Michael Schaffer

Summary

Country: Germany

Publications

  1. ncbi Nitric oxide restores impaired healing in normoglycaemic diabetic rats
    M Schaffer
    I Department of Surgery, University Hospital, Knappschaftskrankenhaus Bochum Langendreer, Germany
    J Wound Care 16:311-6. 2007
  2. ncbi Wound fluid inhibits wound fibroblast nitric oxide synthesis
    Michael R Schäffer
    Department of Surgery, Chirurgische Universitatsklinik, Knappschaftskrankenhaus Bochum Langendreer, Bochum, Germany
    J Surg Res 122:43-8. 2004
  3. ncbi Regulation of nitric oxide synthesis in wounds by IFN-gamma depends on TNF-alpha
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Bochum Langendreer, Germany
    J Invest Surg 19:371-9. 2006
  4. ncbi MHC-class-II-deficiency impairs wound healing
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Knappschaftskrankenhaus, Bochum Langendreer, Germany
    J Surg Res 138:100-5. 2007
  5. ncbi Sirolimus impairs wound healing
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Knappschaftskrankenhaus Bochum Langendreer, In der Schornau 23 25, 44892 Bochum Langendreer, Germany
    Langenbecks Arch Surg 392:297-303. 2007
  6. ncbi [Simultaneous pancreas-kidney transplantation. Influence of donor and recipient gender]
    M Schaffer
    Knappschaftskrankenhaus Bochum Langendreer, Chirurgische Universitatsklinik, In der Schornau 23 25, 44892 Bochum, Deutschland
    Chirurg 78:928-35. 2007
  7. ncbi [Morbidity and mortality of kidney and pancreas transplantation. Analysis of 810 transplantations at one center]
    M Schaffer
    Chirurgische Universitätsklinik Bochum am Knappschaftskrankenhaus, Bochum Langendreer, Deutschland
    Dtsch Med Wochenschr 132:2318-22. 2007
  8. ncbi Differential expression of inflammatory mediators in radiation-impaired wound healing
    Michael Schaffer
    Department of Surgery, University of Tubingen, Germany
    J Surg Res 107:93-100. 2002
  9. ncbi Differential effect of tacrolimus on dermal and intestinal wound healing
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Bochum Langendreer, Germany
    J Invest Surg 18:71-9. 2005

Detail Information

Publications9

  1. ncbi Nitric oxide restores impaired healing in normoglycaemic diabetic rats
    M Schaffer
    I Department of Surgery, University Hospital, Knappschaftskrankenhaus Bochum Langendreer, Germany
    J Wound Care 16:311-6. 2007
    ..This study investigated the role of endogenous and exogenous nitric oxide on incisional wound healing in diabetic rats...
  2. ncbi Wound fluid inhibits wound fibroblast nitric oxide synthesis
    Michael R Schäffer
    Department of Surgery, Chirurgische Universitatsklinik, Knappschaftskrankenhaus Bochum Langendreer, Bochum, Germany
    J Surg Res 122:43-8. 2004
    ..Little is known about the in vivo regulation of wound fibroblast NO synthesis. We investigated the net effect of wound environment on wound fibroblast NO production and characterized a soluble factor mediating this effect...
  3. ncbi Regulation of nitric oxide synthesis in wounds by IFN-gamma depends on TNF-alpha
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Bochum Langendreer, Germany
    J Invest Surg 19:371-9. 2006
    ..Thus we conclude that IFN-gamma-deficiency impairs wound healing and diminishes NO synthesis in wound-derived macrophages. The stimulatory effect of IFN-gamma on macrophage NO production depends on endogenous TNF-alpha synthesis...
  4. ncbi MHC-class-II-deficiency impairs wound healing
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Knappschaftskrankenhaus, Bochum Langendreer, Germany
    J Surg Res 138:100-5. 2007
    ..T cell related immune functions are critical for normal wound healing. We hypothesized that MHC-II-deficiency compromises wound repair by affecting the normal wound immune response...
  5. ncbi Sirolimus impairs wound healing
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Knappschaftskrankenhaus Bochum Langendreer, In der Schornau 23 25, 44892 Bochum Langendreer, Germany
    Langenbecks Arch Surg 392:297-303. 2007
    ..We investigated the effect of sirolimus on wound healing, and we analyzed the expression of stimulating mediators of angiogenesis (VEGF, vascular endothelial growth factor) and collagen synthesis (nitric oxide) in wounds...
  6. ncbi [Simultaneous pancreas-kidney transplantation. Influence of donor and recipient gender]
    M Schaffer
    Knappschaftskrankenhaus Bochum Langendreer, Chirurgische Universitatsklinik, In der Schornau 23 25, 44892 Bochum, Deutschland
    Chirurg 78:928-35. 2007
    ..Differences in graft survival due to gender have been reported after transplantation of the kidney, liver, and heart. However, little is known about the role of donor and recipient gender in simultaneous pancreas-kidney transplantation...
  7. ncbi [Morbidity and mortality of kidney and pancreas transplantation. Analysis of 810 transplantations at one center]
    M Schaffer
    Chirurgische Universitätsklinik Bochum am Knappschaftskrankenhaus, Bochum Langendreer, Deutschland
    Dtsch Med Wochenschr 132:2318-22. 2007
    ..Simultaneous pancreas kidney transplantation (SPK) is well established in the treatment of patients with type 1 diabetes and end-stage renal disease, but despite improved surgical techniques morbidity is still high...
  8. ncbi Differential expression of inflammatory mediators in radiation-impaired wound healing
    Michael Schaffer
    Department of Surgery, University of Tubingen, Germany
    J Surg Res 107:93-100. 2002
    ..We hypothesize that there may be a down-regulation of promoting factors (nitric oxide) and, in turn, an up-regulation of healing inhibiting factors (TNF-alpha and IFN-gamma) in the wound after radiation...
  9. ncbi Differential effect of tacrolimus on dermal and intestinal wound healing
    Michael Schaffer
    Department of Surgery, Chirurgische Universitatsklinik, Bochum Langendreer, Germany
    J Invest Surg 18:71-9. 2005
    ..We concluded that tacrolimus differentially effects tissue healing and expression of cellular mediators in dermal and intestinal wounds...