Research Topics
| Matthias EberlSummaryAffiliation: University of Giessen Country: Germany Publications
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Detail Information
Publications
Differentiation of human gamma-delta T cells towards distinct memory phenotypesMatthias Eberl
Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstr 24, 35392 Giessen, Germany
Cell Immunol 218:1-6. 2002..In contrast, Vgamma9/Vdelta2 T cells grown with IL-21 differentiated into putative central memory CD45RO(+) T cells that did not produce TNF-alpha, IFN-gamma, or IL-4, and maintained expression of CD62L, CD81, and CCR7...- Microbial isoprenoid biosynthesis and human gammadelta T cell activationMatthias Eberl
Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstr 24, Germany
FEBS Lett 544:4-10. 2003..Unexpectedly, the intermediate of the MEP pathway, (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate) (HMB-PP), turned out to be by far the most potent Vgamma9/Vdelta2 T cell activator known, with an EC(50) of 0.1 nM... - Mycoplasma penetrans is capable of activating V gamma 9/V delta 2 T cells while other human pathogenic mycoplasmas fail to do soMatthias Eberl
Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
Infect Immun 72:4881-3. 2004..Consequently, this pathogen is capable of stimulating human V gamma 9/V delta 2 T cells... - Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)Matthias Eberl
Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392 Giessen, Germany
J Leukoc Biol 77:67-70. 2005..Moreover, KLRG1 ligation on Vgamma9/Vdelta2 T cells by antibodies did not inhibit HMB-PP-induced proliferation and cytokine production nor cytolysis of Daudi cells... - A novel and sensitive method to monitor helminth infections by faecal samplingMatthias Eberl
Department of Biology, University of York, P O Box 373, York YO10 5YW, UK
Acta Trop 83:183-7. 2002..Moreover, the sensitivity of our method allows its use in proposed pre-clinical and clinical vaccine trials in non-human primates and humans, where reliable estimates of faecal egg counts are essential... - Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coliMatthias Eberl
Biochemisches Institut, Justus Liebig Universitat Giessen, Giessen, Germany
Immunology 106:200-11. 2002.... - Integrated immune responses to infection - cross-talk between human gammadelta T cells and dendritic cellsMatthias Eberl
Biochemisches Institut, Infektiologie, , Giessen, Germany
Immunology 112:364-8. 2004 - Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzeesM Eberl
Department of Biology, University of York, York YO10 5YW, United Kingdom
Infect Immun 69:5352-62. 2001..Moreover, vaccinated chimpanzees had a 46% lower level of circulating cathodic antigen and a 38% reduction in fecal egg output, compared to controls, during the chronic phase of infection... - Antibodies to glycans dominate the host response to schistosome larvae and eggs: is their role protective or subversive?M Eberl
Department of Biology, University of York, York, United Kingdom
J Infect Dis 183:1238-47. 2001..Their occurrence in humans might explain the long time required for antischistosome immunity to build up after infection... - Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coliM Hintz
Jomaa Pharmaka GmbH, Frankfurter Strasse 50, 35392 Giessen, Germany
FEBS Lett 509:317-22. 2001..HMB-PP is 10(4) times more potent in activating human Vgamma9/Vdelta2 T cells than isopentenyl pyrophosphate... - Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesisAnn Kristin Kollas
Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstrasse 24, 35392, Giessen, Germany
FEBS Lett 532:432-6. 2002..The maximal specific activity was 0.6 micromol x min(-1) x mg(-1) at pH 7.5 and 55 degrees C. The kcat value was 0.4 s(-1) and the K(m) value for HMBPP 0.42 mM... - Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosisMarina Zafranskaya
Biochemisches Institut, Infektiologie, Justus Liebig Universitat Giessen, Germany
Immunology 121:29-39. 2007..Assessment of T-cell subsets and their reactivity to MOG may represent an important diagnostic tool for monitoring successful immunotherapy in MS... - IL-18 potentiates the adjuvant properties of IL-12 in the induction of a strong Th1 type immune response against a recombinant antigenM Eberl
