Research Topics
| S G SakkaSummaryCountry: Germany Publications
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Publications
[Anesthesiological management of patients with an acute abdomen]Samir G Sakka
Klinik fur Anasthesiologie und Operative Intensivmedizin, Kliniken der Stadt Köln gGmbH, Krankenhaus Köln Merheim
Anasthesiol Intensivmed Notfallmed Schmerzther 43:734-43; quiz 744. 2008..This article gives an overview on the major aspects in the different fields in the anesthesiological management of patients with an acute abdomen...
Resuscitation of hemorrhagic shock with normal saline versus lactated Ringer's: effects on oxygenation, extravascular lung water, and hemodynamicsSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Medical Center Cologne Merheim, University of Witten Herdecke, Ostmerheimerstrasse 200, 51109 Cologne, Germany
Crit Care 13:128. 2009....
Effects of changes in blood pressure and airway pressures on parameters of fluid responsivenessSamir G Sakka
Department of Anaesthesiology and Intensive Care Medicine, University Witten Herdecke, Medical Center Cologne Merheim, Cologne, Germany
Eur J Anaesthesiol 26:322-7. 2009..In this clinical study, we analysed SPV and SVV in comparison with static preload parameters during an increase in arterial blood pressure (BP) and airway pressure...
[Intoxication with a tricyclic antidepressant]S G Sakka
Klinik fur Anasthesiologie und Operative Intensivmedizin, Krankenhaus Köln Merheim, Ostmerheimerstr 200, 51109 Köln
Anaesthesist 56:581-6. 2007..This case report questions the efficacy of hemoperfusion during acute doxepin intoxication in the given constellation of a non-life-threatening arrhythmia...
Measurement of cardiac output: a comparison between transpulmonary thermodilution and uncalibrated pulse contour analysisS G Sakka
Department of Anaesthesiology and Operative Intensive Care Medicine, Medical Center Cologne Merheim, Cologne, Germany
Br J Anaesth 99:337-42. 2007..In this clinical study, we evaluated the accuracy of this system by comparing it with the transpulmonary thermodilution technique (TPID) in septic patients...
[Case report: severe thrombocytopenia]Samir G Sakka
Klinik fur Anasthesiologie und Operative Intensivmedizin, Krankenhaus Köln Merheim
Anasthesiol Intensivmed Notfallmed Schmerzther 44:242-5. 2009..The major adverse effects of linezolid are diarrhoea, nausea, and headache. Furthermore, abnormalities in blood count, i.e. leukocytopenia, thrombocytopenia and anaemia, have been reported...
[Intrapulmonary misplacement of a central venous catheter reaching a pulmonary vein]Samir G Sakka
Klinikfür Anästhesiologie und Operative Intensivmedizin, Kliniken der Stadt Köln gGmbH, Krankenhaus Köln Merheim
Anasthesiol Intensivmed Notfallmed Schmerzther 44:96-8. 2009..Adequate antibiotic therapy led to resolution of the pneumonia, and the patient was transferred to the normal ward one week after surgery. The further course was uneventful and the patient was discharged home on day 14...
The influence of venovenous renal replacement therapy on measurements by the transpulmonary thermodilution techniqueSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, University Witten Herdecke Medical Center Cologne Merheim, Germany
Anesth Analg 105:1079-82, table of contents. 2007..Therefore, we analyzed the influence of venovenous RRT on measurement of cardiac index (CI), intrathoracic blood volume index (ITBVI), and extravascular lung water index (EVLWI)...
Positive end-expiratory pressure does not affect indocyanine green plasma disappearance rate or gastric mucosal perfusion after cardiac surgeryA Holland
Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Erlanger Allee 101, D 07747 Jena, Germany
Eur J Anaesthesiol 24:141-7. 2007..We studied whether a PEEP of 10 mbar may negatively influence flow-dependent liver function (indocyanine green plasma disappearance rate, ICG-PDR) and splanchnic microcirculation as estimated by gastric mucosal PCO2 (PRCO2)...
Does the optimization of cardiac output by fluid loading increase splanchnic blood flow?S G Sakka
Department of Anaesthesiology and Intensive Care Medicine, Friedrich-Schiller-University of Jena, Germany
Br J Anaesth 86:657-62. 2001..2 (2.7) to 3.4 (3.1) kPa. Thus, an increase in cardiac output as a result of fluid loading is not necessarily associated with an increase in splanchnic blood flow in patients with stabilized septic shock...
Variability of splanchnic blood flow in patients with sepsisS G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, 07740 Jena, Germany
Intensive Care Med 27:1281-7. 2001..1%) as well as for average values at 2-h intervals (25.6%). CONCLUSION: Stable global hemodynamics during a 4-h period in septic patients does not exclude marked changes in splanchnic blood measured by a hepatic venous catheter technique...
