To investigate and describe the volume, position and shape of venous segments within the human liver and define their spatial correlation to the Couinaud segments (CS) and to the portal vein segments (PVS)... - Fundamental differences in the neural invasion behavior of pancreatic endocrine tumors: relevance for local recurrence rates?Frank Bergmann
Institute of Pathology, University of Heidelberg, D 69120 Heidelberg, Germany
Hum Pathol 40:50-7. 2009..This phenomenon may explain the low rate of local relapses after tumor resection in pancreatic endocrine tumors despite the high frequency of neural invasion... - Effects of STI571 (gleevec) on pancreatic cancer cell growthJunsheng Li
Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
Mol Cancer 2:32. 2003..STI571 has specific activity in inhibiting c-kit, PDGF and Abl receptor tyrosine kinases and has proven successful in the treatment of CML and GIST patients. Here, we investigated the potential role of STI571 in pancreatic cancer... - The stem cell factor-c-kit system and mast cells in human pancreatic cancerIrene Esposito
Department of General Surgery, University of Heidelberg, Heidelberg, Germany
Lab Invest 82:1481-92. 2002..In conclusion, the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation... - Skewed expression of natural-killer (NK)-associated antigens on lymphoproliferations of large granular lymphocytes (LGL)Lars Fischer
Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Germany
Hematol Oncol 24:78-85. 2006..We consistently found a skewed expression pattern of novel NK markers as a pathological feature of LGLL. These antigens should be included in the diagnostic workup of this rare disease... - Unusual sites of Hodgkin's lymphoma: CASE 3. Cholemic nephrosis in Hodgkin's lymphoma with liver involvementPhilipp Kiewe
, Campus Benjamin Franklin, Berlin, Germany
J Clin Oncol 22:4230-1. 2004 - Relapse of primary central nervous system lymphoma: clinical features, outcome and prognostic factorsKristoph Jahnke
Department of Hematology, Oncology and Transfusion Medicine, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, D 12200, Berlin, Germany
J Neurooncol 80:159-65. 2006..Survival of patients with relapsed PCNSL is poor despite high response rates to salvage therapy. Good KPS, isolated systemic relapse and treatment for relapse were significantly associated with longer survival... - Longitudinal analysis of Epstein-Barr viral load in plasma and peripheral blood mononuclear cells of transplanted patients by real-time polymerase chain reactionHans-Joachim Wagner
Department of Pediatrics,
Transplantation 74:656-64. 2002..CONCLUSIONS: EB viral load measurements in plasma and PBMC of patients using RQ-PCR are superior to serology and are a powerful tool for monitoring transplanted patients...