Research Topics
Genomes and Genes
| Edgar DahlSummaryAffiliation: University Hospital Country: Germany Publications
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Detail Information
Publications
Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignanciesMenelaos Zafrakas
Institute of Pathology, University Hospital Aachen, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
BMC Cancer 6:88. 2006....- Infinite mixture-of-experts model for sparse survival regression with application to breast cancerSudhir Raman
Department of Computer Science, University of Basel, Bernoullistr, 16, CH 4056 Basel, Switzerland
BMC Bioinformatics 11:S8. 2010..The model is able to find key explanatory factors (chosen from main effects and higher-order interactions) for each sub-group by enforcing sparsity on the regression coefficients via the Bayesian Group-Lasso... - Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancerEdgar Dahl
Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
Clin Cancer Res 12:3950-60. 2006..The aim of the present study was to identify human genes that might prove useful in the diagnosis and therapy of primary breast cancer... - Systematic identification and molecular characterization of genes differentially expressed in breast and ovarian cancerEdgar Dahl
Institute of Pathology, RWTH Aachen, Germany
J Pathol 205:21-8. 2005..The majority of these differentially expressed genes have not been described previously in the context of breast and ovarian cancer, and may constitute novel diagnostic markers for these tumour entities... - Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinomaE Dahl
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
Oncogene 26:5680-91. 2007..In RCC, promoter hypermethylation seems to be the predominant mechanism of SFRP1 gene silencing and may contribute to initiation and progression of this disease... - Nuclear detection of Y-box protein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancerEdgar Dahl
Molecular Oncology Group, Institute of Pathology, Medical Faculty, RWTH Aachen University, Aachen, Germany
BMC Cancer 9:410. 2009..Given these predictive qualities of YB-1 detection we sought to establish a highly specific monoclonal antibody (Mab) for diagnostic testing and its characterization towards outcome prediction (relapse-free and overall survival)... - Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumoursJürgen Veeck
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH, Aachen, Germany
Breast Cancer Res 10:R82. 2008.... - Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancerNuran Bektas
Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
BMC Cancer 8:42. 2008.... - Promoter hypermethylation of the SFRP2 gene is a high-frequent alteration and tumor-specific epigenetic marker in human breast cancerJürgen Veeck
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
Mol Cancer 7:83. 2008..Here we investigated whether SFRP2 is also implicated in human breast cancer, and if so whether SFRP2 promoter methylation might serve as a potential tumor biomarker... - The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancerNuran Bektas
Department of Pathology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Breast Cancer Res 10:R58. 2008..To the best of our knowledge, in the current study we present for the first time a systematic characterisation of ISG15 expression in human breast cancer and normal breast tissue both at the mRNA and protein level... - Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancerJürgen Veeck
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
BMC Cancer 9:217. 2009.... - Frequent loss of endothelin-3 (EDN3) expression due to epigenetic inactivation in human breast cancerFrank Wiesmann
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
Breast Cancer Res 11:R34. 2009..Here, we aimed at a first comprehensive analysis on EDN3 expression and its implication in human breast cancer... - CD24 expression is a new prognostic marker in breast cancerGlen Kristiansen
Institute of Pathology, Charite University Hospital, Berlin D 10117, Germany
Clin Cancer Res 9:4906-13. 2003..We aimed to evaluate CD24 protein expression in breast cancer and to correlate to clinicopathological data including patient survival... - Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosisJürgen Veeck
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
Carcinogenesis 29:991-8. 2008..SFRP5 methylation may be a novel DNA-based biomarker potentially useful in clinical breast cancer management... - Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survivalAnette Ten Haaf
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
BMC Cancer 9:298. 2009..Furthermore we correlated GLI1 expression with histopathological and clinical data to evaluate whether GLI1 could represent a new prognostic marker in breast cancer treatment... - Dual role of macrophage migration inhibitory factor (MIF) in human breast cancerEva Verjans