Influence of an acute increase in systemic vascular resistance on transpulmonary thermodilution-derived parameters in critically ill patientsJan Kozieras
Friedrich Schiller University of Jena, Department of Anesthesiology and Intensive Care Medicine, Jena, Germany
Intensive Care Med 33:1619-23. 2007..In this study, we analyzed the robustness of this technique during an acute increase in systemic vascular resistance (SVR)...
Influence of systolic-pressure-variation-guided intraoperative fluid management on organ function and oxygen transportM Buettner
Department of Anaesthesiology and Intensive Care Medicine, Hospital Worms, Germany
Br J Anaesth 101:194-9. 2008..We analysed the effects of SPV-guided intraoperative fluid management on organ function and perfusion when compared with routine care...
Influence of prone positioning on the measurement of transpulmonary thermodilution-derived variables in critically ill patientsU Brücken
Department of Anaesthesiology and Operative Intensive Care Medicine, University Hospital Witten Herdecke, Koln, Germany
Acta Anaesthesiol Scand 55:1061-7. 2011..However, it remains unclear whether the measurement of TPTD-derived variables is influenced by PP. We investigated the effects of 135° PP on the accuracy of TPTD-derived variables and their changes over an 8-10 h period of time...
Atropine test and circulatory arrest in the fossa posterior assessed by transcranial DopplerE Huttemann
Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University Jena, Germany
Intensive Care Med 26:422-5. 2000..e., increase in heart rate of less than 3% after intravenous administration of 3 mg atropine) correctly predicts circulatory arrest in the fossa posterior during craniocaudal herniation in patients with primary supratentorial lesions...
Increasing cardiac output by fluid loading: effects on indocyanine green plasma disappearance rate and splanchnic microcirculationD Hofmann
Department of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University of Jena, Jena, Germany
Acta Anaesthesiol Scand 49:1280-6. 2005..8 to 5.5 +/- 1.1 kPa and from 0.9 +/- 0.5 to 1.0 +/- 0.7 kPa, respectively. CONCLUSION: Increasing cardiac output to supranormal values by fluid loading is not associated with a significant change in ICG-PDR or gastric mucosal PRco2...
[Intra-arterial ECG leads of a positive P-wave potential during central venous catheterization]Tobias Urban
Klinik fur Anasthesiologie und Operative Intensivmedizin, Krankenhaus Merheim, Universitat Witten Herdecke
Anasthesiol Intensivmed Notfallmed Schmerzther 46:94-7. 2011..These findings emphasize the P-wave potential in the ECG feeder does not correlate with the transition from the superior vena cava to the right atrium. Consequently, this does not preclude an intra-arterial malposition...
Comparison of cardiac output and circulatory blood volumes by transpulmonary thermo-dye dilution and transcutaneous indocyanine green measurement in critically ill patientsSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
Chest 121:559-65. 2002..We prospectively studied the agreement between transpulmonary aortic fiberoptic-based and pulse dye densitometry (PDD) measurements of cardiac output and circulatory blood volumes...
Unexpected effects on arterial oxygenation during reduction in oxygen flow via a pumpless lung assist systemJ Lange
Department of General and Visceral Surgery, University Hospital of Witten Herdecke, Medical Center Cologne Merheim, Germany
Minerva Anestesiol 77:375-7. 2011..The authors describe the effect of marked increase in PaO2 in a patient with acute respiratory distress syndrome and treatment by a pumpless extracorporeal lung assist following reduction in oxygen sweep flow...
[Fulminant pulmonary artery embolism in the early postoperative phase. Use of transesophageal echocardiography in acute diagnostics]A Hohn
Klinik fur Anasthesiologie und Operative Intensivmedizin, Krankenhaus Merheim, Kliniken der Stadt Köln gGmbH, Klinikum der Privaten Universität Witten Herdecke, Ostmerheimerstrasse 200, 51109 Köln
Anaesthesist 59:812-7. 2010..Persistent life-threatening hemodynamic instability required thrombolysis with 100 mg recombinant tissue-type plasminogen activator (rt-PA). The patient survived this critical situation but sustained permanent paraparesis...
[Invasive pulmonary aspergillosis. Occurrence in a non-neutropenic female patient with abdominal sepsis]D Knüttgen
Klinik fur Anasthesiologie und Operative Intensivmedizin, Krankenhaus Merheim, Kliniken der Stadt Köln gGmbH, Lehrstuhl für Anästhesiologie II der Privaten Universität Witten Herdecke, Koln
Anaesthesist 58:262-7. 2009..However, application of caspofungin, intensive kinetic therapy (including prone position) and airway management by interventional bronchoscopy enabled successful treatment of this severe complication...
Therapeutic options for the treatment of impaired gut functionA Meier-Hellmann
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
J Am Soc Nephrol 12:S65-9. 2001..It has been suggested that dopexamine can improve splanchnic perfusion, but because these effects remain somewhat controversial, a general recommendation for dopexamine to improve gut perfusion is not justified...
