S Uckert

Summary

Country: Germany

Publications

  1. ncbi Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries--immunohistochemical distribution and functional significance
    Eginhard Waldkirch
    Department of Urology, Hannover Medical School, 30625, Hannover, Germany
    World J Urol 23:405-10. 2005
  2. ncbi Rho kinase-related proteins in human vaginal arteries: an immunohistochemical and functional study
    Stefan Uckert
    Hannover Medical School, Division of Surgery, Dept of Urology and Urological Oncology, Hannover, Germany
    J Sex Med 8:2739-45. 2011
  3. ncbi In vitro functional responses of isolated normal human prostatic tissue to compounds interacting with the cyclic guanosine monophosphate pathway
    Giorgi Kedia
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 67:1292-7. 2006
  4. ncbi Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study
    Matthias Oelke
    Department of Urology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Urology 67:1111-6. 2006
  5. ncbi Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
    Stefan Uckert
    Hannover Medical School, Department of Urology, Hannover, Germany
    Eur Urol 49:740-5. 2006
  6. ncbi Distribution and functional significance of phosphodiesterase isoenzymes in the human lower urinary tract
    Stefan Uckert
    Department of Urology, Hannover Medical School, 30625, Hannover, Germany
    World J Urol 23:368-73. 2005
  7. ncbi In vitro functional responses of isolated human vaginal tissue to selective phosphodiesterase inhibitors
    Stefan Uckert
    Department of Urology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    World J Urol 23:398-404. 2005
  8. ncbi Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves
    Stefan Uckert
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 65:604-10. 2005
  9. ncbi Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone
    Stefan Uckert
    Hanover Medical School, Department of Urology, 30625 Hannover, Germany
    World J Urol 22:261-6. 2004
  10. ncbi Current and future trends in the oral pharmacotherapy of male erectile dysfunction
    Stefan Uckert
    Hannover Medical School, Department of Urology, 30625 Hannover, Germany
    Expert Opin Investig Drugs 12:1521-33. 2003

Detail Information

Publications66

  1. ncbi Cyclic AMP-specific and cyclic GMP-specific phosphodiesterase isoenzymes in human cavernous arteries--immunohistochemical distribution and functional significance
    Eginhard Waldkirch
    Department of Urology, Hannover Medical School, 30625, Hannover, Germany
    World J Urol 23:405-10. 2005
    ....
  2. ncbi Rho kinase-related proteins in human vaginal arteries: an immunohistochemical and functional study
    Stefan Uckert
    Hannover Medical School, Division of Surgery, Dept of Urology and Urological Oncology, Hannover, Germany
    J Sex Med 8:2739-45. 2011
    ..Until now, it is not known whether ROKs and related proteins play a role in the control of vaginal blood flow...
  3. ncbi In vitro functional responses of isolated normal human prostatic tissue to compounds interacting with the cyclic guanosine monophosphate pathway
    Giorgi Kedia
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 67:1292-7. 2006
    ....
  4. ncbi Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study
    Matthias Oelke
    Department of Urology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Urology 67:1111-6. 2006
    ..We sought to elucidate the presence of the phosphodiesterase (PDE) isoenzymes 3, 4, and 5 in the human clitoris using immunohistochemical and molecular biology methods...
  5. ncbi Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate
    Stefan Uckert
    Hannover Medical School, Department of Urology, Hannover, Germany
    Eur Urol 49:740-5. 2006
    ..The aim of the present study was to evaluate by means of immunohistochemistry the expression and distribution of some cAMP- and cGMP-PDE isoenzymes in the prostate...
  6. ncbi Distribution and functional significance of phosphodiesterase isoenzymes in the human lower urinary tract
    Stefan Uckert
    Department of Urology, Hannover Medical School, 30625, Hannover, Germany
    World J Urol 23:368-73. 2005
    ..The purpose of this review is to summarize the current knowledge on the distribution and potential functional significance of PDE isoenzymes in the human lower urinary tract...
