Steffi Kopprasch

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. ncbi In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Germany
    Diabetes 51:3102-6. 2002
  2. ncbi [Intravenous oxygen therapy increases the activity of the antioxidative and antiatherogenic serum enzyme paraoxonase 1]
    Steffi Kopprasch
    Medizinische Klinik 3, Pathologische Biochemie, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Forsch Komplementarmed Klass Naturheilkd 12:342-6. 2005
  3. ncbi The protective effects of HDL and its constituents against neutrophil respiratory burst activation by hypochlorite-oxidized LDL
    Steffi Kopprasch
    Department of Internal Medicine 3, Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany
    Mol Cell Biochem 258:121-7. 2004
  4. ncbi The pivotal role of scavenger receptor CD36 and phagocyte-derived oxidants in oxidized low density lipoprotein-induced adhesion to endothelial cells
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Biochem Cell Biol 36:460-71. 2004
  5. ncbi Validation of different chemilumigenic substrates for detecting extracellular generation of reactive oxygen species by phagocytes and endothelial cells
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Dresden, Germany
    Luminescence 18:268-73. 2003
  6. ncbi Lack of association between serum paraoxonase 1 activities and increased oxidized low-density lipoprotein levels in impaired glucose tolerance and newly diagnosed diabetes mellitus
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Germany
    J Clin Endocrinol Metab 88:1711-6. 2003
  7. ncbi Prediabetic and diabetic in vivo modification of circulating low-density lipoprotein attenuates its stimulatory effect on adrenal aldosterone and cortisol secretion
    Steffi Kopprasch
    Department of Internal Medicine 3, Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology Dresden, Dresden, Germany
    J Endocrinol 200:45-52. 2009
  8. ncbi Modulation of adrenal aldosterone release by oxidative modification of low-density lipoprotein
    Ishrath Ansurudeen
    Department of Internal Medicine III, University of Technology Dresden, Germany
    Am J Hypertens 23:1061-8. 2010
  9. ncbi Endothelial factors mediate aldosterone release via PKA-independent pathways
    Ishrath Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 300:66-70. 2009
  10. ncbi Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population
    Juergen Graessler
    Department of Pathological Biochemistry, Clinic of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Arthritis Rheum 54:292-300. 2006

