Research Topics
| Thomas BrandtSummaryAffiliation: University of Munich Country: Germany Publications
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Publications
Medical treatment of vestibular disordersThomas Brandt
Ludwig Maximilians University, Institute of Clinical Neuroscience, Marchioninistr 15, 81377 Munich, Germany
Expert Opin Pharmacother 10:1537-48. 2009..However, the majority of vestibular disorders have a benign cause, take a favorable natural course, and respond positively to therapy...
Spatial neglect: hypothetical mechanisms of disturbed interhemispheric crosstalk for orientationThomas Brandt
Institute of Clinical Neurosciences, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1164:216-21. 2009..The nondominant MSO in the left hemisphere might be involved in the manifestation of the less frequent and more transient right-sided neglect and in the plastic mechanisms of gradual recovery from a left-sided neglect or extinction...
General vestibular testingThomas Brandt
Department of Neurology, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
Clin Neurophysiol 116:406-26. 2005..It must, however, be kept in mind that all signs and ocular motor and vestibular findings have to be interpreted within the context of the patient's history and a complete neurological examination...
Expectation of sensory stimulation modulates brain activation during visual motion stimulationThomas Brandt
Department of Neurology, Ludwig Maximilans University, Marchioninistrasse 15, D 81377 Munich, Germany
Ann N Y Acad Sci 1039:325-36. 2005..If the sensed motion of a visual hemifield is larger than the predicted net motion in the model, activation of the respective neural population is increased; conversely, a smaller actual motion causes less activation...
Vestibular loss causes hippocampal atrophy and impaired spatial memory in humansThomas Brandt
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Brain 128:2732-41. 2005..g. without any actual vestibular or somatosensory stimulation...
[Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders]T Brandt
Institut für Klinische Neurowissenschaften, Klinikum Grosshadern, Universitat Munchen, Marchioninistrasse 15, 81377 Munchen, Deutschland
Nervenarzt 80:875-86. 2009..This should also be seen as an incentive that will attract the best young scientists; to incorporate IFB(LMU) competence into the existing medical and biological graduate schools. The IFB(LMU) is a unique reference center worldwide...
Benign paroxysmal positioning vertigo: a long-term follow-up (6-17 years) of 125 patientsThomas Brandt
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Acta Otolaryngol 126:160-3. 2006..The study disclosed a few predictive factors for benign paroxysmal positioning vertigo (BPPV) recurrences, which are clinically relevant and essential for patient awareness of the often long-term course of the condition...
Institutional profile: integrated center for research and treatment of vertigo, balance and ocular motor disordersThomas Brandt
Institute of Clinical Neurosciences, Ludwig Maximilian University, Klinikum Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
Restor Neurol Neurosci 28:135-43. 2010..This should also be seen as an incentive that will attract the best young scientists; to incorporate (IFB(LMU)) competence into the existing medical and biological graduate schools. The (IFB(LMU)) is a unique center - worldwide...
How to see what you are looking for in fMRI and PET--or the crucial baseline conditionT Brandt
Department of Neurology, University of Munich, Marchioninistr 15, 81377, Munich, Germany
J Neurol 253:551-5. 2006..Therefore, control conditions that are closest to the stimulus or task condition should be used as baseline in most fMRI and PET studies rather than absolute relaxation in darkness and silence (REST)...
Integrated center for research and treatment of vertigo, balance and ocular motor disordersThomas Brandt
Institute of Clinical Neurosciences, Ludwig Maximilian University, D 81377 Munich, Germany
Restor Neurol Neurosci 28:1-8. 2010..With funding of 50 euros million over a ten-year period, the long-term continuation of the IFB(LMU) is envisioned...
Brainstem and cerebellar fMRI-activation during horizontal and vertical optokinetic stimulationSandra Bense
Department of Neurology, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
Exp Brain Res 174:312-23. 2006..Consistent with the animal data, the dorsal ponto-medullary routes were involved bilaterally for hOKN, whereas the rostral mesencephalic routes were involved for vOKN...
