Research Topics
| Rolf TeschkeSummaryCountry: Germany Publications
| Collaborators |
Detail Information
Publications
Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisitedRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Hanau, Germany
Br J Clin Pharmacol 73:170-4. 2012..Rigorous testing of kava raw material is urgently advised, in addition to Pan-Pacific kava manufacturing quality standards...- Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from EuropeRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital, Hanau, Germany
Eur J Gastroenterol Hepatol 24:270-80. 2012..has been causally related to liver injury, but a variety of confounding variables were evident that might have offset causality. This study reanalyses causality levels in these cases with a liver-specific causality evaluation method... - Kava hepatotoxicity: comparative study of two structured quantitative methods for causality assessmentR Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Hanau, Germany
J Clin Pharm Ther 35:545-63. 2010..Ingestion of the medicinal herb kava has been associated with hepatotoxicity. We aimed to compare two different quantitative methods of causality assessment of patients with assumed hepatotoxicity by the herb... - Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate?Rolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Germany
Regul Toxicol Pharmacol 59:1-7. 2011.... - Kava hepatotoxicity solution: A six-point plan for new kava standardizationRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
Phytomedicine 18:96-103. 2011..In conclusion, at different levels of responsibility, new mandatory approaches are now required to implement quality specification for international acceptance of kava as a safe and effective anxiolytic herb... - Kava, the anxiolytic herb: back to basics to prevent liver injury?Rolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
Br J Clin Pharmacol 71:445-8. 2011..This analysis shows poor quality of kava raw material as a cause for its toxicity and suggests preventative measures by going back to the traditional use of kava for the sake of the patients and the South Pacific economy... - Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culpritsRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Germany
Dig Liver Dis 43:676-81. 2011..Whether kava hepatotoxicity may be due to aflatoxicosis or other mould hepatotoxins, requires further studies... - Herb induced liver injury presumably caused by black cohosh: a survey of initially purported cases and herbal quality specificationsRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University, Frankfurt Main, Germany
Ann Hepatol 10:249-59. 2011..It is concluded that the use of BC may not exert an overt hepatotoxicity risk, but quality problems in a few BC products were evident that require additional regulatory quality specifications... - Spontaneous reports of assumed herbal hepatotoxicity by black cohosh: is the liver-unspecific Naranjo scale precise enough to ascertain causality?Rolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Hanau, Germany
Pharmacoepidemiol Drug Saf 20:567-82. 2011..To evaluate various causality assessing methods in cases with suspected herbal hepatotoxicity, two different scales were now used for reasons of comparison... - Kava hepatotoxicity--a clinical reviewRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
Ann Hepatol 9:251-65. 2010.... - Kava hepatotoxicity: pathogenetic aspects and prospective considerationsRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Hanau, Germany
Liver Int 30:1270-9. 2010.... - Black cohosh and suspected hepatotoxicity: inconsistencies, confounding variables, and prospective use of a diagnostic causality algorithm. A critical reviewRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
Menopause 17:426-40. 2010.... - Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessmentRolf Teschke
Department of Internal Medicine II, University of Frankfurt Main and University of Duesseldorf, Germany
Ann Hepatol 8:258-66. 2009..The case is the first report of Indian Ayurvedic herbal products being potentially hepatotoxic in analogy to some other herbs... - Suspected black cohosh hepatotoxicity--challenges and pitfalls of causality assessmentRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Germany
Maturitas 63:302-14. 2009..Recently, however, reports have appeared about the occurrence of rare toxic liver disease in an assumed relationship with the use of BC... - Proposal for a kava quality standardization codeRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Germany
Food Chem Toxicol 49:2503-16. 2011..In conclusion, a sophisticated approach to establish kava quality standardizations is needed for safe human use of kava as relaxing traditional beverages, the anxiolytic drugs, and recreational dietary supplements... - Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected casesRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Hanau, Germany
Menopause 16:956-65. 2009..Recently, worldwide discussions have emerged as to whether its use maybe associated with the risk of rare hepatotoxicity in a few susceptible women... - Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root): critical analysis and structured causality assessmentRolf Teschke
Medical Department II, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
Phytomedicine 16:72-84. 2009..Using a thorough causality assessment in the form of a diagnostic algorithm we have shown that there is no evidence for a causal relationship between treatment by black cohosh and the observed liver disease in the 4 patients... - Causality assessment in hepatotoxicity by drugs and dietary supplementsRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
Br J Clin Pharmacol 66:758-66. 2008..Concomitant genotyping of cytochrome P450 and other enzymes may also be useful in future to minimize the risk of unwanted side-effects, including toxic liver disease elicited by DDS... - Kava hepatotoxicity: comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixturesRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
J Ethnopharmacol 123:378-84. 2009.... - Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected casesRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
Eur J Gastroenterol Hepatol 20:1182-93. 2008..Hepatotoxicity has been previously suspected by national regulatory agencies in 26 patients in causal relationship with the treatment by kava extracts commonly used as herbal anxiolytic drugs... - Kava hepatotoxicity: a European viewRolf Teschke
Department of Internal Medicine II, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
N Z Med J 121:90-8. 2008..A medical advisory is also recommended as part of the labelling... - Hepatotoxicity by drugs and dietary supplements: safety perspectives on clinical and regulatory issuesRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
Ann Hepatol 8:184-95. 2009..Safety aspects in DDS hepatotoxicity represent a major clinical and regulatory issue and should consequently be addressed... - Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: Was causality adequately ascertained?Rolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
Regul Toxicol Pharmacol 63:1-9. 2012..Thus, convincing evidence is lacking that PS was a potential hepatotoxin in the analyzed cases... - Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): Causality assessment of 22 spontaneous reportsRolf Teschke
Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Germany
Regul Toxicol Pharmacol 61:282-91. 2011..Toxicological studies are now warranted to elucidate the mechanism(s) of human GC hepatotoxicity that represents a European issue...