N Schupp

Summary

Country: Germany

Publications

  1. ncbi Genomic damage in chronic renal failure--potential therapeutic interventions
    Helga Stopper
    Department of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany
    J Ren Nutr 15:81-6. 2005
  2. ncbi Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro
    Ursula Schmid
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Diabetes Metab Res Rev 24:371-7. 2008
  3. ncbi AT1 receptor antagonist candesartan attenuates genomic damage in peripheral blood lymphocytes of patients on maintenance hemodialysis treatment
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, Wurzburg, Germany
    Kidney Blood Press Res 34:167-72. 2011
  4. ncbi Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients
    Nicole Schupp
    Department of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:283-91. 2008
  5. ncbi Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Atherosclerosis 199:278-87. 2008
  6. ncbi New approaches for the treatment of genomic damage in end-stage renal disease
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    J Ren Nutr 18:127-33. 2008
  7. ncbi Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists
    N Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 42:458-65. 2010
  8. ncbi Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    FASEB J 25:968-78. 2011
  9. ncbi Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Renal Physiol 292:F1427-34. 2007
  10. ncbi The relation of starch phosphorylases to starch metabolism in wheat
    Nicole Schupp
    Institute of Plant Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Plant Cell Physiol 45:1471-84. 2004

Collaborators

Detail Information

Publications22

  1. ncbi Genomic damage in chronic renal failure--potential therapeutic interventions
    Helga Stopper
    Department of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany
    J Ren Nutr 15:81-6. 2005
    ..Moreover, an improved uremic state by daily hemodialysis ameliorated the genomic damage in lymphocytes, as compared to patients on conventional hemodialysis...
  2. ncbi Benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage in vitro
    Ursula Schmid
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Diabetes Metab Res Rev 24:371-7. 2008
    ..Several mechanisms for these activities have been described. We investigated for the first time direct antioxidant abilities of benfotiamine. Additionally, a potential DNA protective effect of benfotiamine was analysed...
  3. ncbi AT1 receptor antagonist candesartan attenuates genomic damage in peripheral blood lymphocytes of patients on maintenance hemodialysis treatment
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, Wurzburg, Germany
    Kidney Blood Press Res 34:167-72. 2011
    ..In end-stage renal disease (ESRD) the incidence of genomic damage is increased. A stimulation of the renin-angiotensin system and accumulation of AGEs could be involved...
  4. ncbi Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients
    Nicole Schupp
    Department of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:283-91. 2008
    ..The second study gave a hint to the mechanism, as the antioxidative capacity of the plasma of the treated patients clearly increased, which might ameliorate the DNA damage...
  5. ncbi Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Atherosclerosis 199:278-87. 2008
    ..These effects seem to be independent of HMG-CoA reductase inhibition and involve the induction of the expression of antioxidant defense enzymes...
  6. ncbi New approaches for the treatment of genomic damage in end-stage renal disease
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    J Ren Nutr 18:127-33. 2008
    ..A major cause of DNA damage is oxidative stress, which may be induced by various uremic toxins, including advanced glycation end products (AGEs), as well as by activation of the renin-angiotensin system...
  7. ncbi Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists
    N Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Horm Metab Res 42:458-65. 2010
    ....
  8. ncbi Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, 97078 Wurzburg, Germany
    FASEB J 25:968-78. 2011
    ..Our results suggest a mutagenic potential of high mineralocorticoid levels, frequent in hypertensive individuals...
  9. ncbi Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Renal Physiol 292:F1427-34. 2007
    ..The present findings support our hypothesis that ANG II causes DNA damage via ANG II type 1 receptor binding and subsequent formation of oxidative stress...
  10. ncbi The relation of starch phosphorylases to starch metabolism in wheat
    Nicole Schupp
    Institute of Plant Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Plant Cell Physiol 45:1471-84. 2004
    ..Cytosolic phosphorylase may be involved in the processing of incoming carbohydrate during rapid tissue growth...
  11. ncbi Genotoxicity of advanced glycation end products: involvement of oxidative stress and of angiotensin II type 1 receptors
