Research Topics
Species | Ralf KetterSummaryAffiliation: Saarland University Country: Germany Publications
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Detail Information
Publications
Correspondence of tumor localization with tumor recurrence and cytogenetic progression in meningiomasRalf Ketter
Department of Neurosurgery, Saarland University, Homburg Saar, Germany
Neurosurgery 62:61-9; discussion 69-70. 2008..Progression of meningiomas is associated with a non-random pattern of secondary losses of other autosomes. Deletion of the short arm of one chromosome 1 is a decisive step to anaplastic growth in meningiomas...- Application of oncogenetic trees mixtures as a biostatistical model of the clonal cytogenetic evolution of meningiomasRalf Ketter
Department of Neurosurgery, Saarland University, Homburg Saar, Germany
Int J Cancer 121:1473-80. 2007..As a quantitative measure the GPS allows a more precise assessment of the prognosis of meningiomas than categorical cytogenetic markers based on single chromosomal aberrations... - Hyperdiploidy defines a distinct cytogenetic entity of meningiomasRalf Ketter
Neurosurgical Clinic, Saarland University, Homburg Saar, Germany
J Neurooncol 83:213-21. 2007.... - Patients with high-grade gliomas harboring deletions of chromosomes 9p and 10q benefit from temozolomide treatmentSilke Wemmert
Institute of Human Genetics, Saarland University, Homburg/Saar D-66421, Germany
Neoplasia 7:883-93. 2005..This study demonstrates that molecular genetic and cytogenetic analyses potentially predict responses to chemotherapy in patients with newly diagnosed glioblastomas... - Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parametersYoo Jin Kim
School of Medicine, Institute of Neuropathology, Saarland University, Bldg 90 3, 66421 Homburg Saar, Germany
Virchows Arch 449:529-38. 2006..In particular, biologically aggressive meningiomas of histologically benign or "borderline" phenotype could be therefore identified by ALPL detection followed by 1p in situ hybridization... - Clonal cytogenetic progression within intratumorally heterogeneous meningiomas predicts tumor recurrenceSteffi Urbschat
Department of Neurosurgery, Saarland University, D 66421 Homburg Saar, Germany
Int J Oncol 39:1601-8. 2011..We were able to show that the selection of single genetically advanced cells improves the prediction of clinical meningioma progression in a more precise manner... - Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomasYoo Jin Kim
Institute of Neuropathology, Saarland University, School of Medicine, Homburg Saar, Germany
Am J Clin Pathol 128:118-25. 2007..In contrast with the Ki-67 LI, H&E MI and PHH3 MI also remained as independent predictors in the multivariate Cox hazards modeling (P = .0007 and P = .0004, respectively)... - Intratumoral genetic heterogeneity in pilocytic astrocytomas revealed by CGH-analysis of microdissected tumor cells and FISH on tumor tissue sectionsSilke Wemmert
Department of Neurosurgery, Saarland University, D-66421 Homburg/Saar, Germany
Int J Oncol 28:353-60. 2006..In conclusion, pilocytic astrocytomas show a genetic heterogeneity associated with variations of histologic structure as well as an intratumoral heterogeneity observed on single cell level by FISH... - Interstitial loss and gain of sequences on chromosome 22 in meningiomas with normal karyotypeAlexandra Prowald
Department of Neurosurgery, Neuro Oncology, Saarland University, D 66421 Homburg, Germany
Int J Oncol 26:385-93. 2005..ii) deletion of the original sequences on chromosome 22, resulting in disomy again (only visible as translocation in metaphase FISH). iii) loss of chromosome 22... - p15 promoter methylation - a novel prognostic marker in glioblastoma patientsSilke Wemmert
Department of Neurosurgery, Saarland University, D 66421 Homburg Saar, Germany
Int J Oncol 34:1743-8. 2009.... - Nasoethmoidal meningioma with cytogenetic features of tumor aggressiveness in a 16-year-old childRalf Ketter
Department of Neurosurgery, Saarland University, Homburg Saar, Germany
