Research Topics
Species | C M FreitagSummaryAffiliation: Saarland University Country: Germany Publications
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Detail Information
Publications
Imitation and language abilities in adolescents with Autism Spectrum Disorder without language delayChristine M Freitag
Dept of Child and Adolescent Psychiatry, Saarland University Hospital, 66421 Homburg, Saar, Germany
Eur Child Adolesc Psychiatry 15:282-91. 2006..It has been hypothesized that imitation abilities might be precursors of language abilities in young children with autism. No study on imitation and language abilities in adolescents with ASD has been performed to date...- The genetics of autistic disorders and its clinical relevance: a review of the literatureC M Freitag
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
Mol Psychiatry 12:2-22. 2007..Cytogenetic and molecular genetic studies will be presented in detail, and the possibly involved aetiopathological pathways will be described. Implications of the different genetic findings for genetic counselling will be mentioned... - Quantitative assessment of neuromotor function in adolescents with high functioning autism and Asperger SyndromeChristine M Freitag
Department of Child and Adolescent Psychiatry, Saarland University Hospital, 66421 Homburg Saar, Germany
J Autism Dev Disord 37:948-59. 2007..Motor impairment in children with Asperger Syndrome (AS) or High functioning autism (HFA) has been reported previously. This study presents results of a quantitative assessment of neuromotor skills in 14-22 year old HFA/AS... - Interaction of serotonergic and noradrenergic gene variants in panic disorderChristine M Freitag
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
Psychiatr Genet 16:59-65. 2006.... - [The genetics of autistic disorders]Christine M Freitag
Klinik für Kinder und Jugendpsychiatrie, Universitatsklinikum des Saarlandes, Homburg
Z Kinder Jugendpsychiatr Psychother 36:7-14; quiz 14-5. 2008..Important differential diagnoses will be described. The results of genetic studies are especially relevant with regard to genetic counselling for affected families... - Perception of biological motion in autism spectrum disordersChristine M Freitag
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
Neuropsychologia 46:1480-94. 2008.... - Behavioral comorbidity differs in subtypes of enuresis and urinary incontinenceSusanne Zink
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Saarbrucken, Saarland, Germany
J Urol 179:295-8; discussion 298. 2008..The aim of this prospective study is to describe the association of comorbid behavioral and somatic factors in children with different forms of nocturnal enuresis and daytime incontinence referred to a tertiary center... - Neuromotor development in nocturnal enuresisAlexander Von Gontard
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg Saar, Germany
Dev Med Child Neurol 48:744-50. 2006..In addition to a maturational deficit of the brainstem, it is proposed that there is a possible maturational deficit of the motor cortex circuitry and related cortical areas in children with nocturnal enuresis... - Total brain volume and corpus callosum size in medication-naïve adolescents and young adults with autism spectrum disorderChristine M Freitag
Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Biol Psychiatry 66:316-9. 2009..Similarly, studies of corpus callosum (CC) area in ASD differ with regard to inclusion criteria, age, and IQ... - Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorderChristine M Freitag
Department of Child and Adolescent Psychiatry, Johann Wolfgang Goethe Universitat, Deutschordenstrasse 50, 60528 Frankfurt am Main, Germany
Eur Child Adolesc Psychiatry 19:67-74. 2010..Findings point toward a possible mediating role of ADORA2A variants on phenotypic expression in ASD that need to be replicated in a larger sample... - Phenotypic and measurement influences on heritability estimates in childhood ADHDChristine M Freitag
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University, Deutschordenstrasse 50, Frankfurt am Main, Germany
Eur Child Adolesc Psychiatry 19:311-23. 2010.... - Association of a functional variant of neuronal nitric oxide synthase gene with self-reported impulsiveness, venturesomeness and empathy in male offendersWolfgang Retz
Neurocentre, Institute for Forensic Psychology and Psychiatry, Saarland University Hospital, Homburg, Saar, Germany