Saccular function less affected than canal function in bilateral vestibulopathyVera C Zingler
Dept of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany
J Neurol 255:1332-6. 2008..The latencies P1 and N1 were not significantly different between patients and controls. Thus, in our study population saccular function appeared to be less affected than horizontal semicircular canal function...
Mind the bend: cerebral activations associated with mental imagery of walking along a curved pathJudith Wagner
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
Exp Brain Res 191:247-55. 2008..These data complement earlier findings on the role of anticipatory eye movements during initiation of turns and suggest that there is a very close neurophysiologic relation between locomotion and its mental imagery...
Unilateral vestibular failure suppresses cortical visual motion processingAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Brain 131:1025-34. 2008..This study provides for the first time neuroimaging evidence of suppressed cortical visual motion processing in patients with vestibulopathy...
Imaging human supraspinal locomotor centers in brainstem and cerebellumKlaus Jahn
Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
Neuroimage 39:786-92. 2008..This association suggests that deep brain stimulation of locomotion centers may provide new therapeutic approaches for common gait disorders...
Structural and functional plasticity of the hippocampal formation in professional dancers and slacklinersKatharina Hüfner
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Hippocampus 21:855-65. 2011..This is supported by the concomitant larger volumes in visual areas like the lingual and fusiform gyri. Our findings indicate that there is a spatial separation of vestibular and visual processes in the human hippocampus...
Fixation suppression of optokinetic nystagmus modulates cortical visual-vestibular interactionSandra Bense
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
Neuroreport 16:887-90. 2005....
Direction-dependent visual cortex activation during horizontal optokinetic stimulation (fMRI study)Sandra Bense
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
Hum Brain Mapp 27:296-305. 2006..Furthermore, no hemispheric dominance for OKN processing was found in right-handed volunteers...
Functional MRI of galvanic vestibular stimulation with alternating currents at different frequenciesThomas Stephan
Department of Neurology, Center for Sensorimotor Research, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 23, 81377 Munich, Germany
Neuroimage 26:721-32. 2005..These regions represent areas involved in the processing of vestibular information for head and body orientation in space...
Eyes open and eyes closed as rest conditions: impact on brain activation patternsEsther Marx
Center for Sensorimotor Research, Department of Neurology, Ludwig Maximilians University, 81377 Munich, Germany
Neuroimage 21:1818-24. 2004..Activity of the ocular motor system as well as deactivation of sensory cortical areas may go undetected with eyes open as rest condition...
Brain activation patterns during imagined stance and locomotion in functional magnetic resonance imagingKlaus Jahn
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich 81377, Germany
Neuroimage 22:1722-31. 2004..Postural control during standing involves a low intensity cerebellar activity and sensorimotor control via the thalamus and basal ganglia...
The presence of lytic HSV-1 transcripts and clonally expanded T cells with a memory effector phenotype in human sensory gangliaTobias Derfuss
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1164:300-4. 2009..Thus, HSV-1 IE genes are expressed in human TG, and the infiltrating T cells bear several characteristics that suggest viral antigenic stimulation...
Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentationKatharina Hüfner
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Hippocampus 17:471-85. 2007..Volumetry did not reveal any atrophy of the hippocampus in either patient group...
Areas MT/V5 and their transcallosal connectivity in cortical dysplasia by fMRIEva Riedel
Department of Neurology, Ludwig Maximilians University Munich, Klinikum Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
Neuroreport 15:1877-81. 2004..Thus, fMRI is a suitable tool for detecting preserved function and transcallosal connections in patients with focal cortical dysplasia...
fMRI signal increases and decreases in cortical areas during small-field optokinetic stimulation and central fixationMarianne Dieterich
Department of Neurology, Johannes Gutenberg University Mainz, Mainz, Germany
Exp Brain Res 148:117-27. 2003..Both probably correspond to different subregions of the frontal eye field and the premotor cortex for the ocular motor performance of OKN...
