Andre Schrattenholz

Summary

Affiliation: ProteoSys AG
Country: Germany

Publications

  1. ncbi What does it need to be a biomarker? Relationships between resolution, differential quantification and statistical validation of protein surrogate biomarkers
    Andre Schrattenholz
    ProteoSys, Mainz, Germany
    Electrophoresis 28:1970-9. 2007
  2. ncbi What does systems biology mean for drug development?
    Andre Schrattenholz
    ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany
    Curr Med Chem 15:1520-8. 2008
  3. ncbi Differential and quantitative molecular analysis of ischemia complexity reduction by isotopic labeling of proteins using a neural embryonic stem cell model
    A Schrattenholz
    ProteoSys AG, Carl Zeiss Str 51, Germany
    J Neurol Sci 229:261-7. 2005
  4. ncbi Systems biology approaches and tools for analysis of interactomes and multi-target drugs
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    Methods Mol Biol 662:29-58. 2010
  5. ncbi NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    Curr Top Med Chem 6:663-86. 2006
  6. ncbi Synchronization of posttranslational modifications during aging: Time is a crucial biological dimension
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    Ann N Y Acad Sci 1197:118-28. 2010
  7. ncbi Neuronal cell culture from human embryonic stem cells as in vitro model for neuroprotection
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    ALTEX 24:9-15. 2007
  8. ncbi Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin
    Karlfried Groebe
    ProteoSys AG, Mainz, Germany
    Reprod Toxicol 30:121-30. 2010
  9. ncbi Age-dependent posttranslational modifications of voltage-dependent anion channel 1
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Strasse 51, Mainz, Germany
    Exp Gerontol 45:632-7. 2010
  10. ncbi Neurotoxicity of active compounds--establishment of hESC-lines and proteomics technologies for human embryo- and neurotoxicity screening and biomarker identification
    Martina Klemm
    ProteoSys AG, D Mainz, Germany
    ALTEX 21:41-8. 2004