Detail Information

Publications18

  1. ncbi In vivo evidence for increased oxidation of circulating LDL in impaired glucose tolerance
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Germany
    Diabetes 51:3102-6. 2002
    ..OxLDL increase may explain the high atherogenic potency of dyslipidemia in the prediabetic state...
  2. ncbi [Intravenous oxygen therapy increases the activity of the antioxidative and antiatherogenic serum enzyme paraoxonase 1]
    Steffi Kopprasch
    Medizinische Klinik 3, Pathologische Biochemie, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Forsch Komplementarmed Klass Naturheilkd 12:342-6. 2005
    ..The anti-atherogenic enzyme paraoxonase-1 (PON1) is is part of this system...
  3. ncbi The protective effects of HDL and its constituents against neutrophil respiratory burst activation by hypochlorite-oxidized LDL
    Steffi Kopprasch
    Department of Internal Medicine 3, Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany
    Mol Cell Biochem 258:121-7. 2004
    ..Taken together, these findings may offer new insight into atheroprotective mechanisms of HDL...
  4. ncbi The pivotal role of scavenger receptor CD36 and phagocyte-derived oxidants in oxidized low density lipoprotein-induced adhesion to endothelial cells
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Int J Biochem Cell Biol 36:460-71. 2004
    ..It is concluded that oxidized low density lipoprotein-induced respiratory burst activation of phagocytes with subsequent release of oxidants constitutes a crucial step in promoting the adhesion of phagocytes to endothelial cells...
  5. ncbi Validation of different chemilumigenic substrates for detecting extracellular generation of reactive oxygen species by phagocytes and endothelial cells
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Dresden, Germany
    Luminescence 18:268-73. 2003
    ..To get the highest CL quantum in experimental studies, we recommend optimizing the CLS depending on the cell type and the ROS-generating stimulus used...
  6. ncbi Lack of association between serum paraoxonase 1 activities and increased oxidized low-density lipoprotein levels in impaired glucose tolerance and newly diagnosed diabetes mellitus
    Steffi Kopprasch
    Department of Internal Medicine 3, Carl Gustav Carus Medical School, University of Technology Dresden, Germany
    J Clin Endocrinol Metab 88:1711-6. 2003
    ..The data suggest that 1) PON1 activity loss is an event occurring later in the course of diabetes mellitus; and 2) PON1 does not affect oxidation of circulating LDL, at least in early diabetes mellitus...
  7. ncbi Prediabetic and diabetic in vivo modification of circulating low-density lipoprotein attenuates its stimulatory effect on adrenal aldosterone and cortisol secretion
    Steffi Kopprasch
    Department of Internal Medicine 3, Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology Dresden, Dresden, Germany
    J Endocrinol 200:45-52. 2009
    ..We conclude that LDL modifications in IGT and DM2 subjects may have significant clinical benefits by counteracting prediabetic and diabetic overactivity of the renin-angiotensin-aldosterone system and enhanced cortisol generation...
  8. ncbi Modulation of adrenal aldosterone release by oxidative modification of low-density lipoprotein
    Ishrath Ansurudeen
    Department of Internal Medicine III, University of Technology Dresden, Germany
    Am J Hypertens 23:1061-8. 2010
    ..We studied the effect of hypochlorite-oxidized LDL (oxLDL) on adrenal aldosterone secretion...
  9. ncbi Endothelial factors mediate aldosterone release via PKA-independent pathways
    Ishrath Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Mol Cell Endocrinol 300:66-70. 2009
    ..These results provide evidence for the existence of a cAMP-dependent but PKA-independent pathway in mediating the ECM-induced aldosterone release and the significant influence of more than one signaling mechanism...
  10. ncbi Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population
    Juergen Graessler
    Department of Pathological Biochemistry, Clinic of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    Arthritis Rheum 54:292-300. 2006
    ..Loss-of-function mutations result in idiopathic hypouricemia. The present case-control study was designed to analyze whether hURAT1 might also be a candidate gene for hyperuricemia with primary reduced renal urate excretion...
  11. ncbi Hypochlorite-oxidized low-density lipoprotein upregulates CD36 and PPARgamma mRNA expression and modulates SR-BI gene expression in murine macrophages
    Thomas Westendorf
    Department of Internal Medicine III, Pathological Biochemistry, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany
    Mol Cell Biochem 277:143-52. 2005
    ....
  12. ncbi Type 2 diabetes in octogenarians is associated with decreased low molecular weight adiponectin
    Juergen Graessler
    Department of Internal Medicine III, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany
    Gerontology 57:316-26. 2011
    ..We examined whether adiponectin oligomer distribution is associated with aging and type 2 diabetes (T2D) in octogenarians without characteristic features of metabolic syndrome...
  13. ncbi The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells
    Claudia Goettsch
    Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technical University Medical Center, Fetscherstraße 74, D 01307 Dresden, Germany
    Endocrinology 152:4915-26. 2011
    ..Our data suggest that OSCAR, originally described in bone as immunological mediator and regulator of osteoclast differentiation, may be involved in cell activation and inflammation during atherosclerosis...
  14. ncbi Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways
    Sarama Saha
    Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University of Dresden, Fetscherstraße 74, 01307, Dresden, Germany
    Cell Tissue Res 348:71-80. 2012
    ....
  15. ncbi Endothelial cell-mediated regulation of aldosterone release from human adrenocortical cells
    Ishrath Ansurudeen
    Department of Medicine III, Carl Gustav Carus Medical School, University of Technology Dresden, 01307 Dresden, Germany
    Mol Cell Endocrinol 265:150-6. 2007
    ..In conclusion, human endothelial cells are important intra-adrenal regulators of human aldosterone synthesis and release...
  16. ncbi Association of chondromodulin-II Val58Ile polymorphism with radiographic joint destruction in rheumatoid arthritis
    Juergen Graessler
    Department of Pathological Biochemistry, Institute of Medical Informatics and Biometry, Carl Gustav Carus Medical School, University of Technology Dresden, Germany
    J Rheumatol 32:1654-61. 2005
    ..We analyzed ChM-II for polymorphisms and investigated the association with radiographically assessed joint destruction in German patients with RA. Possible interactions with the shared epitope (SE) were examined...
  17. ncbi Analysis of 3-chlorotyrosine as a specific marker of protein oxidation: the use of N(O,S)-ethoxycarbonyltrifluoroethyl ester derivatives and gas chromatography/mass spectrometry
    Jens Pietzsch
    Institute of Bioinorganic and Radiopharmaceutical Chemistry, Research Center Rossendorf Dresden, PO Box 51 01 19, 01314 Dresden, Germany
    Rapid Commun Mass Spectrom 17:767-70. 2003
    ....
  18. ncbi Aldosterone rapidly induces leukocyte adhesion to endothelial cells: a new link between aldosterone and arteriosclerosis?
    Alexander W Krug
    Hypertension 50:e156-7. 2007