F Entschladen

Summary

Affiliation: University of Witten/Herdecke
Country: Germany

Publications

  1. ncbi Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes
    Carina Strell
    Institute of Immunology, Witten Herdecke University, 58448 Witten, Germany
    BMC Immunol 10:62. 2009
  2. ncbi Analysis methods of human cell migration
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Street 10, 58448 Witten, Germany
    Exp Cell Res 307:418-26. 2005
  3. ncbi Neoneurogenesis: tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis
    Frank Entschladen
    Institute for Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    Med Hypotheses 67:33-5. 2006
  4. ncbi Connecting a tumor to the environment
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Curr Pharm Des 13:3440-4. 2007
  5. ncbi The cancer's nervous tooth: Considering the neuronal crosstalk within tumors
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Street 10, 58448 Witten, Germany
    Semin Cancer Biol 18:171-5. 2008
  6. ncbi Tumor interactions with soluble factors and the nervous system
    Melanie J Voss
    Institute of Immunology, ZBAF, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    Cell Commun Signal 8:21. 2010
  7. ncbi Extravasation of leukocytes in comparison to tumor cells
    Carina Strell
    Institute of Immunology, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    Cell Commun Signal 6:10. 2008
  8. ncbi Signal transduction--receptors, mediators, and genes
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Witten, Germany
    Sci Signal 2:mr3. 2009
  9. ncbi Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Germany
    Cell Commun Signal 8:2. 2010
  10. ncbi PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment
    Melanie J Voss
    Institute of Immunology, ZBAF, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    Cell Commun Signal 8:17. 2010

