G Nickenig

Summary

Affiliation: Saarland University
Country: Germany

Publications

  1. ncbi The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, , Homburg/Saar, Germany
    Circulation 105:393-6. 2002
  2. ncbi Acute effects of ACE inhibition on coronary endothelial dysfunction
    G Nickenig
    Universitat des Saarlandes, Homburg, 66421, Germany
    J Renin Angiotensin Aldosterone Syst 1:361-4. 2000
  3. ncbi Destabilization of AT(1) receptor mRNA by calreticulin
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg, Germany
    Circ Res 90:53-8. 2002
  4. ncbi Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo
    Georg Nickenig
    Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere Medizin III, 66424 Homburg Saar, Germany
    FASEB J 16:1077-86. 2002
  5. ncbi The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, , Homburg/Saar, Germany
    Circulation 105:530-6. 2002
  6. ncbi Central role of the AT(1)-receptor in atherosclerosis
    G Nickenig
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hum Hypertens 16:S26-33. 2002
  7. ncbi Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive rats
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Circulation 103:435-41. 2001
  8. ncbi Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Mol Pharmacol 59:646-54. 2001
  9. ncbi HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Hamburg/Saar, Germany
    Hypertension 37:1450-7. 2001
  10. ncbi Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription
    U Laufs
    Medizinische Klinik und Poliklink, Universitatskliniken des Saarlandes, Homburg, Germany
    Circulation 102:3104-10. 2000

