Franz X Beck

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Relationship between intracellular ionic strength and expression of tonicity-responsive genes in rat papillary collecting duct cells
    Wolfgang Neuhofer
    Physiologisches Institut, , Germany
    J Physiol 543:147-53. 2002
  2. ncbi Cellular response to osmotic stress in the renal medulla
    F X Beck
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Pflugers Arch 436:814-27. 1998
  3. ncbi Inner-medullary organic osmolytes and inorganic electrolytes in K depletion
    F X Beck
    Physiologisches Institut der Universität München, Munich, Germany
    Pflugers Arch 439:471-6. 2000
  4. ncbi Molecular chaperones in the kidney: distribution, putative roles, and regulation
    F X Beck
    Physiologisches Institut der Universität München, Munich, Germany
    Am J Physiol Renal Physiol 279:F203-15. 2000
  5. ncbi Heat shock proteins and the cellular response to osmotic stress
    F X Beck
    Physiologisches Institut der Universität München, Munchen, Germany
    Cell Physiol Biochem 10:303-6. 2000
  6. ncbi Response of renal medullary cells to osmotic stress
    Franz X Beck
    Physiologisches Institut der Universitat, Munchen, Germany
    Contrib Nephrol 148:21-34. 2005
  7. ncbi Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice
    Franz X Beck
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, 80336, Munich, Germany
    Pflugers Arch 446:100-5. 2003
  8. ncbi Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    J Physiol 564:715-22. 2005
  9. ncbi EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions
    Christoph Kuper
    Department of Physiology, University of Munich, Munich, Germany
    Am J Physiol Renal Physiol 296:F1100-8. 2009
  10. ncbi PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling
    Daniela Steinert
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    Am J Physiol Cell Physiol 296:C75-87. 2009