Collaborators

Detail Information

Publications51

  1. ncbi Divergent effects of norepinephrine, dopamine and substance P on the activation, differentiation and effector functions of human cytotoxic T lymphocytes
    Carina Strell
    Institute of Immunology, Witten Herdecke University, 58448 Witten, Germany
    BMC Immunol 10:62. 2009
    ..Therefore, we investigated the influence of norepinephrine, dopamine and substance P on the key tasks of CD8+ T lymphocytes: activation, migration, extravasation and cytotoxicity...
  2. ncbi Analysis methods of human cell migration
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Street 10, 58448 Witten, Germany
    Exp Cell Res 307:418-26. 2005
    ..This review therefore gives an overview of the migration assays which are currently in use, describes the methods, and critically enlightens the particular advantages and disadvantages of each method...
  3. ncbi Neoneurogenesis: tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis
    Frank Entschladen
    Institute for Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    Med Hypotheses 67:33-5. 2006
    ....
  4. ncbi Connecting a tumor to the environment
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Curr Pharm Des 13:3440-4. 2007
    ..Furthermore, nerve fibers are used as routes for tumor cell dissemination, too, which is known as perineural invasion...
  5. ncbi The cancer's nervous tooth: Considering the neuronal crosstalk within tumors
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Street 10, 58448 Witten, Germany
    Semin Cancer Biol 18:171-5. 2008
    ..Through these synapses, neurotransmitters are directly supplied to the tumors, which has impact on tumor growth and metastasis formation...
  6. ncbi Tumor interactions with soluble factors and the nervous system
    Melanie J Voss
    Institute of Immunology, ZBAF, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    Cell Commun Signal 8:21. 2010
    ..We also summarize here the current knowledge on the innervation of tumors. Such a process might establish a neuro-neoplastic synapse, with the close interaction of tumor cells and nerve cells supporting metastasis formation...
  7. ncbi Extravasation of leukocytes in comparison to tumor cells
    Carina Strell
    Institute of Immunology, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    Cell Commun Signal 6:10. 2008
    ..We herein compare the extravasation of leukocytes and tumor cells with regard to the involved receptors and the localization signals that direct the cells to certain organs and sites of the body...
  8. ncbi Signal transduction--receptors, mediators, and genes
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Witten, Germany
    Sci Signal 2:mr3. 2009
    ..This international and interdisciplinary scientific gathering induced lively discussions and close interactions between participants...
  9. ncbi Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Germany
    Cell Commun Signal 8:2. 2010
    ..This report gives an overview of the presentations of the conference...
  10. ncbi PC-3 prostate carcinoma cells release signal substances that influence the migratory activity of cells in the tumor's microenvironment
    Melanie J Voss
    Institute of Immunology, ZBAF, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    Cell Commun Signal 8:17. 2010
    ....
  11. ncbi Lessons from tumor and immunocompetent cells. The quantitative engagement of ligand-receptor interactions modulates stop-and-go behavior as well as proliferation
    T Dittmar
    Institute of Immunology, University of Witten Herdecke, Stockumer Str 10, 58448 Witten, Germany
    Medicina (B Aires) 60:27-33. 2000
    ....
  12. ncbi Surface molecules regulating rolling and adhesion to endothelium of neutrophil granulocytes and MDA-MB-468 breast carcinoma cells and their interaction
    C Strell
    Institute of Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448, Witten, Germany
    Cell Mol Life Sci 64:3306-16. 2007
    ..This up-regulation resulted in a significant increase of adherent MDA-MB-468 cells, which are also N-cadherin positive...
  13. ncbi High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells
    K Masur
    Institute of Immunology, Witten Herdecke University, 58448 Witten, Germany
    Mol Biol Cell 12:1973-82. 2001
    ..This correlation was independent of the differentiation grade of the tumor cell lines...
  14. ncbi Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells
    T L Drell
    Institute for Immunology, Witten/Herdecke University, Witten, Germany
    Breast Cancer Res Treat 80:63-70. 2003
    ....
  15. ncbi CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion
    P Friedl
    Institute of Immunology, University of Witten Herdecke, Witten, Germany
    Eur J Immunol 28:2331-43. 1998
    ....
  16. ncbi Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix
    P Bastian
    Institute of Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    Cell Mol Life Sci 62:65-76. 2005
    ....
  17. ncbi Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers
    K Masur
    Institute for Immunology, Witten Herdecke University, Witten, Germany
    Cancer Res 61:2866-9. 2001
    ..In summary, norepinephrine-induced locomotion of SW 480 cells is beta2-adrenoceptor mediated and distinct from spontaneous locomotion concerning the PTK involvement...
  18. ncbi Tumor cell locomotion: differential dynamics of spontaneous and induced migration in a 3D collagen matrix
    Bernd Niggemann
    Institute of Immunology, Witten/Herdecke University, 58448 Witten, Germany
    Exp Cell Res 298:178-87. 2004
    ..We furthermore establish the analytical methodology of investigating both the stimulation and potential pharmaceutical inhibition of tumor cell migration...