  7. ncbi In vitro functional responses of isolated human vaginal tissue to selective phosphodiesterase inhibitors
    Stefan Uckert
    Department of Urology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    World J Urol 23:398-404. 2005
    ..This might be of significance with regard to the pharmacological treatment of disorders connected with female sexual arousal and the ability to achieve orgasm...
  8. ncbi Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves
    Stefan Uckert
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 65:604-10. 2005
    ..Nitric oxide and VIP, mediating biologic signals through cGMP and cAMP, have been assumed to be involved in the control of vaginal smooth muscle...
  9. ncbi Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone
    Stefan Uckert
    Hanover Medical School, Department of Urology, 30625 Hannover, Germany
    World J Urol 22:261-6. 2004
    ..The immunoreactivity specific for PDE3, PDE4, PDE4A and PKA registered in HCC section is also in support of an important role for the cAMP/PKA-system for penile smooth muscle function...
  10. ncbi Current and future trends in the oral pharmacotherapy of male erectile dysfunction
    Stefan Uckert
    Hannover Medical School, Department of Urology, 30625 Hannover, Germany
    Expert Opin Investig Drugs 12:1521-33. 2003
    ..The purpose of this review is to describe the major novel and evolving pharmacological advances in the field of oral pharmacotherapy for the treatment of male erectile dysfunction...
  11. ncbi Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future
    Stefan Uckert
    Hannover Medical School, Department of Urology, Hannover 30625, Germany
    Eur Urol 50:1194-207; discussion 1207. 2006
    ..This review attempts to describe the physiology and pharmacology of phosphodiesterase (PDE) isoenzymes with special regard to their (potential) use in disorders of the human urogenital tract...
  12. ncbi Potential future options in the pharmacotherapy of female sexual dysfunction
    Stefan Uckert
    Department of Urology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    World J Urol 24:630-8. 2006
    ..This article reviews the rationale and potential benefits of using distinct drug formulations in the treatment of FSD...
  13. ncbi Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction
    Stefan Uckert
    Hannover Medical School, Division of Surgery, Department of Urology and Urological Oncology, Hannover, Germany
    Br J Clin Pharmacol 72:197-204. 2011
    ..The strategy of modulating the activity of PDE isoenzymes might represent a novel approach in patients with lower urinary tract dysfunction (LUTD)...
  14. ncbi [Significance of phosphodiesterase isoenzymes in the control of human detrusor smooth muscle function. An immunohistochemical and functional study]
    S Uckert
    Klinik für Urologie und Uro Onkologie, Zentrum Chirurgie, Medizinische Hochschule Hochschule, Carl Neuberg Strasse 1, 30625 Hannover
    Urologe A 48:764-9. 2009
    ..Using immunohistochemical methods, the expression of PDE1, PDE4, and PDE5 in human detrusor was also investigated...
  15. ncbi Effects of phosphodiesterase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue
    George T Kedia
    Division of Surgery, Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 73:1397-401. 2009
    ..To study the effects of selective phosphodiesterase (PDE) inhibitors on the contraction induced by endothelin-1 (ET-1) of isolated human prostatic tissue...
  16. ncbi Effects of phosphodiesterase inhibitors on the contractile responses of isolated human seminal vesicle tissue to adrenergic stimulation
    Stefan Uckert
    Division of Surgery, Department of Urology, Hannover Medical School, Hannover, Germany
    J Sex Med 6:408-14. 2009
    ..In fact, it has been shown that PDE inhibitors can reverse the tension of isolated human SV tissue and enhance the production of cyclic AMP and cyclic GMP...
  17. ncbi Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue
    Stefan Uckert
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 71:526-30. 2008
    ....
  18. ncbi Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles
    Stefan Uckert
    Department of Urology and Urological Oncology, Hannover Medical School, Division of Surgery, Hannover, Germany
    J Sex Med 8:3058-65. 2011
    ..While the expression of PDE isoenzymes in the human seminal vesicles (SVs) has been described, the distribution of cyclic adenosine monophosphate (AMP)- and cyclic guanosine monophosphate (GMP)-PDEs has not yet been investigated...
  19. ncbi Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors
    Stefan Uckert
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 70:185-9. 2007
    ....