Pediatr Neurosurg 39:190-4. 2003..Accordingly, this juvenile meningioma may biologically correspond to a WHO grade II adult-type meningioma with an increased risk of recurrence. Therefore, we incorporated this patient into an intensified schedule of postoperative care... - Monosomy 7p in meningiomas: a rare constituent of tumor progressionWolfram Henn
Institute of Human Genetics, Saarland University, Homburg Saar, Germany
Cancer Genet Cytogenet 144:65-8. 2003..Because monosomy 7p is typically associated with the strongly progression-associated monosomy 1p, however, monosomy 7p represents a cofactor more than a stand-alone feature of meningioma progression... - Ultrasonic radio-frequency spectrum analysis differentiates normal and edematous brain tissue from meningioma intraoperativelyMartin Strowitzki
Department of Neurosurgery, Saarland University Medical School, Homburg Saar, Germany
J Neuroimaging 18:73-80. 2008..If this is also true for infiltrating tumors, the method might serve as a tool to better define tumor borders, thus improving the extent of resection... - Amplicons on chromosome 12q13-21 in glioblastoma recurrencesUlrike Fischer
Department of Human Genetics, Saarland University, 66421 Homburg Saar, Germany
Int J Cancer 126:2594-602. 2010..We recognized a significant longer survival time in glioblastoma patients that lack amplifications of either CDK4, CYP27B1, XRCC6BP1 (KUB3), or MDM2... - Prospective study of p-[123I]iodo-L-phenylalanine and SPECT for the evaluation of newly diagnosed cerebral lesions: specific confirmation of gliomaDirk Hellwig
Department of Nuclear Medicine, Saarland University Medical Center, 66421, Homburg Saar, Germany
Eur J Nucl Med Mol Imaging 37:2344-53. 2010..Recently, p-[123I]iodo-L-phenylalanine (IPA) was validated for the visualization of glioma by SPECT and received orphan drug status. Here we investigated its diagnostic performance for differentiating indeterminate brain lesions... - Intra-individual comparison of p-[123I]-iodo-L-phenylalanine and L-3-[123I]-iodo-alpha-methyl-tyrosine for SPECT imaging of gliomasDirk Hellwig
Department of Nuclear Medicine, Saarland University Medical Center, 66421, Homburg, Germany
Eur J Nucl Med Mol Imaging 35:24-31. 2008..Recently, we introduced p-[(123)I]-iodo-L-phenylalanine (IPA) for the characterisation of brain lesions. This study compares both tracers in glioma patients... - Evidence for gains at 15q and 20q in brain metastases of prostate cancerBernd Wullich
Department of Urology and Pediatric Urology, University of the Saarland, 66421 Homburg Saar, Germany
Cancer Genet Cytogenet 154:119-23. 2004..1, and Xq12 approximately q21. These findings provide new evidence for a putative role of genes at 15q and 20q in the metastatic process of prostate cancer... - Validation of brain tumour imaging with p-[123I]iodo-L-phenylalanine and SPECTDirk Hellwig
Department of Nuclear Medicine, Saarland University Medical Center, 66421 Homburg Saar, Germany
Eur J Nucl Med Mol Imaging 32:1041-9. 2005.... - First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experienceHans Christoph Bock
Department of Neurosurgery, Center of Neurological Medicine, University of Gottingen, Gottingen, Germany
Neurosurg Rev 33:441-9. 2010..Save use of a combined approach will require specific prevention strategies for multimodal treatments... - Increased seroreactivity to glioma-expressed antigen 2 in brain tumor patients under radiationSabrina M Heisel
Department of Human Genetics, Saarland University Medical School, Homburg Saar, Germany
PLoS ONE 3:e2164. 2008..Most recently, cell culture and animal studies provided the first convincing evidence that radiation not only eliminates tumor cells, but also modulates the immune response and likely improves anti-tumor immunotherapy... - Detection of Meningeosis neoplastica by real-time quantitation of telomerase activityGunter Assmann
Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Homburg, Homburg Saar, Germany
Clin Chem Lab Med 47:1271-6. 2009..Recent technical advances in the detection of TA allow for sensitive and specific detection within 4 h. Thus, the detection of TA is suitable for routine clinical testing...