Eccentric eye and head positions in darkness induce deviation from the intended pathKlaus Jahn
Klinikum Grosshadern, Department of Neurology, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Exp Brain Res 174:152-7. 2006..The direction of deviation may reflect the compensation of an expected or perceived deviation in the direction of gaze...
Imaging the visual autokinetic illusion with fMRIEva Riedel
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
Neuroimage 27:163-6. 2005..This second half of the period was associated with bilateral activations in the motion-sensitive middle occipito-temporal area known as MT/V5. Our finding suggests that area MT/V5 is involved in the mediation of autokinesis...
Long-term course and relapses of vestibular and balance disordersThomas Brandt
Institute of Clinical Neurosciences, Germany Integrated Center for Research and Treatment of Vertigo, Balance and Ocular Motor Disorders, Ludwig Maximilian University, Klinikum Grosshadern, Marchioninistr 15, D 81377 Munich, Germany
Restor Neurol Neurosci 28:69-82. 2010....
Imagined locomotion in the blind: an fMRI studyAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Neuroimage 45:122-8. 2009..This is accompanied by enhanced voluntary motor control and enhanced motor-kinesthetic processing. Thus, we provide neuroimaging evidence of distinct sensorimotor strategies in the blind for locomotor control...
Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetriesKlaus Jahn
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1004:485-9. 2003..It is necessary to know the normal range of asymmetry between left- and right-sided stimulation to interpret GVS responses in patients with vestibular diseases...
Aminopyridines for the treatment of cerebellar and ocular motor disordersMichael Strupp
Department of Neurology, University of Munich, Klinikum Grosshadern, Munich, Germany
Prog Brain Res 171:535-41. 2008..In conclusion, the use of aminopyridines in DBN, UBN, and EA2 is a new treatment principle for vestibular, cerebellar, and ocular motor disorders...
Supraspinal locomotor control in quadrupeds and humansKlaus Jahn
Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
Prog Brain Res 171:353-62. 2008..It is conceivable that electrical stimulation of locomotor brain stem centres may initiate and improve gait in selected patients suffering from Parkinson's disease or progressive supranuclear palsy...
Motivating motorists to voluntarily slow downRainer Spiegel
Department of Neurology, Ludwig Maximilians University, Munich, Germany
J Prev Interv Community 38:332-40. 2010..The intervention is a speed-displaying device mounted next to the road (visible to both motorists and the public). Our findings indicate that the device is associated with a significant speed reduction relative to the control condition...
4-aminopyridine restores vertical and horizontal neural integrator function in downbeat nystagmusRoger Kalla
Department of Neurology, Ludwig Maximilian University, Munich, Germany
Brain 130:2441-51. 2007..It may work best when DBN is associated with cerebellar atrophy. Furthermore, 4-AP may be a promising treatment option for patients with a dominant gaze-evoked component of nystagmus, regardless of its etiology...
Comparison of 10-mg doses of 4-aminopyridine and 3,4-diaminopyridine for the treatment of downbeat nystagmusRoger Kalla
Department of Neurology and IFB, Munich University Hospital, Campus Grosshadern, Munich, Germany
J Neuroophthalmol 31:320-5. 2011..In this double-blind, prospective, crossover study, the effects of equivalent doses of 4-AP and 3,4-DAP on the slow-phase velocity (SPV) of downbeat nystagmus were compared...
Gait deviations induced by visual stimulation in rollErich Schneider
Department of Neurology, University Hospital of Munich Grosshadern Ludwig Maximilians University, Marchioninistr 23, 81377, Munich, Germany
Exp Brain Res 185:21-6. 2008..Both kinds of stimulation cause only initial balance responses in the roll plane but do not contribute to the steering of gait in the yaw plane...