  19. ncbi Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs
    Kerstin Lang
    Institute of Immunology, Witten/Herdecke University, Witten, Germany
    Int J Cancer 112:231-8. 2004
    ..Neurotransmitters thus induce a metastatogenic tumor cell type by directly regulating gene expression and increased migratory activity, which can be prevented by established neurotransmitter antagonists...
  20. ncbi Tumour reactions to hypoxia
    M J Voss
    Institute of Immunology, Witten Herdecke University, 58448 Witten, Germany
    Curr Mol Med 10:381-6. 2010
    ....
  21. ncbi N-cadherin engagement provides a dominant stop signal for the migration of MDA-MB-468 breast carcinoma cells
    S Potthoff
    Institute for Immunology, Witten Herdecke University, Stockumer Str 10, Witten, 58448, Germany
    Breast Cancer Res Treat 105:287-95. 2007
    ....
  22. ncbi Locomotion of tumor cells: a molecular comparison to migrating pre- and postmitotic leukocytes
    F Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    J Cancer Res Clin Oncol 126:671-81. 2000
    ..Most potent activators of migration of neutrophil granulocytes, as those of T lymphocytes, are chemokines binding to heterotrimeric G protein-coupled serpentine receptors...
  23. ncbi Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes
    Philipp Bastian
    Institute of Immunology, Witten/Herdecke University, Stockumer Str. 10, 58448 Witten, Germany
    Mol Cancer Res 4:411-21. 2006
    ....
  24. ncbi Neurotransmitters regulate the migration and cytotoxicity in natural killer cells
    Kerstin Lang
    Institute of Immunology, Witten/Herdecke University, 58448 Witten, Germany
    Immunol Lett 90:165-72. 2003
    ..These results further specify the functional basis of the complex interconnection between the immune and neuro-endocrine systems...
  25. ncbi The inhibitory effect of norepinephrine on the migration of ES-2 ovarian carcinoma cells involves a Rap1-dependent pathway
    Philipp Bastian
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Cancer Lett 274:218-24. 2009
    ..In ES-2 cells, this part of the signalling cascade is constitutively active...
  26. ncbi Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes
    Jan Joseph
    Institute of Immunology, Witten/Herdecke University, Stockumer Str. 10, 58448, Witten, Germany
    Cancer Immunol Immunother 53:723-8. 2004
    ..Therefore, specific inhibition of tumor cell migration via CB1-R engagement might be a selective tool to prevent metastasis formation without depreciatory effects on the immune system of cancer patients...
  27. ncbi Neoneurogenesis and the neuro-neoplastic synapse
    Daniel Palm
    Institute of Immunology, Witten Herdecke University, Stockumer Strasse 10, DE 58448 Witten, Germany
    Prog Exp Tumor Res 39:91-8. 2007
    ....
  28. ncbi In vitro and in vivo imaging of cell migration: two interdepending methods to unravel metastasis formation
    Daniel Palm
    Institute of Immunology, Witten/Herdecke University, Stockumer Str. 10, 58448 Witten, Germany
    Semin Cancer Biol 15:396-404. 2005
    ..We herein suggest a combination of three-dimensional in vitro and in vivo methods for the investigation of tumor cell migration and summarize the knowledge, which has been reached so far...
  29. ncbi Influence of enamel matrix derivative on primary CD4+ T-helper lymphocyte migration, CD25 activation, and apoptosis
    Georg Gassmann
    Department of Periodontology, Faculty of Dental Medicine, University of Witten Herdecke, Witten, Germany
    J Periodontol 80:1524-33. 2009
    ..This study investigated the influence of EMD on primary T-lymphocyte migration, CD25 activation, and activation-induced cell death...
  30. ncbi Neurotransmitters and chemokines regulate tumor cell migration: potential for a new pharmacological approach to inhibit invasion and metastasis development
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Curr Pharm Des 11:403-11. 2005
    ....
  31. ncbi Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters
    Frank Entschladen
    Signal Transduction in Cell Migration Group at the Institute for Immunology, Witten Herdecke University, Witten, Germany
    Lancet Oncol 5:254-8. 2004
    ..Understanding how such receptors regulate migration and the availability of specific receptor antagonists could open up new avenues for chemoprevention of tumour-cell migration and metastatic development...
  32. ncbi Tumor immune escape mechanisms: impact of the neuroendocrine system
    Kerstin Lang
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Cancer Immunol Immunother 55:749-60. 2006
    ..This review will describe and summarize current understanding of tumor escape strategies, and also more closely elaborate on the modulatory role of the neuroendocrine system in the immune system-tumor cell interaction...
  33. ncbi Neurotransmitters are regulators for the migration of tumor cells and leukocytes
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    Cancer Immunol Immunother 51:467-82. 2002
    ..This review thus accentuates the complex, interactive involvement of neurotransmitters in the regulation of migration of both leukocytes and tumor cells...
  34. ncbi Signal processing in migrating T24 human bladder carcinoma cells: role of the autocrine interleukin-8 loop
    Kerstin Lang
    Institute for Immunology, Witten Herdecke University, Witten, Germany
    Int J Cancer 99:673-80. 2002
    ..Here, we report on a new autocrine function of secreted interleukin-8 and the intracellular signal transduction leading to the regulation of cytosolic calcium and to a migratory tumor cell phenotype...
