Research Topics
Species | Rainer BirckSummaryAffiliation: University of Heidelberg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritisRainer Birck
Fifth Department of Medicine, University Hospital Mannheim, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
Nephrol Dial Transplant 21:58-63. 2006....- Serial ANCA determinations for monitoring disease activity in patients with ANCA-associated vasculitis: systematic reviewRainer Birck
Fifth Department of Medicine, University Hospital Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
Am J Kidney Dis 47:15-23. 2006..To assess the diagnostic value of serial ANCA testing in the follow-up of patients with AASV, we conducted a systematic review of the available literature... - [Rapidly progressive glomerulonephritis:classification, pathogenesis and clinical management]R Birck
V Medizinische Klinik Universitätsklinikum Mannheim, Fakultät für Klinische Medizin der Universität Heidelberg, Mannheim, Germany
Internist (Berl) 44:1107-19. 2003..Some forms also require the use of plasma exchange therapy. Rapid diagnosis and early therapy improves both renal and overall outcome in the affected patients... - Acetylcysteine for prevention of contrast nephropathy: meta-analysisRainer Birck
Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
Lancet 362:598-603. 2003..We aimed to assess the efficacy of acetylcysteine to prevent contrast nephropathy after administration of radiocontrast media in patients with chronic renal insufficiency... - ANCA-associated vasculitis following influenza vaccination: causal association or mere coincidence?Rainer Birck
Fifth Department of Medicine, University Hospital Mannheim, Germany
J Clin Rheumatol 15:289-91. 2009..Although our report does not prove a causal association between vaccination and vasculitis, it seems possible that in rare cases vaccination might induce vasculitic disease... - Donor desmopressin is associated with superior graft survival after kidney transplantationUrs Benck
5th Department of Medicine, University Medical Centre Mannheim, Mannheim, Germany
Transplantation 92:1252-8. 2011..gov Identifier: NCT00115115). This study determines whether donor exposure to desmopressin (1-deamino-8-d-arginine-vasopressin [DDAVP]) before organ retrieval affects renal transplant outcome... - SCG/Kinjoh mice: a model of ANCA-associated crescentic glomerulonephritis with immune depositsIrmgard Neumann
Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
Kidney Int 64:140-8. 2003..However, the spontaneous and concomitant development of pANCA, small vessel vasculitis, and CGN raises the opportunity to analyze pathogenetic links between these disease manifestations in vivo... - Effects of N-acetylcysteine on renal hemodynamics in contrast media-induced nephropathyStefan Krzossok
Fifth Medical Department, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Mannheim, Germany
Kidney Blood Press Res 34:125-34. 2011..Conclusions: Renal perfusion is not affected by NAC application in a model of experimental contrast nephropathy in rats. Other effects of NAC might thus account for the presumed renoprotective properties... - Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneysUwe Gottmann
V Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
Transpl Int 20:542-9. 2007..Chemically modified heparins without anticoagulatory effects may offer a new treatment option in preventing I/R injury and CAN in human kidney transplantation... - Prolonged treatment of refractory Wegener's granulomatosis with 15-deoxyspergualin: an open study in seven patientsWilhelm H Schmitt
Fifth Medical Clinic, University Hospital Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
Nephrol Dial Transplant 20:1083-92. 2005..A 6 month course of the immunosuppressant 15-deoxyspergualin (DSG) has previously been employed successfully in these refractory cases. However, there are no reports on long-term treatment with DSG... - Dopamine treatment in brain-dead rats mediates anti-inflammatory effects: the role of hemodynamic stabilization and D-receptor stimulationSimone Hoeger
Department of Medicine V, University Medical Center Mannheim, University of Heidelberg, Germany, and Départment de Médecine, Interne et Néphrologie, Centre Hospitalier Kirchberg, Luxembourg
Transpl Int 20:790-9. 2007..Hence, DA might reduce BD-induced monocyte infiltration possibly by hemodynamic stabilization, D-receptor activation, or a combination of both... - Effects of donor pretreatment with dopamine on graft function after kidney transplantation: a randomized controlled trialPeter Schnuelle