  20. ncbi The future of the oral pharmacotherapy of male erectile dysfunction: things to come
    Stefan Uckert
    Hannover Medical School, Department of Urology, 30625 Hannover, Germany
    Expert Opin Emerg Drugs 12:219-28. 2007
    ..The purpose of this review is to describe the major novel and evolving pharmacologic advances in the field of oral pharmacotherapy for the treatment of male erectile dysfunction...
  21. ncbi Oxytocin plasma levels in the systemic and cavernous blood of healthy males during different penile conditions
    Stefan Uckert
    Department of Urology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    World J Urol 20:323-6. 2003
    ..Our results support the hypothesis of a pivotal role of OT in the mechanism of male sexual arousal and penile erection and provide a rationale for the use of apomorphine in the treatment of erectile dysfunction...
  22. ncbi Potential mechanism of action of human growth hormone on isolated human penile erectile tissue
    Stefan Uckert
    Department of Urology and Uro Oncology, Hannover Medical School, Hannover, Germany
    Urology 75:968-73. 2010
    ..Nevertheless, it still remains unclear which intracellular pathways mediate the physiological effects of GH on the human corpus cavernosum (HCC)...
  23. ncbi Possible role of bioactive peptides in the regulation of human detrusor smooth muscle - functional effects in vitro and immunohistochemical presence
    Stefan Uckert
    Hanover Medical School, Department of Urology, Carl Neuberg Str 1, 30625 Hanover, Germany
    World J Urol 20:244-9. 2002
    ....
  24. ncbi Possible role of bradykinin and angiotensin II in the regulation of penile erection and detumescence
    A J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 57:193-8. 2001
    ....
  25. ncbi Systemic and cavernous plasma levels of endothelin (1-21) during different penile conditions in healthy males and patients with erectile dysfunction
    A J Becker
    Hannover Medical School, Department of Urology, Germany
    World J Urol 19:267-71. 2001
    ....
  26. ncbi Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder
    M C Truss
    Department of Urology, Medizinische Hochschule Hannover, Germany
    World J Urol 18:439-43. 2000
    ..Although these initial data are preliminary, they represent the first evidence that isoenzyme-selective PDE inhibition may be a novel approach to the treatment of lower urinary tract disorders...
  27. ncbi In vitro effects of PDE5 inhibitors sildenafil, vardenafil and tadalafil on isolated human ureteral smooth muscle: a basic research approach
    Christian Gratzke
    Department of Urology, Ludwig Maximilians University, University Hospital Grosshadern, Marchioninistr 15, 81377, Munich, Germany
    Urol Res 35:49-54. 2007
    ..Nevertheless, further studies are indicated in order to evaluate as to whether there might be a use for PDE5 inhibitors in the treatment of ureteral stone disease...
  28. ncbi Cavernous and systemic testosterone plasma levels during different penile conditions in healthy males and patients with erectile dysfunction
    A J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 58:435-40. 2001
    ....
  29. ncbi Phosphodiesterase 1 inhibition in the treatment of lower urinary tract dysfunction: from bench to bedside
    M C Truss
    Urologische Klinik, Medizinische Hochschule, Hannover, Germany
    World J Urol 19:344-50. 2001
    ..e. isoenzyme-selective PDE inhibition is a novel approach which possibly avoids the limitations of anticholinergic therapy in patients with lower urinary tract dysfunction...
  30. ncbi Systemic and cavernosal plasma levels of endothelin (1-21) during different penile conditions in healthy males and patients with erectile dysfunction
    A J Becker
    Hannover Medical School, Department of Urology, Germany
    World J Urol 19:371-6. 2001
    ....
  31. ncbi Growth hormone, somatomedins and men's health
    A J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Aging Male 5:258-62. 2002
    ..In an ongoing study, we are evaluating whether growth hormone and somatomedins might be of importance in the regulation of male sexual performance, including penile erection...