Fewer latent herpes simplex virus type 1 and cytotoxic T cells occur in the ophthalmic division than in the maxillary and mandibular divisions of the human trigeminal ganglion and nerveKatharina Hüfner
Department of Neurology, Klinikum Grosshadern, Marchioninistr 23, 81377 Munich, Germany
J Virol 83:3696-703. 2009..In conclusion, the large accumulation of LAT and cytotoxic T cells in the V2 and V3 but not in the V1 division of the TG reflects the sites supplied by the sensory fibers and the clinical reactivation patterns...
Rollvection versus linearvection: comparison of brain activations in PETAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Hum Brain Mapp 21:143-53. 2004..Both stimuli led to simultaneous deactivations of retroinsular regions (more pronounced during linearvection); this is compatible with an inhibitory interaction between the visual and the vestibular systems for motion perception...
The prevalence of human herpesvirus 6 in human sensory ganglia and its co-occurrence with alpha-herpesvirusesKatharina Hüfner
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 23, Munich, Germany
J Neurovirol 13:462-7. 2007..As HHV-6 positivity did not depend on the presence of inflammatory cells, known to harbor the virus, HHV-6 probably resides in the ganglia themselves...
Immunosuppressive treatment in bilateral vestibulopathy with inner ear antibodiesAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Acta Otolaryngol 125:848-51. 2005..These data do not allow us to generally recommend corticosteroid treatment in patients with BVF and inner ear antibodies...
Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal gangliaTobias Derfuss
Institute of Clinical Neuroimmunology, University Clinic, Munich, Germany
Brain Pathol 17:389-98. 2007..Thus, HSV-1 IE genes are expressed in human TG and the infiltrating T-cells bear several characteristics that suggest viral antigenic stimulation...
Vestibular cortex activation during locomotor imagery in the blindAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1164:350-2. 2009..Thus, this fMRI study provides neuroimaging evidence for distinct cortical processing in the multisensory vestibular system in the blind during locomotor control...
Nicotine-induced nystagmus correlates with midpontine activationAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
Neuroimage 41:479-82. 2008....
Causative factors and epidemiology of bilateral vestibulopathy in 255 patientsVera C Zingler
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Ann Neurol 61:524-32. 2007..To determine the causative factors and epidemiology of bilateral vestibulopathy (BV)...
Eye movements and balanceMichael Strupp
Department of Neurology, University of Munich, Klinikum Grosshadern, Munich, Germany
Ann N Y Acad Sci 1004:352-8. 2003
Visual-vestibular and visuovisual cortical interaction: new insights from fMRI and petThomas Brandt
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, 81366 Munich, Germany
Ann N Y Acad Sci 956:230-41. 2002..In terms of mathematical modeling, these findings may reflect the concepts of a sensory conflict mechanism or a mismatch between expected and actual sensory input...
Latency of herpes simplex virus type-1 in human geniculate and vestibular ganglia is associated with infiltration of CD8+ T cellsViktor Arbusow
Clinic of Neurology am Marienplatz, Munich, Germany
J Med Virol 82:1917-20. 2010..Colocalization of latent HSV-1 and CD8+ T cells in geniculate and vestibular ganglia supports further the hypothesis that HSV-1 reactivation is possible in these ganglia and is the cause of Bell's palsy and vestibular neuritis...
Central oculomotor disturbances and nystagmus: a window into the brainstem and cerebellumMichael Strupp
Neurologische Klinik und Integriertes Forschungs und Behandlungszentrum für Schwindel, Gleichgewichts und Agenbewegungsstörungen, Institut für Klinische Neurowissenschaften, Ludwig Maximilians Universitat, Munchen, Germany
Dtsch Arztebl Int 108:197-204. 2011..This review deals mainly with central oculomotor disturbances, i.e., those involving smooth pursuit, saccades, gaze-holding, and central types of nystagmus...
Eye closure in darkness animates sensory systemsEsther Marx
Center for Sensorimotor Research, Department of Neurology, Ludwig Maximilians University, 81377 Munich, Germany
Neuroimage 19:924-34. 2003..Our study also shows that the chosen baseline condition may have a considerable impact on activation patterns and on the interpretation of brain activation studies...