University Medical Centre Mannheim, 5th Department of Medicine, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
JAMA 302:1067-75. 2009..Kidney graft function after transplantation can be improved through pharmacological donor pretreatment to limit organ injury from cold preservation... - 15-Deoxyspergualin in patients with refractory ANCA-associated systemic vasculitis: a six-month open-label trial to evaluate safety and efficacyRainer Birck
Department of Nephrology, University Hospital Mannheim, Mannheim, Germany
J Am Soc Nephrol 14:440-7. 2003..It is concluded that treatment with DSG is successful in patients with refractory Wegener granulomatosis under careful monitoring of WBC count... - Effects of donor pre-treatment with dopamine on survival after heart transplantation: a cohort study of heart transplant recipients nested in a randomized controlled multicenter trialUrs Benck
University Medical Centre Mannheim, Mannheim, Germany
J Am Coll Cardiol 58:1768-77. 2011..We determined the outcome of cardiac allografts from multiorgan donors enrolled in a randomized trial of donor pre-treatment with dopamine... - Persistent T-cell activation and clinical correlations in patients with ANCA-associated systemic vasculitisSmaragdi Marinaki
Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68135 Mannheim, Germany
Nephrol Dial Transplant 21:1825-32. 2006..These phenotypes are persistent and do not reflect disease activity. PTA predominantly occurs in patients with severe disease. This might explain the higher cumulative cyclophosphamide dose found in these patients... - Treatment of proteinuria with low-molecular-weight heparin after renal transplantationStefan Krzossok
Fifth Medical Clinic, Nephrology Endocrinology Rheumatology, University Hospital of Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Transpl Int 17:468-72. 2004..This approach might represent a promising new strategy for treatment of proteinuria after kidney transplantation... - Retinoid X receptor beta polymorphisms do not explain functional differences in vitamins D and A response in Antineutrophil cytoplasmic antibody associated vasculitis patientsAnna Isabelle Kälsch
Fifth Department of Medicine, University Hospital Mannheim, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany
Autoimmunity 42:467-74. 2009..Since the inhibition of TNFalpha was more effective in patients, vitamin D supplementation might be an additional therapeutical approach... - Modulation of brain dead induced inflammation by vagus nerve stimulationS Hoeger
Department of Medicine V Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, and Clinic for Anaesthesiology and Intensive Care Medicine, University Hospital of Mannheim, Mannheim, Germany
Am J Transplant 10:477-89. 2010..Vagus nerve stimulation variably affected gene expression in donor organs and improved renal function in recipients... - Therapeutic administration of an endothelin-A receptor antagonist after acute ischemic renal failure dose-dependently improves recovery of renal functionT Knoll
Department of Urology, University Hospital Mannheim, Faculty of Clinical Medicine of the University of Heidelberg, Germany
J Cardiovasc Pharmacol 37:483-8. 2001..It can be concluded from these results that recovery from ischemic ARF is significantly and dose-dependently enhanced by treatment with a selective ET(A)-receptor antagonist... - Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot studyA Lammert
V Medizinische Klinik, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
Exp Clin Endocrinol Diabetes 116:132-4. 2008..To evaluate the potential effectiveness of 'carbohydrate days' as a dietary intervention to overcome insulin resistance in type 2 diabetes... - The renoprotective potential of endothelin receptor antagonistsT Knoll
Department of Urology, University Hospital Mannheim, University of Heidelberg, Germany Faculty of Clinical Medicine of the University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68135 Mannheim, Germany
Expert Opin Investig Drugs 9:1041-52. 2000..So far, most data were derived from animal models, but they provide strong evidence that endothelin receptor antagonists may represent a powerful therapeutic strategy in ameliorating the course of acute and chronic renal failure... - Impact of donor dopamine on immediate graft function after kidney transplantationP Schnuelle