Collaborators

Detail Information

Publications21

  1. ncbi What does it need to be a biomarker? Relationships between resolution, differential quantification and statistical validation of protein surrogate biomarkers
    Andre Schrattenholz
    ProteoSys, Mainz, Germany
    Electrophoresis 28:1970-9. 2007
    ....
  2. ncbi What does systems biology mean for drug development?
    Andre Schrattenholz
    ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany
    Curr Med Chem 15:1520-8. 2008
    ....
  3. ncbi Differential and quantitative molecular analysis of ischemia complexity reduction by isotopic labeling of proteins using a neural embryonic stem cell model
    A Schrattenholz
    ProteoSys AG, Carl Zeiss Str 51, Germany
    J Neurol Sci 229:261-7. 2005
    ..Our results indicate a particular role of an isoform of the acidic calcium-independent phospholipase A2 in this type of insult...
  4. ncbi Systems biology approaches and tools for analysis of interactomes and multi-target drugs
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    Methods Mol Biol 662:29-58. 2010
    ..But the key is the extraction of relevant molecular information from biological systems by implementing rigid statistical procedures to differential proteomic analytics...
  5. ncbi NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    Curr Top Med Chem 6:663-86. 2006
    ....
  6. ncbi Synchronization of posttranslational modifications during aging: Time is a crucial biological dimension
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    Ann N Y Acad Sci 1197:118-28. 2010
    ..We also present successful examples from research on aging and discuss prerequisites and necessary considerations while moving candidates to validation...
  7. ncbi Neuronal cell culture from human embryonic stem cells as in vitro model for neuroprotection
    Andre Schrattenholz
    ProteoSys AG, Mainz, Germany
    ALTEX 24:9-15. 2007
    ..Also, the broader possibilities for refining surrogate molecular information emerging from the detailed analysis of this model are discussed...
  8. ncbi Unexpected common mechanistic pathways for embryotoxicity of warfarin and lovastatin
    Karlfried Groebe
    ProteoSys AG, Mainz, Germany
    Reprod Toxicol 30:121-30. 2010
    ..We discuss these findings observed in in vitro toxicity tests, in a context of clinical validation and evidence-based toxicology...
  9. ncbi Age-dependent posttranslational modifications of voltage-dependent anion channel 1
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Strasse 51, Mainz, Germany
    Exp Gerontol 45:632-7. 2010
    ..We show that glutamate-induced calcium toxicity in neurons induces changes of voltage-dependent anion channel 1 related to downstream events of mitochondrial apoptosis like poly-ADP-ribosylation...
  10. ncbi Neurotoxicity of active compounds--establishment of hESC-lines and proteomics technologies for human embryo- and neurotoxicity screening and biomarker identification
    Martina Klemm
    ProteoSys AG, D Mainz, Germany
    ALTEX 21:41-8. 2004
    ....
  11. ncbi A connection between the mitochondrial permeability transition pore, autophagy, and cerebral amyloidogenesis
    Vukic Soskic
    ProteoSys AG, Carl Zeiss Strasse 51, D 55129 Mainz, Germany
    J Proteome Res 7:2262-9. 2008
    ..In vivo, a surprising reduction of the beta-amyloid plaque load in a model for cerebral amyloidosis appears to connect release of neurotoxic peptides, mitochondrial apoptosis and autophagy...
  12. ncbi Differential proteomic profiling of mitochondria from Podospora anserina, rat and human reveals distinct patterns of age-related oxidative changes
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany
    Exp Gerontol 42:887-98. 2007
    ..This type of modification is discussed using the example of SAM-dependent O-methyltransferase from P. anserina (PaMTH1), which surprisingly was found to be enriched in mitochondrial preparations of senescent cultures...
  13. ncbi Protein biomarkers for in vitro testing of embryotoxicity
    Karlfried Groebe
    ProteoSys AG, Carl Zeiss Str 51, D 55129 Mainz, Germany
    J Proteome Res 9:5727-38. 2010
    ..On the other hand, Heat shock protein 8 and Fscn1 protein were down-regulated by all compounds from both clusters...
  14. ncbi Comparison of different separation technologies for proteome analyses: isoform resolution as a prerequisite for the definition of protein biomarkers on the level of posttranslational modifications
    Christian Hunzinger
    ProteoSys AG, Carl Zeiss Strasse 51, D 55129 Mainz, Germany
    J Chromatogr A 1123:170-81. 2006
    ..The evaluated methods complement one another and in connection with efficient technologies for differential and quantitative analysis, these approaches have the potential to reveal novel molecular details of protein biomarkers...
  15. ncbi Nonenzymatic posttranslational protein modifications in ageing
    Vukic Soskic
    ProteoSys AG, Mainz, Germany
    Exp Gerontol 43:247-57. 2008
    ..We include the description of a strategy to rapidly exploit the wealth of mass spectrometric information from standard MALDI-TOF peptide fingerprints for the characterisation of age-related oxidative amino acid modifications...
  16. ncbi Metabolically stable isotope labeling prior to electrophoretic protein separation reveals differences in fractional synthesis rates between mitochondrial aldehyde dehydrogenase isoforms
    Michael A Cahill
    ProteoSys AG, Carl Zeiss Strasse 51, D 55129 Mainz, Germany
    J Chromatogr A 1161:67-70. 2007
    ..The ability to quantitatively characterize different protein isoforms of biological origin for ALDH2 and other proteins from living animals provides new avenues for the exploration of protein function...
  17. ncbi Integrative proteomics: functional and molecular characterization of a particular glutamate-related neuregulin isoform
    Simone Schillo
    ProteoSys AG, Carl Zeiss Str 51, 55129 Mainz, Germany
    J Proteome Res 4:900-8. 2005
    ..Here we characterize one specific isoform of neuregulin as a central biomarker for glutamate-related signaling, integrating results from in vitro and in vivo models by a differential functional and proteomic approach...
  18. ncbi Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3
    Wojciech Wozny
    ProteoSys AG, Mainz, Germany
    Proteomics 7:313-22. 2007
    ..Local recurrent androgen ablation therapy-resistant tumours exhibit heterogenous low levels of ANXA3 staining. Results are discussed focussing on the potential implications for tumour tissues...
  19. ncbi Hexadecanedionic acid-sepharose 4B: A new tool for preparation of albumin-depleted plasma
    Vukic Soskic
    ProteoSys AG, Carl Zeiss Strasse 51, 55129 Mainz, Germany
    J Proteome Res 5:3453-8. 2006
    ..The HDA resin shows better performance in terms of specificity than dye-based resins...
  20. ncbi [Stem cell-based in vitro models as alternative methods for toxicity and efficacy tests in animals]
    M Klemm
    ProteoSys AG, Mainz, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51:1033-8. 2008
    ..reprotect.eu), employing murine and human embryonic stem cell models...
  21. ncbi Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease
    A Maelicke
    Laboratory of Molecular Neurobiology, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Medical School, Mainz, Germany
    Behav Brain Res 113:199-206. 2000
    ..The potentiating effect of APL on nicotinic neurotransmission has been shown by whole-cell patch-clamp studies in natural murine and human neurons, and in murine and human cell lines expressing various subtypes of neuronal nAChR...