Research Topics
Genomes and Genes | E StaubSummaryCountry: Germany Publications
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Publications
The DAPIN family: a novel domain links apoptotic and interferon response proteinsE Staub
metaGen Gesellschaft für Genomforschung mbH, 14195, Berlin, Germany
Trends Biochem Sci 26:83-5. 2001..Based on a secondary structure prediction, we suggest an all-alpha fold for DAPIN, which is also adopted by apoptotic protein domains of the CARD, death domain and death effector domain type...- The Spin/Ssty repeat: a new motif identified in proteins involved in vertebrate development from gamete to embryoEike Staub
metaGen Pharmaceuticals GmbH, Oudenarderstrasse 16, D 13347 Berlin, Germany
Genome Biol 3:RESEARCH0003. 2002..Thus, Spin/Ssty genes might be important in the transition from sperm cells and oocytes to the early embryo, as well as in mitosis... - The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disordersEike Staub
metaGen Pharmaceuticals GmbH, Oudenarder Strasse 16, D 13347 Berlin, Germany
Trends Biochem Sci 27:441-4. 2002..Genes encoding proteins of this family are located in genomic regions associated with epilepsy and other neurological disorders... - A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein familyEike Staub
metaGen Pharmaceuticals GmbH, Oudenarder Str 16, D 13347, Berlin, Germany
FEBS Lett 527:114-8. 2002..The phyletic distribution of CSPG repeats suggests that horizontal gene transfer contributed to their evolutionary history... - The SYSTERS Protein Family Database in 2005Thomas Meinel
Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestrasse 63-73, 14195 Berlin, Germany
Nucleic Acids Res 33:D226-9. 2005..A new access point, PhyloMatrix, allows the retrieval of phylogenetic profiles of SYSTERS families across organisms with completely sequenced genomes... - The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognitionEdvards Liepinsh
Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 17177, Stockholm, Sweden
J Mol Biol 332:1155-63. 2003.... - The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosomeYan Qin
Max Planck Institut fur Molekulare Genetik, D 14195 Berlin, Germany
Cell 127:721-33. 2006..We suggest renaming LepA as elongation factor 4 (EF4)... - Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsyJosé M Morante-Redolat
Unitat de Genetica Molecular, Institut de Biomedicina de València CSIC, Jaume Roig 11, E 46010 Valencia, Spain
Hum Mol Genet 11:1119-28. 2002..Moreover, we provide evidence for genetic heterogeneity within this disorder, since several other families with a phenotype consistent with this type of epilepsy lack mutations in the LGI1 gene... - Horizontal gene transfer in aminoacyl-tRNA synthetases including leucine-specific subtypesJuliane C Dohm
Max Planck Institute for Molecular Genetics, Department of Computational Molecular Biology, AG Protein Families and Cellular Evolution, Ihnestrasse 63-73, 14195, Berlin, Germany
J Mol Evol 63:437-47. 2006..We argue that the traditional division of life into Prokaryota (non-chimeric) and Eukaryota (chimeric) is favorable compared to Woese's trichotomy into Archaea/Bacteria/Eukaryota... - Nonribosomal peptide synthesis in Schizosaccharomyces pombe and the architectures of ferrichrome-type siderophore synthetases in fungiTorsten Schwecke
Institute of Chemistry, Technical University Berlin, Franklinstrasse 29, 10587 Berlin, Germany
Chembiochem 7:612-22. 2006..A phylogenetic analysis of both NRPSs and associated L-N5-ornithine monooxygenases revealed that ferrichrome-type siderophore biosynthesis has coevolved in fungi with varying in trans interactions of NRPS domains... - Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2Petra Seemann
Institut fur Medizinische Genetik, Charite, Universitatsmedizin Berlin, Berlin, Germany
J Clin Invest 115:2373-81. 2005..The presented experiments have identified some of the main determinants of GDF5 receptor-binding specificity in vivo and open new prospects for generating antagonists and superagonists of GDF5... - The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progressionGrit Kasper
metaGen Pharmaceuticals GmbH i L, Oudenarderstr 16, 13347 Berlin, Germany
Cancer Lett 224:93-103. 2005.... - Insights into the evolution of the nucleolus by an analysis of its protein domain repertoireEike Staub
metaGen Pharmaceuticals GmbH, Berlin, Germany
Bioessays 26:567-81. 2004..Supplementary material for this article can be found on the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html... - ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancerMarina Himmelfarb
metaGen Pharmaceuticals GmbH, Oudenarder Str 16, 13347 Berlin, Germany
Cancer Lett 204:69-77. 2004..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development... - Different structural organization of the encephalopsin gene in man and mouseGrit Kasper
metaGen Pharmaceuticals, Oudenarderstrasse 16, 13347 Berlin, Germany
Gene 295:27-32. 2002..e. the number of genes within a certain cluster may differ between man and mouse. OPN3 provides an exception to this rule, since it is positionally uncoupled from other genes of the opsin family... - About the interrelation of evolutionary rate and protein ageHannes Luz
Computational Molecular Biology Department, Max Planck Institute for Molecular Genetics, Ihnestr 73, 14195 Berlin, Germany
Genome Inform 17:240-50. 2006..We estimate time points of duplication events that gave rise to novel protein functions and show that younger proteins were duplicated more recently than older ones...