Human hippocampal activation during stance and locomotion: fMRI study on healthy, blind, and vestibular-loss subjectsKlaus Jahn
Ludwig Maximilians University, Klinikum Grosshadern, Department of Neurology, Marchioninistrasse, Munich, Germany
Ann N Y Acad Sci 1164:229-35. 2009..The right-sided dominance reflects the importance of the right hemisphere for spatial orientation...
Spatial separation of visual and vestibular processing in the human hippocampal formationKatharina Hüfner
Department of Neurology Integrated Center for Research and Treatment of Vertigo IFBLMU, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1233:177-86. 2011....
Sensory system interactions during simultaneous vestibular and visual stimulation in PETAngela Deutschlander
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Hum Brain Mapp 16:92-103. 2002..The findings are consistent with the concept of an inhibitory reciprocal vestibulo-visual interaction in all three stimulus conditions...
Cerebellar and visual gray matter brain volume increases in congenital nystagmusKatharina Hüfner
Department of Neurology, Hospital of the University of Munich, Ludwig Maximilians University Munich, Germany
Front Neurol 2:60. 2011....
A clinical test of otolith function: static ocular counterroll with passive head tiltVera C Zingler
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Neuroreport 17:611-5. 2006..Utricular function can thus be tested simply by measuring passive head tilt with video-oculography...
An ipsilateral vestibulothalamic tract adjacent to the medial lemniscus in humansAndreas Zwergal
Department of Neurology, University of Munich, Klinikum Grosshadern, Munich, Germany
Brain 131:2928-35. 2008....
Spatial memory deficits in patients with chronic bilateral vestibular failureFranz Schautzer
Ludwig Maximilians University, 81377 Munich, Germany
Ann N Y Acad Sci 1004:316-24. 2003..These deficits can even be demonstrated with the subjects stationary, i.e., without any actual vestibular or somatosensory stimulation...
Suppression of eye movements improves balanceKlaus Jahn
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377 Munich, Germany
Brain 125:2005-11. 2002..Thus, ocular motor signals rather than afferent visual cues about retinal slip are used for visual control of postural sway, at least in this experimental paradigm...
Prevalence and distribution of HSV-1, VZV, and HHV-6 in human cranial nerve nuclei III, IV, VI, VII, and XIIDiethilde Theil
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
J Med Virol 74:102-6. 2004..The absence of LAT in the samples positive for HSV-1 and the distribution of HSV-1 and HHV-6 do not support the hypothesis that idiopathic cranial nerve palsies result from viral reactivation in the brainstem nuclei...
Clinical, electrophysiological, and MRI findings in patients with cerebellar ataxia and a bilaterally pathological head-impulse testHanni Kirchner
Department of Neurology and IFB LMU Institute for Clinical Neurosciences, University Hospital Munich, Munich, Germany
Ann N Y Acad Sci 1233:127-38. 2011..This multisensory syndrome is most likely caused by a neurodegenerative disorder affecting different systems, leading to severe impairment of affected patients...
Latent herpesvirus infection in human trigeminal ganglia causes chronic immune responseDiethilde Theil
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Am J Pathol 163:2179-84. 2003..The chronic immune response seems to maintain viral latency and influence viral reactivation...
Thalamic infarctions cause side-specific suppression of vestibular cortex activationsM Dieterich
Department of Neurology, Johannes Gutenberg University, Langenbeckstrasse1, 55131 Mainz, Germany
Brain 128:2052-67. 2005..Furthermore, the normal interaction between the two sensory systems--the vestibular and the visual--appears to be impaired...
Bedside differentiation of vestibular neuritis from central "vestibular pseudoneuritis"C D Cnyrim
Department of Neurology, University of Munich, Marchioninistr 15, D 81377 Munich, Germany
J Neurol Neurosurg Psychiatry 79:458-60. 2008..None of the other isolated signs (head thrust test, saccadic pursuit, gaze evoked nystagmus, subjective visual vertical) were reliable; however, multivariate logistic regression increased their sensitivity and specificity to 92%...