J Neural Transm 117:321-4. 2010..The findings give additional evidence that NOS-I is involved in the regulation of impulsive personality traits and support the notion that the NOS1 gene takes part in the regulation of social behavior... - Neurophysiology of nocturnal enuresis: evoked potentials and prepulse inhibition of the startle reflexChristine M Freitag
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg (Saar, Germany
Dev Med Child Neurol 48:278-84. 2006..Differences in VEP latencies might point towards functional cortical differences in children with a family history of nocturnal enuresis... - Genetics of autistic disorders: review and clinical implicationsChristine M Freitag
Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, Johann Wolfgang Goethe University, Deutschordenstrasse 50, Frankfurt am Main, Germany
Eur Child Adolesc Psychiatry 19:169-78. 2010..Implications of the different genetic findings for genetic counselling and genetic testing at present will be described. The article ends with a prospectus on future directions... - Cortisol awakening response in healthy children and children with ADHD: impact of comorbid disorders and psychosocial risk factorsChristine M Freitag
Department of Child and Adolescent Psychiatry, Saarland University Hospital, Homburg, Germany
Psychoneuroendocrinology 34:1019-28. 2009..In addition, current adverse parenting conditions, family conflicts, and acute life events were associated with mean increase in CAR, emphasizing the role of psychosocial risk factors in mediating HPA axis activity in children with ADHD... - Association of the functional V158M catechol-O-methyl-transferase polymorphism with panic disorder in womenKatharina Domschke
Department of Psychiatry, University of Munster, Germany
Int J Neuropsychopharmacol 7:183-8. 2004..Our data support a role of the 472G/A (V158M) COMT polymorphism or a nearby locus in the pathogenesis of panic disorder in women... - Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environmentAndreas Reif
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
Neuropsychopharmacology 32:2375-83. 2007..These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior... - A functional serotonin transporter promoter gene polymorphism increases ADHD symptoms in delinquents: interaction with adverse childhood environmentWolfgang Retz
Institute for Forensic Psychology and Psychiatry, University of the Saarland, Homburg Saar, Germany
Psychiatry Res 158:123-31. 2008..The results support prior findings of association between ADHD and 5-HTTLPR LL-genotype and adverse childhood environment, and they underline the need for further investigation of gene by environment interaction with respect to ADHD... - The novel brain-specific tryptophan hydroxylase-2 gene in panic disorderRainald Mossner
Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Psychopharmacol 20:547-52. 2006..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia... - Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorderYoo J Lee
Department of Psychiatry, University of Munster, Albert Schweitzer Str 11, D 48149 Munster, Germany
Neurosci Lett 377:40-3. 2005..05; T/C (rs2242446): p < 0.01). While our data do not support a major function of the NET gene in the development of panic disorder, it may play a role in the subgroup of panic disorder without agoraphobia... - A functional polymorphism in the IL-10 promoter influences the response after vaccination with HBsAg and hepatitis AThomas Höhler
Department of Internal Medicine, Johannes Gutenberg University, Mainz, Germany
Hepatology 42:72-6. 2005..In conclusion, genetic variability in the IL-10 promoter is an important modulator of the immune response against hepatitis viral antigens... - Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorderJobst Meyer
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
Int J Neuropsychopharmacol 8:495-504. 2005..Our data strongly suggest that rare variants of SLC12A6 may represent risk factors for bipolar disorder... - DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individualsAndreas J Fallgatter
Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry, University of Wurzburg, Wurzburg, Bavaria, Germany
Neuropsychopharmacology 31:2002-10. 2006..Future studies will have to address the relevance of this observation for patients with schizophrenias... - A polymorphism at the 3'-untranslated region of the CLOCK gene is associated with adult attention-deficit hyperactivity disorderChristian Kissling
Department of Psychiatry, Institute of Life Sciences, Swansea University, Swansea, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 147:333-8. 2008..This is the first study suggesting that a polymorphism of a gene within the circadian "clock" mechanism is a direct or linked contributing factor in adult ADHD...