  32. ncbi Plasma levels of cyclic guanosine-3',5'-monophosphate in the cavernous and systemic blood of healthy males during different functional conditions of the penis
    A J Becker
    Hannover Medical School, Department of Urology, Hannover, Germany
    Urol Res 29:366-70. 2001
    ..Thus, we conclude that the quantification of cGMP is of no use in the evaluation of the physiologic mechanisms of penile erection in vivo...
  33. ncbi Phosphodiesterase isoenzymes as pharmacological targets in the treatment of male erectile dysfunction
    S Uckert
    Hannover Medical School, Department of Urology, Germany
    World J Urol 19:14-22. 2001
    ..Further research will possibly allow identification of diagnostic tools for erectile dysfunction and of even more selective drugs in its therapy...
  34. ncbi Plasma levels of angiotensin II during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction
    A J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 58:805-10. 2001
    ..Since the tissue and plasma levels of Ang II are regulated by the activity of angiotensin-converting enzyme, there might be a rationale for the use of angiotensin-converting enzyme inhibitors in the treatment of vasculogenic ED...
  35. ncbi Gene expression of the phosphodiesterases 3A and 5A in human corpus cavernosum penis
    A Kuthe
    Hannover Medical School, Department of Urology and b Lower Saxony Institute for Peptide Research, Germany
    Eur Urol 38:108-14. 2000
    ....
  36. ncbi Characterization and functional relevance of cyclic nucleotide phosphodiesterase isoenzymes of the human prostate
    S Uckert
    Department of Urology, Hannover Medical School, Hannover, Germany
    J Urol 166:2484-90. 2001
    ..These studies support the possible use of inhibitors of PDE 4 and 5 for treating urinary obstruction secondary to benign prostatic hyperplasia...
  37. ncbi Is there an inhibitory role of cortisol in the mechanism of male sexual arousal and penile erection?
    Stefan Uckert
    Department of Urology, Hannover Medical School, 30625 Hannover, Germany
    Urol Res 31:402-6. 2003
    ..Future studies to include patients suffering from erectile dysfunction may reveal whether or not there are differences in the cortisol serum profiles of healthy subjects and patients under different stages of sexual arousal...
  38. ncbi Effects of various nitric oxide donating agents on the contractility and cyclic nucleotide turnover of human seminal vesicles in vitro
    Olaf Heuer
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 59:958-62. 2002
    ..This may give a rationale for the use of S-nitrosothiols, such as GSNO, in the pharmacotherapy of hyperexcitatory disturbances of ejaculation...
  39. ncbi Evaluating the role of the serotoninergic system in the control of human seminal vesicle smooth muscle-an in vitro approach
    Ponco Birowo
    Department of Urology and Uro Oncology, Hannover Medical School, Hannover 30625, Germany
    J Sex Med 6:2672-9. 2009
    ..However, until now, only a very few experimental studies have investigated such potential local (peripheral) effects...
  40. ncbi Expression of messenger ribonucleic acid encoding for phosphodiesterase isoenzymes in human female genital tissues
    Stefan Uckert
    Hannover Medical School Department of Urology, Hannover, Germany, and IPF Pharmaceuticals GmbH Urological Research Unit, Hannover, Germany
    J Sex Med 4:1604-9. 2007
    ..The elevated expression of PDE5 in the human penile erectile tissue is considered the reason for the high clinical efficacy of PDE5 inhibitors in the pharmacotherapy of male erectile dysfunction...
  41. ncbi In vitro effects of a novel class of nitric oxide (NO) donating compounds on isolated human erectile tissue
    Michael Seidler
    Depatment of Urology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany
    Eur Urol 42:523-8. 2002
    ..Since the compounds are assumed to exert no considerable hemodynamic effects, they might be developed into new oral treatments for ED...
  42. ncbi Immunocytochemical distribution of nitric oxide synthase in the human corpus cavernosum: an electron microscopical study using the tyramide signal amplification technique
    A Stanarius
    Department of Urology, Hannover Medical School, Germany
    Urol Res 29:168-72. 2001
    ..Our results counteract the hypothesis of the cavernous smooth muscle as a local source of NO and underline the importance of an intact endothelial function for penile erection and the contribution of eNOS to this process...