Vth Medical Clinic Department of Nephrology and Endocrinology, University Hospital Mannheim, Mannheim, Germany
Am J Transplant 4:419-26. 2004..The beneficial effect of dopamine is achievable without side-effects for the recipients, and correlates with superior long-term graft survival... - In vivo effects of cyclic administration of 15-deoxyspergualin on leucocyte function in patients with Wegener's granulomatosisA I Kälsch
Department of Clinical Chemistry, University Hospital Mannheim, University of Heidelberg, Germany
Clin Exp Immunol 146:455-62. 2006..Our data demonstrate that DSG influences T cell and monocyte activation in a reversible fashion. Although DSG causes neutropenia in these patients, it does not influence neutrophil function... - Abnormalities of CD4 T cell subpopulations in ANCA-associated vasculitisS Marinaki
Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Germany
Clin Exp Immunol 140:181-91. 2005..These findings were confined to the memory population of CD4(+) cells. We conclude that AAV patients are lymphopenic and have low numbers of CD4(+) T cells, which seem to be in a persistent state of activation... - Use of highly sensitive C-reactive protein for followup of Wegener's granulomatosisAnna Isabelle Kälsch
Fifth Medical Department, University Medical Centre Mannheim, Medical Faculty of Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, D 68187 Mannheim, Germany
J Rheumatol 37:2319-25. 2010..We evaluated whether during remission elevated highly sensitive CRP (hsCRP) precedes relapse as a marker of subclinical inflammation and thus might improve clinical assessment... - Comparison of early renal function parameters for the prediction of 5-year graft survival after kidney transplantationPeter Schnuelle
University Hospital Mannheim, Vth Medical Clinic, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
Nephrol Dial Transplant 22:235-45. 2007..Early graft function (EGF) has an enduring effect on the subsequent course after kidney transplantation. This study compares quantitative parameters of EGF for the prediction of graft survival... - Targets for endothelin in the diseased kidney: clues for therapeutic interventionP Rohmeiss
Fifth Department of Medicine, University Hospital Mannheim, University of Heidelberg, Germany
Exp Nephrol 7:1-10. 1999..Future developments concerning the use of endothelin receptor antagonists and the role of endothelin in the kidney transplantation setting are discussed... - Imatinib mesylate, a new kid on the block for the treatment of anti-neutrophil cytoplasmic autoantibodies-associated vasculitis?A I Kälsch
Fifth Medical Department, University Hospital Mannheim, Medical Faculty of Mannheim of the University of Heidelberg, Germany
Clin Exp Immunol 151:391-8. 2008..These observed effects of imatinib were similar in T cells from AASV patients and from healthy individuals. Imatinib might be an alternative therapeutical option for AASV patients refractory to conventional therapy... - Increased activity of the renal kallikrein-kinin system in autosomal dominant polycystic kidney disease in rats, but not in humansClaude Braun
Fifth Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, D 68135 Mannheim, Germany
Int Immunopharmacol 2:1949-56. 2002..These data indicate that there are fundamental differences in the factors influencing the course of the disease in human and rat ADPKD... - Inhibition of neutrophil-mediated production of reactive oxygen species (ROS) by endothelial cells is not impaired in anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis patientsF Al Laham
Vth Medical Department, University Medical Centre Mannheim, University of Heidelberg, Mannheim, Germany
Clin Exp Immunol 161:268-75. 2010..Our data do not support the hypothesis that endothelial cells inhibit ROS production of neutrophils from AAV patients inadequately. Impaired neutrophil degranulation may exist in active patients, but this finding needs to be confirmed... - Nephropathy induced by contrast mediumClaude Braun
N Engl J Med 348:2257-9; author reply 2257-9. 2003 - Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritisIrmgard Neumann
Department of Nephrology, Wilhelminenspital, Vienna, Austria
Nephrol Dial Transplant 18:524-31. 2003..In some patients, however, significant amounts of immune deposits may be detected. Therefore, we evaluated the clinical significance of these immune deposits in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune CGN...