Research Topics
Genomes and GenesSpecies | Susanne AlbanSummaryAffiliation: University of Kiel Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Combination of a two-step fluorescence assay and a two-step anti-Factor Xa assay for detection of heparin falsifications and protein in heparinsSusanne Alban
Pharmaceutical Institute, Christian Albrechts University, Gutenbergstrasse 76, 24118, Kiel, Germany
Anal Bioanal Chem 399:681-90. 2011..Comprehensive information about heparin quality can be obtained by their combined use and the parallel measurement of non-incubated heparin samples...- Pharmacological strategies for inhibition of thrombin activityS Alban
Pharmaceutical Institute, Christian Albrechts University of Kiel, Kiel, Germany
Curr Pharm Des 14:1152-75. 2008..This review describes the pharmacological profile of all these anticoagulants... - [Pharmacology of heparins and direct anticoagulants]S Alban
Pharmazeutisches Institut, Christian Albrechts Universitat, Kiel
Hamostaseologie 28:400-20. 2008..In September 2008 rivaroxaban has been approved as the first oral DXI. This review describes the development of the anticoagualants as well as the pharmacological profile of the clinically used anticoagualants... - [Natural and synthetic glycosaminoglycans. Molecular characteristics as the basis of distinct drug profiles]S Alban
Pharmazeutisches Institut, Christian Albrechts Universitat zu Kiel, Gutenbergstr 76, 24118 Kiel
Hamostaseologie 28:51-61. 2008..This concerns their pharmacodynamics, pharmacokinetics as well as practice-related aspects such as dosage, monitoring, accumulation tendency, antagonisation and HIT-Typ II... - [Chromogenic assay for functional determination of TFP]S Alban
Abteilung Pharmazeutische Biologie, Pharmazeutisches Institut, Christian Albrechts Universitat zu Kiel, Gutenbergstr 76, 24118 Kiel
Hamostaseologie 25:286-92. 2005.... - The 'precautionary principle' as a guide for future drug developmentS Alban
Christian Albrechts University of Kiel, Germany
Eur J Clin Invest 35:33-44. 2005..In principle, it is thus possible that the prophylaxis and therapy of thromboembolic diseases will become completely independent of animal-derived drugs, which would be in line with the precautionary principle... - From heparins to factor Xa inhibitors and beyondS Alban
Christian Albrechts University of Kiel, Germany
Eur J Clin Invest 35:12-20. 2005..In addition to the evaluation of fondaparinux for further indications, chemical modifications of this pentasaccharide such as the long-acting idraparinux are currently under investigation... - [Paradigm change in anticoagulation. Natural substances that are selective factor Xa inhibitors]Susanne Alban
Pharmazeutisches Institut, , Gutenbergstr. 76 24118 Kiel
Pharm Unserer Zeit 33:190-4. 2004 - Pharmacological profiles of animal- and nonanimal-derived sulfated polysaccharides--comparison of unfractionated heparin, the semisynthetic glucan sulfate PS3, and the sulfated polysaccharide fraction isolated from Delesseria sanguineaInken Groth
Pharmaceutical Institute, University of Kiel, 24116 Kiel, Germany
Glycobiology 19:408-17. 2009..s.-SP might have perspectives for cosmetic applications... - Comparison of established and novel purity tests for the quality control of heparin by means of a set of 177 heparin samplesSusanne Alban
Pharmaceutical Institute, Christian Albrechts University, Gutenbergstr 76, 24118, Kiel, Germany
Anal Bioanal Chem 399:605-20. 2011..The two two-step-assays represent options to supplement NMR, especially as tests for the initial screening, since they detect any heparin mimetic without requiring special expertise for interpretation of the results... - Simple fluorescence assay for quantification of OSCS in heparinSusanne Lühn
Pharmaceutical Institute, Christian Albrechts University, Gutenbergstrasse 76, 24118, Kiel, Germany
Anal Bioanal Chem 399:673-80. 2011..It could be applied not only in the quality control of heparin, but also in clinical practice, to check the applied heparin preparation when a patient suffers any adverse effect... - Development and evaluation of a fluorescence microplate assay for quantification of heparins and other sulfated carbohydratesSusanne Lühn
Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany
J Pharm Biomed Anal 52:1-8. 2010..2 and a M(r)>3000 can be quantified as well. By own calibration curves also other sulfated carbohydrates like fondaparinux or other glycosaminoglycans (DS>0.4) can be determined... - Evaluation of seasonal variations of the structure and anti-inflammatory activity of sulfated polysaccharides extracted from the red alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae)Niels Grünewald
Pharmaceutical Institute, University of Kiel, Gutenbergstrasse 76, D 24118 Kiel, Germany
Biomacromolecules 10:1155-62. 2009..48% +/- 1.00%, September, 22.8% +/- 1.2%) due to certain coextraction of starch-like glucans. In principle, algae material can be harvested throughout the year, but the optimum harvesting time is in spring... - Complement modulating and anticoagulant effects of a sulfated exopolysaccharide released by the cyanobacterium Synechocystis aquatilisRainer B Volk
Pharmaceutical Institute, University of Kiel, Kiel, Germany