Collaborators

Detail Information

Publications55

  1. ncbi The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, , Homburg/Saar, Germany
    Circulation 105:393-6. 2002
  2. ncbi Acute effects of ACE inhibition on coronary endothelial dysfunction
    G Nickenig
    Universitat des Saarlandes, Homburg, 66421, Germany
    J Renin Angiotensin Aldosterone Syst 1:361-4. 2000
    ....
  3. ncbi Destabilization of AT(1) receptor mRNA by calreticulin
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg, Germany
    Circ Res 90:53-8. 2002
    ..These findings display a novel mechanism of posttranscriptional mRNA processing...
  4. ncbi Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo
    Georg Nickenig
    Universitatskliniken des Saarlandes, Medizinische Klinik und Poliklinik, Innere Medizin III, 66424 Homburg Saar, Germany
    FASEB J 16:1077-86. 2002
    ..These findings reveal novel mechanisms of redox-controlled cellular proliferation involving GKLF and Id3 that may have general implications for our understanding of vascular and nonvascular growth control...
  5. ncbi The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: Part II: AT(1) receptor regulation
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, , Homburg/Saar, Germany
    Circulation 105:530-6. 2002
  6. ncbi Central role of the AT(1)-receptor in atherosclerosis
    G Nickenig
    Medizinische Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hum Hypertens 16:S26-33. 2002
    ....
  7. ncbi Endothelial dysfunction and oxidative stress during estrogen deficiency in spontaneously hypertensive rats
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Circulation 103:435-41. 2001
    ..Therefore, estrogen deficiency-induced AT(1) receptor overexpression and oxidative stress may play an important role in cardiovascular diseases associated with menopause...
  8. ncbi Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Mol Pharmacol 59:646-54. 2001
    ....
  9. ncbi HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species
    S Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Hamburg/Saar, Germany
    Hypertension 37:1450-7. 2001
    ....
  10. ncbi Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription
    U Laufs
    Medizinische Klinik und Poliklink, Universitatskliniken des Saarlandes, Homburg, Germany
    Circulation 102:3104-10. 2000
    ..Withdrawal of statin treatment could suppress endothelial NO production and may impair vascular function...
  11. ncbi Beneficial effects of statins in patients with non-ischemic heart failure
    U Laufs
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, 66424 Homburg, Germany
    Z Kardiol 93:103-8. 2004
    ..HMG CoA reductase inhibitors (statins) may exert a wide array of cholesterol independent effects including antihypertrophic effects on the heart. Their role in the treatment of heart failure has not been studied...
  12. ncbi [Vascular progenitor cells and atherogenesis. Regression and regeneration using bone marrow?]
    N Werner
    Innere Medizin III (Kardiologie/Angiologie,
    Dtsch Med Wochenschr 129:1269-75. 2004
  13. ncbi Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure
    C Maack
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg, Germany
    J Am Coll Cardiol 38:939-46. 2001
    ..This study investigates the effects of a change of beta-adrenergic blocking agent treatment from metoprolol to carvedilol and vice versa in patients with heart failure (HF)...
  14. ncbi Does statin therapy influence steroid hormone synthesis?
    M Bohm
    Klinik fur Innere Medizin III, Universitatskliniken des Saarlandes, Kirrberger Strasse, 66421 Homburg, Germany
    Z Kardiol 93:43-8. 2004
    ..There was no compensatory change in FSH or LH. It is concluded that pravastatin does not alter steroid hormones or gonadotropins in a clinically applicable dose, which significantly reduces total and LDL cholesterol...
  15. ncbi Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice
    Sven Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Circulation 110:3062-7. 2004
    ..Angiotensin II type 1 (AT1) receptor activation is potentially involved in the multifactorial pathogenesis of atherosclerosis...
  16. ncbi Should angiotensin II receptor blockers and statins be combined?
    Georg Nickenig
    Department of Internal Medicine III, University Hospital of the Saarland, Homburg/Saar, Germany
    Circulation 110:1013-20. 2004
  17. ncbi Modulation of oxidant and antioxidant enzyme expression and function in vascular cells
    Sven Wassmann
    , , Homburg/Saar, Germany
    Hypertension 44:381-6. 2004
    ..This review focuses on the modulation of expression and activity of major antioxidant and oxidant enzymes expressed in vascular cells...
  18. ncbi Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    Ulrich Laufs
    Klinik fur Innere Medizin III, niversitätsklinikum des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 25:809-14. 2005
    ..The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase...
  19. ncbi Progesterone antagonizes the vasoprotective effect of estrogen on antioxidant enzyme expression and function
    Kerstin Wassmann
    Klinik fur Innere Medizin III, Universitatsklinikum des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 97:1046-54. 2005
    ..These findings may in part explain why hormone replacement therapy with estrogen plus progesterone displayed no beneficial effect on cardiovascular event rates in the prospective clinical trials...
  20. ncbi Mechanisms of increased vascular superoxide production in an experimental model of idiopathic dilated cardiomyopathy
    Hanke Mollnau
    Medizinische Klinik II, , Mainz, Germany
    Arterioscler Thromb Vasc Biol 25:2554-9. 2005
    ..CONCLUSIONS: Oxidative stress in CHF is mediated by NADPH oxidase and an uncoupled NOSIII secondary to an activation of the renin-angiotensin system leading to impaired NO downstream signaling...
  21. ncbi Pathophysiological regulation of the AT1-receptor and implications for vascular disease
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Bonn, Germany
    J Hypertens Suppl 24:S15-21. 2006
    ..Numerous studies have demonstrated that activation of the angiotensin II type 1 (AT1) receptor plays an important role in the pathogenesis of cardiovascular diseases...