Department of Biochemistry and Molecular Cell Biology, RWTH Aachen University Hospital, Aachen, Germany
BMC Cancer 9:230. 2009..MIF overexpression is observed in breast cancer but its causal role in the development of this tumour entity is unclear... - Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysisAlexander Hamm
Institute of Pathology, University Hospital of RWTH Aachen, Aachen, Germany
BMC Cancer 8:25. 2008..So far, ITIH molecules have been shown to play a particularly important role in inflammation and carcinogenesis... - Expression profiling of microdissected matched prostate cancer samples reveals CD166/MEMD and CD24 as new prognostic markers for patient survivalGlen Kristiansen
Institute of Pathology, Charite University Hospital, Berlin, Germany
J Pathol 205:359-76. 2005..7, p = 0.006) in a Cox regression model, and was also superior to conventional markers. This combination of molecular markers thus appears to allow improved prediction of patient prognosis, but should be validated in larger studies... - Distinct secreted Frizzled receptor protein 1 staining pattern in patients with hyperplastic polyposis coli syndromeBarbara I Oberschmid
Institute of Pathology, University of Regensburg, Germany
Arch Pathol Lab Med 128:967-73. 2004..Hypermethylation of the secreted Frizzled receptor protein 1 gene on chromosome 8p12 is one of the earliest molecular alterations in colorectal carcinogenesis, potentially disrupting the Wnt signaling cascade of cellular growth control... - Enhancer of the rudimentary gene homologue (ERH) expression pattern in sporadic human breast cancer and normal breast tissueMenelaos Zafrakas
Molecular Oncology Group, Institute of Pathology, University Hospital of RWTH Aachen, Aachen, Germany
BMC Cancer 8:145. 2008..The aim of the present study was a systematic characterization of ERH expression in human breast cancer in order to evaluate possible clinical applications of this molecule... - Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancerHannah Jörissen
Fraunhofer IME, Department of Pharmaceutical Product Development, Aachen, Germany
BMC Cancer 9:200. 2009..To investigate the link with cancer and provide more evidence for its role, we carried out a systematic analysis of RAI3 expression in a large set of human breast cancer specimens... - Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancerRobert Stoehr
Institute of Pathology, University of Regensburg, Regensburg, Germany
Lab Invest 84:465-78. 2004..The sFRP1 gene on chromosome 8p12-11.1 could be a candidate gene for the predicted, progression-related tumor suppressor gene in bladder cancer and could contribute to urothelial carcinogenesis... - Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancerErik Noetzel
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
BMC Cancer 8:154. 2008.... - CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survivalGlen Kristiansen
Institute of Pathology, Charite Hospital, Berlin, Germany
Am J Pathol 161:1215-21. 2002..Our data suggest that the expression of CD24 as detected by immunohistochemistry is a new independent molecular marker for shortened survival time of patients with epithelial ovarian carcinomas... - KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situAnja Dankof
Institute of Pathology, Campus Charite Mitte, Charite, Universitatsmedizin Berlin, Chariteplatz 1, 10098 Berlin, Germany
Virchows Arch 451:877-81. 2007..Additionally, KPNA2 is overexpressed in DCIS, particularly high grade lesions, which emphasizes its potential role in carcinogenesis of invasive breast carcinomas... - Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression?Glen Kristiansen
Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany
J Biol Chem 286:43417-28. 2011..Hypothetically, the mitochondrion-impairing role of MB in hypoxic cancer cells is part of a novel tumor-suppressive function... - Paradox of sonic hedgehog (SHH) transcriptional regulation: Alternative transcription initiation overrides the effect of downstream promoter DNA methylationAnette Ten Haaf
Molecular Oncology Group, Institute of Pathology, Medical Faculty of the RWTH Aachen University, Aachen, Germany
Epigenetics 6:465-77. 2011..These observations lead us to propose a transcriptional model for the SHH gene, in which combined mechanisms of DNA methylation and alternative promoter usage coordinate the transcriptional activity of this important developmental gene... - Insights from a whole cystectomy specimen--association of primary small cell carcinoma of the bladder with transitional cell carcinoma in situNadine Therese Gaisa
Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
Hum Pathol 39:1258-62. 2008..We provide, for the first time, molecular evidence for the development of invasive small cell carcinoma out of transitional cell carcinoma in situ... - Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissueMenelaos Zafrakas
Institute of Pathology, University Hospital of the RWTH, Aachen, Germany