Planta Med 72:1424-7. 2006..The results indicate that this biotechnologically producible, released polysaccharide represents a specifically acting complement modulator... - Elastase inhibition assay with peptide substrates - an example for the limited comparability of in vitro resultsInken Groth
Pharmaceutical Institute, University of Kiel, Kiel, Germany
Planta Med 74:852-8. 2008..In conclusion, by the choice of the enzyme substrate, both the apparent maximum activity and the IC (50) of an inhibitor can be influenced. Therefore, only results from identical test systems should be compared.... - Optimized and standardized isolation and structural characterization of anti-inflammatory sulfated polysaccharides from the red alga Delesseria sanguinea (Hudson) Lamouroux (Ceramiales, Delesseriaceae)Niels Grünewald
Department of Pharmaceutical Biology, Pharmaceutical Institute, Christian Albrechts University of Kiel, Kiel, Germany
Biomacromolecules 10:2998-3008. 2009..8 vs 28.6%). In conclusion, SPs from Delesseria sanguinea can be isolated in reproducibly high quality by using a specific extraction procedure. Thus, an important prerequisite for a potential economical utilization is fulfilled... - Inhibition of PMN-elastase activity by semisynthetic glucan sulfatesMarkus Becker
Pharmaceutical Institute, Christian-Albrechts-University of Kiel, Gutenbergstr. 76, 24118 Kiel, Germany
Thromb Haemost 89:915-25. 2003..According to enzyme-inhibitor binding studies, SC exhibit structure dependent affinity to the enzyme (K(d) for PMNE: beta-1,3 < alpha-1,4/1,6 < UFH). Finally, SC were shown to inhibit cancer cell-mediated elastinolysis... - PS3, a semisynthetic beta-1,3-glucan sulfate, diminishes contact hypersensitivity responses through inhibition of L- and P-selectin functionsSusanne Alban
Pharmaceutical Institute, Christian Albrechts University, Kiel, Germany
J Invest Dermatol 129:1192-202. 2009..Again, PS3 had no effect in P-selectin-deficient mice. PS3 is a potent P- and L-selectin inhibitor that may add to the therapy of inflammatory diseases... - Pharmacokinetic and pharmacodynamic characterization of a medium-molecular-weight heparin in comparison with UFH and LMWHSusanne Alban
Institute of Pharmacy, University of Regensburg, Germany
Semin Thromb Hemost 28:369-78. 2002..Consequently, substantially lower doses are needed to bring about effects comparable to those of UFH and LMWH... - Kinetic analysis of heparin and glucan sulfates binding to P-selectin and its impact on the general understanding of selectin inhibitionDirk Simonis
Department of Pharmacy, Rheinische Friedrich Wilhelms University Bonn, An der Immenburg 4, 53121 Bonn, Germany
Biochemistry 46:6156-64. 2007..Structurally, highly charged compounds with a slow off-rate, such as heparin or glucan sulfates, appear as potent candidates for P-selectin inhibition... - Perioperative bridging with fondaparinux in a woman with antithrombin deficiencyRupert Bauersachs
Thromb Haemost 97:498-9. 2007 - The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacityJuliane Fritzsche
Institute of Pharmaceutical Chemistry, Rheinische Friedrich Wilhelms University Bonn, Germany
Biochem Pharmacol 72:474-85. 2006..Our study indicates that semisynthetic glucan sulfates with optimal structures block P-selectin excellently and might become promising candidates for anti-inflammatory drugs to replace heparin for certain applications... - Molecular weight determines the frequency of delayed type hypersensitivity reactions to heparin and synthetic oligosaccharidesRalf J Ludwig
Department of Dermatology, Klinikum der J W Goethe Universitat, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
Thromb Haemost 94:1265-9. 2005..842, p = 0.009). Hence, fondaparinux may be used as a therapeutic alternative in patients with cutaneous DTH relations towards heparin and other polysaccharides... - Differentiation between the complement modulating effects of an arabinogalactan-protein from Echinacea purpurea and heparinSusanne Alban
Institute of Pharmacy, University of Regensburg, Regensburg, Germany
Planta Med 68:1118-24. 2002..saline containing EGTA and Mg 2+HPS:human pooled serum RT:room temperature LPS:lipopolysaccharide RaE:rabbit erythrocytes RT:room temperature ShE(A):(sensitised) sheep erythrocytes VB:veronal buffered saline containing Ca 2+ and Mg 2+.. - The ability of different forms of heparins to suppress P-selectin function in vitro correlates to their inhibitory capacity on bloodborne metastasis in vivoRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
Thromb Haemost 95:535-40. 2006..Hence, P-selectin inhibition may constitute a valuable feature to identify anticoagulants that are suitable for anticancer therapy... - Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activitiesRalf J Ludwig
Department of Dermatology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
Mini Rev Med Chem 6:1009-23. 2006.... - [Statement from the DPhG: DPhG opinion on the proposed health claims regulation]Susanne Alban
Pharm Unserer Zeit 37:424-5. 2008 - Affinity and kinetics of different heparins binding to P- and L-selectinDirk Simonis
Department of Pharmacy, Rheinische Friedrich Wilhelms University Bonn, Av der Immenburg 4, 531L1 Bonn, Germany
Semin Thromb Hemost 33:534-9. 2007..These data support recent findings of antimetastatic activities, but illustrate that the intrinsic selectin binding does not entirely reflect the antimetastatic activities in vivo...