  43. ncbi Molecular biological characterization of phosphodiesterase 3A from human corpus cavernosum
    A Kuthe
    Hannover Medical School, Department of Urology, Germany
    Chem Biol Interact 119:593-8. 1999
    ..The data obtained indicate that neither the expression levels nor the sequence deviations of PDE3A are the main reasons for erectile dysfunction in men...
  44. ncbi Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)
    S Uckert
    Division of Surgery, Department of Urology and Urological Oncology, Hannover Medical School, Hannover, Germany
    Int J Impot Res 23:206-12. 2011
    ..The results are in favor of a role of the cyclic GMP signaling in the control of clitoral blood flow. It seems likely that PDE2 and PDE11 are also involved in the mechanism of local (neuro)transmission in the clitoris...
  45. ncbi Expression and distribution of cyclic AMP- and cyclic GMP-binding protein kinases in the human vagina- an immunohistochemical study
    Stefan Uckert
    Division of Surgery, Department of Urology and Uro Oncology, Hannover Medical School, Hannover 30625, Germany
    J Sex Med 7:888-95. 2010
    ..cAMP- and cGMP-dependent protein kinases (cAK, cGKI) have been identified as important receptors for cyclic nucleotides downstream the signaling cascades...
  46. ncbi The nitric oxide pathway in the human prostate: clinical implications in men with lower urinary tract symptoms
    George T Kedia
    Department of Urology, Hannover Medical School, Carl Neuberg Str 1, 30625, Hannover, Germany
    World J Urol 26:603-9. 2008
    ..This review serves to focus on the role of NO and the NO-dependent signaling in the control of smooth muscle function in the human prostate. Results from clinical trials in men with LUTS/BPH are also discussed...
  47. ncbi Anatomy, physiology, and pathophysiology of erectile dysfunction
    Christian Gratzke
    Department of Urology, Ludwig Maximilians Universitat, Munchen, Germany
    J Sex Med 7:445-75. 2010
    ..A critical evaluation of the current state of knowledge is essential to provide perspective for future research and development of new therapies...
  48. ncbi Systemic and cavernous plasma levels of vasoactive intestinal polypeptide during sexual arousal in healthy males
    Armin J Becker
    Hannover Medical School, Department of Urology, Germany
    World J Urol 20:59-63. 2002
    ..Nevertheless, our data indicate that the peptide is not the main non-adrenergic, non-cholinergic mediator of penile tumescence and rigidity in human males...
  49. ncbi Is serotonin significant for the control of penile flaccidity and detumescence in the human male?
    Stefan Uckert
    Department of Urology, Hannover Medical School, 30625 Hannover, Germany
    Urol Res 31:55-60. 2003
    ..Thus, our findings may give a rationale for the use of 5-HT antagonists in the pharmacotherapy of erectile dysfunction...
  50. ncbi Female sexual dysfunction: what's new?
    Margit E Mayer
    Faculty of Medicine, Department of Urology, Academic Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Curr Opin Obstet Gynecol 19:536-40. 2007
    ..The aim of this article is to summarize the most important and interesting achievements which have recently been made in the field of female sexual dysfunction...
  51. ncbi Expression and distribution of cyclic GMP-dependent protein kinase-1 isoforms in human penile erectile tissue
    Eginhard Waldkirch
    Department of Urology, Hannover Medical School, Hannover, Germany
    J Sex Med 5:536-43. 2008
    ..So far, the expression of cGKI alpha and beta isoforms has not been evaluated in human penile erectile tissue...
  52. ncbi Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora
    Stefan Uckert
    Hannover Medical School Department of Urology, Hannover, Germany
    J Sex Med 4:602-8. 2007
    ..Some findings indicated that there might be a significance of cyclic nucleotide-mediated pathways in the control of the normal function of female genital tissues...
  53. ncbi Non-genomic effects of androgens on isolated human vascular and nonvascular penile erectile tissue
    Eginhard Waldkirch
    Hannover Medical School, Department of Urology, Hannover, Germany
    BJU Int 101:71-5; discussion 75. 2008
    ....