Detail Information

Publications21

  1. ncbi Relationship between intracellular ionic strength and expression of tonicity-responsive genes in rat papillary collecting duct cells
    Wolfgang Neuhofer
    Physiologisches Institut, , Germany
    J Physiol 543:147-53. 2002
    ....
  2. ncbi Cellular response to osmotic stress in the renal medulla
    F X Beck
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Pflugers Arch 436:814-27. 1998
    ....
  3. ncbi Inner-medullary organic osmolytes and inorganic electrolytes in K depletion
    F X Beck
    Physiologisches Institut der Universität München, Munich, Germany
    Pflugers Arch 439:471-6. 2000
    ..During chronic K depletion, reduced osmolyte accumulation by renomedullary cells may be the consequence, rather than the cause, of lower medullary interstitial tonicity...
  4. ncbi Molecular chaperones in the kidney: distribution, putative roles, and regulation
    F X Beck
    Physiologisches Institut der Universität München, Munich, Germany
    Am J Physiol Renal Physiol 279:F203-15. 2000
    ....
  5. ncbi Heat shock proteins and the cellular response to osmotic stress
    F X Beck
    Physiologisches Institut der Universität München, Munchen, Germany
    Cell Physiol Biochem 10:303-6. 2000
    ..Taken together these results suggest that also in the renal inner medulla, NaCl-induced enhancement of HSP72 expression may help counteract the detrimental effects of high urea concentrations...
  6. ncbi Response of renal medullary cells to osmotic stress
    Franz X Beck
    Physiologisches Institut der Universitat, Munchen, Germany
    Contrib Nephrol 148:21-34. 2005
    ....
  7. ncbi Intracellular Na concentration and Rb uptake in proximal convoluted tubule cells and abundance of Na/K-ATPase alpha1-subunit in NHE3-/- mice
    Franz X Beck
    Physiologisches Institut der Universitat, Pettenkoferstrasse 12, 80336, Munich, Germany
    Pflugers Arch 446:100-5. 2003
    ..There were no significant changes of cell Na concentration and Rb uptake in distal convoluted tubule, connecting tubule, principal and intercalated cells...
  8. ncbi Differential expression of heat shock protein 27 and 70 in renal papillary collecting duct and interstitial cells - implications for urea resistance
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    J Physiol 564:715-22. 2005
    ..These observations indicate that PCD and PI cells employ cell-specific mechanisms for protection against high urea concentrations as present in the renal papilla during antidiuresis...
  9. ncbi EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions
    Christoph Kuper
    Department of Physiology, University of Munich, Munich, Germany
    Am J Physiol Renal Physiol 296:F1100-8. 2009
    ..This EGFR-Ras-MAPK pathway contributes to TonEBP transcriptional activation and targets gene expression during osmotic stress, thus establishing a membrane-associated signal input that contributes to the regulation of TonEBP activity...
  10. ncbi PGE2 potentiates tonicity-induced COX-2 expression in renal medullary cells in a positive feedback loop involving EP2-cAMP-PKA signaling
    Daniela Steinert
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336 Munich, Germany
    Am J Physiol Cell Physiol 296:C75-87. 2009
    ....
  11. ncbi Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells
    Christoph Kuper
    Department of Physiology, University of Munich, Munich, Germany
    Kidney Int 80:938-45. 2011
    ..Thus, tonicity-induced COX-2 expression and PGE2 synthesis in the renal medulla entails phosphorylation and inactivation of the pro-apoptotic protein Bad, thereby counteracting apoptosis in renal medullary epithelial cells...
  12. ncbi Cell volume regulation in the renal papilla
    Franz X Beck
    Department of Physiology, University of Munich, Munich, Germany
    Contrib Nephrol 152:181-97. 2006
    ....
  13. ncbi Cell survival in the hostile environment of the renal medulla
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, D 80336 Munich, Germany
    Annu Rev Physiol 67:531-55. 2005
    ....
  14. ncbi Nitric oxide decreases expression of osmoprotective genes via direct inhibition of TonEBP transcriptional activity
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, 80336, Munich, Germany
    Pflugers Arch 457:831-43. 2009
    ..These observations disclose a novel direct inhibitory effect of NO on TonEBP, a phenomenon that may be relevant for regulation of osmoprotective genes in the renal medulla...
  15. ncbi Survival in hostile environments: strategies of renal medullary cells
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Munich, Germany
    Physiology (Bethesda) 21:171-80. 2006
    ..This article reviews the strategies adopted by these cells to allow them to survive and fulfill their functions under these extreme conditions...
  16. ncbi Ectodomain shedding of pro-TGF-alpha is required for COX-2 induction and cell survival in renal medullary cells exposed to osmotic stress
    Christoph Kuper
    Department of Physiology, University of Munich, Munich, Germany
    Am J Physiol Cell Physiol 293:C1971-82. 2007
    ..We conclude that tonicity-induced TGF-alpha release is required for COX-2 expression, PGE(2) synthesis, and survival of renal medullary cells during osmotic stress...
  17. ncbi Prostaglandin E2 stimulates expression of osmoprotective genes in MDCK cells and promotes survival under hypertonic conditions
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Germany
    J Physiol 583:287-97. 2007
    ..These findings may be relevant in the pathophysiology of medullary damage associated with analgesic drugs...
  18. ncbi Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats
    Wolfgang Neuhofer
    Department of Physiology, University of Munich, Germany
    Kidney Int 65:431-41. 2004
    ....
  19. ncbi Effect of ammonium on the expression of osmosensitive genes in Madin-Darby canine kidney cells
    Wolfgang Neuhofer
    , Pettenkoferstrasse 12, , Germany
    J Physiol 563:497-505. 2005
    ..These results suggest that, in addition to NaCl, NH4Cl may play a role in regulating the intracellular accumulation of organic osmolytes, the abundance of HSP70 and cell turnover in the renal medulla in vivo...
  20. ncbi Regulation of TonEBP transcriptional activator in MDCK cells following changes in ambient tonicity
    Wolfgang Neuhofer
    , , Germany
    Am J Physiol Cell Physiol 283:C1604-11. 2002
    ..We conclude that intracellular ionic strength and water content are major factors that determine the activity of TonEBP...
  21. ncbi Osmoadaptation of Mammalian cells - an orchestrated network of protective genes
    Küper Christoph
    Department of Physiology, University of Munich, Munich, Germany
    Curr Genomics 8:209-18. 2007
    ..The present review summarizes the sequence of genomic responses conferring resistance against osmotic stress. In addition, the regulatory mechanisms mediating the coordinated genomic response to osmotic stress will be highlighted...