Late cardiac arrhythmias after blunt chest traumaS G Sakka
Department of Anaesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Germany
Intensive Care Med 26:792-5. 2000..Case reports of two patients who developed fatal cardiac arrhythmias several days after blunt chest trauma...
Population pharmacokinetics and pharmacodynamics of continuous versus short-term infusion of imipenem-cilastatin in critically ill patients in a randomized, controlled trialSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
Antimicrob Agents Chemother 51:3304-10. 2007..Larger clinical trials are warranted for evaluation of continuous infusions at a reduced dose of imipenem for critically ill patients...
Increasing cardiac output by epinephrine after cardiac surgery: effects on indocyanine green plasma disappearance rate and splanchnic microcirculationSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
J Cardiothorac Vasc Anesth 21:351-6. 2007..The effects of increasing cardiac output by epinephrine on indocyanine green plasma disappearance rate (ICG-PDR) and gastric mucosal PCO(2) (P(R)CO(2)) were studied as indicators of splanchnic microcirculation...
Prognostic value of extravascular lung water in critically ill patientsSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Bachstrasse 18, D 07740 Jena, Germany
Chest 122:2080-6. 2002..In this study, we analyzed the prognostic value of EVLW in critically ill patients...
Prognostic value of the indocyanine green plasma disappearance rate in critically ill patientsSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
Chest 122:1715-20. 2002..In this study, we analyzed the prognostic value of the ICG-PDR in critically ill patients...
Effects of propofol vs methohexital on neutrophil function and immune status in critically ill patientsEgbert Huettemann
Department of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University, Erlanger Allee 101, D-07747 Jena, Germany
J Anesth 20:86-91. 2006..CONCLUSION: Methohexital and propofol exhibited no significant effects on neutrophil function and immune status in patients with severe brain injury requiring long-term sedation...
Relation between indocyanine green (ICG) plasma disappearance rate and ICG blood clearance in critically ill patientsSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Erlanger Allee 101, 07740, Jena, Germany
Intensive Care Med 32:766-9. 2006..In this study, we analyzed the relation between ICG disappearance rate and ICG blood clearance as parameters of liver function in critically patients...
Prognostic value of serum myoglobin in patients after cardiac surgeryDenis Hofmann
Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University of Jena, Jena, Germany
J Anesth 21:304-10. 2007..In this study, we analyzed the prognostic value of serum myoglobin in comparison to other parameters of muscle damage and renal function in patients after cardiac surgery...
Influence of extravascular lung water on transpulmonary thermodilution-derived cardiac output measurementThomas Pohl
Friedrich Schiller University of Jena, Jena, Germany
Intensive Care Med 34:533-7. 2008....
Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shockPierre Asfar
, Centre Hospitalier Universitaire, Angers, France
Crit Care 8:170-9. 2004....
Preserved CO(2) reactivity and increase in middle cerebral arterial blood flow velocity during laparoscopic surgery in childrenEgbert Huettemann
Departments of Anesthesiology and Intensive Care Medicine, Neurology, and Pediatric Surgery, Friedrich-Schiller-University Jena, Jena, Germany
Anesth Analg 94:255-8, table of contents. 2002..Cerebral blood flow velocities increase during insufflation of the intraperitoneal cavity for minimally invasive surgery in children. The vasoreactivity as part of the cerebral autoregulation remains unaffected...
High cardiac output by a continuous cardiac output pulmonary artery catheterSamir G Sakka
Department of Anesthesiology and Intensive Care Medicine, Friedrich-Schiller-University of Jena, Jena, Federal Republic of Germany
J Cardiothorac Vasc Anesth 16:780-1. 2002
Mechanical complications and malpositions of central venous cannulations by experienced operators. A prospective study of 1794 catheterizations in critically ill patientsWolfram Schummer
Friedrich Schiller University of Jena, Clinic for Anesthesiology and Intensive Care Medicine, Erlanger Allee 101, 07747 Jena, Germany
Intensive Care Med 33:1055-9. 2007..Incidence of primary mechanical complications and malpositions associated with landmark-guided central venous access procedures (CVAP) performed by experienced operators...
A persistent left superior vena cava: erroneous measurement of cardiac outputWolfram Schummer
Anesth Analg 103:1340-1. 2006
Continuous monitoring of ScvO(2) by a new fibre-optic technology compared with blood gas oximetry in critically ill patients: a multicentre studyZsolt Molnar
Department of Anaesthesia and Intensive Therapy, University of Pecs, 13 Ifjusag St, 7624, Pecs, Hungary
Intensive Care Med 33:1767-70. 2007..The aim of this study was to compare the accuracy of the CeVOX monitor measuring continuous central venous saturation (ScvO(2)) with laboratory blood gas oximetry under clinical circumstances...