  22. ncbi Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II
    Erik B Friedrich
    Klinik für Innere Medizin III Kardiologie, Angiologie, Internistische Intensivmedizin, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    Biochem Biophys Res Commun 349:883-9. 2006
    ..These data identify ILK as a novel target in VSMC for anti-atherosclerotic therapy...
  23. ncbi Improvement of endothelial function by systemic transfusion of vascular progenitor cells
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Circ Res 99:e74-83. 2006
    ..More than 1 subpopulation of the MNC fraction seems to be involved in this effect...
  24. ncbi Essential role of bone marrow fibroblast growth factor-2 in the effect of estradiol on reendothelialization and endothelial progenitor cell mobilization
    Vincent Fontaine
    INSERM U589, Institut L Bugnard, Centre Hospitalier Universitaire Rangueil, Toulouse Cedex, France
    Am J Pathol 169:1855-62. 2006
    ..In conclusion, FGF2, specifically medullary FGF2, is necessary and sufficient to mediate the accelerative effect of E2 on both reendothelialization and EPC mobilization...
  25. ncbi Differential phosphorylation of calreticulin affects AT1 receptor mRNA stability in VSMC
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Innere Medizin, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Biochem Biophys Res Commun 370:669-74. 2008
    ..These findings imply an important role of serine dephosphorylation and tyrosine phosphorylation on calreticulin mediated AT1 receptor mRNA stability...
  26. ncbi Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, D 66421 Homburg Saar, Germany
    Circ Res 94:534-41. 2004
    ..This interaction of the proinflammatory cytokine IL-6 with the renin-angiotensin system may represent an important pathogenetic mechanism in the atherosclerotic process...
  27. ncbi Identification of a novel redox-sensitive gene, Id3, which mediates angiotensin II-induced cell growth
    Cornelius Mueller
    Klinik und Poliklinik Innere Medizin III, , Homburg, Germany
    Circulation 105:2423-8. 2002
    ..Id3 governs the downstream mitogenic processing via depression of p21(WAF1/Cip1), p27(Kip1), and p53. These findings reveal a novel redox-sensitive pathway involved in growth control...
  28. ncbi Down-regulation of Rac-1 GTPase by Estrogen
    Ulrich Laufs
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, 66421 Homburg Saar, Germany
    J Biol Chem 278:5956-62. 2003
    ..Rac1 GTPase gene-transcription and activity is regulated by 17 beta-estradiol, which may be an important molecular mechanism contributing to the cardiovascular effects of estrogens...
  29. ncbi Angiotensin II type 1 receptor antagonism improves hypercholesterolemia-associated endothelial dysfunction
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1208-12. 2002
    ..Hypercholesterolemia-induced angiotensin II type 1 (AT1) receptor overexpression is thought to be a key event in the development of endothelial dysfunction...
  30. ncbi Interrelationship of free oxygen radicals and endothelial dysfunction--modulation by statins
    Sven Wassmann
    Medizinische Klinik und Poliklinik-Innere Medizin III, Universitatskliniken des Saarlandes, Homburg/Saar, Germany
    Endothelium 10:23-33. 2003
    ....
  31. ncbi Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation
    Kerstin Strehlow
    Klinik und Poliklinik Innere Medizin III, , 66421 Homburg/Saar, Germany
    Circulation 107:3059-65. 2003
    ..CONCLUSIONS: Estrogens increase numbers of EPCs by antiapoptotic effects leading to accelerated vascular repair and decreased neointima formation...
  32. ncbi Modulation of antioxidant enzyme expression and function by estrogen
    Kerstin Strehlow
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Circ Res 93:170-7. 2003
    ..Estrogen acts antioxidative at least to some extent via stimulation of MnSOD and ecSOD expression and activity, which may contribute to its vasoprotective effects...
  33. ncbi Oxygen free radical release in human failing myocardium is associated with increased activity of rac1-GTPase and represents a target for statin treatment
    Christoph Maack
    , , Homburg/Saar, Germany
    Circulation 108:1567-74. 2003
    ..Oral statin treatment inhibits myocardial rac1-GTPase activity. These data suggest that extrahepatic effects of statins can be observed in humans and may be beneficial for patients with chronic heart failure...
  34. ncbi Raloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Circulation 105:2083-91. 2002
    ..These vascular effects cause a profound blood pressure reduction and lead to decreased vascular damage in male spontaneously hypertensive rats...
  35. ncbi Pleiotropic effects of HMG-CoA reductase inhibitors
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Basic Res Cardiol 97:105-16. 2002
    ..These pleiotropic properties of statins may have important clinical implications in addition to lowering serum cholesterol...
  36. ncbi Clinical evidence for the cardiovascular benefits of angiotensin receptor blockers
    Georg Nickenig
    University of Saarland, Homburg, Germany
    J Renin Angiotensin Aldosterone Syst 7:S1-7. 2006
    ..Ongoing trials are aiming to define the place of such agents in lessening morbidity and mortality from CVD...
  37. ncbi Telmisartan inhibits beta2-integrin MAC-1 expression in human T-lymphocytes
    Andreas Link
    Klinik fur Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    J Hypertens 24:1891-8. 2006
    ..Although pro-inflammatory properties of angiotensin II as well as anti-inflammatory effects of AT1 receptor antagonists are well known, the underlying mechanisms are poorly understood...
  38. ncbi Tracking of systemically administered mononuclear cells in the ischemic brain by high-field magnetic resonance imaging
    Albrecht Stroh
    Department of Radiology, Charite Universitaetsmedizin Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Neuroimage 33:886-97. 2006
    ..Taken together, our results demonstrate that brain engraftment of systemically administered mononuclear cells can be visualized non-invasively over time and space using high-resolution MRI...