Gray-matter atrophy after chronic complete unilateral vestibular deafferentationKatharina Hüfner
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1164:383-5. 2009..In comparison to healthy controls, no regional increases in gray-matter volume were seen. No white-matter changes were detected at the selected threshold...
Causative factors, epidemiology, and follow-up of bilateral vestibulopathyVera Carina Zingler
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1164:505-8. 2009..0 +/- 1.4 degrees/s vs. 1.9 +/- 1.6 degrees/s). Forty-three percent of patients subjectively rated the course of their disease as stable, 28% as worsened, and 29% as improved...
Imaging cortical activity after vestibular lesionsMarianne Dieterich
Ludwig Maximilians University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
Restor Neurol Neurosci 28:47-56. 2010....
Medial vestibular nucleus lesions in Wallenberg's syndrome cause decreased activity of the contralateral vestibular cortexMarianne Dieterich
Department of Neurology, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, D 55131 Mainz, Germany
Ann N Y Acad Sci 1039:368-83. 2005..Thus, the activation pattern in the PET study may reflect the vestibular tonic imbalance within the vestibular nuclei circuitry at the cortical level...
Inverse U-shaped curve for age dependency of torsional eye movement responses to galvanic vestibular stimulationKlaus Jahn
MD Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
Brain 126:1579-89. 2003..Thus, the compensatory increase in sensitivity breaks down and GVS-induced eye movements decline-a finding that is reflected by the inverse U-shaped curve for age dependency presented in this study...
Methylprednisolone, valacyclovir, or the combination for vestibular neuritisMichael Strupp
Department of Neurology, University of Munich, Munich, Germany
N Engl J Med 351:354-61. 2004..Its assumed cause is a reactivation of herpes simplex virus type 1 infection. Therefore, corticosteroids, antiviral agents, or a combination of the two might improve the outcome in patients with vestibular neuritis...
Vestibular system: anatomy and functional magnetic resonance imagingM Dieterich
Neurology Department, Neurologische Klinik, Klinikum Grosshadern, Munich, Germany
Neuroimaging Clin N Am 11:263-73, ix. 2001....
Metabolic changes in vestibular and visual cortices in acute vestibular neuritisSandra Bense
Department of Neurology, Johannes Gutenberg University, Mainz, Germany
Ann Neurol 56:624-30. 2004..Contrary to experimental vestibular stimulation, the activation of the vestibular cortex was not bilateral but was unilateral and contralateral to the right-sided labyrinthine failure...
Highly variable distribution of HSV-1-specific DNA in human geniculate, vestibular and spiral gangliaP Schulz
Department of Neurology, Klinikum Grosshadern, University of Munich, Germany
Neurosci Lett 252:139-42. 1998..All combinations of positive and negative ganglia were found in individual temporal bones at roughly equal frequencies. These data support a viral etiology of all three conditions, especially their occasional combinations...
Smoking and balance: correlation of nicotine-induced nystagmus and postural body swayC B Pereira
Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
Neuroreport 12:1223-6. 2001..Transient ocular motor and postural effects are compatible with simultaneous nicotine-induced effects on the vestibulo-ocular and vestibulo-spinal functions...
Low recurrence rate of vestibular neuritis: a long-term follow-upD Huppert
Department of Neurology, Klinikum Grosshadern, Marchioninistrasse 15, , Germany
Neurology 67:1870-1. 2006..VN affected the contralateral ear in both and caused less severe distressing vertigo and postural imbalance. Unlike Bell's palsy and sudden hearing loss, a relapse in the same ear did not occur...
Handing over a cube: spatial features of physical joint-actionMarkus Huber
Center for Sensorimotor Research and Department of Clinical Neurosciences, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Ann N Y Acad Sci 1164:380-2. 2009..In contrast, the spatial position of the handover was found to be invariant and trial-independent. Thus, our results suggest that physical joint-action is guided by on-line adaptation and a priori assumptions...
