B Lehmann

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. ncbi UVB-induced conversion of 7-dehydrocholesterol to 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in the human keratinocyte line HaCaT
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Germany
    Photochem Photobiol 72:803-9. 2000
  2. ncbi Vitamin D metabolism
    Bodo Lehmann
    Department of Dermatology, Dresden University of Technology, Germany
    Dermatol Ther 23:2-12. 2010
  3. ncbi Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    Exp Dermatol 18:97-108. 2009
  4. ncbi The vitamin D3 pathway in human skin and its role for regulation of biological processes
    Bodo Lehmann
    Dresden University of Technology, Medical School Carl Gustav Carus, Department of Dermatology, D 01307 Dresden, Germany
    Photochem Photobiol 81:1246-51. 2005
  5. ncbi Role for tumor necrosis factor-alpha in UVB-induced conversion of 7-dehydrocholesterol to 1alpha,25-dihydroxyvitamin D3 in cultured keratinocytes
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden D 01307, Germany
    J Steroid Biochem Mol Biol 89:561-5. 2004
  6. ncbi [New relevance of vitamin D3 metabolism in the skin]
    B Lehmann
    Klinik und Poliklinik fur Dermatologie, Uniklinikum der TU Dresden, Dresden
    Hautarzt 55:446-52. 2004
  7. ncbi Extrarenal sites of calcitriol synthesis: the particular role of the skin
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Recent Results Cancer Res 164:135-45. 2003
  8. ncbi A novel pathway for hormonally active calcitriol
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    Horm Res 54:312-5. 2000
  9. ncbi UVB-induced conversion of 7-dehydrocholesterol to 1alpha,25-dihydroxyvitamin D3 in an in vitro human skin equivalent model
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Germany
    J Invest Dermatol 117:1179-85. 2001
  10. ncbi Conversion of vitamin D3 to hormonally active 1alpha,25-dihydroxyvitamin D3 in cultured keratinocytes: relevance to cell growth and differentiation
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, D 01307 Dresden, Fetscherstrasse 74, Germany
    J Steroid Biochem Mol Biol 121:322-3. 2010