    Nicole Schupp
    Institute of Pharmacology and Toxicology, University of Wurzburg, Versbacher Strasse 9, 97078 Wurzburg, Germany
    Ann N Y Acad Sci 1043:685-95. 2005
    ..We were able to identify important participants in AGE-induced DNA damage: ROS, NF-kappaB, and Ang II, as well as modulators to prevent this DNA damage: antioxidants, DMF, and AT1 antagonists...
  12. ncbi Relation between different treatment modalities and genomic damage of end-stage renal failure patients
    K Kobras
    Institute of Pharmacology and Toxicology, , , Germany
    Kidney Blood Press Res 29:10-7. 2006
    ..The persisting high levels of DNA damage suggest a need for further improvement. Inhibiting AGE formation may be one promising way for the future...
  13. ncbi Genomic damage and circulating AGE levels in patients undergoing daily versus standard haemodialysis
    Evangelia Fragedaki
    Institute of Pharmacology and Toxicology, , Versbacherstr. 9, , Germany
    Nephrol Dial Transplant 20:1936-43. 2005
    ..Lower plasma concentrations of uraemic toxins, including circulating AGEs, may account for the differences. To confirm these data, prospective clinical trials need to be performed...
  14. ncbi Angiotensin II induces DNA damage in the kidney
    Ursula Schmid
    Institute of Pharmacology and Toxicology, University of Wurzburg, Wurzburg, Germany
    Cancer Res 68:9239-46. 2008
    ..The majority of detected strand breaks was repaired within 1 hour, but double-strand breaks increased and persisted for at least 24 hours...
  15. ncbi Genomic damage in end-stage renal failure: potential involvement of advanced glycation end products and carbonyl stress
    Helga Stopper
    Institute of Pharmacology and Toxicology, , Germany
    Semin Nephrol 24:474-8. 2004
    ..In vitro, incubation of tubulus cells with various AGEs and methylglyoxal induces DNA damage, which is suppressed by antioxidants. This underlines the role played by oxidative stress in DNA damage...
  16. ncbi Reduction of the genomic damage level in haemodialysis patients by folic acid and vitamin B12 supplementation
    Helga Stopper
    Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D 97078 Wuerzburg, Germany
    Nephrol Dial Transplant 23:3272-9. 2008
    ..The aim of this study was to analyse whether this supplementation can also lower the genomic damage in PBL of haemodialysis patients. This may ultimately help to reduce cancer incidence in renal patients...
  17. ncbi Genotoxicity of the neurotransmitter dopamine in vitro
    Helga Stopper
    Department of Toxicology, University of Wuerzburg, Versbacher Strasse 9, D 97078 Wuerzburg, Germany
    Toxicol In Vitro 23:640-6. 2009
    ....
  18. ncbi Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro
    Regina Ebert
    Musculosceletal Research Center, Orthopaedic Department, , Brettreichstrasse 11, , Germany
    Stem Cells 24:1226-35. 2006
    ..Selenite supplementation of BMSC cultures appears to be an important countermeasure to restore their antioxidative capacity and to reduce cell damage in the context of tissue engineering and transplantation procedures...
  19. ncbi Effect of different hemodialysis regimens on genomic damage in end-stage renal failure
    Nicole Schupp
    Institute of Pharmacology and Toxicology, , , Germany
    Semin Nephrol 26:28-32. 2006
    ..In the DHD patients there also was a significant decrease of the plasma concentrations of urea and the advanced glycation end products imidazolone A, carboxymethyllysine, and of advanced glycation end product-associated fluorescence...
  20. ncbi Antigenotoxic effects of the phytoestrogen pelargonidin chloride and the polyphenol chlorogenic acid
    Suresh K Abraham
    School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
    Mol Nutr Food Res 51:880-7. 2007
    ..In conclusion, the phytoestrogen PEL revealed antioxidative and antigenotoxic properties in HL-60 cells, but no significant additive interaction with the abundant nutritional polyphenol CLA under the tested conditions...
  21. ncbi Genomic damage and malignancy in end-stage renal failure: do advanced glycation end products contribute?
    Katarina Sebekova
    Department of Experimental and Clinical Pharmacotherapy, Research Base of Slovak Medical University, Bratislava, Slovakia
    Kidney Blood Press Res 30:56-66. 2007
    ..Considering the in vitro and in vivo findings to date, one has to assume a significant role of AGEs in DNA damage and the potential development of cancer...
  22. ncbi Plastidial alpha-glucan phosphorylase is not required for starch degradation in Arabidopsis leaves but has a role in the tolerance of abiotic stress
    Samuel C Zeeman
    Institute of Plant Sciences, University of Bern, CH 3013 Bern, Switzerland
    Plant Physiol 135:849-58. 2004
    ..We conclude that plastidial phosphorylase is not required for the degradation of starch, but that it plays a role in the capacity of the leaf lamina to endure a transient water deficit...