Changes in cerebellar activation pattern during two successive sequences of saccadesThomas Stephan
Center for Sensorimotor Research, Department of Neurology, Ludwig Maximilians University, Munich, Germany
Hum Brain Mapp 16:63-70. 2002..These findings indicate that similar effects may bias other cerebellar activation studies, in which sensorimotor tasks are repeated in a single session...
Parallel ascending vestibular pathways: anatomical localization and functional specializationAndreas Zwergal
Department of Neurology, Ludwig Maximilians University of Munich, Munich, Germany
Ann N Y Acad Sci 1164:51-9. 2009....
Which medication do I need to manage dizzy patients?Doreen Huppert
Institute of Clinical Neurosciences, University of Munich, Germany
Acta Otolaryngol 131:228-41. 2011....
Artificial neural network: a new diagnostic posturographic tool for disorders of stanceSiegbert Krafczyk
Department of Neurology, University of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
Clin Neurophysiol 117:1692-8. 2006..To determine the accuracy of diagnoses made with artificial neural network techniques (ANNW) that identify postural sway patterns typical for balance disorders...
The effect of dual tasks in locomotor path integrationStefan Glasauer
Institute of Clinical Neurosciences, Ludwig Maximilians University, Munich, Germany
Ann N Y Acad Sci 1164:201-5. 2009..Alternatively, path integration and duration estimation may be based on similar underlying neuronal mechanisms, for example, coincidence detection in neural oscillators...
Dually infected (HSV-1/VZV) single neurons in human trigeminal gangliaDiethilde Theil
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 23, 81377 Munich, Germany
Ann Neurol 54:678-82. 2003..Latency transcripts of both viruses were detected in common areas within the ganglia. Also, a few single neurons were shown to harbor HSV-1 and VZV together...
Noncommutative updating of perceived self-orientation in three dimensionsStefan Glasauer
Department of Neurology with Center for Sensorimotor Research, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
J Neurophysiol 97:2958-64. 2007..Thus perceived final orientation was independent of the path taken, i.e., the noncommutativity of rotations was taken into account...
Episodic ataxia type 2Michael Strupp
Department of Neurology, University of Munich, Munich, Germany
Neurotherapeutics 4:267-73. 2007..Many aspects of the pathophysiology (e.g., induction of the attacks) and treatment of EA 2 (e.g., mode of action of ACTZ and 4-AP) still remain unclear and need to be addressed in further animal and clinical studies...
Inhibitory interhemispheric visuovisual interaction in motion perceptionThomas Brandt
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, 81377 Munich, Germany
Ann N Y Acad Sci 1004:283-8. 2003....
Central compensation of deviated subjective visual vertical in Wallenberg's syndromeChristian Daniel Cnyrim
Department of Neurology, University of Munich, Marchioninistr 15, D 81377 Munich, Germany
J Neurol Neurosurg Psychiatry 78:527-8. 2007..This finding shows that the time courses of the central compensation for dorsolateral medullary infarctions and peripheral vestibular lesions are similar...
Functional output improvement in FES cycling by means of forced smooth pedalingJohann Szecsi
Center for Sensorimotor Research, Department of Neurology, Ludwig Maximillians University, Munich, Germany
Med Sci Sports Exerc 39:764-80. 2007..Investigation of the influence of forced smooth and normal (nonsmooth) pedaling on the functional output of outdoor functional neuromuscular electrical stimulation (FES)-propelled cycling of spinal cord-injured subjects...
Long-term course of Menière's disease revisitedDoreen Huppert
Institute of Clinical Neurosciences, University of Munich, Munich, Germany
Acta Otolaryngol 130:644-51. 2010..The investigated studies disclose a large variability of the many symptoms appearing in the course of Menière's disease...
Vestibular neuritisMichael Strupp
Department of Neurology, University of Munich, Munich, Germany
Semin Neurol 29:509-19. 2009....