Int J Cancer 118:1453-9. 2006..Altogether, these data suggest that GABRP is progressively down-regulated with tumour-progression, and that it may be useful as a prognostic marker in breast cancer... - RNA expression analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridizationJürgen Veeck
Molecular Oncology Group, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
Methods Mol Biol 664:135-50. 2010..A protocol is presented here that has been routinely and successfully used on FFPE tissues assembled on a tissue micro array (TMA)... - The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infectionHermann E Wasmuth
Medical Department III, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
J Hepatol 48:208-15. 2008..The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis... - Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humansHermann E Wasmuth
Department of Medicine III, University Hospital Aachen, Aachen, Germany
Gastroenterology 137:309-19, 319.e1-3. 2009..We investigated the roles of the chemokine CXCL9 and its receptor CXCR3 in liver fibrosis... - Systematic isolation of genes differentially expressed in normal and cancerous tissue of the pancreasRobert Grutzmann
Department of Visceral, Thoracic and Vascular Surgery, University Clinic Carl Gustav Carus, Technical University Dresden, Dresden, Germany
Pancreatology 3:169-78. 2003..Identification of these genes is essential for understanding the molecular events in the development of PaCa... - ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancerMarina Himmelfarb
metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
Cancer Lett 204:69-77. 2004..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development... - Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumorsEva Klopocki
, Berlin, Germany
Int J Oncol 25:641-9. 2004..04). In conclusion, expression of SFRP1 is commonly lost in breast cancer. SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer... - Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patientsGrit Kasper
Center for Musculoskeletal Surgery, Charite University Medicine Berlin, Berlin, Germany
Int J Cancer 117:961-73. 2005..Furthermore, our study presents a revised cDNA sequence of LIV-1 and demonstrates the localization of endogenous LIV-1 in the endoplasmic reticulum... - Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapyRadoslav Chekerov
Department of Obstetrics and Gynecology, Charite University Hospital, Campus Virchow, Berlin, Germany
Neoplasia 8:38-45. 2006..The aim of this study was to evaluate the expression of topoisomerase IIalpha (TOP2A) in epithelial and stromal cells of ovarian cancer... - Prognostic relevance of AGR2 expression in breast cancerFlorian Rudolf Fritzsche
Institute of Pathology and Breast Centre, Charite, Universitatsmedizin Berlin, Berlin, Germany
Clin Cancer Res 12:1728-34. 2006..We aimed to evaluate the expression of the human anterior gradient-2 (AGR2) in breast cancer on RNA and protein level and to correlate it with clinicopathologic data, including patient survival... - Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: association with tumor progressionDominique Koensgen
Department of Obstetrics and Gynecology, Charite University Hospital, Campus Virchow, Berlin, Germany
Gynecol Oncol 107:266-73. 2007..Expression of PAI-RBP1 (the new, approved gene symbol is SERBP1) has not been previously analyzed in human tumors. We present herein for the first time expression analysis of PAI-RBP1 in epithelial ovarian cancer... - Nuclear karyopherin alpha2 expression predicts poor survival in patients with advanced breast cancer irrespective of treatment intensityOleg Gluz
West German Study Group, Department of Gynaecology and Obstetrics, University Hospital Dusseldorf, Dusseldorf, Germany
Int J Cancer 123:1433-8. 2008..KPNA2 expression may be also considered as a marker for global chemoresistance, which can not be overcome by conventional dose-modification of chemotherapy in advanced breast cancer... - Different structural organization of the encephalopsin gene in man and mouseGrit Kasper
metaGen Pharmaceuticals, Oudenarderstrasse 16, 13347 Berlin, Germany
Gene 295:27-32. 2002..e. the number of genes within a certain cluster may differ between man and mouse. OPN3 provides an exception to this rule, since it is positionally uncoupled from other genes of the opsin family... - Sex selection: morality, harm, and the lawEdgar Dahl
Centre for Dermatology and Andrology, 14 Gaffky Street, Giessen, 35392, Germany
South Med J 100:105-6. 2007 - Tissue pretreatment with formic acid might lower HercepTest scores in breast cancerFlorian R Fritzsche
Institute of Pathology, , , 10117 Berlin
Diagn Mol Pathol 15:237-42. 2006..In these cases, a c-erbB2-FISH analysis should be performed. For the immunostaining of hormone receptors in breast cancer, formic acid pretreatment can be applied without negative effects on the sensitivity or specificity of the assay...