  35. ncbi Inhibition of cell migration via G protein-coupled receptors to opioid peptides and angiotensin
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Ann N Y Acad Sci 1028:320-8. 2004
    ....
  36. ncbi Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1
    Carina Strell
    Institute of Immunology, Witten Herdecke University, Stockumer Street 10, 58448 Witten, Germany
    Exp Cell Res 316:138-48. 2010
    ..Thus, neutrophil granulocytes can act as modulators of the metastatic capability of tumor cells by ligation of ICAM-1...
  37. ncbi A novel function for chemokines: downregulation of neutrophil migration
    K Lang
    Institute for Immunology, Witten/Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    Scand J Immunol 57:350-61. 2003
    ..Thus, we show for the first time that a chemokine, IL-8, in concert with fMLP, downregulates the neutrophil migration through the regulation of the intracellular calcium concentration via the adenylyl cyclase and the PLCbeta2...
  38. ncbi DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells
    K Masur
    Institute of Immunology, Witten Herdecke University, Stockumer Str 10, 58448 Witten, Germany
    Regul Pept 137:147-55. 2006
    ..Since both peptides are rapidly degraded by dipeptidyl peptidase-IV (DPPIV), research is focused on the development of DPPIV inhibitors or DPPIV resistant...
  39. ncbi Realtime visualization of tumor cell/endothelial cell interactions during transmigration across the endothelial barrier
    C Heyder
    Institute of Immunology, University of Witten Herdecke, Stockumer Strasse 10, 58448 Witten, Germany
    J Cancer Res Clin Oncol 128:533-8. 2002
    ..Here, we describe a novel in vitro realtime model which shows the complete sequence of the extravasation process...
  40. ncbi The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells
    Jan Joseph
    Institute for Immunology, Witten/Herdecke University, 58448 Witten, Germany
    Cancer Res 62:6467-9. 2002
    ..Cancer cell migration is thus regulated by neurobiological signals, opening new possibilities for pharmacological agonists in cancer therapy...
  41. ncbi The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers
    Daniel Palm
    Institute of Immunology, Witten/Herdecke University, Witten, Germany
    Int J Cancer 118:2744-9. 2006
    ....
  42. ncbi MCP-1 induces migration of adult neural stem cells
    Darius Widera
    , , Witten, Germany
    Eur J Cell Biol 83:381-7. 2004
    ..Expression of the MCP-1 receptor CCR2 in neurosphere cultures was verified by RT-PCR and immunofluorescence microscopy. Supernatants from TNF-treated U373 cells also induced migration of neural stem cells...
  43. ncbi Leptin stimulates the migration of colon carcinoma cells by multiple signaling pathways
    Janina Ratke
    Institute of Immunology, Witten Herdecke University, Stockumer Strasse 10, 58448 Witten, Germany
    Endocr Relat Cancer 17:179-89. 2010
    ....
  44. ncbi Inhibitors for metastasis development
    Kerstin Lang
    Institute of Immunology, Witten/Herdecke University, Witten, Germany
    Recent Patents Anticancer Drug Discov 1:69-80. 2006
    ..This review summarizes the current understanding of the cellular and molecular mechanisms of metastasis development, and suggests possible approaches for its inhibition...
  45. ncbi The selective role of myosin VI in lymphoid leukemia cell migration
    Jbireal M Ali Jbireal
    Institute of Immunology, Witten Herdecke University, Witten, Germany
    Leuk Res 34:1656-62. 2010
    ..Therefore, in contrast to differentiated leukocytes and cells from solid tumors, myosin VI plays a crucial role in the migration of leukemic cells...
  46. ncbi The responsiveness of human V delta 1 gamma delta T cells to Borrelia burgdorferi is largely restricted to synovial-fluid cells from patients with Lyme arthritis
    Andrea Glatzel
    Institute of Immunology, University of Kiel, Kiel, Germany
    J Infect Dis 186:1043-6. 2002
    ..Thus, the responsiveness to Borrelia antigens is not a general property of V delta 1-expressing gamma delta T cells but is largely restricted to V delta 1 gamma delta T cells recruited into the inflamed tissue...
  47. ncbi Paving roads for new drugs in oncology
    Kurt S Zaenker
    Institute of Immunology and Exp Oncology, University Witten Herdecke, Witten, Germany
    Recent Pat Anticancer Drug Discov 4:137-45. 2009
    ..The relevant patents are discussed...
  48. ncbi Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding
    Barbara Belletti
    Experimental Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Clin Cancer Res 14:1325-32. 2008
    ..The proportional reduction of this risk by radiotherapy does not depend on the extent of surgery, suggesting that radiotherapy, in addition to killing tumor cells, may influence the tumor microenvironment...
  49. ncbi 3D-extravasation model -- selection of highly motile and metastatic cancer cells
    Burkhard Brandt
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center, Hamburg-Eppendorf, Martinistr. 52, 20146 Hamburg, Germany
    Semin Cancer Biol 15:387-95. 2005
    ....
  50. ncbi Vinculin acts as a sensor in lipid regulation of adhesion-site turnover
    Indra Chandrasekar
    Cell Biology, Zoological Institute, Technical University of Braunschweig, 38106 Braunschweig, Germany
    J Cell Sci 118:1461-72. 2005
    ..Instead, we propose that PIP(2) levels can regulate the uncoupling of adhesion sites from the actin cytoskeleton, with vinculin functioning as a sensor...
  51. ncbi Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells
    Wanzhou Zhao
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No1 Xiannong Tan Street, Beijing 100050, China
    Cancer Detect Prev 27:67-75. 2003
    ....