Stent grafting resolved brachial plexus neuropathy due to cervical arteriovenous fistulaVera Carina Zingler
Department of Neurology, University of Munich, Munich, Germany
Eur Neurol 52:250-1. 2004
Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosisVera Carina Zingler
Department of Neurology, University of Munich, Munich, Germany
Eur Neurol 54:28-33. 2005..Mitoxantrone did not cause signs of congestive heart failure in any of the patients. Further cardiac monitoring is, however, needed to determine the safety of mitoxantrone after longer follow-up times and at higher cumulative doses...
Vestibular brainstem disorders: clinical syndromes in roll plane and their model simulationThomas Brandt
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Munich, Germany
Mov Disord 17:S58-62. 2002
Effect of 4-aminopyridine on upbeat and downbeat nystagmus elucidates the mechanism of downbeat nystagmusStefan Glasauer
Center for Sensorimotor Research, Department of Neurology, Ludwig Maximilian University, Munich, Germany
Ann N Y Acad Sci 1039:528-31. 2005..We hypothesize that this difference in the effects of 4-AP, which is known to increase the excitability of cerebellar Purkinje cells, can be attributed to the different lesion sites involved in UBN and DBN...
Hemihypomimia in Parkinson's diseaseVera C Zingler
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany
Eur Neurol 53:92-3. 2005
Documentation and teaching of surgery with an eye movement driven head-mounted camera: see what the surgeon sees and doesErich Schneider
Hospital of the University of Munich, Department of Neurology, D 81377 Munich, Germany
Stud Health Technol Inform 119:486-90. 2006..Various documentation and teaching applications in health care, industry, and research are conceivable...
Phobic postural vertigo. Body sway during visually induced roll vectionVeronika Querner
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Marchioninistr 15, 81377 Munich, Germany
Exp Brain Res 143:269-75. 2002..The data support the second explanation...
Stimulus profile and modeling of continuous galvanic vestibular stimulation in functional magnetic resonance imagingThomas Stephan
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munchen, Germany
Ann N Y Acad Sci 1164:472-5. 2009..In addition, the separate modeling of transient and persistent effects of DC-GVS can identify distinct cortical correlates of those effects...
Bilateral vestibular failure as an early sign in Creutzfeldt-Jakob diseaseKlaus Jahn
Departments of Neurology, of Neurology, Klinikum Grosshadern Marchioninistrasse 15, 81377 Munich, Germany
Ann N Y Acad Sci 1164:390-3. 2009..The vestibular nuclei are known to be severely affected in animal spongiform encephalopathies. They might also be a vulnerable target in human prion diseases...
A bucket of static vestibular functionA Zwergal
Department of Neurology, Ludwig Maximilians University, Klinikum Grosshadern, Klinikum Grosshadern, Germany
Neurology 72:1689-92. 2009..Validation of a bedside test to measure the monocular and binocular subjective visual vertical (SVV)...
Unilateral INO is associated with ocular tilt reaction in pontomesencephalic lesions: INO plusA Zwergal
Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, D 81377 Munich, Germany
Neurology 71:590-3. 2008..Correlation of internuclear ophthalmoplegia (INO) with components of the ocular tilt reaction (OTR) in order to localize graviceptive (specifically otolithic) pathways in the brainstem...
Structural and functional MRIs disclose cerebellar pathologies in idiopathic downbeat nystagmusK Hufner
Department of Neurology, Klinikum Grosshadern, Neurologisches Forschungshaus, Munich, Germany
Neurology 69:1128-35. 2007..Forty percent of patients with DBN are classified as having idiopathic DBN, because no underlying pathology can be demonstrated by conventional MRI or laboratory tests...
Vestibular paroxysmia: diagnostic features and medical treatmentK Hufner
Department of Neurology, Klinikum Grosshadern, Neurologisches Forschungshaus, Munich, Germany
Neurology 71:1006-14. 2008..Although VP was described more than 30 years ago by Jannetta and colleagues, we still need more reliable data on its diagnostic features and the efficacy of medical treatment...