Department of Biology, University of York, York, UK
Vaccine 18:2002-8. 2000.... - Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugsH Jomaa
Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
Science 285:1573-6. 1999..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured... - Effect of two complex platinum salts on human sperm motility and acrosome reactionM Eberl
Centre of Dermatology and Andrology, Justus Liebig University, Giessen, Germany
Andrologia 32:303-10. 2000..This stimulatory effect is independent of calcium and seems to be dependent on protein kinase A or C... - Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesisB Altincicek
Jomaa Pharmaka GmbH, Giessen, Germany
J Immunol 166:3655-8. 2001..coli extracts to stimulate gamma delta T cell proliferation is abrogated when genes coding for essential enzymes of the MEP pathway, dxr or gcpE, are disrupted or deleted from the bacterial genome... - Improvement of semen quality by nocturnal scrotal cooling and moderate behavioural change to reduce genital heat stress in men with oligoasthenoteratozoospermiaA Jung
Center of Dermatology and Andrology, Justus Liebig University Giessen, D 35392 Giessen, Germany
Reproduction 121:595-603. 2001..This study shows the importance of genital heat stress as a cofactor in fertility impairment in men and indicates nocturnal scrotal cooling as a therapeutic option... - LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coliB Altincicek
Jomaa Pharmaka GmbH, Giessen, Germany
FEBS Lett 499:37-40. 2001..Cells deleted for the essential lytB gene were viable only if the medium was supplemented with mevalonate or the cells were complemented with an episomal copy of lytB... - Isolation of T-cell antigens by using a recombinant protein library and its application to the identification of novel vaccine candidates against schistosomiasisM Eberl
Biochemisches Institut, Justus Liebig Universitat Giessen, 35392 Giessen, Germany
Infect Immun 67:3383-9. 1999..Further analysis of one particular pool revealed that only one of its constituents stimulated considerable IFN-gamma secretion by CD4(+) T cells and that the expressed antigen is identical to a small fragment of myosin heavy chain... - A genetic basis for human gammadelta T-cell reactivity towards microbial pathogensMatthias Eberl
Trends Immunol 24:407-9. 2003 - Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonismArmin Reichenberg
Jomaa Pharmaka GmbH, Frankfurter Str. 50, D-35392 Giessen, Germany
Bioorg Med Chem Lett 13:1257-60. 2003..However, replacing the pyrophosphate by a P-CH(2)-P function abrogates the bioactivity drastically, with HMB-PCP having a EC(50) of only 5.3 microM... - Sex-specific phenotypical and functional differences in peripheral human Vgamma9/Vdelta2 T cellsNadia Caccamo
Dipartimento di Biopatologia e Metodologie Biomediche, , Italy
J Leukoc Biol 79:663-6. 2006..The phenotypical conversion in men older than 30 years is mirrored by an increased proliferative response of Vgamma9/Vdelta2 T cells and a reduced interferon-gamma secretion upon stimulation with isopentenyl pyrophosphate in vitro... - Distinct cytokine-driven responses of activated blood gammadelta T cells: insights into unconventional T cell pleiotropyDavid Vermijlen
Peter Gorer Department of Immunobiology, Guy s, King s and St Thomas Medical School, King s College London, London, UK
J Immunol 178:4304-14. 2007.... - Targeting human {gamma}delta} T cells with zoledronate and interleukin-2 for immunotherapy of hormone-refractory prostate cancerFrancesco Dieli
Dipartimento di Biopatologia e Metodologie Biomediche, Universita di Palermo, Palermo, Italy
Cancer Res 67:7450-7. 2007..Moreover, gammadelta cell phenotypes and possibly serum TRAIL may constitute novel biomarkers of prognosis upon therapy with zoledronate + IL-2 in metastatic carcinoma... - Don't count your interleukins before they've hatchedMatthias Eberl
Trends Immunol 23:341-2. 2002 - gammadelta T cells: novel initiators of adaptive immunityBernhard Moser
Institute of Cell Biology, University of Bern, Bern, Switzerland
Immunol Rev 215:89-102. 2007..This unexpected finding is discussed with regards to microbial sensing by human gammadelta T cells and a possible role for these cells in anti-microbial immunity...