Collaborators

Detail Information

Publications16

  1. ncbi UVB-induced conversion of 7-dehydrocholesterol to 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in the human keratinocyte line HaCaT
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Germany
    Photochem Photobiol 72:803-9. 2000
    ..Hence, keratinocytes may be a potential source of biologically active calcitriol within epidermis, when irradiated with therapeutical doses of UVB...
  2. ncbi Vitamin D metabolism
    Bodo Lehmann
    Department of Dermatology, Dresden University of Technology, Germany
    Dermatol Ther 23:2-12. 2010
    ..More recently, it has been found that calcitriol or vitamin D analogs have photoprotective effects and can reduce UV-induced deoxyribonucleic acid damage...
  3. ncbi Role of the vitamin D3 pathway in healthy and diseased skin--facts, contradictions and hypotheses
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    Exp Dermatol 18:97-108. 2009
    ..g. treatment of immunological, inflammatory, malignancies and infectious skin diseases) have not been intensified. Why is that?..
  4. ncbi The vitamin D3 pathway in human skin and its role for regulation of biological processes
    Bodo Lehmann
    Dresden University of Technology, Medical School Carl Gustav Carus, Department of Dermatology, D 01307 Dresden, Germany
    Photochem Photobiol 81:1246-51. 2005
    ..A better understanding of the metabolism of vitamin D in the skin opens new perspectives for therapeutic applications of vitamin D analogs...
  5. ncbi Role for tumor necrosis factor-alpha in UVB-induced conversion of 7-dehydrocholesterol to 1alpha,25-dihydroxyvitamin D3 in cultured keratinocytes
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden D 01307, Germany
    J Steroid Biochem Mol Biol 89:561-5. 2004
    ....
  6. ncbi [New relevance of vitamin D3 metabolism in the skin]
    B Lehmann
    Klinik und Poliklinik fur Dermatologie, Uniklinikum der TU Dresden, Dresden
    Hautarzt 55:446-52. 2004
    ..Further studies investigating the role of vitamin D(3) metabolism in the prevention of malignant skin disorders are needed...
  7. ncbi Extrarenal sites of calcitriol synthesis: the particular role of the skin
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Recent Results Cancer Res 164:135-45. 2003
    ..Thus, the skin is apparently the only extrarenal tissue where the complete UVB-induced pathway from 7-DHC to 1alpha,25(OH)2D3 takes place under physiological circumstances...
  8. ncbi A novel pathway for hormonally active calcitriol
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    Horm Res 54:312-5. 2000
    ..The UVB-induced formation of calcitriol in human skin is demonstrable in vivo by the microdialysis technique. These results suggest that human skin is an autonomous source of hormonally active calcitriol...
  9. ncbi UVB-induced conversion of 7-dehydrocholesterol to 1alpha,25-dihydroxyvitamin D3 in an in vitro human skin equivalent model
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Germany
    J Invest Dermatol 117:1179-85. 2001
    ..Hence, keratinocytes in the presence of physiologic concentrations of 7-dehydrocholesterol and irradiated with therapeutic doses of ultraviolet B may be a potential source of biologically active calcitriol within the epidermis...
  10. ncbi Conversion of vitamin D3 to hormonally active 1alpha,25-dihydroxyvitamin D3 in cultured keratinocytes: relevance to cell growth and differentiation
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, D 01307 Dresden, Fetscherstrasse 74, Germany
    J Steroid Biochem Mol Biol 121:322-3. 2010
    ....
  11. ncbi Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis
    B Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstr. 74, 01307 Dresden, Germany
    Arch Dermatol Res 295:24-8. 2003
    ..The link between UVB irradiation and synthesis of calcitriol in the skin may be of great importance for regulation of biological processes such as cell growth, differentiation, apoptosis and immunological reactions...
  12. ncbi Vitamins as hormones
    J Reichrath
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Horm Metab Res 39:71-84. 2007
    ..This review summarizes existing knowledge on vitamins A and D, the major vitamin-hormones of the skin...
  13. ncbi The UVB-induced synthesis of vitamin D3 and 1alpha,25-dihydroxyvitamin D3 (calcitriol) in organotypic cultures of keratinocytes: effectiveness of the narrowband Philips TL-01 lamp (311 nm)
    Bodo Lehmann
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, D 01307 Dresden, Germany
    J Steroid Biochem Mol Biol 103:682-5. 2007
    ..5 nm and 30 mJ/cm(2). Thus, the antipsoriatic effect of UVB emitted from the TL-01 lamp may, at least in part, based on the antiproliferative and prodifferentiative action of newly synthesized calcitriol on epidermal keratinocytes...
  14. ncbi Wavelength-dependent induction of CYP24A1-mRNA after UVB-triggered calcitriol synthesis in cultured human keratinocytes
    Michael Bar
    Department of Dermatology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    J Invest Dermatol 127:206-13. 2007
    ..If confirmed at protein level, these findings could have an impact on epidermal vitamin D3 metabolism and its modulation by UVB in health and disease...
  15. ncbi Vitamin D and skin: new aspects for dermatology
    Bodo Lehmann
    Department of Dermatology, Dresden University of Technology, Medical School Carl Gustav Carus, Dresden, Germany
    Exp Dermatol 13:11-5. 2004
    ..In addition, better understanding of the metabolism of vitamin D in the skin has opened up new perspectives for the therapeutic application of vitamin D analogs, e.g. in inflammatory skin diseases...
  16. ncbi Structural alterations provoked by narrow-band ultraviolet B in immortalized keratinocytes: assessment by atomic force microscopy
    Adam Reich
    Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
    Exp Dermatol 16:1007-15. 2007
    ..We hypothesize that these structural and functional alterations reflect ongoing apoptosis in UVB treated cells...