  54. ncbi Detection of low-molecular-mass plasma peptides in the cavernous and systemic blood of healthy men during penile flaccidity and rigidity--an experimental approach using the novel differential peptide display technology
    Harald Tammen
    BioVisioN AG, Hannover, Germany
    Urology 59:784-9. 2002
    ....
  55. ncbi Serum levels of human growth hormone during different penile conditions in the cavernous and systemic blood of healthy men and patients with erectile dysfunction
    Armin J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 59:609-14. 2002
    ....
  56. ncbi Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?
    Knut Albrecht
    Hannover Medical School, Deparment of Legal Medicine, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Forensic Leg Med 14:270-4. 2007
    ....
  57. ncbi Cavernous and systemic plasma levels of norepinephrine and epinephrine during different penile conditions in healthy men and patients with erectile dysfunction
    Armin J Becker
    Department of Urology, Hannover Medical School, Hannover, Germany
    Urology 59:281-6. 2002
    ....
  58. ncbi Adverse effects of drug therapies on male and female sexual function
    Th Stadler
    Department of Urology, Faculty of Medicine, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    World J Urol 24:623-9. 2006
    ....
  59. ncbi [Is medical therapy useful in the management of stress urinary incontinence?]
    M Oelke
    Klinik für Urologie und Urologische Onkologie, Medizinische Hochschule, Carl Neuberg Strasse 1, 30625 Hannover
    Urologe A 48:228-32. 2009
    ..Furthermore, duloxetine could be useful in women to support pelvic floor physiotherapy or in female patients awaiting incontinence surgery...
  60. ncbi Expression of cAMP-dependent protein kinase isoforms in the human prostate: functional significance and relation to PDE4
    Eginhard Waldkirch
    Hannover Medical School, Department of Urology and Uro Oncology, Hannover, Germany
    Urology 76:515.e8-14. 2010
    ..To investigate the expression of isoforms of the cyclic AMP (cAMP)-dependent protein kinase (cAK) in the transition zone of the human prostate and the functional significance of the enzyme in the control of prostate smooth muscle...
  61. ncbi Immunohistochemical distribution of cyclic GMP-dependent protein kinase-1 in human prostate tissue
    Eginhard S Waldkirch
    Hannover Medical School, Department of Urology, 30625 Hannover, Germany
    Eur Urol 52:495-501. 2007
    ..The aim of the present study was to evaluate, by means of immunohistochemistry and Western blot analysis, the expression and localization of cGKI isoforms in relation to smooth muscle alpha-actin and cGMP in the human prostate...
  62. ncbi Systemic and cavernous plasma levels of vasopressin in healthy males during different functional conditions of the penis
    Armin J Becker
    Hannover Medical School, Department of Urology, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany
    Urol Res 31:66-9. 2003
    ..Nevertheless, our data indicate that the decrease in systemic AVP levels in response to sexual arousal might be a prerequisite to facilitate penile tumescence and rigidity in healthy males...
  63. ncbi Immunocytochemical distribution of nitric oxide synthase in the human seminal vesicle: a light and electron microscopical study
    Stefan Uckert
    Hannover Medical School, Department of Urology, 30625 Hannover, Germany
    Urol Res 31:262-6. 2003
    ..The sparse correlation between NADPH-d-, eNOS- and nNOS-staining might hint at the existence of a previously unidentified NOS isoform in human SV...
  64. ncbi Phosphodiesterase inhibitors in female sexual dysfunction
    Margit Mayer
    Department of Urology, Faculty of Medicine, University Hospital Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377, Munich, Germany
    World J Urol 23:393-7. 2005
    ..Such research efforts will possibly allow the identification of efficacious and diagnostic tools for erectile dysfunction and of even more selective drugs in its therapy...
  65. ncbi Phosphodiesterases (PDEs) and PDE inhibitors for treatment of LUTS
    Karl Erik Andersson
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Neurourol Urodyn 26:928-33. 2007
    ..Information for the review was obtained from searches of the PubMed database, and from the authors' files...