  39. ncbi Impact of HMG CoA reductase inhibition on small GTPases in the heart
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, 66421 Homburg Saar, Germany
    Cardiovasc Res 53:911-20. 2002
    ..Therefore, it was tested if these drugs inhibit Rac1 and RhoA activity in cardiomyocytes and, thereby, prevent angiotensin II-mediated expression of atrial natriuretic factor (ANF) and myosin light chain (MLC)-2 in the heart...
  40. ncbi Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells
    Sven Wassmann
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Mol Cell Cardiol 43:301-7. 2007
    ..The transcription factor GKLF induces inhibition of proliferation of VSMC which is mechanistically linked to a GKLF-induced enhancement of the expression of the tumor suppressor gene p53...
  41. ncbi Angiotensin II: one driving force behind atherogenesis
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, , Sigmund Freud Str. 25, 53105 Bonn, Germany
    Hypertension 51:175-6. 2008
  42. ncbi Cellular antioxidant effects of atorvastatin in vitro and in vivo
    Sven Wassmann
    Medizinische Klinik und Poliklinik-Innere Medizin III, , Homburg/Saar, Germany
    Arterioscler Thromb Vasc Biol 22:300-5. 2002
    ..These effects of atorvastatin may contribute to the vasoprotective effects of statins...
  43. ncbi Effect of atorvastatin 80 mg on endothelial cell function (forearm blood flow) in patients with pretreatment serum low-density lipoprotein cholesterol levels <130 mg/dl
    Sven Wassmann
    Medizinische Klinik und Poliklinik, Innere Medizin III, Universitatskliniken des Saarlandes, Homburg Saar, Germany
    Am J Cardiol 93:84-8. 2004
    ..Statin treatment improved hyperemic forearm blood flow and decreased serum markers of oxidative stress and inflammation...
  44. ncbi Regulation of antioxidant and oxidant enzymes in vascular cells and implications for vascular disease
    Sven Wassmann
    Medizinische Klinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Curr Hypertens Rep 8:69-78. 2006
    ..Identification of key enzymes and mechanisms of vascular oxidative stress is important for the development of novel, specific pharmacologic interventions...
  45. ncbi Differential antiplatelet effects of angiotensin converting enzyme inhibitors: comparison of ex vivo platelet aggregation in cardiovascular patients with ramipril, captopril and enalapril
    Dirk Skowasch
    Department of Internal Medicine II, Cardiology, Heart Center University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Clin Res Cardiol 95:212-6. 2006
    ....
  46. ncbi Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis
    Ulrich Laufs
    Medizinische Klinik und Poliklinik der Universität des Saarlandes, Innere Medizin III, Homburg, Germany
    Circulation 109:220-6. 2004
    ..Bone marrow-derived endothelial progenitor cells (EPCs) are thought to exert beneficial effects on atherosclerosis, angiogenesis, and vascular repair...
  47. ncbi Intravenous transfusion of endothelial progenitor cells reduces neointima formation after vascular injury
    Nikos Werner
    Klinik und Poliklinik, Innere Medizin III, , 66421 Homburg/Saar, Germany
    Circ Res 93:e17-24. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  48. ncbi From fat fighter to risk factor: the zigzag trek of leptin
    Nikos Werner
    Arterioscler Thromb Vasc Biol 24:7-9. 2004
  49. ncbi Vascular response to angiotensin II predicts long-term prognosis in patients undergoing coronary artery bypass grafting
    Pim van der Harst
    Department of Cardiology, University Hospital Groningen, The Netherlands
    Hypertension 44:930-4. 2004
    ..In conclusion, these results suggest that in patients undergoing CABG, a diminished vascular responsiveness of the thoracic artery to exogenous angiotensin II is related to an increased risk of future cardiovascular events...
  50. ncbi The role of the AUUUUA hexamer for the posttranscriptional regulation of the AT1 receptor mRNA stability
    Anja Berger
    Klinik und Poliklinik, Innere Medizin III, Universitat des Saarlandes, 66421 Homburg, Saarland, Germany
    Biochem Biophys Res Commun 330:805-12. 2005
    ..These findings indicate that the AUUUUA hexamer is essential for the posttranscriptional modulation of the AT1 receptor mRNA expression...
  51. ncbi AT1 receptor antagonism improves endothelial dysfunction in postmenopausal women
    Kerstin Wassmann
    , , Homburg/Saar, Germany
    Maturitas 53:176-83. 2006
    ..AT1 receptor antagonism improves vascular function in postmenopausal women without HRT. Thus, AT1 receptor blockade may resemble an efficient approach for the prevention of vascular dysfunction in estrogen-deficient women...
  52. ncbi Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition
    Nikos Werner
    Medizinische Klinik und Poliklinik, Innere Medizin III, , Homburg/Saar, Germany
    Arterioscler Thromb Vasc Biol 22:1567-72. 2002
    ..These findings may help to establish novel pathophysiological concepts and therapeutic strategies in the treatment of various cardiovascular diseases...
  53. ncbi Effect of intensive versus moderate lipid lowering on endothelial function and vascular responsiveness to angiotensin II in stable coronary artery disease
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 96:1361-4. 2005
    ..05). Endothelium improvement was accompanied by decreased vascular response to angiotensin II (p = 0.039). These findings suggest a mechanism for the clinical benefit of intensive lipid-lowering treatment in coronary heart disease...
  54. ncbi 17Beta-estradiol inhibits monocyte adhesion via down-regulation of Rac1 GTPase
    Erik B Friedrich
    Department for Internal Medicine III, University Hospital of the Saarland, 66421 Homburg/Saar, Germany
    J Mol Cell Cardiol 40:87-95. 2006
    ..These studies extend current knowledge about the mechanisms responsible for the vascular recruitment of pro-inflammatory cells, and potentially open up new avenues for the therapy of atherosclerosis...
  55. ncbi Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Circulation 117:2912-8. 2008
    ..To test this hypothesis, we investigated the effects of MRP1 inhibition and LTC(4) receptor blockade (Cys-LT1 receptor) in vitro and in vivo...